ID   A0A0W8AVJ6_KLEPN        Unreviewed;       588 AA.
AC   A0A0W8AVJ6; A0A0J2GHB5; A0A4V0HIQ6;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   27-NOV-2024, entry version 67.
DE   RecName: Full=Peptidoglycan D,D-transpeptidase FtsI {ECO:0000256|HAMAP-Rule:MF_02080};
DE            EC=3.4.16.4 {ECO:0000256|HAMAP-Rule:MF_02080};
DE   AltName: Full=Penicillin-binding protein 3 {ECO:0000256|HAMAP-Rule:MF_02080};
DE            Short=PBP-3 {ECO:0000256|HAMAP-Rule:MF_02080};
GN   Name=ftsI {ECO:0000256|HAMAP-Rule:MF_02080,
GN   ECO:0000313|EMBL:MRL34674.1};
GN   Synonyms=ftsI_1 {ECO:0000313|EMBL:STT52506.1}, ftsI_2
GN   {ECO:0000313|EMBL:SBH25343.1}, ftsI_3 {ECO:0000313|EMBL:STT50626.1},
GN   ftsI_4 {ECO:0000313|EMBL:SQC48283.1}, ftsI_5
GN   {ECO:0000313|EMBL:STU32598.1}, ftsI_7 {ECO:0000313|EMBL:STV70103.1};
GN   ORFNames=APT92_01945 {ECO:0000313|EMBL:KSX90961.1}, B5L96_26605
GN   {ECO:0000313|EMBL:OVF65434.1}, B6I68_11965
GN   {ECO:0000313|EMBL:PLE27478.1}, BANRA_00921
GN   {ECO:0000313|EMBL:VCV73108.1}, BANRA_04330
GN   {ECO:0000313|EMBL:VCX99666.1}, BL124_00027960
GN   {ECO:0000313|EMBL:ROG87213.1}, BV369_06175
GN   {ECO:0000313|EMBL:OWA83148.1}, CP554_02775
GN   {ECO:0000313|EMBL:PVU64124.1}, DM083_11500
GN   {ECO:0000313|EMBL:RCJ52101.1}, DW281_06270
GN   {ECO:0000313|EMBL:RDT90881.1}, EAO17_18230
GN   {ECO:0000313|EMBL:RRF08000.1}, EXT45_14640
GN   {ECO:0000313|EMBL:RZG36124.1}, FXN67_14725
GN   {ECO:0000313|EMBL:TYL78263.1}, G4V31_07195
GN   {ECO:0000313|EMBL:NGN71919.1}, GJJ01_07030
GN   {ECO:0000313|EMBL:MRJ95711.1}, GJJ08_022575
GN   {ECO:0000313|EMBL:QOU51083.1}, GJJ18_04425
GN   {ECO:0000313|EMBL:MRL34674.1}, GNF00_08110
GN   {ECO:0000313|EMBL:MUA39810.1}, H3G96_005050
GN   {ECO:0000313|EMBL:QQL34600.1}, HV185_21660
GN   {ECO:0000313|EMBL:QLO20895.1}, I8R04_20830
GN   {ECO:0000313|EMBL:MBH8352443.1}, JMZ77_22240
GN   {ECO:0000313|EMBL:QQZ70867.1}, KPZU09_40050
GN   {ECO:0000313|EMBL:GHK54269.1}, LS45_00680
GN   {ECO:0000313|EMBL:KII08708.1}, NCTC11679_04757
GN   {ECO:0000313|EMBL:STV70103.1}, NCTC13465_04475
GN   {ECO:0000313|EMBL:SQC48283.1}, NCTC13635_05081
GN   {ECO:0000313|EMBL:VEB05243.1}, NCTC5052_02861
GN   {ECO:0000313|EMBL:STT94424.1}, NCTC5053_04312
GN   {ECO:0000313|EMBL:STV35655.1}, NCTC8849_01042
GN   {ECO:0000313|EMBL:STT52506.1}, NCTC9637_05624
GN   {ECO:0000313|EMBL:STT50626.1}, NCTC9661_05284
GN   {ECO:0000313|EMBL:STU32598.1}, Q6294_16150
GN   {ECO:0000313|EMBL:MDP0968559.1}, SAMEA2273558_03096
GN   {ECO:0000313|EMBL:SBH25343.1}, SAMEA3499874_03070
GN   {ECO:0000313|EMBL:SXG16586.1}, SAMEA3499901_00823
GN   {ECO:0000313|EMBL:SXN29830.1}, SAMEA3515122_03018
GN   {ECO:0000313|EMBL:SYH33035.1}, SAMEA3538551_02771
GN   {ECO:0000313|EMBL:SYC19817.1}, SAMEA3538828_00863
GN   {ECO:0000313|EMBL:SYR31589.1}, SAMEA3649591_02181
GN   {ECO:0000313|EMBL:SVN64074.1}, SAMEA3649615_03484
GN   {ECO:0000313|EMBL:SYU74220.1}, SAMEA3720909_02183
GN   {ECO:0000313|EMBL:SWF71742.1}, SAMEA3729652_02919
GN   {ECO:0000313|EMBL:SWT15818.1}, SAMEA4364603_03511
GN   {ECO:0000313|EMBL:SSK45838.1}, SAMEA4873597_03160
GN   {ECO:0000313|EMBL:VGJ31063.1}, SAMEA4873632_03788
GN   {ECO:0000313|EMBL:VGL03660.1};
OS   Klebsiella pneumoniae.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=573 {ECO:0000313|EMBL:MRL34674.1};
