ID A0A140LHN1_MOUSE Unreviewed; 423 AA. AC A0A140LHN1; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 10-OCT-2018, entry version 18. DE SubName: Full=Neuregulin 1 {ECO:0000313|Ensembl:ENSMUSP00000146478}; GN Name=Nrg1 {ECO:0000313|Ensembl:ENSMUSP00000146478, GN ECO:0000313|MGI:MGI:96083}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000146478}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000146478, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000146478, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000146478} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000146478}; RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC113586; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC127369; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC127374; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC132256; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC132407; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC133091; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC134895; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC136147; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSMUST00000208598; ENSMUSP00000146478; ENSMUSG00000062991. DR MGI; MGI:96083; Nrg1. DR GeneTree; ENSGT00900000140940; -. DR Reactome; R-MMU-1227986; Signaling by ERBB2. DR Reactome; R-MMU-1236394; Signaling by ERBB4. DR Reactome; R-MMU-1250196; SHC1 events in ERBB2 signaling. DR Reactome; R-MMU-1250342; PI3K events in ERBB4 signaling. DR Reactome; R-MMU-1250347; SHC1 events in ERBB4 signaling. DR Reactome; R-MMU-1257604; PIP3 activates AKT signaling. DR Reactome; R-MMU-1306955; GRB7 events in ERBB2 signaling. DR Reactome; R-MMU-1358803; Downregulation of ERBB2:ERBB3 signaling. DR Reactome; R-MMU-1963640; GRB2 events in ERBB2 signaling. DR Reactome; R-MMU-1963642; PI3K events in ERBB2 signaling. DR Reactome; R-MMU-5673001; RAF/MAP kinase cascade. DR Reactome; R-MMU-6785631; ERBB2 Regulates Cell Motility. DR Reactome; R-MMU-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling. DR Reactome; R-MMU-8847993; ERBB2 Activates PTK6 Signaling. DR Reactome; R-MMU-8863795; Downregulation of ERBB2 signaling. DR Proteomes; UP000000589; Chromosome 8. DR ExpressionAtlas; A0A140LHN1; baseline and differential. DR GO; GO:0030673; C:axolemma; IDA:MGI. DR GO; GO:0030424; C:axon; IDA:MGI. DR GO; GO:0044297; C:cell body; IDA:MGI. DR GO; GO:0005737; C:cytoplasm; IDA:MGI. DR GO; GO:0030425; C:dendrite; IDA:MGI. DR GO; GO:0009897; C:external side of plasma membrane; IDA:MGI. DR GO; GO:0005576; C:extracellular region; IDA:MGI. DR GO; GO:0005887; C:integral component of plasma membrane; IDA:MGI. DR GO; GO:0031594; C:neuromuscular junction; IDA:MGI. DR GO; GO:0005634; C:nucleus; IDA:MGI. DR GO; GO:0005886; C:plasma membrane; IDA:MGI. DR GO; GO:0045202; C:synapse; IDA:MGI. DR GO; GO:0045499; F:chemorepellent activity; IDA:MGI. DR GO; GO:0005176; F:ErbB-2 class receptor binding; IDA:MGI. DR GO; GO:0030971; F:receptor tyrosine kinase binding; ISO:MGI. DR GO; GO:0003712; F:transcription coregulator activity; ISO:MGI. DR GO; GO:0008366; P:axon ensheathment; IMP:MGI. DR GO; GO:0007420; P:brain development; IMP:MGI. DR GO; GO:0003161; P:cardiac conduction system development; IDA:MGI. DR GO; GO:0048738; P:cardiac muscle tissue development; IDA:MGI. DR GO; GO:0016477; P:cell migration; IGI:MGI. DR GO; GO:0000902; P:cell morphogenesis; IDA:MGI. DR GO; GO:0043624; P:cellular protein complex disassembly; ISO:MGI. DR GO; GO:0021842; P:chemorepulsion involved in interneuron migration from the subpallium to the cortex; IMP:MGI. DR GO; GO:0009790; P:embryo development; IEA:InterPro. DR