ID A0A158SIU0_HUMAN Unreviewed; 2002 AA. AC A0A158SIU0; DT 08-JUN-2016, integrated into UniProtKB/TrEMBL. DT 08-JUN-2016, sequence version 1. DT 07-JUN-2017, entry version 9. DE SubName: Full=Tet oncogene family member 2 {ECO:0000313|EMBL:CAX30492.1}; GN Name=TET2 {ECO:0000313|EMBL:CAX30492.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:CAX30492.1}; RN [1] {ECO:0000313|EMBL:CAX30492.1} RP NUCLEOTIDE SEQUENCE. RA Madupu R., Sebastian Y., Durkin A.S., Torralba M., Methe B., RA Sutton G.G., Strausberg R.L., Nelson K.E.; RL Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:CAX30492.1} RP NUCLEOTIDE SEQUENCE. RA Delhommeau F., Dupont S., DellaValle V., James C., Trannoy S., RA Masse A., Kosmider O., Le Couedic J.P., Robert F., Alberdi A., RA Lecluse Y., Plo I., Dreyfus F.J., Marzac C., Casadevall N., RA Lacombe C., Romana S.P., Dessen P., Soulier J., Viguie F., RA Fontenay M., Vainchenker W., Bernard O.A.; RT "TET2 is a tumor suppressor gene inactivated in myeloid RT malignancies."; RL Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; FM992369; CAX30492.1; -; mRNA. DR RefSeq; NP_001120680.1; NM_001127208.2. DR RefSeq; XP_005263139.1; XM_005263082.2. DR UniGene; Hs.367639; -. DR UniGene; Hs.706276; -. DR ProteinModelPortal; A0A158SIU0; -. DR SMR; A0A158SIU0; -. DR GeneID; 54790; -. DR KEGG; hsa:54790; -. DR CTD; 54790; -. DR PhylomeDB; A0A158SIU0; -. DR ExpressionAtlas; A0A158SIU0; baseline and differential. DR GO; GO:0070579; F:methylcytosine dioxygenase activity; IEA:Ensembl. DR GO; GO:0019857; P:5-methylcytosine metabolic process; IEA:Ensembl. DR GO; GO:0019858; P:cytosine metabolic process; IEA:Ensembl. DR GO; GO:0080111; P:DNA demethylation; IEA:Ensembl. DR GO; GO:0061484; P:hematopoietic stem cell homeostasis; IEA:Ensembl. DR GO; GO:0020027; P:hemoglobin metabolic process; IEA:Ensembl. DR GO; GO:0080182; P:histone H3-K4 trimethylation; IEA:Ensembl. DR GO; GO:0001822; P:kidney development; IEA:Ensembl. DR GO; GO:0072576; P:liver morphogenesis; IEA:Ensembl. DR GO; GO:0030099; P:myeloid cell differentiation; IEA:Ensembl. DR GO; GO:0002318; P:myeloid progenitor cell differentiation; IEA:Ensembl. DR GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl. DR GO; GO:0009791; P:post-embryonic development; IEA:Ensembl. DR GO; GO:0006493; P:protein O-linked glycosylation; IEA:Ensembl. DR GO; GO:0014070; P:response to organic cyclic compound; IEA:Ensembl. DR GO; GO:0048536; P:spleen development; IEA:Ensembl. DR Gene3D; 2.130.10.10; -; 1. DR InterPro; IPR024779; 