ID A0A0W8AVJ6_KLEPN Unreviewed; 588 AA. AC A0A0W8AVJ6; A0A0J2GHB5; A0A4V0HIQ6; DT 13-APR-2016, integrated into UniProtKB/TrEMBL. DT 13-APR-2016, sequence version 1. DT 27-NOV-2024, entry version 67. DE RecName: Full=Peptidoglycan D,D-transpeptidase FtsI {ECO:0000256|HAMAP-Rule:MF_02080}; DE EC=3.4.16.4 {ECO:0000256|HAMAP-Rule:MF_02080}; DE AltName: Full=Penicillin-binding protein 3 {ECO:0000256|HAMAP-Rule:MF_02080}; DE Short=PBP-3 {ECO:0000256|HAMAP-Rule:MF_02080}; GN Name=ftsI {ECO:0000256|HAMAP-Rule:MF_02080, GN ECO:0000313|EMBL:MRL34674.1}; GN Synonyms=ftsI_1 {ECO:0000313|EMBL:STT52506.1}, ftsI_2 GN {ECO:0000313|EMBL:SBH25343.1}, ftsI_3 {ECO:0000313|EMBL:STT50626.1}, GN ftsI_4 {ECO:0000313|EMBL:SQC48283.1}, ftsI_5 GN {ECO:0000313|EMBL:STU32598.1}, ftsI_7 {ECO:0000313|EMBL:STV70103.1}; GN ORFNames=APT92_01945 {ECO:0000313|EMBL:KSX90961.1}, B5L96_26605 GN {ECO:0000313|EMBL:OVF65434.1}, B6I68_11965 GN {ECO:0000313|EMBL:PLE27478.1}, BANRA_00921 GN {ECO:0000313|EMBL:VCV73108.1}, BANRA_04330 GN {ECO:0000313|EMBL:VCX99666.1}, BL124_00027960 GN {ECO:0000313|EMBL:ROG87213.1}, BV369_06175 GN {ECO:0000313|EMBL:OWA83148.1}, CP554_02775 GN {ECO:0000313|EMBL:PVU64124.1}, DM083_11500 GN {ECO:0000313|EMBL:RCJ52101.1}, DW281_06270 GN {ECO:0000313|EMBL:RDT90881.1}, EAO17_18230 GN {ECO:0000313|EMBL:RRF08000.1}, EXT45_14640 GN {ECO:0000313|EMBL:RZG36124.1}, FXN67_14725 GN {ECO:0000313|EMBL:TYL78263.1}, G4V31_07195 GN {ECO:0000313|EMBL:NGN71919.1}, GJJ01_07030 GN {ECO:0000313|EMBL:MRJ95711.1}, GJJ08_022575 GN {ECO:0000313|EMBL:QOU51083.1}, GJJ18_04425 GN {ECO:0000313|EMBL:MRL34674.1}, GNF00_08110 GN {ECO:0000313|EMBL:MUA39810.1}, H3G96_005050 GN {ECO:0000313|EMBL:QQL34600.1}, HV185_21660 GN {ECO:0000313|EMBL:QLO20895.1}, I8R04_20830 GN {ECO:0000313|EMBL:MBH8352443.1}, JMZ77_22240 GN {ECO:0000313|EMBL:QQZ70867.1}, KPZU09_40050 GN {ECO:0000313|EMBL:GHK54269.1}, LS45_00680 GN {ECO:0000313|EMBL:KII08708.1}, NCTC11679_04757 GN {ECO:0000313|EMBL:STV70103.1}, NCTC13465_04475 GN {ECO:0000313|EMBL:SQC48283.1}, NCTC13635_05081 GN {ECO:0000313|EMBL:VEB05243.1}, NCTC5052_02861 GN {ECO:0000313|EMBL:STT94424.1}, NCTC5053_04312 GN {ECO:0000313|EMBL:STV35655.1}, NCTC8849_01042 GN {ECO:0000313|EMBL:STT52506.1}, NCTC9637_05624 GN {ECO:0000313|EMBL:STT50626.1}, NCTC9661_05284 GN {ECO:0000313|EMBL:STU32598.1}, Q6294_16150 GN {ECO:0000313|EMBL:MDP0968559.1}, SAMEA2273558_03096 GN {ECO:0000313|EMBL:SBH25343.1}, SAMEA3499874_03070 GN {ECO:0000313|EMBL:SXG16586.1}, SAMEA3499901_00823 GN {ECO:0000313|EMBL:SXN29830.1}, SAMEA3515122_03018 GN {ECO:0000313|EMBL:SYH33035.1}, SAMEA3538551_02771 GN {ECO:0000313|EMBL:SYC19817.1}, SAMEA3538828_00863 GN {ECO:0000313|EMBL:SYR31589.1}, SAMEA3649591_02181 GN {ECO:0000313|EMBL:SVN64074.1}, SAMEA3649615_03484 GN {ECO:0000313|EMBL:SYU74220.1}, SAMEA3720909_02183 GN {ECO:0000313|EMBL:SWF71742.1}, SAMEA3729652_02919 GN {ECO:0000313|EMBL:SWT15818.1}, SAMEA4364603_03511 GN {ECO:0000313|EMBL:SSK45838.1}, SAMEA4873597_03160 GN {ECO:0000313|EMBL:VGJ31063.1}, SAMEA4873632_03788 GN {ECO:0000313|EMBL:VGL03660.1}; OS Klebsiella pneumoniae. OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella. OX NCBI_TaxID=573 {ECO:0000313|EMBL:MRL34674.1}; RN [1] {ECO:0000313|EMBL:KII08708.1, ECO:0000313|Proteomes:UP000031820} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=UMNturkey9 {ECO:0000313|EMBL:KII08708.1, RC ECO:0000313|Proteomes:UP000031820}; RA Lang K., Dorn K., Danzeisen J., Johnson T.; RT "Plasmid movement, recombination, and chromosomal integration amongst RT multidrug resistant commensal Escherichia coli clones within a single RT commercial turkey flock."; RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:KSX90961.1, ECO:0000313|Proteomes:UP000052969} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=50627996 {ECO:0000313|EMBL:KSX90961.1, RC ECO:0000313|Proteomes:UP000052969}; RA Samuelsen O.; RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:PLE27478.1, ECO:0000313|Proteomes:UP000234439} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=COL-Kpn30 {ECO:0000313|EMBL:PLE27478.1, RC ECO:0000313|Proteomes:UP000234439}; RX PubMed=29029188; DOI=.1093/infdis/jix524; RA Rojas L.J., Weinstock G.M., De La Cadena E., Diaz L., Rios R., Hanson B.M., RA Brown J.S., Vats P., Phillips D.S., Nguyen H., Hujer K.M., Correa A., RA Adams M.D., Perez F., Sodergren E., Narechania A., Planet P.J., RA Villegas M.V., Bonomo R.A., Arias C.A.; RT "An Analysis of the Epidemic of Klebsiella pneumoniae Carbapenemase- RT Producing K. pneumoniae: Convergence of Two Evolutionary Mechanisms Creates RT the Perfect Storm."; RL J. Infect. Dis. 217:82-92(2017). RN [4] {ECO:0000313|EMBL:OWA83148.1, ECO:0000313|Proteomes:UP000195348} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C6-E2-14 {ECO:0000313|EMBL:OWA83148.1, RC ECO:0000313|Proteomes:UP000195348}; RA Jaidane N., Mansour W., Bonnin R., Boujafar N., Bouallegue O., Naas T.; RT "Colistin Resistant Klebsiella pneumoniae C6."; RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases. RN [5] {ECO:0000313|EMBL:OVF65434.1, ECO:0000313|Proteomes:UP000196447} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=39383 {ECO:0000313|EMBL:OVF65434.1, RC ECO:0000313|Proteomes:UP000196447}; RA Fouts D., Stalin M.J., Chen L., Wright M., Sutton G., Nguyen K., RA Vanduin D., Rojas L., Hujer A., Hujer K., Bonomo R., Kreiswirth B., RA Adams M.; RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases. RN [6] {ECO:0000313|EMBL:PVU64124.1, ECO:0000313|Proteomes:UP000245817} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=HH516E4IA {ECO:0000313|EMBL:PVU64124.1, RC ECO:0000313|Proteomes:UP000245817}; RA Founou L., Founou R.C., Allam M., Ismail A., Essack S.Y.; RT "Molecular Epidemiology of Livestock-Associated Methicillin Resistant RT Staphylococcus aureus (LA-MRSA) and Extended-Spectrum Beta-Lactamase RT (ESBL)-Producing Enterobacteriaceae in Pigs and Exposed Workers in Cameroon RT and South Africa."; RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases. RN [7] {ECO:0000313|EMBL:RRF08000.1, ECO:0000313|Proteomes:UP000275975} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KLPN_104 {ECO:0000313|EMBL:RRF08000.1, RC ECO:0000313|Proteomes:UP000275975}; RX PubMed=30373801; RA Tamma P.D., Fan Y., Bergman Y., Pertea G., Kazmi A., Lewis S., RA Carroll K.C., Schatz M.C., Timp W., Simner P.J.; RT "Applying Rapid Whole Genome Sequencing to Predict Phenotypic Antimicrobial RT Susceptibility Testing Results Among Carbapenem-Resistant Klebsiella RT pneumoniae Clinical Isolates."; RL Antimicrob. Agents Chemother. 