GO; GO:0010001; P:glial cell differentiation; IMP:MGI. DR GO; GO:0021781; P:glial cell fate commitment; IDA:MGI. DR GO; GO:0007507; P:heart development; IMP:MGI. DR GO; GO:0007626; P:locomotory behavior; IMP:MGI. DR GO; GO:0000165; P:MAPK cascade; IDA:MGI. DR GO; GO:0007517; P:muscle organ development; IMP:MGI. DR GO; GO:2001223; P:negative regulation of neuron migration; IDA:MGI. DR GO; GO:0042177; P:negative regulation of protein catabolic process; IDA:MGI. DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISO:MGI. DR GO; GO:0007399; P:nervous system development; IMP:MGI. DR GO; GO:0022008; P:neurogenesis; IMP:MGI. DR GO; GO:0048663; P:neuron fate commitment; IMP:MGI. DR GO; GO:0045213; P:neurotransmitter receptor metabolic process; IMP:MGI. DR GO; GO:0048709; P:oligodendrocyte differentiation; IMP:MGI. DR GO; GO:0007422; P:peripheral nervous system development; IMP:MGI. DR GO; GO:0045773; P:positive regulation of axon extension; IMP:MGI. DR GO; GO:0070886; P:positive regulation of calcineurin-NFAT signaling cascade; IGI:MGI. DR GO; GO:2000727; P:positive regulation of cardiac muscle cell differentiation; IEA:Ensembl. DR GO; GO:0060999; P:positive regulation of dendritic spine development; IMP:MGI. DR GO; GO:0010628; P:positive regulation of gene expression; IDA:MGI. DR GO; GO:0031643; P:positive regulation of myelination; IMP:MGI. DR GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IDA:MGI. DR GO; GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; IGI:MGI. DR GO; GO:0045860; P:positive regulation of protein kinase activity; IDA:MGI. DR GO; GO:0051897; P:positive regulation of protein kinase B signaling; IDA:MGI. DR GO; GO:2000010; P:positive regulation of protein localization to cell surface; IGI:MGI. DR GO; GO:0046579; P:positive regulation of Ras protein signal transduction; IDA:MGI. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:MGI. DR GO; GO:0045595; P:regulation of cell differentiation; IMP:MGI. DR GO; GO:0001964; P:startle response; IMP:MGI. DR GO; GO:0007416; P:synapse assembly; IMP:MGI. DR Gene3D; 2.60.40.10; -; 1. DR InterPro; IPR013032; EGF-like_CS. DR InterPro; IPR000742; EGF-like_dom. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR013098; Ig_I-set. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR002154; Neuregulin_C. DR InterPro; IPR018250; NRG1. DR PANTHER; PTHR11100:SF7; PTHR11100:SF7; 1. DR Pfam; PF00008; EGF; 1. DR Pfam; PF07679; I-set; 1. DR Pfam; PF02158; Neuregulin; 1. DR PRINTS; PR01089; NEUREGULIN. DR SMART; SM00181; EGF; 1. DR SMART; SM00409; IG; 1. DR SMART; SM00408; IGc2; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR PROSITE; PS00022; EGF_1; 1. DR PROSITE; PS01186; EGF_2; 1. DR PROSITE; PS50026; EGF_3; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076}; KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|MaxQB:A0A140LHN1}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 243 264 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 37 128 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 178 222 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DISULFID 212 221 {ECO:0000256|PROSITE-ProRule:PRU00076}. SQ SEQUENCE 423 AA; 46576 MW; 2AA34373111BF5F8 CRC64; MSERKEGRGK GKGKKKDRGS RGKPAPAEGD PSPALPPRLK EMKSQESAAG SKLVLRCETS SEYSSLRFKW FKNGNELNRR NKPQNVKIQK KPGKSELRIN KASLADSGEY MCKVISKLGN DSASANITIV ESNDLTTGMS ASTERPYVSS ESPIRISVST EGANTSSSTS TSTTGTSHLI KCAEKEKTFC VNGGECFMVK DLSNPSRYLC KCQPGFTGAR CTENVPMKVQ TQEKAEELYQ KRVLTITGIC IALLVVGIMC VVAYCKTKKQ RQKLHDRLRQ SLRSERNNMV NIANGPHHPN PPPENVQLVN QYVSKNVISS EHIVEREVET SFSTSHYTST AHHSTTVTQT PSHSWSNGHT ESIISESHSV IMMSSVENSR HSSPAGGPRG RLHGLGGPRE CNSFLRHARE TPDSYRDSPH SER //