ID A0A127GXA5_9GAMM Unreviewed; 291 AA. AC A0A127GXA5; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 14-DEC-2022, entry version 22. DE RecName: Full=Small-conductance mechanosensitive channel {ECO:0000256|RuleBase:RU369025}; GN ORFNames=AK825_03495 {ECO:0000313|EMBL:AMN66895.1}; OS Psychrobacter sp. P11G5. OC Bacteria; Proteobacteria; Gammaproteobacteria; Moraxellales; Moraxellaceae; OC Psychrobacter. OX NCBI_TaxID=1699624 {ECO:0000313|EMBL:AMN66895.1, ECO:0000313|Proteomes:UP000073122}; RN [1] {ECO:0000313|EMBL:AMN66895.1, ECO:0000313|Proteomes:UP000073122} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=P11G5 {ECO:0000313|EMBL:AMN66895.1, RC ECO:0000313|Proteomes:UP000073122}; RX PubMed=26879123; DOI=10.1186/s12864-016-2445-4; RA Moghadam M.S., Albersmeier A., Winkler A., Cimmino L., Rise K., RA Hohmann-Marriott M.F., Kalinowski J., Ruckert C., Wentzel A., Lale R.; RT "Isolation and genome sequencing of four Arctic marine Psychrobacter RT strains exhibiting multicopper oxidase activity."; RL BMC Genomics 17:117-117(2016). CC -!- FUNCTION: Mechanosensitive channel that participates in the regulation CC of osmotic pressure changes within the cell, opening in response to CC stretch forces in the membrane lipid bilayer, without the need for CC other proteins. Contributes to normal resistance to hypoosmotic shock. CC Forms an ion channel of 1.0 nanosiemens conductance with a slight CC preference for anions. {ECO:0000256|RuleBase:RU369025}. CC -!- SUBUNIT: Homoheptamer. {ECO:0000256|RuleBase:RU369025}. CC -!- SUBCELLULAR LOCATION: Cell inner membrane CC {ECO:0000256|RuleBase:RU369025}; Multi-pass membrane protein CC {ECO:0000256|RuleBase:RU369025}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the MscS (TC 1.A.23) family. CC {ECO:0000256|ARBA:ARBA00008017, ECO:0000256|RuleBase:RU369025}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of CC feature annotation. {ECO:0000256|RuleBase:RU369025}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP012533; AMN66895.1; -; Genomic_DNA. DR RefSeq; WP_068034776.1; NZ_CP012533.1. DR AlphaFoldDB; A0A127GXA5; -. DR EnsemblBacteria; AMN66895; AMN66895; AK825_03495. DR KEGG; psyg:AK825_03495; -. DR PATRIC; fig|1699624.3.peg.713; -. DR OrthoDB; 1903165at2; -. DR Proteomes; UP000073122; Chromosome. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0008381; F:mechanosensitive ion channel activity; IEA:InterPro. DR Gene3D; 2.30.30.60; -; 1. DR InterPro; IPR010920; LSM_dom_sf. DR InterPro; IPR045275; MscS_archaea/bacteria_type. DR InterPro; IPR023408; MscS_beta-dom_sf. DR InterPro; IPR006685; MscS_channel. DR InterPro; IPR011066; MscS_channel_C. DR InterPro; IPR011014; MscS_channel_TM-2. DR PANTHER; PTHR30221; SMALL-CONDUCTANCE MECHANOSENSITIVE CHANNEL; 1. DR Pfam; PF00924; MS_channel; 1. DR SUPFAM; SSF82689; Mechanosensitive channel protein MscS (YggB), C-terminal domain; 1. DR SUPFAM; SSF82861; Mechanosensitive channel protein MscS (YggB), transmembrane region; 1. DR SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1. PE 3: Inferred from homology; KW Cell inner membrane {ECO:0000256|RuleBase:RU369025}; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475}; KW Ion channel {ECO:0000256|RuleBase:RU369025}; KW Ion transport {ECO:0000256|RuleBase:RU369025}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU369025}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU369025}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|RuleBase:RU369025}; Transport {ECO:0000256|RuleBase:RU369025}. FT TRANSMEM 20..38 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU369025" FT TRANSMEM 58..79 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU369025" FT TRANSMEM 85..104 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU369025" SQ SEQUENCE 291 AA; 31735 MW; C8E518D2720CC93C CRC64; MEFLGFTIDV ATLTSNALSL ALKVVLAILI FVVGRWLAKK AVTFAHSIML RSRLDDTVAS FLGRLIYGVL LVVVALAALS KVGVQTTSVV AILGGAAVAI GLSLKDQLSN FAAGIMIVTF RPFVRGDYVQ ISSYTGTVTE ITLVNTHLTT INNHDIIIPN SDITTSAVIN YTALPNRRVD ITVGIGYDAD IKTAKNVMLS LAKNNAMAFT DPEPIVRVTN LGDNSVDLTL NVWTTNADWW TMQCDLLEQF KHALDDEKIE IPFPQRSVHV KGLDQMINQM GQSQKLPMTK D //