ID A0A140GL81_9ENTO Unreviewed; 2193 AA. AC A0A140GL81; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 30-NOV-2016, entry version 5. DE RecName: Full=Genome polyprotein {ECO:0000256|SAAS:SAAS00495321}; OS Coxsackievirus A16. OC Viruses; ssRNA viruses; ssRNA positive-strand viruses, no DNA stage; OC Picornavirales; Picornaviridae; Enterovirus; Enterovirus A. OX NCBI_TaxID=31704 {ECO:0000313|EMBL:AMN10105.1}; RN [1] {ECO:0000313|EMBL:AMN10105.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=CA16-193 {ECO:0000313|EMBL:AMN10105.1}; RX PubMed=27667023; DOI=10.1038/srep34299; RA Sun Y.S., Li Y.J., Xia Y., Xu F., Wang W.W., Yang Z.N., Lu H.J., RA Chen Z.P., Miao Z.P., Liang W.F., Xu Z.Y., Dong H.J., Qiu D.H., RA Zhu Z.Y., van der Veen S., Qian J., Zhou B., Yao P.P., Zhu H.P.; RT "Coxsackievirus A16 induced neurological disorders in young gerbils RT which could serve as a new animal model for vaccine evaluation."; RL Sci. Rep. 6:34299-34299(2016). RN [2] {ECO:0000313|EMBL:AMN10105.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=CA16-193 {ECO:0000313|EMBL:AMN10105.1}; RA Wen L., He K., Yang H.; RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: NTP + H(2)O = NDP + phosphate. CC {ECO:0000256|SAAS:SAAS00495312}. CC -!- CATALYTIC ACTIVITY: Nucleoside triphosphate + RNA(n) = diphosphate CC + RNA(n+1). {ECO:0000256|SAAS:SAAS00510455}. CC -!- CATALYTIC ACTIVITY: Selective cleavage of Gln-|-Gly bond in the CC poliovirus polyprotein. In other picornavirus reactions Glu may be CC substituted for Gln, and Ser or Thr for Gly. CC {ECO:0000256|SAAS:SAAS00495499}. CC -!- SUBCELLULAR LOCATION: Host cytoplasmic vesicle membrane CC {ECO:0000256|SAAS:SAAS00539907}; Peripheral membrane protein CC {ECO:0000256|SAAS:SAAS00539907}; Cytoplasmic side CC {ECO:0000256|SAAS:SAAS00539907}. CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000256|SAAS:SAAS00632018}. CC -!- SIMILARITY: Belongs to the picornaviruses polyprotein family. CC {ECO:0000256|SAAS:SAAS00539246}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KU854873; AMN10105.1; -; Genomic_RNA. DR GO; GO:0044162; C:host cell cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell. DR GO; GO:0044385; C:integral to membrane of host cell; IEA:UniProtKB-KW. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0019028; C:viral capsid; IEA:UniProtKB-KW. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro. DR GO; GO:0005216; F:ion channel activity; IEA:UniProtKB-KW. DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW. DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro. DR GO; GO:0003968; F:RNA-directed RNA polymerase activity; IEA:UniProtKB-KW. DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro. DR GO; GO:0039707; P:pore formation by virus in membrane of