0:0-0(2018). RN [8] {ECO:0000313|Proteomes:UP000251721, ECO:0000313|Proteomes:UP000254103} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=NCTC11679 {ECO:0000313|EMBL:STV70103.1, RC ECO:0000313|Proteomes:UP000255239}, NCTC13465 RC {ECO:0000313|EMBL:SQC48283.1, ECO:0000313|Proteomes:UP000251721}, RC NCTC5052 {ECO:0000313|EMBL:STT94424.1, RC ECO:0000313|Proteomes:UP000254103}, NCTC5053 RC {ECO:0000313|EMBL:STV35655.1, ECO:0000313|Proteomes:UP000254387}, RC NCTC8849 {ECO:0000313|EMBL:STT52506.1, RC ECO:0000313|Proteomes:UP000254799}, NCTC9637 RC {ECO:0000313|EMBL:STT50626.1, ECO:0000313|Proteomes:UP000255099}, and RC NCTC9661 {ECO:0000313|EMBL:STU32598.1, RC ECO:0000313|Proteomes:UP000255137}; RG Pathogen Informatics; RA Doyle S.; RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|EMBL:RDT90881.1, ECO:0000313|Proteomes:UP000254680} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K280 {ECO:0000313|EMBL:RDT90881.1, RC ECO:0000313|Proteomes:UP000254680}; RA He F.; RT "Draft genome sequence of Klebsiella pneumoniae K280."; RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases. RN [10] {ECO:0000313|Proteomes:UP000253135} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BC_4987 {ECO:0000313|Proteomes:UP000253135}; RA Martins R.C.R., Perdigao-Neto L.V., Costa S.F., Levin A.S.S.; RT "Klebsiella pneumoniae genome sequencing and assembly."; RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases. RN [11] {ECO:0000313|EMBL:RCJ52101.1, ECO:0000313|Proteomes:UP000253135} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BC_4987 {ECO:0000313|EMBL:RCJ52101.1, RC ECO:0000313|Proteomes:UP000253135}; RA Martins R.C., Perdigao-Neto L.V., Costa S.F., Levin A.S.S.; RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases. RN [12] {ECO:0000313|EMBL:RCJ52101.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BC_4987 {ECO:0000313|EMBL:RCJ52101.1}; RA Martins R.C.R., Perdigao-Neto L.V., Costa S.F., Levin A.S.S.; RT "Klebsiella pneumoniae genome sequencing and assembly."; RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases. RN [13] {ECO:0000313|Proteomes:UP000257587, ECO:0000313|Proteomes:UP000258232} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=4300STDY6470422 {ECO:0000313|EMBL:SSK45838.1, RC ECO:0000313|Proteomes:UP000252603}, 5012STDY7626396 RC {ECO:0000313|EMBL:VGJ31063.1, ECO:0000313|Proteomes:UP000295133}, RC 5012STDY7626430 {ECO:0000313|EMBL:VGL03660.1, RC ECO:0000313|Proteomes:UP000376235}, EuSCAPE_AT002 RC {ECO:0000313|EMBL:SXG16586.1, ECO:0000313|Proteomes:UP000257587}, RC EuSCAPE_AT029 {ECO:0000313|EMBL:SXN29830.1, RC ECO:0000313|Proteomes:UP000259975}, EuSCAPE_ES277 RC {ECO:0000313|EMBL:SYU74220.1, ECO:0000313|Proteomes:UP000259417}, RC EuSCAPE_GR003 {ECO:0000313|EMBL:SVN64074.1, RC ECO:0000313|Proteomes:UP000258905}, EuSCAPE_HU047 RC {ECO:0000313|EMBL:SYR31589.1, ECO:0000313|Proteomes:UP000258253}, RC EuSCAPE_IT093 {ECO:0000313|EMBL:SYH33035.1, RC ECO:0000313|Proteomes:UP000258673}, EuSCAPE_ME009 RC {ECO:0000313|EMBL:SYC19817.1, ECO:0000313|Proteomes:UP000258232}, RC EuSCAPE_TR125 {ECO:0000313|EMBL:SWT15818.1, RC ECO:0000313|Proteomes:UP000258798}, EuSCAPE_UK014 RC {ECO:0000313|EMBL:SWF71742.1, ECO:0000313|Proteomes:UP000259364}, K480 RC {ECO:0000313|EMBL:SBH25343.1}, k480 RC {ECO:0000313|Proteomes:UP000077826}, and