ID   A0A0W8AVJ6_KLEPN        Unreviewed;       588 AA.
AC   A0A0W8AVJ6; A0A0J2GHB5; A0A4V0HIQ6;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   24-JUL-2024, entry version 65.
DE   RecName: Full=Peptidoglycan D,D-transpeptidase FtsI {ECO:0000256|HAMAP-Rule:MF_02080};
DE            EC=3.4.16.4 {ECO:0000256|HAMAP-Rule:MF_02080};
DE   AltName: Full=Penicillin-binding protein 3 {ECO:0000256|HAMAP-Rule:MF_02080};
DE            Short=PBP-3 {ECO:0000256|HAMAP-Rule:MF_02080};
GN   Name=ftsI {ECO:0000256|HAMAP-Rule:MF_02080,
GN   ECO:0000313|EMBL:MRL34674.1};
GN   Synonyms=ftsI_1 {ECO:0000313|EMBL:STT52506.1}, ftsI_2
GN   {ECO:0000313|EMBL:SVN64074.1}, ftsI_3 {ECO:0000313|EMBL:SLS44422.1},
GN   ftsI_4 {ECO:0000313|EMBL:CAH1473959.1}, ftsI_5
GN   {ECO:0000313|EMBL:STU32598.1}, ftsI_7 {ECO:0000313|EMBL:STV70103.1};
GN   ORFNames=B5L96_26605 {ECO:0000313|EMBL:OVF65434.1}, B6I68_11965
GN   {ECO:0000313|EMBL:PLE27478.1}, BANRA_04330
GN   {ECO:0000313|EMBL:VCX99666.1}, BL124_00027960
GN   {ECO:0000313|EMBL:ROG87213.1}, DW281_06270
GN   {ECO:0000313|EMBL:RDT90881.1}, EAO17_18230
GN   {ECO:0000313|EMBL:RRF08000.1}, FXN67_14725
GN   {ECO:0000313|EMBL:TYL78263.1}, G4V31_07195
GN   {ECO:0000313|EMBL:NGN71919.1}, GJD52_09765
GN   {ECO:0000313|EMBL:MTH01440.1}, GJJ08_022575
GN   {ECO:0000313|EMBL:QOU51083.1}, GJJ18_04425
GN   {ECO:0000313|EMBL:MRL34674.1}, GNF00_08110
GN   {ECO:0000313|EMBL:MUA39810.1}, IMY55_21825
GN   {ECO:0000313|EMBL:QOX12614.1}, KPZU09_40050
GN   {ECO:0000313|EMBL:GHK54269.1}, LS45_00680
GN   {ECO:0000313|EMBL:KII08708.1}, NCTC11679_04757
GN   {ECO:0000313|EMBL:STV70103.1}, NCTC13465_04475
GN   {ECO:0000313|EMBL:SQC48283.1}, NCTC13635_05081
GN   {ECO:0000313|EMBL:VEB05243.1}, NCTC5052_02861
GN   {ECO:0000313|EMBL:STT94424.1}, NCTC5053_04312
GN   {ECO:0000313|EMBL:STV35655.1}, NCTC8849_01042
GN   {ECO:0000313|EMBL:STT52506.1}, NCTC9637_05624
GN   {ECO:0000313|EMBL:STT50626.1}, NCTC9661_05284
GN   {ECO:0000313|EMBL:STU32598.1}, QIG75_05580
GN   {ECO:0000313|EMBL:MDH8288076.1}, SAMEA104216642_04395
GN   {ECO:0000313|EMBL:SZA67696.1}, SAMEA3499874_03070
GN   {ECO:0000313|EMBL:SXG16586.1}, SAMEA3499901_00823
GN   {ECO:0000313|EMBL:SXN29830.1}, SAMEA3512100_03536
GN   {ECO:0000313|EMBL:SXU34073.1}, SAMEA3515122_03018
GN   {ECO:0000313|EMBL:SYH33035.1}, SAMEA3538424_03150
GN   {ECO:0000313|EMBL:VVL57598.1}, SAMEA3538658_00994
GN   {ECO:0000313|EMBL:SYK76929.1}, SAMEA3538828_00863
GN   {ECO:0000313|EMBL:SYR31589.1}, SAMEA3649591_02181
GN   {ECO:0000313|EMBL:SVN64074.1}, SAMEA3649615_03484
GN   {ECO:0000313|EMBL:SYU74220.1}, SAMEA3727706_03809