RN   [1] {ECO:0000313|EMBL:KII08708.1, ECO:0000313|Proteomes:UP000031820}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UMNturkey9 {ECO:0000313|EMBL:KII08708.1,
RC   ECO:0000313|Proteomes:UP000031820};
RA   Lang K., Dorn K., Danzeisen J., Johnson T.;
RT   "Plasmid movement, recombination, and chromosomal integration amongst
RT   multidrug resistant commensal Escherichia coli clones within a single
RT   commercial turkey flock.";
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:KSX90961.1, ECO:0000313|Proteomes:UP000052969}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=50627996 {ECO:0000313|EMBL:KSX90961.1,
RC   ECO:0000313|Proteomes:UP000052969};
RA   Samuelsen O.;
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:PLE27478.1, ECO:0000313|Proteomes:UP000234439}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=COL-Kpn30 {ECO:0000313|EMBL:PLE27478.1,
RC   ECO:0000313|Proteomes:UP000234439};
RX   PubMed=29029188; DOI=.1093/infdis/jix524;
RA   Rojas L.J., Weinstock G.M., De La Cadena E., Diaz L., Rios R., Hanson B.M.,
RA   Brown J.S., Vats P., Phillips D.S., Nguyen H., Hujer K.M., Correa A.,
RA   Adams M.D., Perez F., Sodergren E., Narechania A., Planet P.J.,
RA   Villegas M.V., Bonomo R.A., Arias C.A.;
RT   "An Analysis of the Epidemic of Klebsiella pneumoniae Carbapenemase-
RT   Producing K. pneumoniae: Convergence of Two Evolutionary Mechanisms Creates
RT   the Perfect Storm.";
RL   J. Infect. Dis. 217:82-92(2017).
RN   [4] {ECO:0000313|EMBL:OWA83148.1, ECO:0000313|Proteomes:UP000195348}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C6-E2-14 {ECO:0000313|EMBL:OWA83148.1,
RC   ECO:0000313|Proteomes:UP000195348};
RA   Jaidane N., Mansour W., Bonnin R., Boujafar N., Bouallegue O., Naas T.;
RT   "Colistin Resistant Klebsiella pneumoniae C6.";
RL   Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|EMBL:OVF65434.1, ECO:0000313|Proteomes:UP000196447}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=39383 {ECO:0000313|EMBL:OVF65434.1,
RC   ECO:0000313|Proteomes:UP000196447};
RA   Fouts D., Stalin M.J., Chen L., Wright M., Sutton G., Nguyen K.,
RA   Vanduin D., Rojas L., Hujer A., Hujer K., Bonomo R., Kreiswirth B.,
RA   Adams M.;
RL   Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|EMBL:PVU64124.1, ECO:0000313|Proteomes:UP000245817}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HH516E4IA {ECO:0000313|EMBL:PVU64124.1,
RC   ECO:0000313|Proteomes:UP000245817};
RA   Founou L., Founou R.C., Allam M., Ismail A., Essack S.Y.;
RT   "Molecular Epidemiology of Livestock-Associated Methicillin Resistant
RT   Staphylococcus aureus (LA-MRSA) and Extended-Spectrum Beta-Lactamase
RT   (ESBL)-Producing Enterobacteriaceae in Pigs and Exposed Workers in Cameroon
RT   and South Africa.";
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|EMBL:RRF08000.1, ECO:0000313|Proteomes:UP000275975}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KLPN_104 {ECO:0000313|EMBL:RRF08000.1,
RC   ECO:0000313|Proteomes:UP000275975};
RX   PubMed=30373801;
RA   Tamma P.D., Fan Y., Bergman Y., Pertea G., Kazmi A., Lewis S.,
RA   Carroll K.C., Schatz M.C., Timp W., Simner P.J.;
RT   "Applying Rapid Whole Genome Sequencing to Predict Phenotypic Antimicrobial
RT   Susceptibility Testing Results Among Carbapenem-Resistant Klebsiella
RT   pneumoniae Clinical Isolates.";
RL   Antimicrob. Agents Chemother. 0:0-0(2018).
