ID A0A0W8AVJ6_KLEPN Unreviewed; 588 AA. AC A0A0W8AVJ6; A0A0J2GHB5; A0A4V0HIQ6; DT 13-APR-2016, integrated into UniProtKB/TrEMBL. DT 13-APR-2016, sequence version 1. DT 02-OCT-2024, entry version 66. DE RecName: Full=Peptidoglycan D,D-transpeptidase FtsI {ECO:0000256|HAMAP-Rule:MF_02080}; DE EC=3.4.16.4 {ECO:0000256|HAMAP-Rule:MF_02080}; DE AltName: Full=Penicillin-binding protein 3 {ECO:0000256|HAMAP-Rule:MF_02080}; DE Short=PBP-3 {ECO:0000256|HAMAP-Rule:MF_02080}; GN Name=ftsI {ECO:0000256|HAMAP-Rule:MF_02080, GN ECO:0000313|EMBL:MRL34674.1}; GN Synonyms=ftsI_1 {ECO:0000313|EMBL:STT52506.1}, ftsI_2 GN {ECO:0000313|EMBL:SBI56609.1}, ftsI_3 {ECO:0000313|EMBL:SLS44422.1}, GN ftsI_4 {ECO:0000313|EMBL:CAH1473959.1}, ftsI_5 GN {ECO:0000313|EMBL:STU32598.1}, ftsI_7 {ECO:0000313|EMBL:STV70103.1}; GN ORFNames=AI2879V1_3142 {ECO:0000313|EMBL:CAH5398093.1}, APT76_01165 GN {ECO:0000313|EMBL:KSW89901.1}, B5L96_26605 GN {ECO:0000313|EMBL:OVF65434.1}, B6I68_11965 GN {ECO:0000313|EMBL:PLE27478.1}, BANRA_04163 GN {ECO:0000313|EMBL:VCX73290.1}, BANRA_04330 GN {ECO:0000313|EMBL:VCX99666.1}, BL124_00027960 GN {ECO:0000313|EMBL:ROG87213.1}, BVZ24_06870 GN {ECO:0000313|EMBL:OSZ19546.1}, DM078_11140 GN {ECO:0000313|EMBL:RBZ23802.1}, DM087_13315 GN {ECO:0000313|EMBL:RCJ68611.1}, DMR11_10785 GN {ECO:0000313|EMBL:PXJ24645.1}, DW281_06270 GN {ECO:0000313|EMBL:RDT90881.1}, EAO17_18230 GN {ECO:0000313|EMBL:RRF08000.1}, FCH06_005300 GN {ECO:0000313|EMBL:TYY86933.1}, FNZ01_07255 GN {ECO:0000313|EMBL:TRV91703.1}, FXN67_14725 GN {ECO:0000313|EMBL:TYL78263.1}, G4V31_07195 GN {ECO:0000313|EMBL:NGN71919.1}, GJD55_09275 GN {ECO:0000313|EMBL:MTG00975.1}, GJJ08_022575 GN {ECO:0000313|EMBL:QOU51083.1}, GJJ13_021115 GN {ECO:0000313|EMBL:QOU78006.1}, GJJ18_04425 GN {ECO:0000313|EMBL:MRL34674.1}, GJJ21_08515 GN {ECO:0000313|EMBL:MRK26065.1}, GNF00_08110 GN {ECO:0000313|EMBL:MUA39810.1}, HV207_22200 GN {ECO:0000313|EMBL:QLO32631.1}, KPZU09_40050 GN {ECO:0000313|EMBL:GHK54269.1}, NCTC11679_04757 GN {ECO:0000313|EMBL:STV70103.1}, NCTC13465_04475 GN {ECO:0000313|EMBL:SQC48283.1}, NCTC13635_05081 GN {ECO:0000313|EMBL:VEB05243.1}, NCTC5052_02861 GN {ECO:0000313|EMBL:STT94424.1}, NCTC5053_04312 GN {ECO:0000313|EMBL:STV35655.1}, NCTC8849_01042 GN {ECO:0000313|EMBL:STT52506.1}, NCTC9637_05624 GN {ECO:0000313|EMBL:STT50626.1}, NCTC9661_05284 GN {ECO:0000313|EMBL:STU32598.1}, QIG75_05580 GN {ECO:0000313|EMBL:MDH8288076.1}, SAMEA2273811_01544 GN {ECO:0000313|EMBL:SBI56609.1}, SAMEA3499874_03070 GN {ECO:0000313|EMBL:SXG16586.1}, SAMEA3499901_00823 GN {ECO:0000313|EMBL:SXN29830.1}, SAMEA3512100_03536 GN {ECO:0000313|EMBL:SXU34073.1}, SAMEA3515122_03018 GN {ECO:0000313|EMBL:SYH33035.1}, SAMEA3531867_04079 GN {ECO:0000313|EMBL:VTT47853.1}, SAMEA3538424_03150 GN {ECO:0000313|EMBL:VVL57598.1}, SAMEA3538658_00994 GN {ECO:0000313|EMBL:SYK76929.1}, SAMEA3538828_00863 GN {ECO:0000313|EMBL:SYR31589.1}, SAMEA3649591_02181 GN {ECO:0000313|EMBL:SVN64074.1}, SAMEA3649615_03484 GN {ECO:0000313|EMBL:SYU74220.1}, SAMEA3649733_02927 GN {ECO:0000313|EMBL:SVS26238.1}, SAMEA3727706_03809 GN {ECO:0000313|EMBL:SWV83240.1}, SAMEA4364603_03511 GN {ECO:0000313|EMBL:SSK45838.1}, SAMEA4370542_02578 GN {ECO:0000313|EMBL:SLS44422.1}, SAMEA4873597_03160 GN {ECO:0000313|EMBL:VGJ31063.1}, SAMEA4873632_03788 GN {ECO:0000313|EMBL:VGL03660.1}, VKR_04209 GN {ECO:0000313|EMBL:CAH1473959.1}; OS Klebsiella