GN   {ECO:0000313|EMBL:SWV83240.1}, SAMEA4364603_03511
GN   {ECO:0000313|EMBL:SSK45838.1}, SAMEA4370542_02578
GN   {ECO:0000313|EMBL:SLS44422.1}, SAMEA4873597_03160
GN   {ECO:0000313|EMBL:VGJ31063.1}, SAMEA4873632_03788
GN   {ECO:0000313|EMBL:VGL03660.1}, VKR_04209
GN   {ECO:0000313|EMBL:CAH1473959.1};
OS   Klebsiella pneumoniae.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=573 {ECO:0000313|EMBL:MRL34674.1};
RN   [1] {ECO:0000313|EMBL:KII08708.1, ECO:0000313|Proteomes:UP000031820}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UMNturkey9 {ECO:0000313|EMBL:KII08708.1,
RC   ECO:0000313|Proteomes:UP000031820};
RA   Lang K., Dorn K., Danzeisen J., Johnson T.;
RT   "Plasmid movement, recombination, and chromosomal integration amongst
RT   multidrug resistant commensal Escherichia coli clones within a single
RT   commercial turkey flock.";
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:PLE27478.1, ECO:0000313|Proteomes:UP000234439}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=COL-Kpn30 {ECO:0000313|EMBL:PLE27478.1,
RC   ECO:0000313|Proteomes:UP000234439};
RX   PubMed=29029188; DOI=.1093/infdis/jix524;
RA   Rojas L.J., Weinstock G.M., De La Cadena E., Diaz L., Rios R., Hanson B.M.,
RA   Brown J.S., Vats P., Phillips D.S., Nguyen H., Hujer K.M., Correa A.,
RA   Adams M.D., Perez F., Sodergren E., Narechania A., Planet P.J.,
RA   Villegas M.V., Bonomo R.A., Arias C.A.;
RT   "An Analysis of the Epidemic of Klebsiella pneumoniae Carbapenemase-
RT   Producing K. pneumoniae: Convergence of Two Evolutionary Mechanisms Creates
RT   the Perfect Storm.";
RL   J. Infect. Dis. 217:82-92(2017).
RN   [3] {ECO:0000313|EMBL:OVF65434.1, ECO:0000313|Proteomes:UP000196447}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=39383 {ECO:0000313|EMBL:OVF65434.1,
RC   ECO:0000313|Proteomes:UP000196447};
RA   Fouts D., Stalin M.J., Chen L., Wright M., Sutton G., Nguyen K.,
RA   Vanduin D., Rojas L., Hujer A., Hujer K., Bonomo R., Kreiswirth B.,
RA   Adams M.;
RL   Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:RRF08000.1, ECO:0000313|Proteomes:UP000275975}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KLPN_104 {ECO:0000313|EMBL:RRF08000.1,
RC   ECO:0000313|Proteomes:UP000275975};
RX   PubMed=30373801;
RA   Tamma P.D., Fan Y., Bergman Y., Pertea G., Kazmi A., Lewis S.,
RA   Carroll K.C., Schatz M.C., Timp W., Simner P.J.;
RT   "Applying Rapid Whole Genome Sequencing to Predict Phenotypic Antimicrobial
RT   Susceptibility Testing Results Among Carbapenem-Resistant Klebsiella
RT   pneumoniae Clinical Isolates.";
RL   Antimicrob. Agents Chemother. 0:0-0(2018).