NCTC13635 RC {ECO:0000313|EMBL:VEB05243.1, ECO:0000313|Proteomes:UP000282433}; RG Pathogen Informatics; RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases. RN [14] {ECO:0000313|Proteomes:UP000269921, ECO:0000313|Proteomes:UP000278966} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Kpneu006 {ECO:0000313|EMBL:VCV73108.1}, and Kpneu025 RC {ECO:0000313|EMBL:VCX99666.1}; RA Noll B N.; RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases. RN [15] {ECO:0000313|EMBL:ROG87213.1, ECO:0000313|Proteomes:UP000283322} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CRK0165 {ECO:0000313|EMBL:ROG87213.1, RC ECO:0000313|Proteomes:UP000283322}; RA Vanduin D., Fouts D., Wright M., Sutton G., Nguyen K., Kreiswirth B., RA Chen L., Rojas L., Hujer A., Hujer K., Bonomo R., Adams M.; RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases. RN [16] {ECO:0000313|EMBL:RZG36124.1, ECO:0000313|Proteomes:UP000293472} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=53 {ECO:0000313|EMBL:RZG36124.1, RC ECO:0000313|Proteomes:UP000293472}; RA Newire E., Aydin A., Juma S., Enne V., Roberts A.P.; RT "Identification of a Type IV CRISPR-Cas system located exclusively on RT IncHI1B/ IncFIB plasmids in Enterobacteriaceae."; RL Submitted (FEB-2019) to the EMBL/GenBank/DDBJ databases. RN [17] {ECO:0000313|EMBL:TYL78263.1, ECO:0000313|Proteomes:UP000322977} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=UCO-494 {ECO:0000313|EMBL:TYL78263.1, RC ECO:0000313|Proteomes:UP000322977}; RA Morales-Leon F., Caro C., Opazo-Capurro A., Lincopan N., RA Dominguez-Yevenes M., Lima C., Bello-Toledo H., Gonzalez-Rocha G.; RT "Phenotypic and genetic characterization of extended-spectrum b-lactamase- RT producing hypermucoviscous Klebsiella pneumoniae from Chile."; RL Submitted (AUG-2019) to the EMBL/GenBank/DDBJ databases. RN [18] {ECO:0000313|EMBL:MRL34674.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CriePir115 {ECO:0000313|EMBL:MRL34674.1}, and CriePir226 RC {ECO:0000313|EMBL:MRJ95711.1, ECO:0000313|Proteomes:UP000441029}; RA Shelenkov A., Mikhaylova Y., Yanushevich Y., Samoilov A., Petrova L., RA Fomina V., Gusarov V., Zamyatin M., Shagin D.; RT "Molecular typing, antibiotic resistance determination and virulence RT profiling for 36 multidrug-resistant clinical Klebsiella pneumoniae RT isolates using second- and third-generation sequencing."; RL Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases. RN [19] {ECO:0000313|EMBL:MUA39810.1, ECO:0000313|Proteomes:UP000485085} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KP_38044 {ECO:0000313|EMBL:MUA39810.1, RC ECO:0000313|Proteomes:UP000485085}; RA Zhou K.; RT "Emergence of a novel subclone of carbapenem-resistant Klebsiella RT pneumoniae ST11 with enhanced virulence and transmissibility: a molecular RT epidemiological, clinical, genomic study."; RL Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases. RN [20] {ECO:0000313|EMBL:QOU51083.1, ECO:0000313|Proteomes:UP000439817} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CriePir120 {ECO:0000313|EMBL:QOU51083.1, RC ECO:0000313|Proteomes:UP000439817}; RX PubMed=32429555; RA Shelenkov A., Mikhaylova Y., Yanushevich Y., Samoilov A., Petrova L., RA Fomina V., Gusarov V., Zamyatin M., Shagin D., Akimkin