RN   [8] {ECO:0000313|Proteomes:UP000251721, ECO:0000313|Proteomes:UP000254103}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC11679 {ECO:0000313|EMBL:STV70103.1,
RC   ECO:0000313|Proteomes:UP000255239}, NCTC13465
RC   {ECO:0000313|EMBL:SQC48283.1, ECO:0000313|Proteomes:UP000251721},
RC   NCTC5052 {ECO:0000313|EMBL:STT94424.1,
RC   ECO:0000313|Proteomes:UP000254103}, NCTC5053
RC   {ECO:0000313|EMBL:STV35655.1, ECO:0000313|Proteomes:UP000254387},
RC   NCTC8849 {ECO:0000313|EMBL:STT52506.1,
RC   ECO:0000313|Proteomes:UP000254799}, NCTC9637
RC   {ECO:0000313|EMBL:STT50626.1, ECO:0000313|Proteomes:UP000255099}, and
RC   NCTC9661 {ECO:0000313|EMBL:STU32598.1,
RC   ECO:0000313|Proteomes:UP000255137};
RG   Pathogen Informatics;
RA   Doyle S.;
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [9] {ECO:0000313|EMBL:RDT90881.1, ECO:0000313|Proteomes:UP000254680}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K280 {ECO:0000313|EMBL:RDT90881.1,
RC   ECO:0000313|Proteomes:UP000254680};
RA   He F.;
RT   "Draft genome sequence of Klebsiella pneumoniae K280.";
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN   [10] {ECO:0000313|Proteomes:UP000253135}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BC_4987 {ECO:0000313|Proteomes:UP000253135};
RA   Martins R.C.R., Perdigao-Neto L.V., Costa S.F., Levin A.S.S.;
RT   "Klebsiella pneumoniae genome sequencing and assembly.";
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN   [11] {ECO:0000313|EMBL:RCJ52101.1, ECO:0000313|Proteomes:UP000253135}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BC_4987 {ECO:0000313|EMBL:RCJ52101.1,
RC   ECO:0000313|Proteomes:UP000253135};
RA   Martins R.C., Perdigao-Neto L.V., Costa S.F., Levin A.S.S.;
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN   [12] {ECO:0000313|EMBL:RCJ52101.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BC_4987 {ECO:0000313|EMBL:RCJ52101.1};
RA   Martins R.C.R., Perdigao-Neto L.V., Costa S.F., Levin A.S.S.;
RT   "Klebsiella pneumoniae genome sequencing and assembly.";
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
RN   [13] {ECO:0000313|Proteomes:UP000257587, ECO:0000313|Proteomes:UP000258232}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=4300STDY6470422 {ECO:0000313|EMBL:SSK45838.1,
RC   ECO:0000313|Proteomes:UP000252603}, 5012STDY7626396
RC   {ECO:0000313|EMBL:VGJ31063.1, ECO:0000313|Proteomes:UP000295133},
RC   5012STDY7626430 {ECO:0000313|EMBL:VGL03660.1,
RC   ECO:0000313|Proteomes:UP000376235}, EuSCAPE_AT002
RC   {ECO:0000313|EMBL:SXG16586.1, ECO:0000313|Proteomes:UP000257587},
RC   EuSCAPE_AT029 {ECO:0000313|EMBL:SXN29830.1,
RC   ECO:0000313|Proteomes:UP000259975}, EuSCAPE_ES277
RC   {ECO:0000313|EMBL:SYU74220.1, ECO:0000313|Proteomes:UP000259417},
RC   EuSCAPE_GR003 {ECO:0000313|EMBL:SVN64074.1,
RC   ECO:0000313|Proteomes:UP000258905}, EuSCAPE_HU047
RC   {ECO:0000313|EMBL:SYR31589.1, ECO:0000313|Proteomes:UP000258253},
