ID A0A142AHG6_9CALI Unreviewed; 249 AA. AC A0A142AHG6; DT 08-JUN-2016, integrated into UniProtKB/TrEMBL. DT 08-JUN-2016, sequence version 1. DT 14-DEC-2022, entry version 18. DE SubName: Full=RNA-dependent RNA polymerase protein {ECO:0000313|EMBL:AMO28409.1}; DE Flags: Fragment; OS Norovirus GII. OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; OC Picornavirales; Caliciviridae; Norovirus. OX NCBI_TaxID=122929 {ECO:0000313|EMBL:AMO28409.1}; RN [1] {ECO:0000313|EMBL:AMO28409.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Norovirus GII/Hu/KR/2015/GII.P21_GII.21/20150321_GL02BLP3 RC {ECO:0000313|EMBL:AMO28409.1}; RA Koo E.S., Kim M.S., Choi Y.S., Jeong Y.S.; RT "Occurrence of the Novel Human Norovirus in Coastal Stream Water of South RT Korea, 2015."; RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Viral genome-linked protein is covalently linked to the 5'- CC end of the positive-strand, negative-strand genomic RNAs and subgenomic CC RNA. Acts as a genome-linked replication primer. May recruit ribosome CC to viral RNA thereby promoting viral proteins translation. CC {ECO:0000256|ARBA:ARBA00025359}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KU687031; AMO28409.1; -; Genomic_RNA. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0004386; F:helicase activity; IEA:InterPro. DR GO; GO:0003723; F:RNA binding; IEA:InterPro. DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW. DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro. DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro. DR Gene3D; 3.30.70.270; -; 1. DR InterPro; IPR043502; DNA/RNA_pol_sf. DR InterPro; IPR004004; Helic/Pol/Pept_Calicivir-typ. DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase. DR InterPro; IPR001205; RNA-dir_pol_C. DR InterPro; IPR007094; RNA-dir_pol_PSvirus. DR Pfam; PF00680; RdRP_1; 1. DR PRINTS; PR00918; CALICVIRUSNS. DR SUPFAM; SSF56672; DNA/RNA polymerases; 1. DR PROSITE; PS50507; RDRP_SSRNA_POS; 1. PE 4: Predicted; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}; KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695}; KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484, KW ECO:0000313|EMBL:AMO28409.1}; Transferase {ECO:0000256|ARBA:ARBA00022679}; KW Viral RNA replication {ECO:0000256|ARBA:ARBA00022953}. FT DOMAIN 1..96 FT /note="RdRp catalytic" FT /evidence="ECO:0000259|PROSITE:PS50507" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:AMO28409.1" SQ SEQUENCE 249 AA; 28018 MW; 66574712731CA476 CRC64; MVKFSPEPHL AQVVAEDLLS PSVMDVGDFK ISINEGLPSG VPCTSQWNSI AHWLLTLCAL SEVTDLSPDI IQANSLFSFY GDDEIVSTDI KLDPEKLTVK LKEYGLKPTR PDKTEGPLII SEDLDGLTFL RRTVTRDPAG WFGKLDQSSI LRQMYWTRGP NHEDPSETMI PHSQRPIQLM SLLGEAALHG PSFYSKISKL VISELKEGGM DFYVPRQEPM FRWMRFSDLS TWEGDRNLAP SFVNEDGVE //