ID A0A126GW95_HUMAN Unreviewed; 311 AA. AC A0A126GW95; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 26-FEB-2020, entry version 23. DE SubName: Full=OR8G5 {ECO:0000313|EMBL:ALI87678.1}; DE SubName: Full=Olfactory receptor 8G5 {ECO:0000313|Ensembl:ENSP00000493069}; GN Name=OR8G5 {ECO:0000313|EMBL:ALI87678.1, GN ECO:0000313|Ensembl:ENSP00000493069}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:ALI87678.1}; RN [1] {ECO:0000313|Ensembl:ENSP00000493069, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16554811; DOI=10.1038/nature04632; RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., RA Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T., RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G., RA Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C., RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., RA Hattori M., Rogers J., Lander E.S., Sakaki Y.; RT "Human chromosome 11 DNA sequence and analysis including novel gene RT identification."; RL Nature 440:497-500(2006). RN [2] {ECO:0000313|EMBL:ALI87678.1} RP NUCLEOTIDE SEQUENCE. RA Mainland J.D., Li Y.R., Zhou T., Liu W.L.L., Matsunami H.; RT "Human Olfactory Receptor Responses to Odorants."; RL Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSP00000493069} RP IDENTIFICATION. RG Ensembl; RL Submitted (OCT-2017) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|SAAS:SAAS00857205}; CC Multi-pass membrane protein {ECO:0000256|SAAS:SAAS00857205}. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000256|SAAS:SAAS00857212}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AP002965; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KP290517; ALI87678.1; -; Genomic_DNA. DR RefSeq; XP_011540964.1; XM_011542662.2. DR RefSeq; XP_011540965.1; XM_011542663.2. DR RefSeq; XP_011540966.1; XM_011542664.2. DR RefSeq; XP_011540967.1; XM_011542665.2. DR RefSeq; XP_011540968.1; XM_011542666.2. DR RefSeq; XP_011540969.1; XM_011542667.2. DR Ensembl; ENST00000641707; ENSP00000493069; ENSG00000255298. DR Ensembl; ENST00000641992; ENSP00000493127; ENSG00000255298. DR HGNC; HGNC:19622; OR8G5. DR OpenTargets; ENSG00000255298; -. DR GeneTree; ENSGT00980000198557; -. DR PhylomeDB; A0A126GW95; -. DR GenomeRNAi; 219865; -. DR Proteomes; UP000005640; Chromosome 11. DR ExpressionAtlas; A0A126GW95; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW. DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR InterPro; IPR000725; Olfact_rcpt. DR Pfam; PF13853; 7tm_4; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 3: Inferred from homology; KW Cell membrane {ECO:0000256|SAAS:SAAS00857207}; KW G-protein coupled receptor {ECO:0000256|SAAS:SAAS00857203}; KW Membrane {ECO:0000256|SAAS:SAAS00857208, ECO:0000256|SAM:Phobius}; KW Olfaction {ECO:0000256|SAAS:SAAS00857209}; KW Receptor {ECO:0000256|SAAS:SAAS00857193}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Sensory transduction {ECO:0000256|SAAS:SAAS00857210}; KW Transducer {ECO:0000256|SAAS:SAAS00857213}; KW Transmembrane {ECO:0000256|SAAS:SAAS00857211, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00857194, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 27..48 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 141..160 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 197..226 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 238..261 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 273..292 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 41..290 FT /note="G_PROTEIN_RECEP_F1_2" FT /evidence="ECO:0000259|PROSITE:PS50262" SQ SEQUENCE 311 AA; 34636 MW; 3965961AD1EC9ECD CRC64; MAAENHSFVT KFILVGLTEK SELQLPLFLV FLGIYVVTVL GNLGMITLIG LSSHLHTPMY CFLSSLSFID FCHSTVITPK MLVNFVTEKN IISYPECMTQ LYFFLVFAIA ECHMLAAMAY DGYVAICSPL LYSIIISNKA CFSLILVVYV IGLICASAHI GCMFRVQFCK FDVINHYFCD LISILKLSCS STYINELLIL IFSGINILVP SLTILSSYIF IIASILRIRY TEGRSKAFST CSSHISAVSV FFGSAAFMYL QPSSVSSMDQ GKVSSVFYTI VVPMLNPLIY SLRNKDVHVA LKKTLGKRTF L //