2OGFeDO_noxygenase_dom. DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom. DR Pfam; PF12851; Tet_JBP; 1. DR SMART; SM01333; Tet_JBP; 1. PE 2: Evidence at transcript level; FT DOMAIN 1290 1905 Tet_JBP. {ECO:0000259|SMART:SM01333}. SQ SEQUENCE 2002 AA; 223811 MW; 6D740305EE2A8D46 CRC64; MEQDRTNHVE GNRLSPFLIP SPPICQTEPL ATKLQNGSPL PERAHPEVNG DTKWHSFKSY YGIPCMKGSQ NSRVSPDFTQ ESRGYSKCLQ NGGIKRTVSE PSLSGLLQIK KLKQDQKANG ERRNFGVSQE RNPGESSQPN VSDLSDKKES VSSVAQENAV KDFTSFSTHN CSGPENPELQ ILNEQEGKSA NYHDKNIVLL KNKAVLMPNG ATVSASSVEH THGELLEKTL SQYYPDCVSI AVQKTTSHIN AINSQATNEL SCEITHPSHT SGQINSAQTS NSELPPKPAA VVSEACDADD ADNASKLAAM LNTCSFQKPE QLQQQKSVFE ICPSPAENNI QGTTKLASGE EFCSGSSSNL QAPGGSSERY LKQNEMNGAY FKQSSVFTKD SFSATTTPPP PSQLLLSPPP PLPQVPQLPS EGKSTLNGGV LEEHHHYPNQ SNTTLLREVK IEGKPEAPPS QSPNPSTHVC SPSPMLSERP QNNCVNRNDI QTAGTMTVPL CSEKTRPMSE HLKHNPPIFG SSGELQDNCQ QLMRNKEQEI LKGRDKEQTR DLVPPTQHYL KPGWIELKAP RFHQAESHLK RNEASLPSIL QYQPNLSNQM TSKQYTGNSN MPGGLPRQAY TQKTTQLEHK SQMYQVEMNQ GQSQGTVDQH LQFQKPSHQV HFSKTDHLPK AHVQSLCGTR FHFQQRADSQ TEKLMSPVLK QHLNQQASET EPFSNSHLLQ HKPHKQAAQT QPSQSSHLPQ NQQQQQKLQI KNKEEILQTF PHPQSNNDQQ REGSFFGQTK VEECFHGENQ YSKSSEFETH NVQMGLEEVQ NINRRNSPYS QTMKSSACKI QVSCSNNTHL VSENKEQTTH PELFAGNKTQ NLHHMQYFPN NVIPKQDLLH RCFQEQEQKS QQASVLQGYK NRNQDMSGQQ AAQLAQQRYL IHNHANVFPV PDQGGSHTQT PPQKDTQKHA ALRWHLLQKQ EQQQTQQPQT ESCHSQMHRP IKVEPGCKPH ACMHTAPPEN KTWKKVTKQE NPPASCDNVQ QKSIIETMEQ HLKQFHAKSL FDHKALTLKS QKQVKVEMSG PVTVLTRQTT AAELDSHTPA LEQQTTSSEK TPTKRTAASV LNNFIESPSK LLDTPIKNLL DTPVKTQYDF PSCRCVEQII EKDEGPFYTH LGAGPNVAAI REIMEERFGQ KGKAIRIERV IYTGKEGKSS QGCPIAKWVV RRSSSEEKLL CLVRERAGHT CEAAVIVILI LVWEGIPLSL ADKLYSELTE TLRKYGTLTN RRCALNEERT CACQGLDPET CGASFSFGCS WSMYYNGCKF ARSKIPRKFK LLGDDPKEEE KLESHLQNLS TLMAPTYKKL APDAYNNQIE YEHRAPECRL GLKEGRPFSG VTACLDFCAH AHRDLHNMQN GSTLVCTLTR EDNREFGGKP EDEQLHVLPL YKVSDVDEFG SVEAQEEKKR SGAIQVLSSF RRKVRMLAEP VKTCRQRKLE AKKAAAEKLS SLENSSNKNE KEKSAPSRTK QTENASQAKQ LAELLRLSGP VMQQSQQPQP LQKQPPQPQQ QQRPQQQQPH HPQTESVNSY SASGSTNPYM RRPNPVSPYP NSSHTSDIYG STSPMNFYST SSQAAGSYLN SSNPMNPYPG LLNQNTQYPS YQCNGNLSVD NCSPYLGSYS PQSQPMDLYR YPSQDPLSKL SLPPIHTLYQ PRFGNSQSFT SKYLGYGNQN MQGDGFSSCT IRPNVHHVGK LPPYPTHEMD GHFMGATSRL PPNLSNPNMD YKNGEHHSPS HIIHNYSAAP GMFNSSLHAL HLQNKENDML SHTANGLSKM LPALNHDRTA CVQGGLHKLS DANGQEKQPL ALVQGVASGA EDNDEVWSDS EQSFLDPDIG GVAVAPTHGS ILIECAKREL HATTPLKNPN RNHPTRISLV FYQHKSMNEP KHGLALWEAK MAEKAREKEE ECEKYGPDYV PQKSHGKKVK REPAEPHETS EPTYLRFIKS LAERTMSVTT DSTVTTSPYA FTRVTGPYNR YI //