RC   EuSCAPE_IT093 {ECO:0000313|EMBL:SYH33035.1,
RC   ECO:0000313|Proteomes:UP000258673}, EuSCAPE_ME009
RC   {ECO:0000313|EMBL:SYC19817.1, ECO:0000313|Proteomes:UP000258232},
RC   EuSCAPE_TR125 {ECO:0000313|EMBL:SWT15818.1,
RC   ECO:0000313|Proteomes:UP000258798}, EuSCAPE_UK014
RC   {ECO:0000313|EMBL:SWF71742.1, ECO:0000313|Proteomes:UP000259364}, K480
RC   {ECO:0000313|EMBL:SBH25343.1}, k480
RC   {ECO:0000313|Proteomes:UP000077826}, and NCTC13635
RC   {ECO:0000313|EMBL:VEB05243.1, ECO:0000313|Proteomes:UP000282433};
RG   Pathogen Informatics;
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
RN   [14] {ECO:0000313|Proteomes:UP000269921, ECO:0000313|Proteomes:UP000278966}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Kpneu006 {ECO:0000313|EMBL:VCV73108.1}, and Kpneu025
RC   {ECO:0000313|EMBL:VCX99666.1};
RA   Noll B N.;
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN   [15] {ECO:0000313|EMBL:ROG87213.1, ECO:0000313|Proteomes:UP000283322}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CRK0165 {ECO:0000313|EMBL:ROG87213.1,
RC   ECO:0000313|Proteomes:UP000283322};
RA   Vanduin D., Fouts D., Wright M., Sutton G., Nguyen K., Kreiswirth B.,
RA   Chen L., Rojas L., Hujer A., Hujer K., Bonomo R., Adams M.;
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN   [16] {ECO:0000313|EMBL:RZG36124.1, ECO:0000313|Proteomes:UP000293472}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=53 {ECO:0000313|EMBL:RZG36124.1,
RC   ECO:0000313|Proteomes:UP000293472};
RA   Newire E., Aydin A., Juma S., Enne V., Roberts A.P.;
RT   "Identification of a Type IV CRISPR-Cas system located exclusively on
RT   IncHI1B/ IncFIB plasmids in Enterobacteriaceae.";
RL   Submitted (FEB-2019) to the EMBL/GenBank/DDBJ databases.
RN   [17] {ECO:0000313|EMBL:TYL78263.1, ECO:0000313|Proteomes:UP000322977}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UCO-494 {ECO:0000313|EMBL:TYL78263.1,
RC   ECO:0000313|Proteomes:UP000322977};
RA   Morales-Leon F., Caro C., Opazo-Capurro A., Lincopan N.,
RA   Dominguez-Yevenes M., Lima C., Bello-Toledo H., Gonzalez-Rocha G.;
RT   "Phenotypic and genetic characterization of extended-spectrum b-lactamase-
RT   producing hypermucoviscous Klebsiella pneumoniae from Chile.";
RL   Submitted (AUG-2019) to the EMBL/GenBank/DDBJ databases.
RN   [18] {ECO:0000313|EMBL:MRL34674.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CriePir115 {ECO:0000313|EMBL:MRL34674.1}, and CriePir226
RC   {ECO:0000313|EMBL:MRJ95711.1, ECO:0000313|Proteomes:UP000441029};
RA   Shelenkov A., Mikhaylova Y., Yanushevich Y., Samoilov A., Petrova L.,
RA   Fomina V., Gusarov V., Zamyatin M., Shagin D.;
RT   "Molecular typing, antibiotic resistance determination and virulence
RT   profiling for 36 multidrug-resistant clinical Klebsiella pneumoniae
RT   isolates using second- and third-generation sequencing.";
RL   Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases.