V.; RT "Molecular Typing, Characterization of Antimicrobial Resistance, Virulence RT Profiling and Analysis of Whole-Genome Sequence of Clinical Klebsiella RT pneumoniae Isolates."; RL Antibiotics 9:E261-E261(2020). RN [21] {ECO:0000313|EMBL:NGN71919.1, ECO:0000313|Proteomes:UP000479475} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=2429 {ECO:0000313|EMBL:NGN71919.1, RC ECO:0000313|Proteomes:UP000479475}; RA Starkova P.S., Sulyan O.S., Likholetova D.V., Ageevets V.A., Lazareva I.V., RA Sopova J.V., Sidorenko S.V.; RT "Klebsiella pneumoniae genome sequencing and assembly."; RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases. RN [22] {ECO:0000313|Proteomes:UP000512241} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=RHBSTW-00405 {ECO:0000313|Proteomes:UP000512241}; RA Shaw L.P.; RT "REHAB project genomes."; RL Submitted (JUN-2020) to the EMBL/GenBank/DDBJ databases. RN [23] {ECO:0000313|EMBL:GHK54269.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Zam_UTH_09 {ECO:0000313|EMBL:GHK54269.1}; RA Shawa M., Furuta Y., Simbotwe M., Mulenga E., Mubanga M., Mulenga G., RA Kaile C., Zorigt T., Hang'ombe B., Higashi H.; RT "Genome Sequence of ESBL Producing Zambian Clinical Strains."; RL Submitted (OCT-2020) to the EMBL/GenBank/DDBJ databases. RN [24] {ECO:0000313|EMBL:QQL34600.1, ECO:0000313|Proteomes:UP000532829} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=WCHKP090374 {ECO:0000313|EMBL:QQL34600.1, RC ECO:0000313|Proteomes:UP000532829}; RA Wei L., Wen H., Liu L., Feng Y., Zong Z.; RT "The complete genome of Klebsiella pneumoniae strain 090374."; RL Submitted (DEC-2020) to the EMBL/GenBank/DDBJ databases. RN [25] {ECO:0000313|EMBL:MBH8352443.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=CCBH27695 {ECO:0000313|EMBL:MBH8352443.1}; RA Silveira M.C., Claudio R.-D.-S.M., Ana Paula C.-A.D.; RT "WGS of multidrug-resistant bacteria from different Brazilian states."; RL Submitted (DEC-2020) to the EMBL/GenBank/DDBJ databases. RN [26] {ECO:0000313|EMBL:QLO20895.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=RHBSTW-00405 {ECO:0000313|EMBL:QLO20895.1}; RX PubMed=34609275; RA AbuOun M., Jones H., Stubberfield E., Gilson D., Shaw L.P., Hubbard A.T.M., RA Chau K.K., Sebra R., Peto T.E.A., Crook D.W., Read D.S., Gweon H.S., RA Walker A.S., Stoesser N., Smith R.P., Anjum M.F., RA On Behalf Of The Rehab Consortium.; RT "A genomic epidemiological study shows that prevalence of antimicrobial RT resistance in Enterobacterales is associated with the livestock host, as RT well as antimicrobial usage."; RL Microb. Genom. 7:0-0(2021). RN [27] {ECO:0000313|EMBL:QQZ70867.1, ECO:0000313|Proteomes:UP000595568} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=59493 {ECO:0000313|EMBL:QQZ70867.1, RC ECO:0000313|Proteomes:UP000595568}; RA Chen L., Kreiswirth B.; RT "Genome sequencing of apramycin resistant K. pneumoniae."; RL Submitted (JAN-2021) to the EMBL/GenBank/DDBJ databases. RN [28] {ECO:0000313|EMBL:MDP0968559.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=KP219 {ECO:0000313|EMBL:MDP0968559.1}; RA Peng Z.; RL Submitted (JUL-2023) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Catalyzes cross-linking of the peptidoglycan cell wall at the CC division septum. {ECO:0000256|HAMAP-Rule:MF_02080}. CC -!