ID A0A140LHN1_MOUSE Unreviewed; 423 AA. AC A0A140LHN1; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 12-OCT-2022, entry version 39. DE SubName: Full=Neuregulin 1 {ECO:0000313|Ensembl:ENSMUSP00000146478}; GN Name=Nrg1 {ECO:0000313|Ensembl:ENSMUSP00000146478, GN ECO:0000313|MGI:MGI:96083}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000146478, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000146478, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000146478, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000146478} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000146478}; RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single- CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}. Secreted CC {ECO:0000256|ARBA:ARBA00004613}. CC -!- SIMILARITY: Belongs to the neuregulin family. CC {ECO:0000256|ARBA:ARBA00008216}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR ProteomicsDB; 357096; -. DR Antibodypedia; 3706; 987 antibodies from 44 providers. DR Ensembl; ENSMUST00000208598.2; ENSMUSP00000146478.2; ENSMUSG00000062991.10. DR MGI; MGI:96083; Nrg1. DR VEuPathDB; HostDB:ENSMUSG00000062991; -. DR GeneTree; ENSGT00940000157326; -. DR ChiTaRS; Nrg1; mouse. DR Proteomes; UP000000589; Chromosome 8. DR Bgee; ENSMUSG00000062991; Expressed in pia mater and 169 other tissues. DR ExpressionAtlas; A0A140LHN1; baseline and differential. DR GO; GO:0016324; C:apical plasma membrane; ISO:MGI. DR GO; GO:0030424; C:axon; IDA:MGI. DR GO; GO:0005737; C:cytoplasm; IDA:MGI. DR GO; GO:0005615; C:extracellular space; ISO:MGI. DR GO; GO:0098982; C:GABA-ergic synapse; IDA:SynGO. DR GO; GO:0098978; C:glutamatergic synapse; IDA:SynGO. DR GO; GO:0005887; C:integral component of plasma membrane; IDA:MGI. DR GO; GO:0099061; C:integral component of postsynaptic density membrane; ISO:MGI. DR GO; GO:0099059; C:integral component of presynaptic active zone membrane; ISO:MGI. DR GO; GO:0031594; C:neuromuscular junction; IDA:MGI. DR GO; GO:0005654; C:nucleoplasm; ISO:MGI. DR GO; GO:0005886; C:plasma membrane; IDA:MGI. DR GO; GO:0045202; C:synapse; IDA:MGI. DR GO; GO:0045499; F:chemorepellent activity; IDA:MGI. DR GO; GO:0005176; F:ErbB-2 class receptor binding; IDA:MGI. DR GO; GO:0043125; F:ErbB-3 class receptor binding; ISO:MGI. DR GO; GO:0008083; F:growth factor activity; ISO:MGI. DR GO; GO:0005178; F:integrin binding; ISO:MGI. DR GO; GO:0030296; F:protein tyrosine kinase activator activity; ISO:MGI. DR GO; GO:0048018; F:receptor ligand activity; IDA:MGI. DR GO; GO:0030971; F:receptor tyrosine kinase binding; ISO:MGI. DR GO; GO:0005102; F:signaling receptor binding; ISO:MGI. DR GO; GO:0003712; F:transcription coregulator activity; ISO:MGI. DR GO; GO:0032148; P:activation of protein kinase B activity; ISO:MGI. DR GO; GO:0007171; P:activation of transmembrane receptor protein tyrosine kinase activity; ISO:MGI. DR GO; GO:0048513; P:animal organ development; IBA:GO_Central. DR GO; GO:0003161; P:cardiac conduction system development; IDA:MGI. DR GO; GO:0060379; P:cardiac muscle cell myoblast differentiation; ISO:MGI. DR GO; GO:0048738; P:cardiac muscle tissue development; IDA:MGI. DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central. DR GO; GO:0000902; P:cell morphogenesis; IDA:MGI. DR GO; GO:0008283; P:cell population proliferation; ISO:MGI. DR GO; GO:0021842; P:chemorepulsion involved in interneuron migration from the subpallium to the cortex; IMP:MGI. DR GO; GO:0060956; P:endocardial cell differentiation; ISO:MGI. DR GO; GO:0038127; P:ERBB signaling pathway; ISO:MGI. DR GO; GO:0038133; P:ERBB2-ERBB3 signaling pathway; ISO:MGI. DR GO; GO:0038135; P:ERBB2-ERBB4 signaling pathway; ISO:MGI. DR GO; GO:0038129; P:ERBB3 signaling pathway; ISO:MGI. DR GO; GO:0038130; P:ERBB4 signaling pathway; IDA:MGI. DR GO; GO:0038138; P:ERBB4-ERBB4 signaling pathway; ISO:MGI. DR GO; GO:0010001; P:glial cell differentiation; IMP:MGI. DR GO; GO:0021781; P:glial cell fate commitment; IDA:MGI. DR GO; GO:0007507; P:heart development; IMP:MGI. DR GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central. DR GO; GO:0007626; P:locomotory behavior; IMP:MGI. DR GO; GO:0000165; P:MAPK cascade; IDA:MGI. DR GO; GO:0007613; P:memory; ISO:MGI. DR GO; GO:0007517; P:muscle organ development; IMP:MGI. DR GO; GO:0022011; P:myelination in peripheral nervous system; IMP:MGI. DR GO; GO:0010667; P:negative regulation of cardiac muscle cell apoptotic process; ISO:MGI. DR GO; GO:2000853; P:negative regulation of corticosterone secretion; ISO:MGI. DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; ISO:MGI. DR GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; ISO:MGI. DR GO; GO:2001223; P:negative regulation of neuron migration; IDA:MGI. DR GO; GO:0042177; P:negative regulation of protein catabolic