RN   [5] {ECO:0000313|Proteomes:UP000251721, ECO:0000313|Proteomes:UP000254103}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC11679 {ECO:0000313|EMBL:STV70103.1,
RC   ECO:0000313|Proteomes:UP000255239}, NCTC13465
RC   {ECO:0000313|EMBL:SQC48283.1, ECO:0000313|Proteomes:UP000251721},
RC   NCTC5052 {ECO:0000313|EMBL:STT94424.1,
RC   ECO:0000313|Proteomes:UP000254103}, NCTC5053
RC   {ECO:0000313|EMBL:STV35655.1, ECO:0000313|Proteomes:UP000254387},
RC   NCTC8849 {ECO:0000313|EMBL:STT52506.1,
RC   ECO:0000313|Proteomes:UP000254799}, NCTC9637
RC   {ECO:0000313|EMBL:STT50626.1, ECO:0000313|Proteomes:UP000255099}, and
RC   NCTC9661 {ECO:0000313|EMBL:STU32598.1,
RC   ECO:0000313|Proteomes:UP000255137};
RG   Pathogen Informatics;
RA   Doyle S.;
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|EMBL:RDT90881.1, ECO:0000313|Proteomes:UP000254680}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K280 {ECO:0000313|EMBL:RDT90881.1,
RC   ECO:0000313|Proteomes:UP000254680};
RA   He F.;
RT   "Draft genome sequence of Klebsiella pneumoniae K280.";
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|Proteomes:UP000257587, ECO:0000313|Proteomes:UP000258253}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2485STDY7054541 {ECO:0000313|EMBL:SZA67696.1,
RC   ECO:0000313|Proteomes:UP000326249}, 4300STDY6470422
RC   {ECO:0000313|EMBL:SSK45838.1, ECO:0000313|Proteomes:UP000252603},
RC   5012STDY7626396 {ECO:0000313|EMBL:VGJ31063.1,
RC   ECO:0000313|Proteomes:UP000295133}, 5012STDY7626430
RC   {ECO:0000313|EMBL:VGL03660.1, ECO:0000313|Proteomes:UP000376235},
RC   EuSCAPE_AT002 {ECO:0000313|EMBL:SXG16586.1,
RC   ECO:0000313|Proteomes:UP000257587}, EuSCAPE_AT029
RC   {ECO:0000313|EMBL:SXN29830.1, ECO:0000313|Proteomes:UP000259975},
RC   EuSCAPE_BE110 {ECO:0000313|EMBL:SWV83240.1,
RC   ECO:0000313|Proteomes:UP000259375}, EuSCAPE_DE072
RC   {ECO:0000313|EMBL:SXU34073.1, ECO:0000313|Proteomes:UP000259753},
RC   EuSCAPE_ES277 {ECO:0000313|EMBL:SYU74220.1,
RC   ECO:0000313|Proteomes:UP000259417}, EuSCAPE_GR003
RC   {ECO:0000313|EMBL:SVN64074.1, ECO:0000313|Proteomes:UP000258905},
RC   EuSCAPE_HU047 {ECO:0000313|EMBL:SYR31589.1,
RC   ECO:0000313|Proteomes:UP000258253}, EuSCAPE_IT093
RC   {ECO:0000313|EMBL:SYH33035.1, ECO:0000313|Proteomes:UP000258673},
RC   EuSCAPE_IT290 {ECO:0000313|EMBL:SYK76929.1,
RC   ECO:0000313|Proteomes:UP000258808}, EuSCAPE_NO017
RC   {ECO:0000313|EMBL:VVL57598.1, ECO:0000313|Proteomes:UP000257312},
RC   NCTC13635 {ECO:0000313|EMBL:VEB05243.1,
RC   ECO:0000313|Proteomes:UP000282433}, and VRES1272
RC   {ECO:0000313|EMBL:SLS44422.1, ECO:0000313|Proteomes:UP000191996};
RG   Pathogen Informatics;
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
RN   [8] {ECO:0000313|EMBL:ROG87213.1, ECO:0000313|Proteomes:UP000283322}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CRK0165 {ECO:0000313|EMBL:ROG87213.1,
RC   ECO:0000313|Proteomes:UP000283322};
RA   Vanduin D., Fouts D., Wright M., Sutton G., Nguyen K., Kreiswirth B.,
RA   Chen L., Rojas L., Hujer A., Hujer K., Bonomo R., Adams M.;
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN   [9] {ECO:0000313|EMBL:VCX99666.1, ECO:0000313|Proteomes:UP000278966}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Kpneu025 {ECO:0000313|EMBL:VCX99666.1};
RA   Noll B N.;
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN   [10] {ECO:0000313|EMBL:TYL78263.1, ECO:0000313|Proteomes:UP000322977}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UCO-494 {ECO:0000313|EMBL:TYL78263.1,
RC   ECO:0000313|Proteomes:UP000322977};
RA   Morales-Leon F., Caro C., Opazo-Capurro A., Lincopan N.,
RA   Dominguez-Yevenes M., Lima C., Bello-Toledo H., Gonzalez-Rocha G.;
RT   "Phenotypic and genetic characterization of extended-spectrum b-lactamase-
RT   producing hypermucoviscous Klebsiella pneumoniae from Chile.";
RL   Submitted (AUG-2019) to the EMBL/GenBank/DDBJ databases.