pneumoniae. OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella. OX NCBI_TaxID=573 {ECO:0000313|EMBL:MRL34674.1}; RN [1] {ECO:0000313|EMBL:KSW89901.1, ECO:0000313|Proteomes:UP000053094} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K66-45 {ECO:0000313|EMBL:KSW89901.1, RC ECO:0000313|Proteomes:UP000053094}; RA Samuelsen O.; RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:SBI56609.1, ECO:0000313|Proteomes:UP000078105} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=4300STDY6470422 {ECO:0000313|EMBL:SSK45838.1, RC ECO:0000313|Proteomes:UP000252603}, 5012STDY7626396 RC {ECO:0000313|EMBL:VGJ31063.1, ECO:0000313|Proteomes:UP000295133}, RC 5012STDY7626430 {ECO:0000313|EMBL:VGL03660.1, RC ECO:0000313|Proteomes:UP000376235}, EuSCAPE_AT002 RC {ECO:0000313|EMBL:SXG16586.1, ECO:0000313|Proteomes:UP000257587}, RC EuSCAPE_AT029 {ECO:0000313|EMBL:SXN29830.1, RC ECO:0000313|Proteomes:UP000259975}, EuSCAPE_BE110 RC {ECO:0000313|EMBL:SWV83240.1, ECO:0000313|Proteomes:UP000259375}, RC EuSCAPE_DE072 {ECO:0000313|EMBL:SXU34073.1, RC ECO:0000313|Proteomes:UP000259753}, EuSCAPE_ES277 RC {ECO:0000313|EMBL:SYU74220.1, ECO:0000313|Proteomes:UP000259417}, RC EuSCAPE_GR003 {ECO:0000313|EMBL:SVN64074.1, RC ECO:0000313|Proteomes:UP000258905}, EuSCAPE_GR114 RC {ECO:0000313|EMBL:SVS26238.1, ECO:0000313|Proteomes:UP000259497}, RC EuSCAPE_HU047 {ECO:0000313|EMBL:SYR31589.1, RC ECO:0000313|Proteomes:UP000258253}, EuSCAPE_IT093 RC {ECO:0000313|EMBL:SYH33035.1, ECO:0000313|Proteomes:UP000258673}, RC EuSCAPE_IT290 {ECO:0000313|EMBL:SYK76929.1, RC ECO:0000313|Proteomes:UP000258808}, EuSCAPE_NO017 RC {ECO:0000313|EMBL:VVL57598.1, ECO:0000313|Proteomes:UP000257312}, RC F1-8-ERB4 {ECO:0000313|EMBL:VTT47853.1, RC ECO:0000313|Proteomes:UP000095528}, k2328 RC {ECO:0000313|Proteomes:UP000078105}, K2328 RC {ECO:0000313|EMBL:SBI56609.1}, NCTC13635 {ECO:0000313|EMBL:VEB05243.1, RC ECO:0000313|Proteomes:UP000282433}, and VRES1272 RC {ECO:0000313|EMBL:SLS44422.1, ECO:0000313|Proteomes:UP000191996}; RG Pathogen Informatics; RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:PLE27478.1, ECO:0000313|Proteomes:UP000234439} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=COL-Kpn30 {ECO:0000313|EMBL:PLE27478.1, RC ECO:0000313|Proteomes:UP000234439}; RX PubMed=29029188; DOI=.1093/infdis/jix524; RA Rojas L.J., Weinstock G.M., De La Cadena E., Diaz L., Rios R., Hanson B.M., RA Brown J.S., Vats P., Phillips D.S., Nguyen H., Hujer K.M., Correa A., RA Adams M.D., Perez F., Sodergren E., Narechania A., Planet P.J., RA Villegas M.V., Bonomo R.A., Arias C.A.; RT "An Analysis of the Epidemic of Klebsiella pneumoniae Carbapenemase- RT Producing K. pneumoniae: Convergence of Two Evolutionary Mechanisms Creates RT the Perfect Storm."; RL J. Infect. Dis. 217:82-92(2017). RN [4] {ECO:0000313|EMBL:OSZ19546.1, ECO:0000313|Proteomes:UP000194193} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KP024 {ECO:0000313|EMBL:OSZ19546.1, RC ECO:0000313|Proteomes:UP000194193}; RA Cienfuegos-Gallet A.V., Chen L., Kreiswirth B., Jimenez J.N.; RT "Chromosomal integration of plasmid sequences mediated colistin resistance RT in carbapenem-resistant Klebsiella pneumoniae."; RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases. RN [5] {ECO:0000313|EMBL:OVF65434.1, ECO:0000313|Proteomes:UP000196447} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=39383 {ECO:0000313|EMBL:OVF65434.1, RC