ID A0A140LIV0_MOUSE Unreviewed; 152 AA. AC A0A140LIV0; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 27-NOV-2024, entry version 41. DE RecName: Full=Troponin I, cardiac muscle {ECO:0000256|ARBA:ARBA00018910}; DE Flags: Fragment; GN Name=Tnni3 {ECO:0000313|Ensembl:ENSMUSP00000146966.2, GN ECO:0000313|MGI:MGI:98783}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000146966.2, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000146966.2, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000146966.2, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RG Mouse Genome Sequencing Consortium; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0007829|PubMed:21183079} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and expression."; RL Cell 143:1174-1189(2010). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000146966.2} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000146966.2}; RX PubMed=21750661; RA Church D.M., Schneider V.A., Graves T., Auger K., Cunningham F., Bouk N., RA Chen H.C., Agarwala R., McLaren W.M., Ritchie G.R., Albracht D., RA Kremitzki M., Rock S., Kotkiewicz H., Kremitzki C., Wollam A., Trani L., RA Fulton L., Fulton R., Matthews L., Whitehead S., Chow W., Torrance J., RA Dunn M., Harden G., Threadgold G., Wood J., Collins J., Heath P., RA Griffiths G., Pelan S., Grafham D., Eichler E.E., Weinstock G., RA Mardis E.R., Wilson R.K., Howe K., Flicek P., Hubbard T.; RT "Modernizing reference genome assemblies."; RL PLoS Biol. 9:e1001091-e1001091(2011). RN [4] {ECO:0000313|Ensembl:ENSMUSP00000146966.2} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000146966.2}; RG Ensembl; RL Submitted (AUG-2024) to UniProtKB. CC -!- FUNCTION: Troponin I is the inhibitory subunit of troponin, the thin CC filament regulatory complex which confers calcium-sensitivity to CC striated muscle actomyosin ATPase activity. CC {ECO:0000256|ARBA:ARBA00001988}. CC -!- SIMILARITY: Belongs to the troponin I family. CC {ECO:0000256|ARBA:ARBA00009930}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR AlphaFoldDB; A0A140LIV0; -. DR SMR; A0A140LIV0; -. DR Antibodypedia; 4354; 2592 antibodies from 52 providers. DR Ensembl; ENSMUST00000209148.2; ENSMUSP00000146966.2; ENSMUSG00000035458.16. DR AGR; MGI:98783; -. DR MGI; MGI:98783; Tnni3. DR VEuPathDB; HostDB:ENSMUSG00000035458; -. DR GeneTree; ENSGT01030000234588; -. DR ChiTaRS; Tnni3; mouse. DR Proteomes; UP000000589; Chromosome 7. DR Bgee; ENSMUSG00000035458; Expressed in myocardium and 114 other cell types or tissues. DR ExpressionAtlas; A0A140LIV0; baseline and differential. DR GO; GO:0005861; C:troponin complex; IEA:InterPro. DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW. DR Gene3D; 1.20.5.350; -; 1. DR InterPro; IPR001978; Troponin. DR InterPro; IPR050875; Troponin_I. DR InterPro; IPR038077; Troponin_sf. DR PANTHER; PTHR13738; TROPONIN I; 1. DR PANTHER; PTHR13738:SF2; TROPONIN I, CARDIAC MUSCLE; 1. DR Pfam; PF00992; Troponin; 1. DR SUPFAM; SSF90250; Troponin coil-coiled subunits; 1. PE 1: Evidence at protein level; KW Actin-binding {ECO:0000256|ARBA:ARBA00023203}; KW Muscle protein {ECO:0000256|ARBA:ARBA00023179}; KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A140LIV0, KW ECO:0007829|ProteomicsDB:A0A140LIV0}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}. FT REGION 69..88 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 152 FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000146966.2" SQ SEQUENCE 152 AA; 16527 MW; 6BD7B387C585362B CRC64; MADEYVNLRS LGVETSTGRG AVGLEGATRL DTCPERVGGK GGWISVEMRS SDAVSCELRS GVGNLRSRVG AAGRGLGTSG QGNLPLEKKS KISASRKLQL KTLMLQIAKQ EMEREAEERR GEKGRVLRTR CQPLELDGLG FEELQDLCRQ LH //