RN   [11] {ECO:0000313|EMBL:MRL34674.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CriePir115 {ECO:0000313|EMBL:MRL34674.1};
RA   Shelenkov A., Mikhaylova Y., Yanushevich Y., Samoilov A., Petrova L.,
RA   Fomina V., Gusarov V., Zamyatin M., Shagin D.;
RT   "Molecular typing, antibiotic resistance determination and virulence
RT   profiling for 36 multidrug-resistant clinical Klebsiella pneumoniae
RT   isolates using second- and third-generation sequencing.";
RL   Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases.
RN   [12] {ECO:0000313|EMBL:MUA39810.1, ECO:0000313|Proteomes:UP000485085}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KP_38044 {ECO:0000313|EMBL:MUA39810.1,
RC   ECO:0000313|Proteomes:UP000485085};
RA   Zhou K.;
RT   "Emergence of a novel subclone of carbapenem-resistant Klebsiella
RT   pneumoniae ST11 with enhanced virulence and transmissibility: a molecular
RT   epidemiological, clinical, genomic study.";
RL   Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
RN   [13] {ECO:0000313|EMBL:MTH01440.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=RADAR29 {ECO:0000313|EMBL:MTH01440.1};
RA   Surleac M., Paraschiv S., Czobor Barbu I., Popa L.I., Gheorghe I.,
RA   Otelea D., Chifiriuc M.C.;
RL   Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
RN   [14] {ECO:0000313|EMBL:QOU51083.1, ECO:0000313|Proteomes:UP000439817}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CriePir120 {ECO:0000313|EMBL:QOU51083.1,
RC   ECO:0000313|Proteomes:UP000439817};
RX   PubMed=32429555;
RA   Shelenkov A., Mikhaylova Y., Yanushevich Y., Samoilov A., Petrova L.,
RA   Fomina V., Gusarov V., Zamyatin M., Shagin D., Akimkin V.;
RT   "Molecular Typing, Characterization of Antimicrobial Resistance, Virulence
RT   Profiling and Analysis of Whole-Genome Sequence of Clinical Klebsiella
RT   pneumoniae Isolates.";
RL   Antibiotics 9:E261-E261(2020).
RN   [15] {ECO:0000313|EMBL:MTH01440.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=RADAR29 {ECO:0000313|EMBL:MTH01440.1};
RA   Surleac M., Paraschiv S., Czobor Barbu I., Popa L.I., Gheorghe I.,
RA   Otelea D., Chifiriuc M.C.;
RT   "Whole genome sequencing snapshot of multi-drug resistant Klebsiella
RT   pneumoniae strains from hospitals and receiving wastewater treatment plants
RT   in Southern Romania.";
RL   PLoS ONE 0:0-0(2020).
RN   [16] {ECO:0000313|EMBL:NGN71919.1, ECO:0000313|Proteomes:UP000479475}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2429 {ECO:0000313|EMBL:NGN71919.1,
RC   ECO:0000313|Proteomes:UP000479475};
RA   Starkova P.S., Sulyan O.S., Likholetova D.V., Ageevets V.A., Lazareva I.V.,
RA   Sopova J.V., Sidorenko S.V.;
RT   "Klebsiella pneumoniae genome sequencing and assembly.";
RL   Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
RN   [17] {ECO:0000313|EMBL:GHK54269.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Zam_UTH_09 {ECO:0000313|EMBL:GHK54269.1};
RA   Shawa M., Furuta Y., Simbotwe M., Mulenga E., Mubanga M., Mulenga G.,
RA   Kaile C., Zorigt T., Hang'ombe B., Higashi H.;
RT   "Genome Sequence of ESBL Producing Zambian Clinical Strains.";
RL   Submitted (OCT-2020) to the EMBL/GenBank/DDBJ databases.
