ID A0A109XX23_9ORTH Unreviewed; 200 AA. AC A0A109XX23; DT 13-APR-2016, integrated into UniProtKB/TrEMBL. DT 13-APR-2016, sequence version 1. DT 02-OCT-2024, entry version 20. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 1 {ECO:0000256|ARBA:ARBA00021009, ECO:0000256|RuleBase:RU000473}; DE EC=7.1.1.2 {ECO:0000256|RuleBase:RU000473}; DE Flags: Fragment; GN Name=ND1 {ECO:0000313|EMBL:AMA07738.1}; OS Tettigonia ussuriana. OG Mitochondrion {ECO:0000313|EMBL:AMA07738.1}. OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Polyneoptera; Orthoptera; Ensifera; Tettigoniidea; OC Tettigonioidea; Tettigoniidae; Tettigoniinae; Tettigonia. OX NCBI_TaxID=420852 {ECO:0000313|EMBL:AMA07738.1}; RN [1] {ECO:0000313|EMBL:AMA07738.1} RP NUCLEOTIDE SEQUENCE. RA Kim T.-K., Han T., Kim T.-W., Park H.; RT "A Molecular Taxonomy of the Korean Tettigonia Linnaeus (Orthoptera: RT Ensifera: Tettigoniidae)."; RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain CC NADH dehydrogenase (Complex I) that is believed to belong to the CC minimal assembly required for catalysis. Complex I functions in the CC transfer of electrons from NADH to the respiratory chain. The immediate CC electron acceptor for the enzyme is believed to be ubiquinone. CC {ECO:0000256|ARBA:ARBA00003257}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA- CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2; CC Evidence={ECO:0000256|RuleBase:RU000473}; CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion CC inner membrane {ECO:0000256|RuleBase:RU000471}; Multi-pass membrane CC protein {ECO:0000256|RuleBase:RU000471}. CC -!- SIMILARITY: Belongs to the complex I subunit 1 family. CC {ECO:0000256|ARBA:ARBA00010535, ECO:0000256|RuleBase:RU000471}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KT371861; AMA07734.1; -; Genomic_DNA. DR EMBL; KT371862; AMA07735.1; -; Genomic_DNA. DR EMBL; KT371863; AMA07736.1; -; Genomic_DNA. DR EMBL; KT371864; AMA07737.1; -; Genomic_DNA. DR EMBL; KT371865; AMA07738.1; -; Genomic_DNA. DR EMBL; KT371866; AMA07739.1; -; Genomic_DNA. DR EMBL; KT371867; AMA07740.1; -; Genomic_DNA. DR EMBL; KT371868; AMA07741.1; -; Genomic_DNA. DR EMBL; KT371869; AMA07742.1; -; Genomic_DNA. DR AlphaFoldDB; A0A109XX23; -. DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IEA:TreeGrafter. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC. DR GO; GO:0003954; F:NADH dehydrogenase activity; IEA:TreeGrafter. DR GO; GO:0009060; P:aerobic respiration; IEA:TreeGrafter. DR InterPro; IPR001694; NADH_UbQ_OxRdtase_su1/FPO. DR InterPro; IPR018086; NADH_UbQ_OxRdtase_su1_CS. DR PANTHER; PTHR11432; NADH DEHYDROGENASE SUBUNIT 1; 1. DR PANTHER; PTHR11432:SF3; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 1; 1. DR Pfam; PF00146; NADHdh; 1. DR PROSITE; PS00667; COMPLEX1_ND1_1; 1. DR PROSITE; PS00668; COMPLEX1_ND1_2; 1. PE 3: Inferred from homology; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Mitochondrion {ECO:0000256|RuleBase:RU000473, ECO:0000313|EMBL:AMA07738.1}; KW NAD {ECO:0000256|RuleBase:RU000471}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU000471}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; Ubiquinone {ECO:0000256|RuleBase:RU000473}. FT TRANSMEM 30..50 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 57..81 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 101..124 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 131..149 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 176..199 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:AMA07738.1" FT NON_TER 200 FT /evidence="ECO:0000313|EMBL:AMA07738.1" SQ SEQUENCE 200 AA; 22602 MW; 6C0CF9CB66D2C675 CRC64; VGFVGLPQPF ADAIKLFSKE GTYPMLSNYL MYYFAPIFSL FLALLTWMIF PFITMLFTFN LGILFFLVCT SLGVYTVMVA GWSSNSNYAL LGALRAMAQT ISYEVSLALI LLSFVFLVDS YCLMDFMNLQ NYIWFVFLTI PLMLAWFSSC LAETNRTPFD FAEGESELVS GFNVEYSAGG FALIFLAEYA SILFMSMLFC //