ECO:0000313|Proteomes:UP000196447}; RA Fouts D., Stalin M.J., Chen L., Wright M., Sutton G., Nguyen K., RA Vanduin D., Rojas L., Hujer A., Hujer K., Bonomo R., Kreiswirth B., RA Adams M.; RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases. RN [6] {ECO:0000313|EMBL:RRF08000.1, ECO:0000313|Proteomes:UP000275975} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KLPN_104 {ECO:0000313|EMBL:RRF08000.1, RC ECO:0000313|Proteomes:UP000275975}; RX PubMed=30373801; RA Tamma P.D., Fan Y., Bergman Y., Pertea G., Kazmi A., Lewis S., RA Carroll K.C., Schatz M.C., Timp W., Simner P.J.; RT "Applying Rapid Whole Genome Sequencing to Predict Phenotypic Antimicrobial RT Susceptibility Testing Results Among Carbapenem-Resistant Klebsiella RT pneumoniae Clinical Isolates."; RL Antimicrob. Agents Chemother. 0:0-0(2018). RN [7] {ECO:0000313|EMBL:PXJ24645.1, ECO:0000313|Proteomes:UP000247406} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=WUSM_KP_72 {ECO:0000313|EMBL:PXJ24645.1, RC ECO:0000313|Proteomes:UP000247406}; RA Potter R.F., Lainhart W., Twentyman J., Wallace M., Wang B., RA Burnham C.-A.D., Rosen D.A., Dantas G.; RT "Population structure, antibiotic resistance, and uropathogenecity of RT Klebsiella variicola."; RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases. RN [8] {ECO:0000313|Proteomes:UP000251721, ECO:0000313|Proteomes:UP000254103} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=NCTC11679 {ECO:0000313|EMBL:STV70103.1, RC ECO:0000313|Proteomes:UP000255239}, NCTC13465 RC {ECO:0000313|EMBL:SQC48283.1, ECO:0000313|Proteomes:UP000251721}, RC NCTC5052 {ECO:0000313|EMBL:STT94424.1, RC ECO:0000313|Proteomes:UP000254103}, NCTC5053 RC {ECO:0000313|EMBL:STV35655.1, ECO:0000313|Proteomes:UP000254387}, RC NCTC8849 {ECO:0000313|EMBL:STT52506.1, RC ECO:0000313|Proteomes:UP000254799}, NCTC9637 RC {ECO:0000313|EMBL:STT50626.1, ECO:0000313|Proteomes:UP000255099}, and RC NCTC9661 {ECO:0000313|EMBL:STU32598.1, RC ECO:0000313|Proteomes:UP000255137}; RG Pathogen Informatics; RA Doyle S.; RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|EMBL:RDT90881.1, ECO:0000313|Proteomes:UP000254680} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K280 {ECO:0000313|EMBL:RDT90881.1, RC ECO:0000313|Proteomes:UP000254680}; RA He F.; RT "Draft genome sequence of Klebsiella pneumoniae K280."; RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases. RN [10] {ECO:0000313|Proteomes:UP000252644, ECO:0000313|Proteomes:UP000253559} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BC_5001 {ECO:0000313|Proteomes:UP000253559}, and BC_5003 RC {ECO:0000313|EMBL:RCJ68611.1, ECO:0000313|Proteomes:UP000252644}; RA Martins R.C.R., Perdigao-Neto L.V., Costa S.F., Levin A.S.S.; RT "Klebsiella pneumoniae genome sequencing and assembly."; RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases. RN [11] {ECO:0000313|Proteomes:UP000252644, ECO:0000313|Proteomes:UP000253559} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BC_5001 {ECO:0000313|EMBL:RBZ23802.1, RC ECO:0000313|Proteomes:UP000253559}, and BC_5003 RC {ECO:0000313|EMBL:RCJ68611.1, ECO:0000313|Proteomes:UP000252644}; RA Martins R.C., Perdigao-Neto L.V., Costa S.F., Levin A.S.S.; RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases. RN [12] {ECO:0000313|EMBL:RBZ23802.