RN   [19] {ECO:0000313|EMBL:MUA39810.1, ECO:0000313|Proteomes:UP000485085}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KP_38044 {ECO:0000313|EMBL:MUA39810.1,
RC   ECO:0000313|Proteomes:UP000485085};
RA   Zhou K.;
RT   "Emergence of a novel subclone of carbapenem-resistant Klebsiella
RT   pneumoniae ST11 with enhanced virulence and transmissibility: a molecular
RT   epidemiological, clinical, genomic study.";
RL   Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
RN   [20] {ECO:0000313|EMBL:QOU51083.1, ECO:0000313|Proteomes:UP000439817}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CriePir120 {ECO:0000313|EMBL:QOU51083.1,
RC   ECO:0000313|Proteomes:UP000439817};
RX   PubMed=32429555;
RA   Shelenkov A., Mikhaylova Y., Yanushevich Y., Samoilov A., Petrova L.,
RA   Fomina V., Gusarov V., Zamyatin M., Shagin D., Akimkin V.;
RT   "Molecular Typing, Characterization of Antimicrobial Resistance, Virulence
RT   Profiling and Analysis of Whole-Genome Sequence of Clinical Klebsiella
RT   pneumoniae Isolates.";
RL   Antibiotics 9:E261-E261(2020).
RN   [21] {ECO:0000313|EMBL:NGN71919.1, ECO:0000313|Proteomes:UP000479475}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2429 {ECO:0000313|EMBL:NGN71919.1,
RC   ECO:0000313|Proteomes:UP000479475};
RA   Starkova P.S., Sulyan O.S., Likholetova D.V., Ageevets V.A., Lazareva I.V.,
RA   Sopova J.V., Sidorenko S.V.;
RT   "Klebsiella pneumoniae genome sequencing and assembly.";
RL   Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
RN   [22] {ECO:0000313|Proteomes:UP000512241}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RHBSTW-00405 {ECO:0000313|Proteomes:UP000512241};
RA   Shaw L.P.;
RT   "REHAB project genomes.";
RL   Submitted (JUN-2020) to the EMBL/GenBank/DDBJ databases.
RN   [23] {ECO:0000313|EMBL:GHK54269.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Zam_UTH_09 {ECO:0000313|EMBL:GHK54269.1};
RA   Shawa M., Furuta Y., Simbotwe M., Mulenga E., Mubanga M., Mulenga G.,
RA   Kaile C., Zorigt T., Hang'ombe B., Higashi H.;
RT   "Genome Sequence of ESBL Producing Zambian Clinical Strains.";
RL   Submitted (OCT-2020) to the EMBL/GenBank/DDBJ databases.
RN   [24] {ECO:0000313|EMBL:QQL34600.1, ECO:0000313|Proteomes:UP000532829}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WCHKP090374 {ECO:0000313|EMBL:QQL34600.1,
RC   ECO:0000313|Proteomes:UP000532829};
RA   Wei L., Wen H., Liu L., Feng Y., Zong Z.;
RT   "The complete genome of Klebsiella pneumoniae strain 090374.";
RL   Submitted (DEC-2020) to the EMBL/GenBank/DDBJ databases.
RN   [25] {ECO:0000313|EMBL:MBH8352443.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CCBH27695 {ECO:0000313|EMBL:MBH8352443.1};
RA   Silveira M.C., Claudio R.-D.-S.M., Ana Paula C.-A.D.;
RT   "WGS of multidrug-resistant bacteria from different Brazilian states.";
RL   Submitted (DEC-2020) to the EMBL/GenBank/DDBJ databases.
RN   [26] {ECO:0000313|EMBL:QLO20895.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=RHBSTW-00405 {ECO:0000313|EMBL:QLO20895.1};
RX   PubMed=34609275;
RA   AbuOun M., Jones H., Stubberfield E., Gilson D., Shaw L.P., Hubbard A.T.M.,
RA   Chau K.K., Sebra R., Peto T.E.A., Crook D.W., Read D.S., Gweon H.S.,
RA   Walker A.S., Stoesser N., Smith R.P., Anjum M.F.,
RA   On Behalf Of The Rehab Consortium.;
RT   "A genomic epidemiological study shows that prevalence of antimicrobial
RT   resistance in Enterobacterales is associated with the livestock host, as
RT   well as antimicrobial usage.";
RL   Microb. Genom. 7:0-0(2021).
RN   [27] {ECO:0000313|EMBL:QQZ70867.1, ECO:0000313|Proteomes:UP000595568}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=59493 {ECO:0000313|EMBL:QQZ70867.1,
RC   ECO:0000313|Proteomes:UP000595568};
RA   Chen L., Kreiswirth B.;
RT   "Genome sequencing of apramycin resistant K. pneumoniae.";
RL   Submitted (JAN-2021) to the EMBL/GenBank/DDBJ databases.