RN   [18] {ECO:0000313|EMBL:QOX12614.1, ECO:0000313|Proteomes:UP000594100}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KP19-3023 {ECO:0000313|EMBL:QOX12614.1,
RC   ECO:0000313|Proteomes:UP000594100};
RA   Qin s., Peng j.;
RT   "Klebsiella Pneumoniae KP19-3023.";
RL   Submitted (OCT-2020) to the EMBL/GenBank/DDBJ databases.
RN   [19] {ECO:0000313|EMBL:CAH1473959.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BB1542 {ECO:0000313|EMBL:CAH1473959.1};
RA   Delgado-Blas J.;
RL   Submitted (JAN-2022) to the EMBL/GenBank/DDBJ databases.
RN   [20] {ECO:0000313|EMBL:MDH8288076.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Sgh23 {ECO:0000313|EMBL:MDH8288076.1};
RA   Chen Y., Gan Y.-H.;
RT   "WGS of Klebsiella strains from the Antibiotics for Klebsiella Liver
RT   Abscess Syndrome Study (A-KLASS) clinical trial, Singapore.";
RL   Submitted (APR-2023) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes cross-linking of the peptidoglycan cell wall at the
CC       division septum. {ECO:0000256|HAMAP-Rule:MF_02080}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Preferential cleavage: (Ac)2-L-Lys-D-Ala-|-D-Ala. Also
CC         transpeptidation of peptidyl-alanyl moieties that are N-acyl
CC         substituents of D-alanine.; EC=3.4.16.4; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_02080};
CC   -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC       {ECO:0000256|HAMAP-Rule:MF_02080}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000256|HAMAP-
CC       Rule:MF_02080}; Single-pass membrane protein {ECO:0000256|HAMAP-
CC       Rule:MF_02080}.
CC   -!- SIMILARITY: Belongs to the transpeptidase family. FtsI subfamily.
CC       {ECO:0000256|HAMAP-Rule:MF_02080}.
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DR   EMBL; OV753987; CAH1473959.1; -; Genomic_DNA.
DR   EMBL; BNFF01000001; GHK54269.1; -; Genomic_DNA.
DR   EMBL; JRRF01000002; KII08708.1; -; Genomic_DNA.
DR   EMBL; JARYWG010000004; MDH8288076.1; -; Genomic_DNA.
DR   EMBL; WJWF01000003; MRL34674.1; -; Genomic_DNA.
DR   EMBL; WMJT01000006; MTH01440.1; -; Genomic_DNA.
DR   EMBL; WNPO01000011; MUA39810.1; -; Genomic_DNA.
DR   EMBL; JAAKYD010000005; NGN71919.1; -; Genomic_DNA.
DR   EMBL; NDBK01000112; OVF65434.1; -; Genomic_DNA.
DR   EMBL; NCMJ01000062; PLE27478.1; -; Genomic_DNA.
DR   EMBL; CP063008; QOU51083.1; -; Genomic_DNA.
DR   EMBL; CP063747; QOX12614.1; -; Genomic_DNA.
DR   EMBL; QRCD01000005; RDT90881.1; -; Genomic_DNA.
DR   EMBL; MPYG04000224; ROG87213.1; -; Genomic_DNA.
DR   EMBL; RDAM01000001; RRF08000.1; -; Genomic_DNA.
DR   EMBL; FWJM01000007; SLS44422.1; -; Genomic_DNA.
DR   EMBL; UAWQ01000019; SQC48283.1; -; Genomic_DNA.
DR   EMBL; UFEU01000009; SSK45838.1; -; Genomic_DNA.
DR   EMBL; UGLB01000003; STT50626.1; -; Genomic_DNA.
DR   EMBL; UGLC01000002; STT52506.1; -; Genomic_DNA.
