ID A0A172MEF5_9SAUR Unreviewed; 345 AA. AC A0A172MEF5; DT 07-SEP-2016, integrated into UniProtKB/TrEMBL. DT 07-SEP-2016, sequence version 1. DT 16-JAN-2019, entry version 6. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 2 {ECO:0000256|RuleBase:RU003403, ECO:0000256|SAAS:SAAS00387861}; DE EC=7.1.1.2 {ECO:0000256|RuleBase:RU003403, ECO:0000256|SAAS:SAAS01109717}; GN Name=ND2 {ECO:0000313|EMBL:ANC96279.1}; OS Bavayia cyclura. OG Mitochondrion {ECO:0000313|EMBL:ANC96279.1}. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Gekkota; Pygopoidea; OC Diplodactylidae; Bavayia. OX NCBI_TaxID=143557 {ECO:0000313|EMBL:ANC96279.1}; RN [1] {ECO:0000313|EMBL:ANC96279.1} RP NUCLEOTIDE SEQUENCE. RA Skipwith P.L., Bauer A.M., Jackman T.R., Sadlier R.A.; RT "Old but not ancient: coalescent species tree of New Caledonian geckos RT reveals recent post-inundation diversification."; RL J. Biogeogr. 0:0-0(2016). CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory CC chain NADH dehydrogenase (Complex I) that is believed to belong to CC the minimal assembly required for catalysis. Complex I functions CC in the transfer of electrons from NADH to the respiratory chain. CC The immediate electron acceptor for the enzyme is believed to be CC ubiquinone. {ECO:0000256|RuleBase:RU003403, CC ECO:0000256|SAAS:SAAS00093760}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 CC H(+)(out) + NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, CC Rhea:RHEA-COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, CC ChEBI:CHEBI:17976, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; CC EC=7.1.1.2; Evidence={ECO:0000256|RuleBase:RU003403, CC ECO:0000256|SAAS:SAAS01125045}; CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane CC {ECO:0000256|RuleBase:RU003403, ECO:0000256|SAAS:SAAS00093751}; CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU003403, CC ECO:0000256|SAAS:SAAS00093751}. CC -!- SIMILARITY: Belongs to the complex I subunit 2 family. CC {ECO:0000256|RuleBase:RU003403, ECO:0000256|SAAS:SAAS00573211}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KU158041; ANC96279.1; -; Genomic_DNA. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell. DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC. DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:InterPro. DR InterPro; IPR010933; NADH_DH_su2_C. DR InterPro; IPR003917; NADH_UbQ_OxRdtase_chain2. DR InterPro; IPR001750; ND/Mrp_mem. DR Pfam; PF06444; NADH_dehy_S2_C; 1. DR Pfam; PF00361; Proton_antipo_M; 1. DR PRINTS; PR01436; NADHDHGNASE2. PE 3: Inferred from homology; KW Electron transport {ECO:0000256|RuleBase:RU003403, KW ECO:0000256|SAAS:SAAS00464461}; KW Membrane {ECO:0000256|RuleBase:RU003403, KW ECO:0000256|SAAS:SAAS00093718}; KW Mitochondrion {ECO:0000256|RuleBase:RU003403, KW ECO:0000256|SAAS:SAAS00464403, ECO:0000313|EMBL:ANC96279.1}; KW Mitochondrion inner membrane {ECO:0000256|RuleBase:RU003403, KW ECO:0000256|SAAS:SAAS00464436}; KW NAD {ECO:0000256|RuleBase:RU003403, ECO:0000256|SAAS:SAAS00093707}; KW Respiratory chain {ECO:0000256|RuleBase:RU003403, KW ECO:0000256|SAAS:SAAS00093685}; KW Translocase {ECO:0000256|RuleBase:RU003403, KW ECO:0000256|SAAS:SAAS01109684}; KW Transmembrane {ECO:0000256|RuleBase:RU003403, KW ECO:0000256|SAAS:SAAS00093696}; KW Transmembrane helix {ECO:0000256|RuleBase:RU003403, KW ECO:0000256|SAAS:SAAS00464584}; KW Transport {ECO:0000256|SAAS:SAAS00093687}; KW Ubiquinone {ECO:0000256|RuleBase:RU003403, KW ECO:0000256|SAAS:SAAS00093675}. FT TRANSMEM 56 75 Helical. {ECO:0000256|RuleBase:RU003403}. FT TRANSMEM 95 115 Helical. {ECO:0000256|RuleBase:RU003403}. FT TRANSMEM 152 171 Helical. {ECO:0000256|RuleBase:RU003403}. FT TRANSMEM 202 221 Helical. {ECO:0000256|RuleBase:RU003403}. FT TRANSMEM 233 254 Helical. {ECO:0000256|RuleBase:RU003403}. FT TRANSMEM 274 294 Helical. {ECO:0000256|RuleBase:RU003403}. FT TRANSMEM 324 342 Helical. {ECO:0000256|RuleBase:RU003403}. FT DOMAIN 23 285 Proton_antipo_M. {ECO:0000259|Pfam: FT PF00361}. FT DOMAIN 290 342 NADH_dehy_S2_C. {ECO:0000259|Pfam: FT PF06444}. SQ SEQUENCE 345 AA; 38033 MW; 3153D7D7428AC6E6 CRC64; MNPATLTLLY LSMILGTIIT MTSSHWILAW AGLEMNTLAI IPIISKQHHP RATEAATKYF LIQATASAVI LFASSLNAWK TGQWNIYYTP SPESIILLTL AIAMKLGLAP LHFWLPEVLQ GSPLLTTAII STWQKLAPTT ILYMIMDNLN QHTLMILGLT SAVLGGWMGL NQTQTRKIMA FSSIAHMGWV FMALAIDPNL TLLTLSIYLL LTMAMFTSLM TTTSKTLLDL GTAWPQTPTL LSITMLTLVS LGGLPPLTGF MPKWLILKEL ITNNLSTIST LMALSTLPSL FFYIRMSHMT SLTLPPETTS TGHKWRFKLN QAPATTPIIL ASLLLPLTPL IMNFC //