host cell; IEA:UniProtKB-KW. DR GO; GO:0051259; P:protein oligomerization; IEA:UniProtKB-KW. DR GO; GO:0018144; P:RNA-protein covalent cross-linking; IEA:InterPro. DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro. DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW. DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro. DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW. DR CDD; cd00205; rhv_like; 3. DR Gene3D; 2.60.120.20; -; 3. DR Gene3D; 3.40.50.300; -; 1. DR Gene3D; 4.10.80.10; -; 2. DR InterPro; IPR003593; AAA+_ATPase. DR InterPro; IPR000605; Helicase_SF3_ssDNA/RNA_vir. DR InterPro; IPR014759; Helicase_SF3_ssRNA_vir. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR014838; P3A. DR InterPro; IPR000081; Peptidase_C3. DR InterPro; IPR000199; Peptidase_C3A/C3B_picornavir. DR InterPro; IPR009003; Peptidase_S1_PA. DR InterPro; IPR003138; Pico_P1A. DR InterPro; IPR002527; Pico_P2B. DR InterPro; IPR001676; Picornavirus_capsid. DR InterPro; IPR033703; Rhv-like. DR InterPro; IPR001205; RNA-dir_pol_C. DR InterPro; IPR007094; RNA-dir_pol_PSvirus. DR InterPro; IPR029053; Viral_coat. DR Pfam; PF08727; P3A; 1. DR Pfam; PF00548; Peptidase_C3; 1. DR Pfam; PF02226; Pico_P1A; 1. DR Pfam; PF00947; Pico_P2A; 1. DR Pfam; PF01552; Pico_P2B; 1. DR Pfam; PF00680; RdRP_1; 1. DR Pfam; PF00073; Rhv; 3. DR Pfam; PF00910; RNA_helicase; 1. DR ProDom; PD001306; Peptidase_C3; 1. DR ProDom; PD649346; Pico_P2B; 1. DR SMART; SM00382; AAA; 1. DR SUPFAM; SSF50494; SSF50494; 2. DR SUPFAM; SSF52540; SSF52540; 1. DR SUPFAM; SSF89043; SSF89043; 1. DR PROSITE; PS50507; RDRP_SSRNA_POS; 1. DR PROSITE; PS51218; SF3_HELICASE_2; 1. PE 3: Inferred from homology; KW ATP-binding {ECO:0000256|SAAS:SAAS00510945}; KW Capsid protein {ECO:0000256|SAAS:SAAS00632233}; KW Helicase {ECO:0000256|SAAS:SAAS00481789}; KW Host cytoplasm {ECO:0000256|SAAS:SAAS00495503}; KW Host cytoplasmic vesicle {ECO:0000256|SAAS:SAAS00495307}; KW Host membrane {ECO:0000256|SAAS:SAAS00503033}; KW Host-virus interaction {ECO:0000256|SAAS:SAAS00495493}; KW Hydrolase {ECO:0000256|SAAS:SAAS00510997}; KW Ion channel {ECO:0000256|SAAS:SAAS00495442}; KW Ion transport {ECO:0000256|SAAS:SAAS00495456}; KW Membrane {ECO:0000256|SAAS:SAAS00503061}; KW Nucleotide-binding {ECO:0000256|SAAS:SAAS00510884}; KW Nucleotidyltransferase {ECO:0000256|SAAS:SAAS00510590}; KW Protease {ECO:0000256|SAAS:SAAS00482667}; KW RNA-binding {ECO:0000256|SAAS:SAAS00495317}; KW RNA-directed RNA polymerase {ECO:0000256|SAAS:SAAS00510600}; KW Thiol protease {ECO:0000256|SAAS:SAAS00482329}; KW Transferase {ECO:0000256|SAAS:SAAS00510371}; KW Transport {ECO:0000256|SAAS:SAAS00495481}; KW Viral attachment to host cell {ECO:0000256|SAAS:SAAS00495304}; KW Viral ion channel {ECO:0000256|SAAS:SAAS00495447}; KW Viral