- CATALYTIC ACTIVITY: CC Reaction=Preferential cleavage: (Ac)2-L-Lys-D-Ala-|-D-Ala. Also CC transpeptidation of peptidyl-alanyl moieties that are N-acyl CC substituents of D-alanine.; EC=3.4.16.4; Evidence={ECO:0000256|HAMAP- CC Rule:MF_02080}; CC -!- CATALYTIC ACTIVITY: CC Reaction=a beta-lactam + H2O = a substituted beta-amino acid; CC Xref=Rhea:RHEA:20401, ChEBI:CHEBI:15377, ChEBI:CHEBI:35627, CC ChEBI:CHEBI:140347; EC=3.5.2.6; CC Evidence={ECO:0000256|ARBA:ARBA00001526}; CC -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis. CC {ECO:0000256|HAMAP-Rule:MF_02080}. CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000256|HAMAP- CC Rule:MF_02080}; Single-pass membrane protein {ECO:0000256|HAMAP- CC Rule:MF_02080}. Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass CC membrane protein {ECO:0000256|ARBA:ARBA00004167}. CC -!- SIMILARITY: Belongs to the transpeptidase family. FtsI subfamily. CC {ECO:0000256|HAMAP-Rule:MF_02080}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BNFF01000001; GHK54269.1; -; Genomic_DNA. DR EMBL; JRRF01000002; KII08708.1; -; Genomic_DNA. DR EMBL; LNHP01000013; KSX90961.1; -; Genomic_DNA. DR EMBL; JAECTB010000019; MBH8352443.1; -; Genomic_DNA. DR EMBL; JAUUIA010000013; MDP0968559.1; -; Genomic_DNA. DR EMBL; WJVL01000004; MRJ95711.1; -; Genomic_DNA. DR EMBL; WJWF01000003; MRL34674.1; -; Genomic_DNA. DR EMBL; WNPO01000011; MUA39810.1; -; Genomic_DNA. DR EMBL; JAAKYD010000005; NGN71919.1; -; Genomic_DNA. DR EMBL; NDBK01000112; OVF65434.1; -; Genomic_DNA. DR EMBL; MSYX01000008; OWA83148.1; -; Genomic_DNA. DR EMBL; NCMJ01000062; PLE27478.1; -; Genomic_DNA. DR EMBL; PCFF01000002; PVU64124.1; -; Genomic_DNA. DR EMBL; CP055517; QLO20895.1; -; Genomic_DNA. DR EMBL; CP063008; QOU51083.1; -; Genomic_DNA. DR EMBL; CP066534; QQL34600.1; -; Genomic_DNA. DR EMBL; CP068602; QQZ70867.1; -; Genomic_DNA. DR EMBL; QOUB01000006; RCJ52101.1; -; Genomic_DNA. DR EMBL; QRCD01000005; RDT90881.1; -; Genomic_DNA. DR EMBL; MPYG04000224; ROG87213.1; -; Genomic_DNA. DR EMBL; RDAM01000001; RRF08000.1; -; Genomic_DNA. DR EMBL; SGOL01000011; RZG36124.1; -; Genomic_DNA. DR EMBL; FLDK01000007; SBH25343.1; -; Genomic_DNA. DR EMBL; UAWQ01000019; SQC48283.1; -; Genomic_DNA. DR EMBL; UFEU01000009; SSK45838.1; -; Genomic_DNA. DR EMBL; UGLB01000003; STT50626.1; -; Genomic_DNA. DR EMBL; UGLC01000002; STT52506.1; -; Genomic_DNA. DR EMBL; UGLJ01000002; STT94424.1; -; Genomic_DNA. DR EMBL; UGLQ01000003; STU32598.1; -; Genomic_DNA. DR EMBL; UGMN01000004; STV35655.1; -; Genomic_DNA. DR EMBL; UGMG01000001; STV70103.1; -; Genomic_DNA. DR EMBL; UIUC01000006; SVN64074.1; -; Genomic_DNA. DR EMBL; UJHH01000008; SWF71742.1; -; Genomic_DNA. DR EMBL; UJRG01000008; SWT15818.1; -; Genomic_DNA. DR EMBL; UKAW01000007; SXG16586.1; -; Genomic_DNA. DR EMBL; UKGE01000003; SXN29830.1; -; Genomic_DNA. DR EMBL; UKRD01000005; SYC19817.1; -; Genomic_DNA. DR EMBL; UKUT01000006; SYH33035.1; -; Genomic_DNA. DR EMBL; ULCI01000003; SYR31589.1; -; Genomic_DNA. DR EMBL; ULET01000009; SYU74220.1; -; Genomic_DNA. DR EMBL; VSSY01000011; TYL78263.1; -; Genomic_DNA. DR EMBL; UWVH01000001; VCV73108.1; -; Genomic_DNA. DR EMBL; UWWS01000001; VCX99666.1; -; Genomic_DNA. DR EMBL; LR134162; VEB05243.1; -; Genomic_DNA. DR EMBL; CAAHAW010000008; VGJ31063.1; -; Genomic_DNA. DR