ID A0A178VNS1_ARATH Unreviewed; 576 AA. AC A0A178VNS1; A0A5S9X5F0; DT 07-SEP-2016, integrated into UniProtKB/TrEMBL. DT 07-SEP-2016, sequence version 1. DT 19-JAN-2022, entry version 25. DE RecName: Full=MLO-like protein {ECO:0000256|RuleBase:RU280816}; GN Name=MLO {ECO:0000256|RuleBase:RU280816}; GN OrderedLocusNames=AXX17_At2g36100 {ECO:0000313|EMBL:OAP07466.1}; GN ORFNames=AN1_LOCUS10382 {ECO:0000313|EMBL:VYS54927.1}, GN AT9943_LOCUS8919 {ECO:0000313|EMBL:CAD5320821.1}, C24_LOCUS10226 GN {ECO:0000313|EMBL:CAA0375624.1}; OS Arabidopsis thaliana (Mouse-ear cress). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis. OX NCBI_TaxID=3702 {ECO:0000313|EMBL:OAP07466.1, ECO:0000313|Proteomes:UP000078284}; RN [1] {ECO:0000313|Proteomes:UP000078284} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Landsberg erecta {ECO:0000313|Proteomes:UP000078284}; RX PubMed=27354520; DOI=10.1073/pnas.1607532113; RA Zapata L., Ding J., Willing E.M., Hartwig B., Bezdan D., Jiao W.B., RA Patel V., Velikkakam James G., Koornneef M., Ossowski S., Schneeberger K.; RT "Chromosome-level assembly of Arabidopsis thaliana Ler reveals the extent RT of translocation and inversion polymorphisms."; RL Proc. Natl. Acad. Sci. U.S.A. 113:E4052-E4060(2016). RN [2] {ECO:0000313|EMBL:OAP07466.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC TISSUE=Leaf {ECO:0000313|EMBL:OAP07466.1}; RA Zapata L., Schneeberger K., Ossowski S.; RT "Full-length assembly of Arabidopsis thaliana Ler reveals the complement of RT translocations and inversions."; RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:CAA0375624.1, ECO:0000313|Proteomes:UP000434276} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. An-1 {ECO:0000313|Proteomes:UP000426265}, and cv. C24 RC {ECO:0000313|Proteomes:UP000434276}; RA Jiao W.-B., Schneeberger K.; RL Submitted (DEC-2019) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|EMBL:CAD5320821.1, ECO:0000313|Proteomes:UP000516314} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Cdm-0 {ECO:0000313|Proteomes:UP000516314}; RA Ashkenazy H.; RL Submitted (SEP-2020) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: May be involved in modulation of pathogen defense and leaf CC cell death. {ECO:0000256|RuleBase:RU280816}. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU280816}; Multi- CC pass membrane protein {ECO:0000256|RuleBase:RU280816}. CC -!- DOMAIN: The C-terminus contains a calmodulin-binding domain, which CC binds calmodulin in a calcium-dependent fashion. CC {ECO:0000256|RuleBase:RU280816}. CC -!- SIMILARITY: Belongs to the MLO family. {ECO:0000256|ARBA:ARBA00006574, CC ECO:0000256|RuleBase:RU280816}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CACSHJ010000088; CAA0375624.1; -; Genomic_DNA. DR EMBL; LR881467; CAD5320821.1; -; Genomic_DNA. DR EMBL; LUHQ01000002; OAP07466.1; -; Genomic_DNA. DR EMBL; CACRSJ010000105; VYS54927.1; -; Genomic_DNA. DR RefSeq; NP_565902.1; NM_129478.5. DR EnsemblPlants; AT2G39200.1; AT2G39200.1; AT2G39200. DR GeneID; 818505; -. DR Gramene; AT2G39200.1; AT2G39200.1; AT2G39200. DR KEGG; ath:AT2G39200; -. DR OMA; LIWCIAV; -. DR OrthoDB; 387177at2759; -. DR Proteomes; UP000078284; Chromosome 2. DR Proteomes; UP000426265; Unassembled WGS sequence. DR Proteomes; UP000434276; Unassembled WGS sequence. DR Proteomes; UP000516314; Chromosome 2. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule. DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW. DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW. DR GO; GO:0009607; P:response to biotic stimulus; IEA:UniProtKB-KW. DR InterPro; IPR004326; Mlo. DR PANTHER; PTHR31942; PTHR31942; 1. DR Pfam; PF03094; Mlo; 1. PE 3: Inferred from homology; KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860, KW ECO:0000256|RuleBase:RU280816}; KW Membrane {ECO:0000256|RuleBase:RU280816, ECO:0000256|SAM:Phobius}; KW Pathogenesis-related protein {ECO:0000256|ARBA:ARBA00023265, KW ECO:0000256|RuleBase:RU280816}; KW Plant defense {ECO:0000256|RuleBase:RU280816}; KW Transmembrane {ECO:0000256|RuleBase:RU280816, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|RuleBase:RU280816, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 14..37 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 58..77 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 154..175 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 279..300 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 306..325 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 363..384 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 404..427 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT REGION 450..557 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 460..478 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 484..510 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 525..549 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 576 AA; 66548 MW; 43DA9F6AED64D8E6 CRC64; MAIKERSLEE TPTWAVAVVC FVLLFISIMI EYFLHFIGHW FKKKHKKALS EALEKVKAEL MLLGFISLLL VVLQTPVSEI CIPRNIAATW HPCSNHQEIA KYGKDYIDDG RKILEDFDSN DFYSPRRNLA TKGYDKCAEK GKVALVSAYG IHQLHIFIFV LAVFHVLYCI ITYALGKTKM KKWKSWERET KTIEYQYAND PERFRFARDT SFGRRHLNIW SKSTFTLWIT CFFRQFFGSV TKVDYLTLRH GFIMAHLPAG SAARFDFQKY IERSLEQDFT VVVGISPLIW CIAVLFILTN THGWDSYLWL PFLPLIVILI VGAKLQMIIS KLGLRIQEKG DVVKGAPVVE PGDDLFWFGR PRFILFLIHL VLFTNAFQLA FFVWSTYEFT LKNCFHHKTE DIAIRITMGV LIQVLCSYIT LPLYALVTQM GTSMRPTIFN DRVANALKKW HHTAKKQTKH GHSGSNTPHS SRPTTPTHGM SPVHLLHNYN NRSLDQQTSF TASPSPPRFS DYSGQGHGHQ HFFDPESQNH SYQREITDSE FSNSHHPQVD MASPVREEKE IVEHVKVDLS EFTFKK //