ID A0A140LHN1_MOUSE Unreviewed; 423 AA. AC A0A140LHN1; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 05-JUN-2019, entry version 23. DE SubName: Full=Neuregulin 1 {ECO:0000313|Ensembl:ENSMUSP00000146478}; GN Name=Nrg1 {ECO:0000313|Ensembl:ENSMUSP00000146478, GN ECO:0000313|MGI:MGI:96083}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000146478}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000146478, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000146478, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000146478} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000146478}; RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC113586; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC127369; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC127374; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC132256; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC132407; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC133091; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC134895; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC136147; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR SMR; A0A140LHN1; -. DR Ensembl; ENSMUST00000208598; ENSMUSP00000146478; ENSMUSG00000062991. DR MGI; MGI:96083; Nrg1. DR GeneTree; ENSGT00940000157326; -. DR Proteomes; UP000000589; Chromosome 8. DR ExpressionAtlas; A0A140LHN1; baseline and differential. DR GO; GO:0030424; C:axon; IDA:MGI. DR GO; GO:0005737; C:cytoplasm; IDA:MGI. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0098982; C:GABA-ergic synapse; IDA:SynGO. DR GO; GO:0098978; C:glutamatergic synapse; IDA:SynGO. DR GO; GO:0005887; C:integral component of plasma membrane; IDA:MGI. DR GO; GO:0031594; C:neuromuscular junction; IDA:MGI. DR GO; GO:0005886; C:plasma membrane; IDA:MGI. DR GO; GO:0045202; C:synapse; IDA:MGI. DR GO; GO:0045499; F:chemorepellent activity; IDA:MGI. DR GO; GO:0005176; F:ErbB-2 class receptor binding; IDA:MGI. DR GO; GO:0030296; F:protein tyrosine kinase activator activity; IBA:GO_Central. DR GO; GO:0030971; F:receptor tyrosine kinase binding; ISO:MGI. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0003712; F:transcription coregulator activity; ISO:MGI. DR GO; GO:0007171; P:activation of transmembrane receptor protein tyrosine kinase activity; IBA:GO_Central. DR GO; GO:0003161; P:cardiac conduction system development; IDA:MGI. DR GO; GO:0048738; P:cardiac muscle tissue development; IDA:MGI. DR GO; GO:0016477; P:cell migration; IGI:MGI. DR GO; GO:0000902; P:cell morphogenesis; IDA:MGI. DR GO; GO:0043624; P:cellular protein complex disassembly; ISO:MGI. DR GO; GO:0021842; P:chemorepulsion involved in interneuron migration from the subpallium to the cortex; IMP:MGI. DR GO; GO:0010001; P:glial cell differentiation; IMP:MGI. DR GO; GO:0021781; P:glial cell fate commitment; IDA:MGI. DR GO; GO:0007507; P:heart development; IMP:MGI. DR GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central. DR GO; GO:0007626; P:locomotory behavior; IMP:MGI. DR GO; GO:0000165; P:MAPK cascade; IDA:MGI. DR GO; GO:0007517; P:muscle organ development; IMP:MGI. DR GO; GO:0022011; P:myelination in peripheral nervous system; IMP:MGI. DR GO; GO:2001223; P:negative regulation of neuron migration; IDA:MGI. DR GO; GO:0042177; P:negative regulation of protein catabolic process; IDA:MGI. DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISO:MGI. DR GO; GO:0007399; P:nervous system development; IMP:MGI. DR GO; GO:0048663; P:neuron fate commitment; IMP:MGI. DR GO; GO:0045213; P:neurotransmitter receptor metabolic process; IMP:MGI. DR GO; GO:0048709; P:oligodendrocyte differentiation; IMP:MGI. DR GO; GO:0007422; P:peripheral nervous system development; IMP:MGI. DR GO; GO:0070886; P:positive regulation of calcineurin-NFAT signaling cascade; IGI:MGI. DR GO; GO:0010628; P:positive regulation of gene expression; IDA:MGI. DR GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IDA:MGI. DR GO; GO:0045860; P:positive regulation of protein kinase activity; IDA:MGI. DR GO; GO:0051897; P:positive regulation of protein kinase B signaling; IDA:MGI. DR GO; GO:0046579; P:positive regulation of Ras protein signal transduction; IDA:MGI. DR GO; GO:0099527; P:postsynapse to nucleus signaling pathway; IDA:SynGO. DR GO; GO:0045595; P:regulation of cell differentiation; IMP:MGI. DR GO; GO:0007416; P:synapse assembly; IDA:SynGO. DR Gene3D; 2.60.40.10; -; 1. DR InterPro; IPR013032; EGF-like_CS. DR InterPro; IPR000742; EGF-like_dom. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR013098; Ig_I-set. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR040180; Neuregulin. DR InterPro; IPR002154; Neuregulin_C. DR InterPro; IPR018250; NRG1. DR PANTHER; PTHR11100; PTHR11100; 1. DR PANTHER; PTHR11100:SF7; PTHR11100:SF7; 1. DR Pfam; PF00008; EGF; 1. DR Pfam; PF07679; I-set; 1. DR Pfam; PF02158; Neuregulin; 1. DR PRINTS; PR01089; NEUREGULIN. DR SMART; SM00181; EGF; 1. DR SMART; SM00409; IG; 1. DR SMART; SM00408; IGc2; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR PROSITE; PS00022; EGF_1; 1. DR PROSITE; PS01186; EGF_2; 1. DR PROSITE; PS50026; EGF_3; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076}; KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|MaxQB:A0A140LHN1}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 243 264 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 37 128 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 178 222 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT REGION 1 52 Disordered. {ECO:0000256|MobiDB-lite: FT A0A140LHN1}. FT REGION 138 175 Disordered. {ECO:0000256|MobiDB-lite: FT A0A140LHN1}. FT REGION 335 359 Disordered. {ECO:0000256|MobiDB-lite: FT A0A140LHN1}. FT REGION 375 423 Disordered. {ECO:0000256|MobiDB-lite: FT A0A140LHN1}. FT COMPBIAS 403 423 Polyampholyte. {ECO:0000256|MobiDB-lite: FT A0A140LHN1}. FT DISULFID 212 221 {ECO:0000256|PROSITE-ProRule:PRU00076}. SQ SEQUENCE 423 AA; 46576 MW; 2AA34373111BF5F8 CRC64; MSERKEGRGK GKGKKKDRGS RGKPAPAEGD PSPALPPRLK EMKSQESAAG SKLVLRCETS SEYSSLRFKW FKNGNELNRR NKPQNVKIQK KPGKSELRIN KASLADSGEY MCKVISKLGN DSASANITIV ESNDLTTGMS ASTERPYVSS ESPIRISVST EGANTSSSTS TSTTGTSHLI KCAEKEKTFC VNGGECFMVK DLSNPSRYLC KCQPGFTGAR CTENVPMKVQ TQEKAEELYQ KRVLTITGIC IALLVVGIMC VVAYCKTKKQ RQKLHDRLRQ SLRSERNNMV NIANGPHHPN PPPENVQLVN QYVSKNVISS EHIVEREVET SFSTSHYTST AHHSTTVTQT PSHSWSNGHT ESIISESHSV IMMSSVENSR HSSPAGGPRG RLHGLGGPRE CNSFLRHARE TPDSYRDSPH SER //