RN   [28] {ECO:0000313|EMBL:MDP0968559.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=KP219 {ECO:0000313|EMBL:MDP0968559.1};
RA   Peng Z.;
RL   Submitted (JUL-2023) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes cross-linking of the peptidoglycan cell wall at the
CC       division septum. {ECO:0000256|HAMAP-Rule:MF_02080}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Preferential cleavage: (Ac)2-L-Lys-D-Ala-|-D-Ala. Also
CC         transpeptidation of peptidyl-alanyl moieties that are N-acyl
CC         substituents of D-alanine.; EC=3.4.16.4; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_02080};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a beta-lactam + H2O = a substituted beta-amino acid;
CC         Xref=Rhea:RHEA:20401, ChEBI:CHEBI:15377, ChEBI:CHEBI:35627,
CC         ChEBI:CHEBI:140347; EC=3.5.2.6;
CC         Evidence={ECO:0000256|ARBA:ARBA00001526};
CC   -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC       {ECO:0000256|HAMAP-Rule:MF_02080}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000256|HAMAP-
CC       Rule:MF_02080}; Single-pass membrane protein {ECO:0000256|HAMAP-
CC       Rule:MF_02080}. Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass
CC       membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC   -!- SIMILARITY: Belongs to the transpeptidase family. FtsI subfamily.
CC       {ECO:0000256|HAMAP-Rule:MF_02080}.
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DR   EMBL; BNFF01000001; GHK54269.1; -; Genomic_DNA.
DR   EMBL; JRRF01000002; KII08708.1; -; Genomic_DNA.
DR   EMBL; LNHP01000013; KSX90961.1; -; Genomic_DNA.
DR   EMBL; JAECTB010000019; MBH8352443.1; -; Genomic_DNA.
DR   EMBL; JAUUIA010000013; MDP0968559.1; -; Genomic_DNA.
DR   EMBL; WJVL01000004; MRJ95711.1; -; Genomic_DNA.
DR   EMBL; WJWF01000003; MRL34674.1; -; Genomic_DNA.
DR   EMBL; WNPO01000011; MUA39810.1; -; Genomic_DNA.
DR   EMBL; JAAKYD010000005; NGN71919.1; -; Genomic_DNA.
DR   EMBL; NDBK01000112; OVF65434.1; -; Genomic_DNA.
DR   EMBL; MSYX01000008; OWA83148.1; -; Genomic_DNA.
DR   EMBL; NCMJ01000062; PLE27478.1; -; Genomic_DNA.
DR   EMBL; PCFF01000002; PVU64124.1; -; Genomic_DNA.
DR   EMBL; CP055517; QLO20895.1; -; Genomic_DNA.
DR   EMBL; CP063008; QOU51083.1; -; Genomic_DNA.
DR   EMBL; CP066534; QQL34600.1; -; Genomic_DNA.
DR   EMBL; CP068602; QQZ70867.1; -; Genomic_DNA.
DR   EMBL; QOUB01000006; RCJ52101.1; -; Genomic_DNA.
DR   EMBL; QRCD01000005; RDT90881.1; -; Genomic_DNA.
DR   EMBL; MPYG04000224; ROG87213.1; -; Genomic_DNA.
DR   EMBL; RDAM01000001; RRF08000.1; -; Genomic_DNA.
DR   EMBL; SGOL01000011; RZG36124.1; -; Genomic_DNA.
DR   EMBL; FLDK01000007; SBH25343.1; -; Genomic_DNA.
DR   EMBL; UAWQ01000019; SQC48283.1; -; Genomic_DNA.
DR   EMBL; UFEU01000009; SSK45838.1; -; Genomic_DNA.
DR   EMBL; UGLB01000003; STT50626.1; -; Genomic_DNA.
DR   EMBL; UGLC01000002; STT52506.1; -; Genomic_DNA.
DR   EMBL; UGLJ01000002; STT94424.1; -; Genomic_DNA.
DR   EMBL; UGLQ01000003; STU32598.1; -; Genomic_DNA.
DR   EMBL; UGMN01000004; STV35655.1; -; Genomic_DNA.
DR   EMBL; UGMG01000001; STV70103.1; -; Genomic_DNA.
DR   EMBL; UIUC01000006; SVN64074.1; -; Genomic_DNA.
DR   EMBL; UJHH01000008; SWF71742.1; -; Genomic_DNA.
DR   EMBL; UJRG01000008; SWT15818.1; -; Genomic_DNA.
DR   EMBL; UKAW01000007; SXG16586.1; -; Genomic_DNA.
DR   EMBL; UKGE01000003; SXN29830.1; -; Genomic_DNA.