RNA replication {ECO:0000256|SAAS:SAAS00664279}; KW Virion {ECO:0000256|SAAS:SAAS00632213}; KW Virus entry into host cell {ECO:0000256|SAAS:SAAS00495301}. FT DOMAIN 1216 1374 SF3 helicase. {ECO:0000259|PROSITE: FT PS51218}. FT DOMAIN 1958 2074 RdRp catalytic. {ECO:0000259|PROSITE: FT PS50507}. SQ SEQUENCE 2193 AA; 243302 MW; B81B96ED25B19D4F CRC64; MGSQVSTQRS GSHENSNSAS EGSTINYTTI NYYKDAYAAS AGRQDMSQDP KKFTDPVMDV IHEMAPPLKS PSAEACGYSD RVAQLTIGNS TITTQEAANI VIAYGEWPEY CPDTDATAVD KPTRPDVSVN RFFTLDTKSW AKDSKGWYWK FPDVLTEVGV FGQNAQFHYL YRSGFCVHVQ CNASKFHQGA LLVAVLPEYV LGTIAGGTGN ENSHPPYATT QPGQVGAVLT HPYVLDAGIP LSQLTVCPHQ WINLRTNNCA TIIVPYMNTV PFDSALNHCN FGLLVIPVVP LDFNTGATSE IPITVTIAPM CAEFAGLRQA VKQGIPTELK PGTNQFLTTD DGVSAPILPG FHPTPPIHIP GEVHNLLEIC RVETILEVNN LKTNETTPMQ RLCFPVSVQS KTGELCAAFR ADPGRDGPWQ STILGQLCRY YTQWSGSLEV TFMFAGSFMA TGKMLIAYTP PGGNVPADRI TAMLGTHVIW DFGLQSSVTL VVPWISNTHY RAHARAGYFD YYTTGIITIW YQTNYVVPIG APTTAYIVAL AAAQDNFTMK LCKDTEDIEQ TANIQGDPIA DMIDQTVNNQ VNRSLTALQV LPTAANTEAS SHRLGTGVVP ALQAAETGAS SNASDKNLIE TRCVLNHHST QETAIGNFFS RAGLVSIITM PTTGTQNTDG YVNWDIDLMG YAQLRRKCEL FTYMRFDAEF TFVVAKPNGE LVPQLLQYMY VPPGAPKPTS RDSFAWQTAT NPSVFVKMTD PPAQVSVPFM SPASAYQWFY DGYPTFGEHL QANDLDYGQC PNNMMGTFSI RTVGTEKSPH SITLRVYMRI KHVRAWIPRP LRNQPYLFKT NPNYKGNDIK CTSTSRDKIT TLGEFGQQSG AIYVGNYRVV NRHLATHNDW ANLVWEDSSR DLLVSSTTAQ GCDTIARCNC QTGIYYCSSK RKHYPVSFTK PSLIFVEASE YYPARYQSHL MLAVGHSEPG DCGGILRCQH GVVGIVSTGG NGLVGFADVR DLLWLDEEAM EQGVSDYIKG LGDAFGMGFT DAVSREVEAL KNHLIGSEGA VEKILKNLVK LISALVIVVR SDYDMVTLTA TLALIGCHGS PWAWIKAKTA SILGIPIVQK QSASWLKKFN DMANAAKGLE WISSKISKFI DWLKEKIIPA AKEKVEFLNN LKQLPLLENQ ISNLEQSAAS QEDLEAMFGN VSYLAHFCRK FQPLYATEAK RVYALEKRMN NYMQFKSKHR IEPVCLIIRG SPGTGKSLAT GIIARAIADK YHSSVYSLPP DPDHFDGYKQ QVVTVMDDLC QNPDGKDMSL FCQMVSTVDF IPPMASLEEK GVSFTSKFVV ASTNASNIVV PTVSDSDAIR RRFYMDCDIE VTDSYKTDLG RLDAGRAAKL CTENNTANFK RCSPLVCGKA IQLRDRKSKV RYSIDTVVSE LIREYNNRSA IGNTIEALFQ GPPKFKPIRI SLEEKPAPDA ISDLLASVDS EEVRQYCREQ GWIIPETPTN VERHLNRAVL VMQSIATVVA VVSLVYVIYK LFAGFQGAYS GAPKQALKKP VLRTATVQGP SLDFALSLLR RNIRQVQTDQ GHFTMLGVRD RLAILPRHSQ PGKTIWVEHK LINVLDAVEL VDEQGVNLEL TLITLDTNEK FRDVTKFIPE TITGASDATL IINTEHMPSM FVPVGDVVQY GFLNLSGKPT HRTMMYNFPT KAGQCGGVVT SVGKIIGIHI GGNGRQGFCA GLKRSYFASE QGEIQWMKPN KETGRLNING PTRTKLEPSV FHDVFEGSKE PAVLTSKDPR LEVNFEQALF SKYVGNTLHE PDEYVTQAAL HYANQLKQLD INTNKMSMEE ACYGTEYLEA IDLHTSAGYP YSALGVKKRD ILDPITRDTT KMKFYMDKYG LDLPYSTYVK DELRSLDKIK KGKSRLIEAS SLNDSVYLRM TFGHLYETFH ANPGTVTGSA VGCNPDVFWS KLPILLPGSL FAFDYSGYDA SLSPVWFRAL EVVLREIGYS EEAVSLIEGI NHTHHVYRNK TYCVLGGMPS GCSGTSIFNS MINNIIIRTL LIKTFKGIDL DELNMVAYGD DVLASYPFPV DCSELARTGK EYGLTMTPAD KSPCFNEVTW ENATFLKRGF LPDYQFPFLI HPTMPMREIH ESIRWTKDAR NTQDHVRSLC LLAWHNGKEE YEKFVSTIRS VPIGKALAIP NFENLRRNWL ELF //