ID A0A151L5X0_PLARE Unreviewed; 815 AA. AC A0A151L5X0; DT 08-JUN-2016, integrated into UniProtKB/TrEMBL. DT 08-JUN-2016, sequence version 1. DT 06-JUL-2016, entry version 2. DE RecName: Full=Phosphodiesterase {ECO:0000256|RuleBase:RU363067}; DE EC=3.1.4.- {ECO:0000256|RuleBase:RU363067}; GN ORFNames=PRSY57_1469700 {ECO:0000313|EMBL:KYN94355.1}; OS Plasmodium reichenowi. OC Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; OC Plasmodiidae; Plasmodium; Plasmodium (Laverania). OX NCBI_TaxID=5854 {ECO:0000313|EMBL:KYN94355.1, ECO:0000313|Proteomes:UP000076359}; RN [1] {ECO:0000313|EMBL:KYN94355.1, ECO:0000313|Proteomes:UP000076359} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=SY57 {ECO:0000313|EMBL:KYN94355.1, RC ECO:0000313|Proteomes:UP000076359}; RX PubMed=27002652; DOI=10.1038/ncomms11078; RA Sundararaman S.A., Plenderleith L.J., Liu W., Loy D.E., Learn G.H., RA Li Y., Shaw K.S., Ayouba A., Peeters M., Speede S., Shaw G.M., RA Bushman F.D., Brisson D., Rayner J.C., Sharp P.M., Hahn B.H.; RT "Genomes of cryptic chimpanzee Plasmodium species reveal key RT evolutionary events leading to human malaria."; RL Nat. Commun. 7:11078-11078(2016). CC -!- COFACTOR: CC Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; CC Evidence={ECO:0000256|RuleBase:RU363067}; CC Note=Binds 2 divalent metal cations per subunit. Site 1 may CC preferentially bind zinc ions, while site 2 has a preference for CC magnesium and/or manganese ions. {ECO:0000256|RuleBase:RU363067}; CC -!- SIMILARITY: Belongs to the cyclic nucleotide phosphodiesterase CC family. {ECO:0000256|RuleBase:RU363067, CC ECO:0000256|SAAS:SAAS00540521}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:KYN94355.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; LVLA01000015; KYN94355.1; -; Genomic_DNA. DR Proteomes; UP000076359; Unassembled WGS sequence. DR Gene3D; 1.10.1300.10; -; 2. DR InterPro; IPR023088; PDEase. DR InterPro; IPR002073; PDEase_catalytic_dom. DR InterPro; IPR023174; PDEase_CS. DR Pfam; PF00233; PDEase_I; 1. DR PRINTS; PR00387; PDIESTERASE1. DR PROSITE; PS00126; PDEASE_I; 1. PE 3: Inferred from homology; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000076359}; KW Hydrolase {ECO:0000256|RuleBase:RU363067, KW ECO:0000256|SAAS:SAAS00540518}; Membrane {ECO:0000256|SAM:Phobius}; KW Metal-binding {ECO:0000256|RuleBase:RU363067, KW ECO:0000256|SAAS:SAAS00540563}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 56 77 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 89 111 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 123 141 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 162 181 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 187 204 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 216 235 Helical. {ECO:0000256|SAM:Phobius}. FT COILED 1 29 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 815 AA; 97114 MW; 566E0C2B95341676 CRC64; MNEYNNDNME QEKEKKKEEE KYKNIIKKEY FIFPRLYDKN KEIEYNKLRI HNIKEYICIH LTISLFIILI ECFVFSFNLN IKDTTYVEIC VVIFSILNCL MHIVVLIKMY FFTSESVYTK GVFIGYIVLN QVFQFLSLYF FTKRNEQNKN DIAHLKYYDN SFNLYVHFFV DSVFILCLPT LSFCLSVLFV MMFLCLNILL INMIKFNKIS YGGDIYYIGL LSVVLLMFFI LRYMMEERNR LLFFFLKDMM FDNYKKWYCD YIGAHYDKDK DSTTVNGENN RYEKEKCEDY KFLFFNKCIL FHDFTMNACY KDYYSMICFL NKLLKSCNIK GDMVSNTSVN INGDTYQNMN CHDNISSNIP KNYNSFYEEL EKNLNESDIL TIAYEVEVLK NIKKINCDEI GKNWDYSFID SEYGKSTLVI LEVGYHLISP YIENNENKKK KLQLFLLLIN SMYFPNPYHN ANHGATVCHL SKCLAHITDY DSYLNNTYMI CYLIASIAHD VGHPGKTNSY LSETNHILSI RYNDMSILEN YHCSITFSIL QLIGFDFLIN NEDTKLVEKN NYTNMRKFII ELIISTDMKL HFEYVDIFKK RKKSQNFDIS DTDAINLGTI NIKLADIGHT CLKWKDHAKW TMLVSEEFFS QKRVEELHKN KNIDPLNFSN FGREDNIDEG MIFNYENIYI NYINNINNIN TYDYSYIKLN FIHHHDFVKS IPSTQVYFFE IIVMPLIKEL QSMEKSKKEI TQKVLHNLNI NLQTWRLIEN NINLFYNTEK MTGTDYYKNL EKQKLLRGIR LLDIAEEDVI SLTKNFKEEI KHAKS //