DR   EMBL; UKRD01000005; SYC19817.1; -; Genomic_DNA.
DR   EMBL; UKUT01000006; SYH33035.1; -; Genomic_DNA.
DR   EMBL; ULCI01000003; SYR31589.1; -; Genomic_DNA.
DR   EMBL; ULET01000009; SYU74220.1; -; Genomic_DNA.
DR   EMBL; VSSY01000011; TYL78263.1; -; Genomic_DNA.
DR   EMBL; UWVH01000001; VCV73108.1; -; Genomic_DNA.
DR   EMBL; UWWS01000001; VCX99666.1; -; Genomic_DNA.
DR   EMBL; LR134162; VEB05243.1; -; Genomic_DNA.
DR   EMBL; CAAHAW010000008; VGJ31063.1; -; Genomic_DNA.
DR   EMBL; CAAHCC010000007; VGL03660.1; -; Genomic_DNA.
DR   RefSeq; WP_002888559.1; NZ_WYAM01000022.1.
DR   KEGG; kpb:FH42_21260; -.
DR   KEGG; kpne:KU54_022460; -.
DR   KEGG; kpnu:LI86_22300; -.
DR   KEGG; kpx:PMK1_02396; -.
DR   OMA; SCIVVIH; -.
DR   UniPathway; UPA00219; -.
DR   Proteomes; UP000031820; Unassembled WGS sequence.
DR   Proteomes; UP000052969; Unassembled WGS sequence.
DR   Proteomes; UP000077826; Unassembled WGS sequence.
DR   Proteomes; UP000195348; Unassembled WGS sequence.
DR   Proteomes; UP000196447; Unassembled WGS sequence.
DR   Proteomes; UP000234439; Unassembled WGS sequence.
DR   Proteomes; UP000245817; Unassembled WGS sequence.
DR   Proteomes; UP000251721; Unassembled WGS sequence.
DR   Proteomes; UP000252603; Unassembled WGS sequence.
DR   Proteomes; UP000253135; Unassembled WGS sequence.
DR   Proteomes; UP000254103; Unassembled WGS sequence.
DR   Proteomes; UP000254387; Unassembled WGS sequence.
DR   Proteomes; UP000254680; Unassembled WGS sequence.
DR   Proteomes; UP000254799; Unassembled WGS sequence.
DR   Proteomes; UP000255099; Unassembled WGS sequence.
DR   Proteomes; UP000255137; Unassembled WGS sequence.
DR   Proteomes; UP000255239; Unassembled WGS sequence.
DR   Proteomes; UP000257587; Unassembled WGS sequence.
DR   Proteomes; UP000258232; Unassembled WGS sequence.
DR   Proteomes; UP000258253; Unassembled WGS sequence.
DR   Proteomes; UP000258673; Unassembled WGS sequence.
DR   Proteomes; UP000258798; Unassembled WGS sequence.
DR   Proteomes; UP000258905; Unassembled WGS sequence.
DR   Proteomes; UP000259364; Unassembled WGS sequence.
DR   Proteomes; UP000259417; Unassembled WGS sequence.
DR   Proteomes; UP000259975; Unassembled WGS sequence.
DR   Proteomes; UP000269921; Unassembled WGS sequence.
DR   Proteomes; UP000275975; Unassembled WGS sequence.
DR   Proteomes; UP000278966; Unassembled WGS sequence.
DR   Proteomes; UP000282433; Chromosome 1.
DR   Proteomes; UP000283322; Unassembled WGS sequence.
DR   Proteomes; UP000293472; Unassembled WGS sequence.
DR   Proteomes; UP000295133; Unassembled WGS sequence.
DR   Proteomes; UP000322977; Unassembled WGS sequence.
DR   Proteomes; UP000376235; Unassembled WGS sequence.
DR   Proteomes; UP000439817; Chromosome.
DR   Proteomes; UP000441029; Unassembled WGS sequence.
DR   Proteomes; UP000479475; Unassembled WGS sequence.
DR   Proteomes; UP000485085; Unassembled WGS sequence.
DR   Proteomes; UP000512241; Chromosome.
DR   Proteomes; UP000532829; Chromosome.
DR   Proteomes; UP000595568; Chromosome.
DR   Proteomes; UP000622626; Unassembled WGS sequence.
DR   Proteomes; UP000655094; Unassembled WGS sequence.
DR   Proteomes; UP001244490; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:InterPro.
