ID   A0A101LFD8_9MICC        Unreviewed;       473 AA.
AC   A0A101LFD8;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   24-JAN-2024, entry version 37.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|ARBA:ARBA00018893, ECO:0000256|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=AR539_02200 {ECO:0000313|EMBL:KUM38074.1};
OS   Arthrobacter sp. EPSL27.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC   Arthrobacter.
OX   NCBI_TaxID=1745378 {ECO:0000313|EMBL:KUM38074.1, ECO:0000313|Proteomes:UP000054971};
RN   [1] {ECO:0000313|EMBL:KUM38074.1, ECO:0000313|Proteomes:UP000054971}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EPSL27 {ECO:0000313|EMBL:KUM38074.1,
RC   ECO:0000313|Proteomes:UP000054971};
RA   Presta L., Bosi E., Fondi M., Maida I., Maggini V., Bogani P.,
RA   Firenzuoli F., Chiellini C., de Pascale D., Palma F., Di Pilato V.,
RA   Rossolini G.M., Mengoni A., Fani R.;
RT   "Genome Announcement of three Arthrobacter strains isolated from Echinacea
RT   purpurea rhizospheric soil and leaf.";
RL   Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation of
CC       chromosomal replication. Binds to the origin of replication; it binds
CC       specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC       TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.
CC       {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC       ECO:0000256|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|ARBA:ARBA00006583,
CC       ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU004227}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KUM38074.1}.
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DR   EMBL; LNUT01000003; KUM38074.1; -; Genomic_DNA.
DR   RefSeq; WP_066432160.1; NZ_LNUT01000003.1.
DR   AlphaFoldDB; A0A101LFD8; -.
DR   STRING; 1745378.AR539_02200; -.
DR   OrthoDB; 9807019at2; -.
DR   Proteomes; UP000054971; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd00009; AAA; 1.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 1.10.8.60; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   NCBIfam; TIGR00362; DnaA; 1.
DR   PANTHER; PTHR30050; CHROMOSOMAL REPLICATION INITIATOR PROTEIN DNAA; 1.
DR   PANTHER; PTHR30050:SF2; CHROMOSOMAL REPLICATION INITIATOR PROTEIN DNAA; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF48295; TrpR-like; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW   Rule:MF_00377};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00377};
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705, ECO:0000256|HAMAP-
KW   Rule:MF_00377};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW   Rule:MF_00377};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW   Rule:MF_00377}.
FT   DOMAIN          164..292
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   DOMAIN          376..445
FT                   /note="Chromosomal replication initiator DnaA C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00760"
FT   BINDING         172..179
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00377"
SQ   SEQUENCE   473 AA;  53034 MW;  97EA0408952CEFE4 CRC64;
     MTVDEANQAN TVGSSWRRVV SLLENDHRVS PRQRGFVILA QAQGLIGSTL LVAVPNELTR
     EVLQTQVKEA LDDALRSVFS DEIRCAIDVD TDLVPLHTEP EPAVELSLVA DPSVELKPQP
     MLPSTSHEFG RLNPKYVFDT FVIGSSNRFA HAAAVAVAEA PAKAYNPLFI YGDSGLGKTH
     LLHAIGHYAR RLYSGIRVRY VNSEEFTNDF INSIRDDEGT SFKTTYRNVD VLLIDDIQFL
     AGKDRTLEEF FHTFNALHNN NKQVVITSDQ PPKLLAGFED RMKSRFEWGL LTDIQPPELE
     TRIAILRKKA LSEGLSAPDD ALEYIASKIS SNIRELEGAL IRVTAFASLN RQPVDVALAE
     MVLKDLITDD GAQEITSAQI LTQTADYFKL SMEELCSKSR TRTLVTARQI AMYLCRELTD
     MSLPKIGQEL GGRDHTTVIH ADRKIRELMA ERRVIYNQVT ELTNRIKQQQ RNA
//