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BC_5001 {ECO:0000313|EMBL:RBZ23802.1}; RA Martins R.C.R., Perdigao-Neto L.V., Costa S.F., Levin A.S.S.; RT "Klebsiella pneumoniae genome sequencing and assembly."; RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases. RN [13] {ECO:0000313|EMBL:ROG87213.1, ECO:0000313|Proteomes:UP000283322} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CRK0165 {ECO:0000313|EMBL:ROG87213.1, RC ECO:0000313|Proteomes:UP000283322}; RA Vanduin D., Fouts D., Wright M., Sutton G., Nguyen K., Kreiswirth B., RA Chen L., Rojas L., Hujer A., Hujer K., Bonomo R., Adams M.; RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases. RN [14] {ECO:0000313|Proteomes:UP000270483, ECO:0000313|Proteomes:UP000278966} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Kpneu022 {ECO:0000313|EMBL:VCX73290.1}, and Kpneu025 RC {ECO:0000313|EMBL:VCX99666.1}; RA Noll B N.; RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases. RN [15] {ECO:0000313|EMBL:TRV91703.1, ECO:0000313|Proteomes:UP000317008} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=SCPM-O-B-7878 {ECO:0000313|EMBL:TRV91703.1}, and SCPM-O-B-7878 RC (KPB1802) {ECO:0000313|Proteomes:UP000317008}; RA Myakinina V., Fursova N., Volozhantsev N., Sizova A., Kislichkina A., RA Bogun A., Mukhina T., Mayskaya N.; RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases. RN [16] {ECO:0000313|EMBL:TYY86933.1, ECO:0000313|Proteomes:UP000323143} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=AS001328 {ECO:0000313|EMBL:TYY86933.1, RC ECO:0000313|Proteomes:UP000323143}; RA Beisken S.; RT "Evaluating DNBSEQ for clinical isolate sequencing and identification of RT antibiotic resistance."; RL Submitted (AUG-2019) to the EMBL/GenBank/DDBJ databases. RN [17] {ECO:0000313|EMBL:TYL78263.1, ECO:0000313|Proteomes:UP000322977} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=UCO-494 {ECO:0000313|EMBL:TYL78263.1, RC ECO:0000313|Proteomes:UP000322977}; RA Morales-Leon F., Caro C., Opazo-Capurro A., Lincopan N., RA Dominguez-Yevenes M., Lima C., Bello-Toledo H., Gonzalez-Rocha G.; RT "Phenotypic and genetic characterization of extended-spectrum b-lactamase- RT producing hypermucoviscous Klebsiella pneumoniae from Chile."; RL Submitted (AUG-2019) to the EMBL/GenBank/DDBJ databases. RN [18] {ECO:0000313|EMBL:MRL34674.1, ECO:0000313|Proteomes:UP000437018} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CriePir115 {ECO:0000313|EMBL:MRL34674.1}, and CriePir140 RC {ECO:0000313|EMBL:MRK26065.1, ECO:0000313|Proteomes:UP000437018}; RA Shelenkov A., Mikhaylova Y., Yanushevich Y., Samoilov A., Petrova L., RA Fomina V., Gusarov V., Zamyatin M., Shagin D.; RT "Molecular typing, antibiotic resistance determination and virulence RT profiling for 36 multidrug-resistant clinical Klebsiella pneumoniae RT isolates using second- and third-generation sequencing."; RL Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases. RN [19] {ECO:0000313|EMBL:MUA39810.1, ECO:0000313|Proteomes:UP000485085} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KP_38044 {ECO:0000313|EMBL:MUA39810.1, RC ECO:0000313|Proteomes:UP000485085}; RA Zhou K.; RT "Emergence of a novel subclone of carbapenem-resistant Klebsiella RT pneumoniae ST11 with enhanced virulence and transmissibility: a molecular RT epidemiological, clinical, genomic study."; RL Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases. RN [20] {ECO:0000313|EMBL:MTG00975.