EMBL; CAAHCC010000007; VGL03660.1; -; Genomic_DNA. DR RefSeq; WP_002888559.1; NZ_WYAM01000022.1. DR KEGG; kpb:FH42_21260; -. DR KEGG; kpne:KU54_022460; -. DR KEGG; kpnu:LI86_22300; -. DR KEGG; kpx:PMK1_02396; -. DR OMA; SCIVVIH; -. DR UniPathway; UPA00219; -. DR Proteomes; UP000031820; Unassembled WGS sequence. DR Proteomes; UP000052969; Unassembled WGS sequence. DR Proteomes; UP000077826; Unassembled WGS sequence. DR Proteomes; UP000195348; Unassembled WGS sequence. DR Proteomes; UP000196447; Unassembled WGS sequence. DR Proteomes; UP000234439; Unassembled WGS sequence. DR Proteomes; UP000245817; Unassembled WGS sequence. DR Proteomes; UP000251721; Unassembled WGS sequence. DR Proteomes; UP000252603; Unassembled WGS sequence. DR Proteomes; UP000253135; Unassembled WGS sequence. DR Proteomes; UP000254103; Unassembled WGS sequence. DR Proteomes; UP000254387; Unassembled WGS sequence. DR Proteomes; UP000254680; Unassembled WGS sequence. DR Proteomes; UP000254799; Unassembled WGS sequence. DR Proteomes; UP000255099; Unassembled WGS sequence. DR Proteomes; UP000255137; Unassembled WGS sequence. DR Proteomes; UP000255239; Unassembled WGS sequence. DR Proteomes; UP000257587; Unassembled WGS sequence. DR Proteomes; UP000258232; Unassembled WGS sequence. DR Proteomes; UP000258253; Unassembled WGS sequence. DR Proteomes; UP000258673; Unassembled WGS sequence. DR Proteomes; UP000258798; Unassembled WGS sequence. DR Proteomes; UP000258905; Unassembled WGS sequence. DR Proteomes; UP000259364; Unassembled WGS sequence. DR Proteomes; UP000259417; Unassembled WGS sequence. DR Proteomes; UP000259975; Unassembled WGS sequence. DR Proteomes; UP000269921; Unassembled WGS sequence. DR Proteomes; UP000275975; Unassembled WGS sequence. DR Proteomes; UP000278966; Unassembled WGS sequence. DR Proteomes; UP000282433; Chromosome 1. DR Proteomes; UP000283322; Unassembled WGS sequence. DR Proteomes; UP000293472; Unassembled WGS sequence. DR Proteomes; UP000295133; Unassembled WGS sequence. DR Proteomes; UP000322977; Unassembled WGS sequence. DR Proteomes; UP000376235; Unassembled WGS sequence. DR Proteomes; UP000439817; Chromosome. DR Proteomes; UP000441029; Unassembled WGS sequence. DR Proteomes; UP000479475; Unassembled WGS sequence. DR Proteomes; UP000485085; Unassembled WGS sequence. DR Proteomes; UP000512241; Chromosome. DR Proteomes; UP000532829; Chromosome. DR Proteomes; UP000595568; Chromosome. DR Proteomes; UP000622626; Unassembled WGS sequence. DR Proteomes; UP000655094; Unassembled WGS sequence. DR Proteomes; UP001244490; Unassembled WGS sequence. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0008658; F:penicillin binding; IEA:InterPro. DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:InterPro. DR GO; GO:0009002; F:serine-type D-Ala-D-Ala carboxypeptidase activity; IEA:UniProtKB-UniRule. DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW. DR GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW. DR GO; GO:0043093; P:FtsZ-dependent cytokinesis; IEA:UniProtKB-UniRule. DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-UniRule. DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW. DR GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW. DR FunFam; 1.10.150.770:FF:000001; Peptidoglycan D,D-transpeptidase