DR   EMBL; UGLJ01000002; STT94424.1; -; Genomic_DNA.
DR   EMBL; UGLQ01000003; STU32598.1; -; Genomic_DNA.
DR   EMBL; UGMN01000004; STV35655.1; -; Genomic_DNA.
DR   EMBL; UGMG01000001; STV70103.1; -; Genomic_DNA.
DR   EMBL; UIUC01000006; SVN64074.1; -; Genomic_DNA.
DR   EMBL; UJTF01000010; SWV83240.1; -; Genomic_DNA.
DR   EMBL; UKAW01000007; SXG16586.1; -; Genomic_DNA.
DR   EMBL; UKGE01000003; SXN29830.1; -; Genomic_DNA.
DR   EMBL; UKLK01000007; SXU34073.1; -; Genomic_DNA.
DR   EMBL; UKUT01000006; SYH33035.1; -; Genomic_DNA.
DR   EMBL; UKXO01000003; SYK76929.1; -; Genomic_DNA.
DR   EMBL; ULCI01000003; SYR31589.1; -; Genomic_DNA.
DR   EMBL; ULET01000009; SYU74220.1; -; Genomic_DNA.
DR   EMBL; UNRX01000001; SZA67696.1; -; Genomic_DNA.
DR   EMBL; VSSY01000011; TYL78263.1; -; Genomic_DNA.
DR   EMBL; UWWS01000001; VCX99666.1; -; Genomic_DNA.
DR   EMBL; LR134162; VEB05243.1; -; Genomic_DNA.
DR   EMBL; CAAHAW010000008; VGJ31063.1; -; Genomic_DNA.
DR   EMBL; CAAHCC010000007; VGL03660.1; -; Genomic_DNA.
DR   EMBL; UKIO02000009; VVL57598.1; -; Genomic_DNA.
DR   RefSeq; WP_002888559.1; NZ_WYAL01000016.1.
DR   KEGG; kpb:FH42_21260; -.
DR   KEGG; kpne:KU54_022460; -.
DR   KEGG; kpnu:LI86_22300; -.
DR   KEGG; kpx:PMK1_02396; -.
DR   OMA; SCIVVIH; -.
DR   UniPathway; UPA00219; -.
DR   Proteomes; UP000031820; Unassembled WGS sequence.
DR   Proteomes; UP000191996; Unassembled WGS sequence.
DR   Proteomes; UP000196447; Unassembled WGS sequence.
DR   Proteomes; UP000234439; Unassembled WGS sequence.
DR   Proteomes; UP000251721; Unassembled WGS sequence.
DR   Proteomes; UP000252603; Unassembled WGS sequence.
DR   Proteomes; UP000254103; Unassembled WGS sequence.
DR   Proteomes; UP000254387; Unassembled WGS sequence.
DR   Proteomes; UP000254680; Unassembled WGS sequence.
DR   Proteomes; UP000254799; Unassembled WGS sequence.
DR   Proteomes; UP000255099; Unassembled WGS sequence.
DR   Proteomes; UP000255137; Unassembled WGS sequence.
DR   Proteomes; UP000255239; Unassembled WGS sequence.
DR   Proteomes; UP000257312; Unassembled WGS sequence.
DR   Proteomes; UP000257587; Unassembled WGS sequence.
DR   Proteomes; UP000258253; Unassembled WGS sequence.
DR   Proteomes; UP000258673; Unassembled WGS sequence.
DR   Proteomes; UP000258808; Unassembled WGS sequence.
DR   Proteomes; UP000258905; Unassembled WGS sequence.
DR   Proteomes; UP000259375; Unassembled WGS sequence.
DR   Proteomes; UP000259417; Unassembled WGS sequence.
DR   Proteomes; UP000259753; Unassembled WGS sequence.
DR   Proteomes; UP000259975; Unassembled WGS sequence.
DR   Proteomes; UP000275975; Unassembled WGS sequence.
DR   Proteomes; UP000278966; Unassembled WGS sequence.
DR   Proteomes; UP000282433; Chromosome 1.
DR   Proteomes; UP000283322; Unassembled WGS sequence.