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=RADAR32 {ECO:0000313|EMBL:MTG00975.1}; RA Surleac M., Paraschiv S., Czobor Barbu I., Popa L.I., Gheorghe I., RA Otelea D., Chifiriuc M.C.; RL Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases. RN [21] {ECO:0000313|Proteomes:UP000438340, ECO:0000313|Proteomes:UP000439817} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CriePir120 {ECO:0000313|EMBL:QOU51083.1, RC ECO:0000313|Proteomes:UP000439817}, and CriePir45 RC {ECO:0000313|EMBL:QOU78006.1, ECO:0000313|Proteomes:UP000438340}; RX PubMed=32429555; RA Shelenkov A., Mikhaylova Y., Yanushevich Y., Samoilov A., Petrova L., RA Fomina V., Gusarov V., Zamyatin M., Shagin D., Akimkin V.; RT "Molecular Typing, Characterization of Antimicrobial Resistance, Virulence RT Profiling and Analysis of Whole-Genome Sequence of Clinical Klebsiella RT pneumoniae Isolates."; RL Antibiotics 9:E261-E261(2020). RN [22] {ECO:0000313|EMBL:MTG00975.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=RADAR32 {ECO:0000313|EMBL:MTG00975.1}; RA Surleac M., Paraschiv S., Czobor Barbu I., Popa L.I., Gheorghe I., RA Otelea D., Chifiriuc M.C.; RT "Whole genome sequencing snapshot of multi-drug resistant Klebsiella RT pneumoniae strains from hospitals and receiving wastewater treatment plants RT in Southern Romania."; RL PLoS ONE 0:0-0(2020). RN [23] {ECO:0000313|EMBL:NGN71919.1, ECO:0000313|Proteomes:UP000479475} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=2429 {ECO:0000313|EMBL:NGN71919.1, RC ECO:0000313|Proteomes:UP000479475}; RA Starkova P.S., Sulyan O.S., Likholetova D.V., Ageevets V.A., Lazareva I.V., RA Sopova J.V., Sidorenko S.V.; RT "Klebsiella pneumoniae genome sequencing and assembly."; RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases. RN [24] {ECO:0000313|Proteomes:UP000510943} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=RHBSTW-00472 {ECO:0000313|Proteomes:UP000510943}; RA Shaw L.P.; RT "REHAB project genomes."; RL Submitted (JUN-2020) to the EMBL/GenBank/DDBJ databases. RN [25] {ECO:0000313|EMBL:GHK54269.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Zam_UTH_09 {ECO:0000313|EMBL:GHK54269.1}; RA Shawa M., Furuta Y., Simbotwe M., Mulenga E., Mubanga M., Mulenga G., RA Kaile C., Zorigt T., Hang'ombe B., Higashi H.; RT "Genome Sequence of ESBL Producing Zambian Clinical Strains."; RL Submitted (OCT-2020) to the EMBL/GenBank/DDBJ databases. RN [26] {ECO:0000313|EMBL:QLO32631.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=RHBSTW-00472 {ECO:0000313|EMBL:QLO32631.1}; RX PubMed=34609275; RA AbuOun M., Jones H., Stubberfield E., Gilson D., Shaw L.P., Hubbard A.T.M., RA Chau K.K., Sebra R., Peto T.E.A., Crook D.W., Read D.S., Gweon H.S., RA Walker A.S., Stoesser N., Smith R.P., Anjum M.F., RA On Behalf Of The Rehab Consortium.; RT "A genomic epidemiological study shows that prevalence of antimicrobial RT resistance in Enterobacterales is associated with the livestock host, as RT well as antimicrobial usage."; RL Microb. Genom. 0:0-0(2021). RN [27] {ECO:0000313|EMBL:CAH1473959.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BB1542 {ECO:0000313|EMBL:CAH1473959.1}; RA Delgado-Blas J.; RL Submitted (JAN-2022) to the EMBL/GenBank/DDBJ databases. RN [28] {ECO:0000313|EMBL:CAH5398093.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=11 {ECO:0000313|EMBL:CAH5398093.1}; RA Alioto T., Alioto T., Gomez Garrido J.; RL Submitted (MAY-2022) to the EMBL/GenBank/DDBJ databases. RN [29] {ECO:0000313|EMBL:MDH8288076.