ID A0A126GW95_HUMAN Unreviewed; 311 AA. AC A0A126GW95; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 22-NOV-2017, entry version 11. DE SubName: Full=OR8G5 {ECO:0000313|EMBL:ALI87678.1}; DE SubName: Full=Olfactory receptor 8G5 {ECO:0000313|Ensembl:ENSP00000493069}; GN Name=OR8G5 {ECO:0000313|EMBL:ALI87678.1, GN ECO:0000313|Ensembl:ENSP00000493069}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:ALI87678.1}; RN [1] {ECO:0000313|Ensembl:ENSP00000493069} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., RA Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., RA Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., RA Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., RA Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., RA Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., RA Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., RA Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., RA Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., RA Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., RA Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., RA Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., RA Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., RA Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., RA Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., RA Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., RA Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., RA Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., RA McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., RA Waterston R.H., Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 RT and 4."; RL Nature 434:724-731(2005). RN [2] {ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16554811; DOI=10.1038/nature04632; RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., RA Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T., RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G., RA Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C., RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., RA Hattori M., Rogers J., Lander E.S., Sakaki Y.; RT "Human chromosome 11 DNA sequence and analysis including novel gene RT identification."; RL Nature 440:497-500(2006). RN [3] {ECO:0000313|EMBL:ALI87678.1} RP NUCLEOTIDE SEQUENCE. RA Mainland J.D., Li Y.R., Zhou T., Liu W.L.L., Matsunami H.; RT "Human Olfactory Receptor Responses to Odorants."; RL Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|Ensembl:ENSP00000493069} RP IDENTIFICATION. RG Ensembl; RL Submitted (OCT-2017) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Cell membrane CC {ECO:0000256|SAAS:SAAS00857205}; Multi-pass membrane protein CC {ECO:0000256|SAAS:SAAS00857205}. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000256|SAAS:SAAS00857212}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AP002965; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KP290517; ALI87678.1; -; Genomic_DNA. DR RefSeq; XP_011540964.1; XM_011542662.2. DR RefSeq; XP_011540965.1; XM_011542663.2. DR RefSeq; XP_011540966.1; XM_011542664.2. DR RefSeq; XP_011540967.1; XM_011542665.2. DR RefSeq; XP_011540968.1; XM_011542666.2. DR RefSeq; XP_011540969.1; XM_011542667.2. DR UniGene; Hs.722725; -. DR ProteinModelPortal; A0A126GW95; -. DR PeptideAtlas; A0A126GW95; -. DR Ensembl; ENST00000641707; ENSP00000493069; ENSG00000255298. DR Ensembl; ENST00000641992; ENSP00000493127; ENSG00000255298. DR GeneID; 219865; -. DR CTD; 219865; -. DR HGNC; HGNC:19622; OR8G5. DR OpenTargets; ENSG00000255298; -. DR GeneTree; ENSGT00900000140900; -. DR PhylomeDB; A0A126GW95; -. DR Proteomes; UP000005640; Chromosome 11. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW. DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR InterPro; IPR000725; Olfact_rcpt. DR Pfam; PF13853; 7tm_4; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 3: Inferred from homology; KW Cell membrane {ECO:0000256|SAAS:SAAS00857207}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW G-protein coupled receptor {ECO:0000256|SAAS:SAAS00857203}; KW Membrane {ECO:0000256|SAAS:SAAS00857208, ECO:0000256|SAM:Phobius}; KW Olfaction {ECO:0000256|SAAS:SAAS00857209}; KW Receptor {ECO:0000256|SAAS:SAAS00857193}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Sensory transduction {ECO:0000256|SAAS:SAAS00857210}; KW Transducer {ECO:0000256|SAAS:SAAS00857213}; KW Transmembrane {ECO:0000256|SAAS:SAAS00857211, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00857194, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 27 48 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 141 160 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 197 226 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 238 261 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 273 292 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 41 290 G_PROTEIN_RECEP_F1_2. FT {ECO:0000259|PROSITE:PS50262}. SQ SEQUENCE 311 AA; 34636 MW; 3965961AD1EC9ECD CRC64; MAAENHSFVT KFILVGLTEK SELQLPLFLV FLGIYVVTVL GNLGMITLIG LSSHLHTPMY CFLSSLSFID FCHSTVITPK MLVNFVTEKN IISYPECMTQ LYFFLVFAIA ECHMLAAMAY DGYVAICSPL LYSIIISNKA CFSLILVVYV IGLICASAHI GCMFRVQFCK FDVINHYFCD LISILKLSCS STYINELLIL IFSGINILVP SLTILSSYIF IIASILRIRY TEGRSKAFST CSSHISAVSV FFGSAAFMYL QPSSVSSMDQ GKVSSVFYTI VVPMLNPLIY SLRNKDVHVA LKKTLGKRTF L //