FtsI; 1. DR FunFam; 3.40.710.10:FF:000003; Peptidoglycan D,D-transpeptidase FtsI; 1. DR FunFam; 3.90.1310.10:FF:000003; Peptidoglycan D,D-transpeptidase FtsI; 1. DR Gene3D; 1.10.150.770; -; 1. DR Gene3D; 3.30.450.330; -; 1. DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1. DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1. DR HAMAP; MF_02080; FtsI_transpept; 1. DR InterPro; IPR050515; Bact_Transpept/Beta-Lactamase. DR InterPro; IPR012338; Beta-lactam/transpept-like. DR InterPro; IPR037532; FtsI_transpept. DR InterPro; IPR005311; PBP_dimer. DR InterPro; IPR036138; PBP_dimer_sf. DR InterPro; IPR001460; PCN-bd_Tpept. DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1. DR PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1. DR Pfam; PF03717; PBP_dimer; 1. DR Pfam; PF00905; Transpeptidase; 1. DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1. DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1. PE 3: Inferred from homology; KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645, ECO:0000256|HAMAP- KW Rule:MF_02080}; KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|HAMAP- KW Rule:MF_02080}; KW Cell division {ECO:0000256|ARBA:ARBA00022618, ECO:0000256|HAMAP- KW Rule:MF_02080}; KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519, ECO:0000256|HAMAP- KW Rule:MF_02080}; Cell membrane {ECO:0000256|HAMAP-Rule:MF_02080}; KW Cell shape {ECO:0000256|ARBA:ARBA00022960, ECO:0000256|HAMAP- KW Rule:MF_02080}; KW Cell wall biogenesis/degradation {ECO:0000256|ARBA:ARBA00023316, KW ECO:0000256|HAMAP-Rule:MF_02080}; KW Glycosyltransferase {ECO:0000313|EMBL:SBH25343.1}; KW Hydrolase {ECO:0000256|HAMAP-Rule:MF_02080, ECO:0000313|EMBL:MRL34674.1}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_02080}; KW Peptidoglycan synthesis {ECO:0000256|ARBA:ARBA00022984, ECO:0000256|HAMAP- KW Rule:MF_02080}; Protease {ECO:0000256|HAMAP-Rule:MF_02080}; KW Septation {ECO:0000256|ARBA:ARBA00023210, ECO:0000256|HAMAP-Rule:MF_02080}; KW Transferase {ECO:0000313|EMBL:OVF65434.1}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP- KW Rule:MF_02080}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP- KW Rule:MF_02080}. FT TRANSMEM 20..44 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_02080" FT DOMAIN 69..220 FT /note="Penicillin-binding protein dimerisation" FT /evidence="ECO:0000259|Pfam:PF03717" FT DOMAIN 260..554 FT /note="Penicillin-binding protein transpeptidase" FT /evidence="ECO:0000259|Pfam:PF00905" FT ACT_SITE 307 FT /note="Acyl-ester intermediate" FT /evidence="ECO:0000256|HAMAP-Rule:MF_02080" SQ SEQUENCE 588 AA; 64003 MW; 2FE4408506D51A55 CRC64; MKAAPKTPKA KRQEEQANFI SWRFALLCGC ILLALAFLLG RVAWLQVISP DMLVRQGDMR SLRVQEVSTA RGMITDRSGR PLAVSVPVKA IWADPKELHD AGGVTLDTRW KALADALNMP LDQLATRINT NPRMRFIYLA RQVNPDMADY IKKLKLPGIH LREESRRYYP SGEVTAHLIG FTNVDSQGIE GVEKSFDKWL TGQPGERIVR KDRYGRVIED ISSTDSQAAH NLALSIDERL QALVYRELNN AVAFNKAESG SAVLVDVNTG EVLAMANSPS YNPNNFAGTA KDTMRNRAIT DVFEPGSTVK PMVVMTALQR GIVNENTVLN TVPYRINGHE IKDVARYSEL TLTGVLQKSS NVGVSKLALA MPSSALVDTY SRFGLGKATN LGLVGERSGL YPQKQRWSDI ERATFSFGYG LMVTPLQLAR VYATIGSYGI YRPLSITKVD PPVPGERVFP ESLVRTVVHM MESVALPGGG GVKAAIKGYR IAIKTGTAKK VGPDGRYINK YIAYTAGVAP ASHPRFALVV VINDPQAGKY YGGAVSAPVF GAIMGGVLRT MNIEPDALAT GEKSEFVINQ GEGTGGRS //