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Sgh23 {ECO:0000313|EMBL:MDH8288076.1}; RA Chen Y., Gan Y.-H.; RT "WGS of Klebsiella strains from the Antibiotics for Klebsiella Liver RT Abscess Syndrome Study (A-KLASS) clinical trial, Singapore."; RL Submitted (APR-2023) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Catalyzes cross-linking of the peptidoglycan cell wall at the CC division septum. {ECO:0000256|HAMAP-Rule:MF_02080}. CC -!- CATALYTIC ACTIVITY: CC Reaction=Preferential cleavage: (Ac)2-L-Lys-D-Ala-|-D-Ala. Also CC transpeptidation of peptidyl-alanyl moieties that are N-acyl CC substituents of D-alanine.; EC=3.4.16.4; Evidence={ECO:0000256|HAMAP- CC Rule:MF_02080}; CC -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis. CC {ECO:0000256|HAMAP-Rule:MF_02080}. CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000256|HAMAP- CC Rule:MF_02080}; Single-pass membrane protein {ECO:0000256|HAMAP- CC Rule:MF_02080}. CC -!- SIMILARITY: Belongs to the transpeptidase family. FtsI subfamily. CC {ECO:0000256|HAMAP-Rule:MF_02080}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; OV753987; CAH1473959.1; -; Genomic_DNA. DR EMBL; CAJNUY030000001; CAH5398093.1; -; Genomic_DNA. DR EMBL; BNFF01000001; GHK54269.1; -; Genomic_DNA. DR EMBL; LNGZ01000101; KSW89901.1; -; Genomic_DNA. DR EMBL; JARYWG010000004; MDH8288076.1; -; Genomic_DNA. DR EMBL; WJVZ01000005; MRK26065.1; -; Genomic_DNA. DR EMBL; WJWF01000003; MRL34674.1; -; Genomic_DNA. DR EMBL; WMJQ01000004; MTG00975.1; -; Genomic_DNA. DR EMBL; WNPO01000011; MUA39810.1; -; Genomic_DNA. DR EMBL; JAAKYD010000005; NGN71919.1; -; Genomic_DNA. DR EMBL; MSZJ01000004; OSZ19546.1; -; Genomic_DNA. DR EMBL; NDBK01000112; OVF65434.1; -; Genomic_DNA. DR EMBL; NCMJ01000062; PLE27478.1; -; Genomic_DNA. DR EMBL; QIWC01000008; PXJ24645.1; -; Genomic_DNA. DR EMBL; CP055509; QLO32631.1; -; Genomic_DNA. DR EMBL; CP063008; QOU51083.1; -; Genomic_DNA. DR EMBL; CP063023; QOU78006.1; -; Genomic_DNA. DR EMBL; QOHW01000006; RBZ23802.1; -; Genomic_DNA. DR EMBL; QOTY01000007; RCJ68611.1; -; Genomic_DNA. DR EMBL; QRCD01000005; RDT90881.1; -; Genomic_DNA. DR EMBL; MPYG04000224; ROG87213.1; -; Genomic_DNA. DR EMBL; RDAM01000001; RRF08000.1; -; Genomic_DNA. DR EMBL; FLGH01000004; SBI56609.1; -; Genomic_DNA. DR EMBL; FWJM01000007; SLS44422.1; -; Genomic_DNA. DR EMBL; UAWQ01000019; SQC48283.1; -; Genomic_DNA. DR EMBL; UFEU01000009; SSK45838.1; -; Genomic_DNA. DR EMBL; UGLB01000003; STT50626.1; -; Genomic_DNA. DR EMBL; UGLC01000002; STT52506.1; -; Genomic_DNA. DR EMBL; UGLJ01000002; STT94424.1; -; Genomic_DNA. DR EMBL; UGLQ01000003; STU32598.1; -; Genomic_DNA. DR EMBL; UGMN01000004; STV35655.1; -; Genomic_DNA. DR EMBL; UGMG01000001; STV70103.1; -; Genomic_DNA. DR EMBL; UIUC01000006; SVN64074.1; -; Genomic_DNA. DR EMBL; UIXM01000008; SVS26238.1; -; Genomic_DNA. DR EMBL; UJTF01000010; SWV83240.1; -; Genomic_DNA. DR EMBL; UKAW01000007; SXG16586.1; -; Genomic_DNA. DR EMBL; UKGE01000003; SXN29830.1; -; Genomic_DNA. DR EMBL; UKLK01000007; SXU34073.1; -; Genomic_DNA. DR EMBL; UKUT01000006; SYH33035.1; -; Genomic_DNA. DR EMBL; UKXO01000003; SYK76929.1; -; Genomic_DNA. DR EMBL; ULCI01000003; SYR31589.1; -; Genomic_DNA. DR EMBL; ULET01000009; SYU74220.1; -; Genomic_DNA. DR EMBL; VKCV01000005; TRV91703.1; -; Genomic_DNA. DR EMBL; VSSY01000011; TYL78263.1; -; Genomic_DNA. DR