ID   A0A161HS39_9EUGL        Unreviewed;       517 AA.
AC   A0A161HS39;
DT   06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT   06-JUL-2016, sequence version 1.
DT   28-FEB-2018, entry version 5.
DE   SubName: Full=5-aminolevulinate synthase {ECO:0000313|EMBL:ANB27657.1};
OS   Perkinsela sp. SMB-60.
OC   Eukaryota; Euglenozoa; Kinetoplastida; Perkinsela.
OX   NCBI_TaxID=1840652 {ECO:0000313|EMBL:ANB27657.1};
RN   [1] {ECO:0000313|EMBL:ANB27657.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=SMB-60 {ECO:0000313|EMBL:ANB27657.1};
RX   PubMed=27193376; DOI=10.1186/s12862-016-0664-6;
RA   Cenci U., Moog D., Curtis B.A., Tanifuji G., Eme L., Lukes J.,
RA   Archibald J.M.;
RT   "Heme pathway evolution in kinetoplastid protists.";
RL   BMC Evol. Biol. 16:109-109(2016).
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|RuleBase:RU003693};
CC   -!- SIMILARITY: Belongs to the class-II pyridoxal-phosphate-dependent
CC       aminotransferase family. {ECO:0000256|RuleBase:RU003693}.
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DR   EMBL; KU609011; ANB27657.1; -; mRNA.
DR   GO; GO:0003870; F:5-aminolevulinate synthase activity; IEA:InterPro.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0033014; P:tetrapyrrole biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.640.10; -; 1.
DR   Gene3D; 3.90.1150.10; -; 2.
DR   InterPro; IPR010961; 4pyrrol_synth_NH2levulA_synth.
DR   InterPro; IPR001917; Aminotrans_II_pyridoxalP_BS.
DR   InterPro; IPR004839; Aminotransferase_I/II.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_dom1.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   Pfam; PF00155; Aminotran_1_2; 1.
DR   SUPFAM; SSF53383; SSF53383; 1.
DR   TIGRFAMs; TIGR01821; 5aminolev_synth; 1.
DR   PROSITE; PS00599; AA_TRANSFER_CLASS_2; 1.
PE   2: Evidence at transcript level;
KW   Pyridoxal phosphate {ECO:0000256|RuleBase:RU003693}.
FT   DOMAIN      133    483       Aminotran_1_2. {ECO:0000259|Pfam:
FT                                PF00155}.
SQ   SEQUENCE   517 AA;  56588 MW;  EFC376E929C39D48 CRC64;
     MSLPNNVMSR FAQPKRAALL NFTSQVMHKS TQKPKGKACK QIPKTSKRKP IGEQMASPPV
     QCPYHHLHTP ITPSVTVIPS RQPVASPSYD QFFENYVQQI KTEGRYRVFT EVSRQERRHP
     RITWHAPNGK EKPVTVWCSN DYVCMSQHPA VVRAARNSLS THGVGAGGTR NISGNSHSIA
     ALEKDIAQWH GKAQGLVFSS GYVANEAALS ALGSILPETV FISDEENHAS MIMGMMHARG
     ASRKIWKHNN VEHLRELLIQ TRLNHPNASV VIAFESVYSM SGTIAPVREI VDLAKQFNAL
     TYVDEVHAVG LYGHTGTGLC ESLGLAGSID IIMGTLGKAV GVFGGYIASS STIVDALRCR
     APGFIFTTAL PPMIADAARK SIAVLAGDEG RGHRARFNAA HNYMKKLFVE NGLPIHPGES
     HILPLLVLDS TLCKRASDLL LNTHGHYVQP INYPTVPQGR ERLRITPGAK HTKKMCDSLL
     EAVLSVWKAL GLPLHHSYVA ANPYGRCPVM LSSRKLP
//