DR   Proteomes; UP000295133; Unassembled WGS sequence.
DR   Proteomes; UP000322977; Unassembled WGS sequence.
DR   Proteomes; UP000326249; Unassembled WGS sequence.
DR   Proteomes; UP000376235; Unassembled WGS sequence.
DR   Proteomes; UP000439817; Chromosome.
DR   Proteomes; UP000449475; Unassembled WGS sequence.
DR   Proteomes; UP000479475; Unassembled WGS sequence.
DR   Proteomes; UP000485085; Unassembled WGS sequence.
DR   Proteomes; UP000594100; Chromosome.
DR   Proteomes; UP000655094; Unassembled WGS sequence.
DR   Proteomes; UP001157099; Unassembled WGS sequence.
DR   Proteomes; UP001158595; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:InterPro.
DR   GO; GO:0009002; F:serine-type D-Ala-D-Ala carboxypeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR   GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR   GO; GO:0043093; P:FtsZ-dependent cytokinesis; IEA:UniProtKB-UniRule.
DR   GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.150.770; -; 1.
DR   Gene3D; 3.30.450.330; -; 1.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR   HAMAP; MF_02080; FtsI_transpept; 1.
DR   InterPro; IPR050515; Bact_Transpept/Beta-Lactamase.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR037532; FtsI_transpept.
DR   InterPro; IPR005311; PBP_dimer.
DR   InterPro; IPR036138; PBP_dimer_sf.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR   PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1.
DR   Pfam; PF03717; PBP_dimer; 1.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR   SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE   3: Inferred from homology;
KW   Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645, ECO:0000256|HAMAP-
KW   Rule:MF_02080}; Cell cycle {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Cell division {ECO:0000256|HAMAP-Rule:MF_02080,
KW   ECO:0000313|EMBL:KII08708.1};
KW   Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Cell membrane {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Cell shape {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Cell wall biogenesis/degradation {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Glycosyltransferase {ECO:0000313|EMBL:CAH1473959.1};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_02080, ECO:0000313|EMBL:MRL34674.1};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_02080};
KW   Peptidoglycan synthesis {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Protease {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Septation {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Transferase {ECO:0000313|EMBL:CAH1473959.1};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW   Rule:MF_02080};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW   Rule:MF_02080}.
FT   TRANSMEM        20..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_02080"
FT   DOMAIN          69..220
FT                   /note="Penicillin-binding protein dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF03717"
FT   DOMAIN          260..554
FT                   /note="Penicillin-binding protein transpeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF00905"
FT   ACT_SITE        307
FT                   /note="Acyl-ester intermediate"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_02080"
SQ   SEQUENCE   588 AA;  64003 MW;  2FE4408506D51A55 CRC64;
     MKAAPKTPKA KRQEEQANFI SWRFALLCGC ILLALAFLLG RVAWLQVISP DMLVRQGDMR
     SLRVQEVSTA RGMITDRSGR PLAVSVPVKA IWADPKELHD AGGVTLDTRW KALADALNMP
     LDQLATRINT NPRMRFIYLA RQVNPDMADY IKKLKLPGIH LREESRRYYP SGEVTAHLIG
     FTNVDSQGIE GVEKSFDKWL TGQPGERIVR KDRYGRVIED ISSTDSQAAH NLALSIDERL
     QALVYRELNN AVAFNKAESG SAVLVDVNTG EVLAMANSPS YNPNNFAGTA KDTMRNRAIT
     DVFEPGSTVK PMVVMTALQR GIVNENTVLN TVPYRINGHE IKDVARYSEL TLTGVLQKSS
     NVGVSKLALA MPSSALVDTY SRFGLGKATN LGLVGERSGL YPQKQRWSDI ERATFSFGYG
     LMVTPLQLAR VYATIGSYGI YRPLSITKVD PPVPGERVFP ESLVRTVVHM MESVALPGGG
     GVKAAIKGYR IAIKTGTAKK VGPDGRYINK YIAYTAGVAP ASHPRFALVV VINDPQAGKY
     YGGAVSAPVF GAIMGGVLRT MNIEPDALAT GEKSEFVINQ GEGTGGRS
//