EMBL; SUOY02000004; TYY86933.1; -; Genomic_DNA. DR EMBL; UWWN01000001; VCX73290.1; -; Genomic_DNA. DR EMBL; UWWS01000001; VCX99666.1; -; Genomic_DNA. DR EMBL; LR134162; VEB05243.1; -; Genomic_DNA. DR EMBL; CAAHAW010000008; VGJ31063.1; -; Genomic_DNA. DR EMBL; CAAHCC010000007; VGL03660.1; -; Genomic_DNA. DR EMBL; FLXF02000005; VTT47853.1; -; Genomic_DNA. DR EMBL; UKIO02000009; VVL57598.1; -; Genomic_DNA. DR RefSeq; WP_002888559.1; NZ_WYAL01000016.1. DR KEGG; kpb:FH42_21260; -. DR KEGG; kpne:KU54_022460; -. DR KEGG; kpnu:LI86_22300; -. DR KEGG; kpx:PMK1_02396; -. DR OMA; SCIVVIH; -. DR UniPathway; UPA00219; -. DR Proteomes; UP000053094; Unassembled WGS sequence. DR Proteomes; UP000078105; Unassembled WGS sequence. DR Proteomes; UP000095528; Unassembled WGS sequence. DR Proteomes; UP000191996; Unassembled WGS sequence. DR Proteomes; UP000194193; Unassembled WGS sequence. DR Proteomes; UP000196447; Unassembled WGS sequence. DR Proteomes; UP000234439; Unassembled WGS sequence. DR Proteomes; UP000247406; Unassembled WGS sequence. DR Proteomes; UP000251721; Unassembled WGS sequence. DR Proteomes; UP000252603; Unassembled WGS sequence. DR Proteomes; UP000252644; Unassembled WGS sequence. DR Proteomes; UP000253559; Unassembled WGS sequence. DR Proteomes; UP000254103; Unassembled WGS sequence. DR Proteomes; UP000254387; Unassembled WGS sequence. DR Proteomes; UP000254680; Unassembled WGS sequence. DR Proteomes; UP000254799; Unassembled WGS sequence. DR Proteomes; UP000255099; Unassembled WGS sequence. DR Proteomes; UP000255137; Unassembled WGS sequence. DR Proteomes; UP000255239; Unassembled WGS sequence. DR Proteomes; UP000257312; Unassembled WGS sequence. DR Proteomes; UP000257587; Unassembled WGS sequence. DR Proteomes; UP000258253; Unassembled WGS sequence. DR Proteomes; UP000258673; Unassembled WGS sequence. DR Proteomes; UP000258808; Unassembled WGS sequence. DR Proteomes; UP000258905; Unassembled WGS sequence. DR Proteomes; UP000259375; Unassembled WGS sequence. DR Proteomes; UP000259417; Unassembled WGS sequence. DR Proteomes; UP000259497; Unassembled WGS sequence. DR Proteomes; UP000259753; Unassembled WGS sequence. DR Proteomes; UP000259975; Unassembled WGS sequence. DR Proteomes; UP000270483; Unassembled WGS sequence. DR Proteomes; UP000275975; Unassembled WGS sequence. DR Proteomes; UP000278966; Unassembled WGS sequence. DR Proteomes; UP000282433; Chromosome 1. DR Proteomes; UP000283322; Unassembled WGS sequence. DR Proteomes; UP000295133; Unassembled WGS sequence. DR Proteomes; UP000317008; Unassembled WGS sequence. DR Proteomes; UP000322977; Unassembled WGS sequence. DR Proteomes; UP000323143; Unassembled WGS sequence. DR Proteomes; UP000376235; Unassembled WGS sequence. DR Proteomes; UP000430325; Unassembled WGS sequence. DR Proteomes; UP000437018; Unassembled WGS sequence. DR Proteomes; UP000438340; Chromosome. DR Proteomes; UP000439817; Chromosome. DR Proteomes; UP000479475; Unassembled WGS sequence. DR Proteomes; UP000485085; Unassembled WGS sequence. DR Proteomes; UP000510943; Chromosome. DR Proteomes; UP000655094; Unassembled WGS sequence. DR Proteomes; UP000789788; Unassembled WGS sequence. DR Proteomes; UP001157099; Unassembled WGS sequence. DR Proteomes; UP001158595; Chromosome. