ID A0A126GW95_HUMAN Unreviewed; 311 AA. AC A0A126GW95; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 24-JUL-2024, entry version 46. DE SubName: Full=OR8G5 {ECO:0000313|EMBL:ALI87678.1}; DE SubName: Full=Olfactory receptor family 8 subfamily G member 5 {ECO:0000313|Ensembl:ENSP00000493069.1}; GN Name=OR8G5 {ECO:0000313|EMBL:ALI87678.1, GN ECO:0000313|Ensembl:ENSP00000493069.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:ALI87678.1}; RN [1] {ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16554811; DOI=10.1038/nature04632; RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., RA Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T., RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G., RA Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C., RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., RA Hattori M., Rogers J., Lander E.S., Sakaki Y.; RT "Human chromosome 11 DNA sequence and analysis including novel gene RT identification."; RL Nature 440:497-500(2006). RN [2] {ECO:0000313|EMBL:ALI87678.1} RP NUCLEOTIDE SEQUENCE. RA Mainland J.D., Li Y.R., Zhou T., Liu W.L.L., Matsunami H.; RT "Human Olfactory Receptor Responses to Odorants."; RL Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSP00000493069.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2024) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AP002965; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KP290517; ALI87678.1; -; Genomic_DNA. DR RefSeq; NP_001005198.1; NM_001005198.1. DR RefSeq; XP_011540964.1; XM_011542662.2. DR RefSeq; XP_011540965.1; XM_011542663.2. DR RefSeq; XP_011540966.1; XM_011542664.2. DR RefSeq; XP_011540967.1; XM_011542665.2. DR RefSeq; XP_011540968.1; XM_011542666.2. DR RefSeq; XP_011540969.1; XM_011542667.2. DR Antibodypedia; 71805; 44 antibodies from 14 providers. DR DNASU; 219865; -. DR Ensembl; ENST00000641707.1; ENSP00000493069.1; ENSG00000255298.5. DR Ensembl; ENST00000641992.2; ENSP00000493127.1; ENSG00000255298.5. DR GeneID; 219865; -. DR KEGG; hsa:219865; -. DR MANE-Select; ENST00000641992.2; ENSP00000493127.1; NM_001005198.2; NP_001005198.2. DR CTD; 219865; -. DR DisGeNET; 219865; -. DR HGNC; HGNC:19622; OR8G5. DR VEuPathDB; HostDB:ENSG00000255298; -. DR GeneTree; ENSGT01040000240383; -. DR OMA; CFSALNI; -. DR OrthoDB; 5317957at2759; -. DR BioGRID-ORCS; 219865; 5 hits in 706 CRISPR screens. DR Proteomes; UP000005640; Chromosome 11. DR Bgee; ENSG00000255298; Expressed in primordial germ cell in gonad and 16 other cell types or tissues. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro. DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro. DR CDD; cd15406; 7tmA_OR8D-like; 1. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR InterPro; IPR000725; Olfact_rcpt. DR PANTHER; PTHR48018; OLFACTORY RECEPTOR; 1. DR PANTHER; PTHR48018:SF48; OLFACTORY RECEPTOR 8G5; 1. DR Pfam; PF13853; 7tm_4; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 4: Predicted; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Transducer {ECO:0000256|ARBA:ARBA00023224}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 27..48 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 141..160 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 197..226 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 238..261 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 273..292 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 41..290 FT /note="G-protein coupled receptors family 1 profile" FT /evidence="ECO:0000259|PROSITE:PS50262" SQ SEQUENCE 311 AA; 34636 MW; 3965961AD1EC9ECD CRC64; MAAENHSFVT KFILVGLTEK SELQLPLFLV FLGIYVVTVL GNLGMITLIG LSSHLHTPMY CFLSSLSFID FCHSTVITPK MLVNFVTEKN IISYPECMTQ LYFFLVFAIA ECHMLAAMAY DGYVAICSPL LYSIIISNKA CFSLILVVYV IGLICASAHI GCMFRVQFCK FDVINHYFCD LISILKLSCS STYINELLIL IFSGINILVP SLTILSSYIF IIASILRIRY TEGRSKAFST CSSHISAVSV FFGSAAFMYL QPSSVSSMDQ GKVSSVFYTI VVPMLNPLIY SLRNKDVHVA LKKTLGKRTF L //