ID A0A143PXH5_9BACT Unreviewed; 125 AA. AC A0A143PXH5; DT 08-JUN-2016, integrated into UniProtKB/TrEMBL. DT 08-JUN-2016, sequence version 1. DT 18-JUL-2018, entry version 17. DE RecName: Full=Ribonuclease VapC {ECO:0000256|HAMAP-Rule:MF_00265}; DE Short=RNase VapC {ECO:0000256|HAMAP-Rule:MF_00265}; DE EC=3.1.-.- {ECO:0000256|HAMAP-Rule:MF_00265}; DE AltName: Full=Toxin VapC {ECO:0000256|HAMAP-Rule:MF_00265}; GN Name=vapC {ECO:0000256|HAMAP-Rule:MF_00265}; GN ORFNames=LuPra_06157 {ECO:0000313|EMBL:AMY12873.1}; OS Luteitalea pratensis. OC Bacteria; Acidobacteria; Acidobacteria subdivision 6; OC Vicinamibacteraceae; Luteitalea. OX NCBI_TaxID=1855912 {ECO:0000313|EMBL:AMY12873.1, ECO:0000313|Proteomes:UP000076079}; RN [1] {ECO:0000313|Proteomes:UP000076079} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=DSM 100886 HEG_-6_39 {ECO:0000313|Proteomes:UP000076079}; RA Huang S., Vieira S., Bunk B., Riedel T., Sproeer C., Overmann J.; RT "First Complete Genome Sequence of a Subdivision 6 Acidobacterium."; RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Toxic component of a toxin-antitoxin (TA) system. An CC RNase. {ECO:0000256|HAMAP-Rule:MF_00265}. CC -!- COFACTOR: CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|HAMAP- CC Rule:MF_00265, ECO:0000256|SAAS:SAAS00608033}; CC -!- SIMILARITY: Belongs to the PINc/VapC protein family. CC {ECO:0000256|HAMAP-Rule:MF_00265, ECO:0000256|SAAS:SAAS00541436}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP015136; AMY12873.1; -; Genomic_DNA. DR EnsemblBacteria; AMY12873; AMY12873; LuPra_06157. DR KEGG; abac:LuPra_06157; -. DR Proteomes; UP000076079; Chromosome. DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule. DR GO; GO:0004540; F:ribonuclease activity; IEA:InterPro. DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW. DR HAMAP; MF_00265; VapC_Nob1; 1. DR InterPro; IPR029060; PIN-like_dom_sf. DR InterPro; IPR002716; PIN_dom. DR InterPro; IPR022907; VapC_family. DR Pfam; PF01850; PIN; 1. DR SUPFAM; SSF88723; SSF88723; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000076079}; KW Hydrolase {ECO:0000256|HAMAP-Rule:MF_00265, KW ECO:0000256|SAAS:SAAS00019787}; KW Magnesium {ECO:0000256|HAMAP-Rule:MF_00265, KW ECO:0000256|SAAS:SAAS00541414}; KW Metal-binding {ECO:0000256|HAMAP-Rule:MF_00265, KW ECO:0000256|SAAS:SAAS00019946}; KW Nuclease {ECO:0000256|HAMAP-Rule:MF_00265, KW ECO:0000256|SAAS:SAAS00019885}; KW Reference proteome {ECO:0000313|Proteomes:UP000076079}; KW Toxin {ECO:0000256|HAMAP-Rule:MF_00265}; KW Toxin-antitoxin system {ECO:0000256|HAMAP-Rule:MF_00265, KW ECO:0000256|SAAS:SAAS00986330}. FT DOMAIN 7 118 PINc. {ECO:0000259|Pfam:PF01850}. FT METAL 8 8 Magnesium. {ECO:0000256|HAMAP-Rule: FT MF_00265}. FT METAL 93 93 Magnesium. {ECO:0000256|HAMAP-Rule: FT MF_00265}. SQ SEQUENCE 125 AA; 13145 MW; 9335D9AE119A7407 CRC64; MTTPVHLDTS FLVRSVCPEN VEAASLLEWL EQGRPVMISA MVWAEFLCGP LTDGQRTLAM QVVGEPVAVG GREAELAARL YNTSGRRRGS LADCLIAAAA IEGGAPLATA DNSFARFADA GLLLA //