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0008658; F:penicillin binding; IEA:InterPro. DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:InterPro. DR GO; GO:0009002; F:serine-type D-Ala-D-Ala carboxypeptidase activity; IEA:UniProtKB-UniRule. DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW. DR GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW. DR GO; GO:0043093; P:FtsZ-dependent cytokinesis; IEA:UniProtKB-UniRule. DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-UniRule. DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW. DR GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW. DR Gene3D; 1.10.150.770; -; 1. DR Gene3D; 3.30.450.330; -; 1. DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1. DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1. DR HAMAP; MF_02080; FtsI_transpept; 1. DR InterPro; IPR050515; Bact_Transpept/Beta-Lactamase. DR InterPro; IPR012338; Beta-lactam/transpept-like. DR InterPro; IPR037532; FtsI_transpept. DR InterPro; IPR005311; PBP_dimer. DR InterPro; IPR036138; PBP_dimer_sf. DR InterPro; IPR001460; PCN-bd_Tpept. DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1. DR PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1. DR Pfam; PF03717; PBP_dimer; 1. DR Pfam; PF00905; Transpeptidase; 1. DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1. DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1. PE 3: Inferred from homology; KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645, ECO:0000256|HAMAP- KW Rule:MF_02080}; Cell cycle {ECO:0000256|HAMAP-Rule:MF_02080}; KW Cell division {ECO:0000256|HAMAP-Rule:MF_02080, KW ECO:0000313|EMBL:KSW89901.1}; KW Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_02080}; KW Cell membrane {ECO:0000256|HAMAP-Rule:MF_02080}; KW Cell shape {ECO:0000256|HAMAP-Rule:MF_02080}; KW Cell wall biogenesis/degradation {ECO:0000256|HAMAP-Rule:MF_02080}; KW Glycosyltransferase {ECO:0000313|EMBL:CAH1473959.1}; KW Hydrolase {ECO:0000256|HAMAP-Rule:MF_02080, ECO:0000313|EMBL:MRL34674.1}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_02080}; KW Peptidoglycan synthesis {ECO:0000256|HAMAP-Rule:MF_02080}; KW Protease {ECO:0000256|HAMAP-Rule:MF_02080}; KW Septation {ECO:0000256|HAMAP-Rule:MF_02080}; KW Transferase {ECO:0000313|EMBL:CAH1473959.1}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP- KW Rule:MF_02080}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP- KW Rule:MF_02080}. FT TRANSMEM 20..44 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_02080" FT DOMAIN 69..220 FT /note="Penicillin-binding protein dimerisation" FT /evidence="ECO:0000259|Pfam:PF03717" FT DOMAIN 260..554 FT /note="Penicillin-binding protein transpeptidase" FT /evidence="ECO:0000259|Pfam:PF00905" FT ACT_SITE 307 FT /note="Acyl-ester intermediate" FT /evidence="ECO:0000256|HAMAP-Rule:MF_02080" SQ SEQUENCE 588 AA; 64003 MW; 2FE4408506D51A55 CRC64; MKAAPKTPKA KRQEEQANFI SWRFALLCGC ILLALAFLLG RVAWLQVISP DMLVRQGDMR SLRVQEVSTA RGMITDRSGR PLAVSVPVKA IWADPKELHD AGGVTLDTRW KALADALNMP LDQLATRINT NPRMRFIYLA RQVNPDMADY IKKLKLPGIH LREESRRYYP SGEVTAHLIG FTNVDSQGIE GVEKSFDKWL TGQPGERIVR KDRYGRVIED ISSTDSQAAH NLALSIDERL QALVYRELNN AVAFNKAESG SAVLVDVNTG EVLAMANSPS YNPNNFAGTA KDTMRNRAIT DVFEPGSTVK PMVVMTALQR GIVNENTVLN TVPYRINGHE IKDVARYSEL TLTGVLQKSS NVGVSKLALA MPSSALVDTY SRFGLGKATN LGLVGERSGL YPQKQRWSDI ERATFSFGYG LMVTPLQLAR VYATIGSYGI YRPLSITKVD PPVPGERVFP ESLVRTVVHM MESVALPGGG GVKAAIKGYR IAIKTGTAKK VGPDGRYINK YIAYTAGVAP ASHPRFALVV VINDPQAGKY YGGAVSAPVF GAIMGGVLRT MNIEPDALAT GEKSEFVINQ GEGTGGRS //