DR   GO; GO:0009002; F:serine-type D-Ala-D-Ala carboxypeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR   GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR   GO; GO:0043093; P:FtsZ-dependent cytokinesis; IEA:UniProtKB-UniRule.
DR   GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR   FunFam; 1.10.150.770:FF:000001; Peptidoglycan D,D-transpeptidase FtsI; 1.
DR   FunFam; 3.40.710.10:FF:000003; Peptidoglycan D,D-transpeptidase FtsI; 1.
DR   FunFam; 3.90.1310.10:FF:000003; Peptidoglycan D,D-transpeptidase FtsI; 1.
DR   Gene3D; 1.10.150.770; -; 1.
DR   Gene3D; 3.30.450.330; -; 1.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR   HAMAP; MF_02080; FtsI_transpept; 1.
DR   InterPro; IPR050515; Bact_Transpept/Beta-Lactamase.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR037532; FtsI_transpept.
DR   InterPro; IPR005311; PBP_dimer.
DR   InterPro; IPR036138; PBP_dimer_sf.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR   PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1.
DR   Pfam; PF03717; PBP_dimer; 1.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR   SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE   3: Inferred from homology;
KW   Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645, ECO:0000256|HAMAP-
KW   Rule:MF_02080};
KW   Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|HAMAP-
KW   Rule:MF_02080};
KW   Cell division {ECO:0000256|ARBA:ARBA00022618, ECO:0000256|HAMAP-
KW   Rule:MF_02080};
KW   Cell inner membrane {ECO:0000256|ARBA:ARBA00022519, ECO:0000256|HAMAP-
KW   Rule:MF_02080}; Cell membrane {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Cell shape {ECO:0000256|ARBA:ARBA00022960, ECO:0000256|HAMAP-
KW   Rule:MF_02080};
KW   Cell wall biogenesis/degradation {ECO:0000256|ARBA:ARBA00023316,
KW   ECO:0000256|HAMAP-Rule:MF_02080};
KW   Glycosyltransferase {ECO:0000313|EMBL:SBH25343.1};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_02080, ECO:0000313|EMBL:MRL34674.1};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_02080};
KW   Peptidoglycan synthesis {ECO:0000256|ARBA:ARBA00022984, ECO:0000256|HAMAP-
KW   Rule:MF_02080}; Protease {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Septation {ECO:0000256|ARBA:ARBA00023210, ECO:0000256|HAMAP-Rule:MF_02080};
KW   Transferase {ECO:0000313|EMBL:OVF65434.1};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW   Rule:MF_02080};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW   Rule:MF_02080}.
FT   TRANSMEM        20..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_02080"
FT   DOMAIN          69..220
FT                   /note="Penicillin-binding protein dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF03717"
FT   DOMAIN          260..554
FT                   /note="Penicillin-binding protein transpeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF00905"
FT   ACT_SITE        307
FT                   /note="Acyl-ester intermediate"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_02080"
SQ   SEQUENCE   588 AA;  64003 MW;  2FE4408506D51A55 CRC64;
     MKAAPKTPKA KRQEEQANFI SWRFALLCGC ILLALAFLLG RVAWLQVISP DMLVRQGDMR
     SLRVQEVSTA RGMITDRSGR PLAVSVPVKA IWADPKELHD AGGVTLDTRW KALADALNMP
     LDQLATRINT NPRMRFIYLA RQVNPDMADY IKKLKLPGIH LREESRRYYP SGEVTAHLIG
     FTNVDSQGIE GVEKSFDKWL TGQPGERIVR KDRYGRVIED ISSTDSQAAH NLALSIDERL
     QALVYRELNN AVAFNKAESG SAVLVDVNTG EVLAMANSPS YNPNNFAGTA KDTMRNRAIT
     DVFEPGSTVK PMVVMTALQR GIVNENTVLN TVPYRINGHE IKDVARYSEL TLTGVLQKSS
     NVGVSKLALA MPSSALVDTY SRFGLGKATN LGLVGERSGL YPQKQRWSDI ERATFSFGYG
     LMVTPLQLAR VYATIGSYGI YRPLSITKVD PPVPGERVFP ESLVRTVVHM MESVALPGGG
     GVKAAIKGYR IAIKTGTAKK VGPDGRYINK YIAYTAGVAP ASHPRFALVV VINDPQAGKY
     YGGAVSAPVF GAIMGGVLRT MNIEPDALAT GEKSEFVINQ GEGTGGRS
//