process; IDA:MGI. DR GO; GO:0051048; P:negative regulation of secretion; ISO:MGI. DR GO; GO:0007399; P:nervous system development; IMP:MGI. DR GO; GO:0048663; P:neuron fate commitment; IMP:MGI. DR GO; GO:0001764; P:neuron migration; IGI:MGI. DR GO; GO:0045213; P:neurotransmitter receptor metabolic process; IMP:MGI. DR GO; GO:0048709; P:oligodendrocyte differentiation; IMP:MGI. DR GO; GO:0007422; P:peripheral nervous system development; IMP:MGI. DR GO; GO:0048680; P:positive regulation of axon regeneration; ISO:MGI. DR GO; GO:0070886; P:positive regulation of calcineurin-NFAT signaling cascade; IGI:MGI. DR GO; GO:0060045; P:positive regulation of cardiac muscle cell proliferation; ISO:MGI. DR GO; GO:0045785; P:positive regulation of cell adhesion; ISO:MGI. DR GO; GO:0030307; P:positive regulation of cell growth; ISO:MGI. DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:MGI. DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISO:MGI. DR GO; GO:0010628; P:positive regulation of gene expression; IDA:MGI. DR GO; GO:0010976; P:positive regulation of neuron projection development; ISO:MGI. DR GO; GO:1900086; P:positive regulation of peptidyl-tyrosine autophosphorylation; ISO:MGI. DR GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IDA:MGI. DR GO; GO:0045860; P:positive regulation of protein kinase activity; IDA:MGI. DR GO; GO:0051897; P:positive regulation of protein kinase B signaling; IDA:MGI. DR GO; GO:0031334; P:positive regulation of protein-containing complex assembly; ISO:MGI. DR GO; GO:0046579; P:positive regulation of Ras protein signal transduction; IDA:MGI. DR GO; GO:0010625; P:positive regulation of Schwann cell proliferation; ISO:MGI. DR GO; GO:0099527; P:postsynapse to nucleus signaling pathway; IDA:SynGO. DR GO; GO:0030163; P:protein catabolic process; IDA:MGI. DR GO; GO:0043491; P:protein kinase B signaling; IDA:MGI. DR GO; GO:0032984; P:protein-containing complex disassembly; ISO:MGI. DR GO; GO:0045595; P:regulation of cell differentiation; IMP:MGI. DR GO; GO:0099149; P:regulation of postsynaptic neurotransmitter receptor internalization; ISO:MGI. DR GO; GO:0014037; P:Schwann cell differentiation; IMP:MGI. DR GO; GO:0007416; P:synapse assembly; IDA:SynGO. DR GO; GO:0099560; P:synaptic membrane adhesion; ISO:MGI. DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; ISO:MGI. DR GO; GO:0055012; P:ventricular cardiac muscle cell differentiation; ISO:MGI. DR GO; GO:0003222; P:ventricular trabecula myocardium morphogenesis; ISO:MGI. DR GO; GO:0042060; P:wound healing; ISO:MGI. DR Gene3D; 2.60.40.10; -; 1. DR InterPro; IPR000742; EGF-like_dom. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR013098; Ig_I-set. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR040180; Neuregulin. DR InterPro; IPR002154; Neuregulin_C. DR InterPro; IPR018250; NRG1. DR PANTHER; PTHR11100; PTHR11100; 1. DR PANTHER; PTHR11100:SF25; PTHR11100:SF25; 1. DR Pfam; PF00008; EGF; 1. DR Pfam; PF07679; I-set; 1. DR Pfam; PF02158; Neuregulin; 1. DR PRINTS; PR01089; NEUREGULIN. DR SMART; SM00181; EGF; 1. DR SMART; SM00409; IG; 1. DR SMART; SM00408; IGc2; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR PROSITE; PS00022; EGF_1; 1. DR PROSITE; PS01186; EGF_2; 1. DR PROSITE; PS50026; EGF_3; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 1: Evidence at protein level; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE- KW ProRule:PRU00076}; KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE- KW ProRule:PRU00076}; Growth factor {ECO:0000256|ARBA:ARBA00023030}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0007829|MaxQB:A0A140LHN1}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 243..264 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 37..128 FT /note="Ig-like" FT /evidence="ECO:0000259|PROSITE:PS50835" FT DOMAIN 178..222 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT REGION 1..52 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 138..175 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 335..359 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 375..423 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 403..423 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT DISULFID 212..221 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076" SQ SEQUENCE 423 AA; 46576 MW; 2AA34373111BF5F8 CRC64; MSERKEGRGK GKGKKKDRGS RGKPAPAEGD PSPALPPRLK EMKSQESAAG SKLVLRCETS SEYSSLRFKW FKNGNELNRR NKPQNVKIQK KPGKSELRIN KASLADSGEY MCKVISKLGN DSASANITIV ESNDLTTGMS ASTERPYVSS ESPIRISVST EGANTSSSTS TSTTGTSHLI KCAEKEKTFC VNGGECFMVK DLSNPSRYLC KCQPGFTGAR CTENVPMKVQ TQEKAEELYQ KRVLTITGIC IALLVVGIMC VVAYCKTKKQ RQKLHDRLRQ SLRSERNNMV NIANGPHHPN PPPENVQLVN QYVSKNVISS EHIVEREVET SFSTSHYTST AHHSTTVTQT PSHSWSNGHT ESIISESHSV IMMSSVENSR HSSPAGGPRG RLHGLGGPRE CNSFLRHARE TPDSYRDSPH SER //