ID A0A126GVC9_HUMAN Unreviewed; 318 AA. AC A0A126GVC9; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 29-MAY-2024, entry version 52. DE RecName: Full=Olfactory receptor {ECO:0000256|RuleBase:RU363047}; GN Name=OR13C4 {ECO:0000313|EMBL:ALI87368.1}; GN ORFNames=hCG_1804868 {ECO:0000313|EMBL:EAW58981.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:ALI87368.1}; RN [1] {ECO:0000313|EMBL:EAW58981.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=11181995; DOI=10.1126/science.1058040; RA Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., RA Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., RA Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H., RA Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J., RA Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J., RA McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C., RA Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., RA Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., RA Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., RA Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., RA Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., RA Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P., RA Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y., RA Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N., RA Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B., RA Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., RA Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., RA Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., RA Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., RA Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., RA Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L., RA Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., RA Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., RA Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., RA Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., RA McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., RA Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., RA Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., RA Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S., RA Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., RA Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R., RA Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B., RA Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., RA Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., RA Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., RA Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M., RA Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., RA Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., RA Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., RA Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., RA Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., RA Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., RA Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., RA Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.; RT "The sequence of the human genome."; RL Science 291:1304-1351(2001). RN [2] {ECO:0000313|EMBL:EAW58981.1} RP NUCLEOTIDE SEQUENCE. RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:ALI87368.1} RP NUCLEOTIDE SEQUENCE. RA Mainland J.D., Li Y.R., Zhou T., Liu W.L.L., Matsunami H.; RT "Human Olfactory Receptor Responses to Odorants."; RL Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU363047}; CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU363047}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000256|RuleBase:RU000688}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KP290184; ALI87368.1; -; Genomic_DNA. DR EMBL; CH471105; EAW58981.1; -; Genomic_DNA. DR RefSeq; NP_001001919.1; NM_001001919.1. DR AlphaFoldDB; A0A126GVC9; -. DR SMR; A0A126GVC9; -. DR Antibodypedia; 54611; 47 antibodies from 15 providers. DR DNASU; 138804; -. DR GeneID; 138804; -. DR KEGG; hsa:138804; -. DR CTD; 138804; -. DR DisGeNET; 138804; -. DR VEuPathDB; HostDB:ENSG00000148136; -. DR OMA; RINKTFV; -. DR OrthoDB; 4632618at2759; -. DR BioGRID-ORCS; 138804; 8 hits in 749 CRISPR screens. DR GenomeRNAi; 138804; -. DR ExpressionAtlas; A0A126GVC9; baseline and differential. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW. DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro. DR CDD; cd15430; 7tmA_OR13-like; 1. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR InterPro; IPR000725; Olfact_rcpt. DR PANTHER; PTHR26453; OLFACTORY RECEPTOR; 1. DR PANTHER; PTHR26453:SF14; OLFACTORY RECEPTOR 13C4; 1. DR Pfam; PF13853; 7tm_4; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 3: Inferred from homology; KW Cell membrane {ECO:0000256|RuleBase:RU363047}; KW G-protein coupled receptor {ECO:0000256|RuleBase:RU000688}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363047}; KW Olfaction {ECO:0000256|ARBA:ARBA00022725, ECO:0000256|RuleBase:RU363047}; KW Receptor {ECO:0000256|RuleBase:RU000688, ECO:0000313|EMBL:EAW58981.1}; KW Sensory transduction {ECO:0000256|RuleBase:RU363047}; KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU000688}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU000688}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|RuleBase:RU363047}. FT TRANSMEM 25..48 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU363047" FT TRANSMEM 60..86 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU363047" FT TRANSMEM 92..118 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU363047" FT TRANSMEM 139..158 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU363047" FT TRANSMEM 204..226 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU363047" FT TRANSMEM 238..259 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU363047" FT TRANSMEM 279..298 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU363047" FT DOMAIN 41..296 FT /note="G-protein coupled receptors family 1 profile" FT /evidence="ECO:0000259|PROSITE:PS50262" SQ SEQUENCE 318 AA; 35576 MW; A2E9E00E9D2F818B CRC64; MDKINQTFVR EFILLGLSGY PKLEIIFFAL ILVMYVVILI GNGVLIIASI LDSRLHMPMY FFLGNLSFLD ICYTTSSIPS TLVSLISKKR NISFSGCAVQ MFFGFAMGST ECFLLGMMAF DRYVAICNPL RYPIIMNKVV YVLLTSVSWL SGGINSTVQT SLAMRWPFCG NNIINHFLCE ILAVLKLACS DISVNIVTLA VSNIAFLVLP LLVIFFSYMF ILYTILRTNS ATGRHKAFST CSAHLTVVII FYGTIFFMYA KPKSQDLLGK DNLQATEGLV SMFYGVVTPM LNPIIYSLRN KDVKAAIKYL LSRKAINQ //