ID A0A0W8AVJ6_KLEPN Unreviewed; 588 AA. AC A0A0W8AVJ6; A0A0J2GHB5; A0A4V0HIQ6; DT 13-APR-2016, integrated into UniProtKB/TrEMBL. DT 13-APR-2016, sequence version 1. DT 13-SEP-2023, entry version 60. DE RecName: Full=Peptidoglycan D,D-transpeptidase FtsI {ECO:0000256|HAMAP-Rule:MF_02080}; DE EC=3.4.16.4 {ECO:0000256|HAMAP-Rule:MF_02080}; DE AltName: Full=Penicillin-binding protein 3 {ECO:0000256|HAMAP-Rule:MF_02080}; DE Short=PBP-3 {ECO:0000256|HAMAP-Rule:MF_02080}; GN Name=ftsI_3 {ECO:0000313|EMBL:SVS26238.1}; GN Synonyms=ftsI {ECO:0000256|HAMAP-Rule:MF_02080, GN ECO:0000313|EMBL:MRL34674.1}, ftsI_1 {ECO:0000313|EMBL:STT52506.1}, GN ftsI_2 {ECO:0000313|EMBL:SXN29830.1}, ftsI_4 GN {ECO:0000313|EMBL:SQC48283.1}, ftsI_5 {ECO:0000313|EMBL:STU32598.1}, GN ftsI_7 {ECO:0000313|EMBL:STV70103.1}; GN ORFNames=AGE78_22120 {ECO:0000313|EMBL:APP22148.1}, AI2671V1_4115 GN {ECO:0000313|EMBL:CAH3882701.1}, B5L96_26605 GN {ECO:0000313|EMBL:OVF65434.1}, B6I55_13165 GN {ECO:0000313|EMBL:PLD46453.1}, B6I68_11965 GN {ECO:0000313|EMBL:PLE27478.1}, BANRA_04330 GN {ECO:0000313|EMBL:VCX99666.1}, BANRA_04461 GN {ECO:0000313|EMBL:VCZ83850.1}, BL124_00027960 GN {ECO:0000313|EMBL:ROG87213.1}, CK244_006335 GN {ECO:0000313|EMBL:QBH42635.1}, DUW81_15065 GN {ECO:0000313|EMBL:RCR75314.1}, DW281_06270 GN {ECO:0000313|EMBL:RDT90881.1}, EAO17_18230 GN {ECO:0000313|EMBL:RRF08000.1}, FXN67_14725 GN {ECO:0000313|EMBL:TYL78263.1}, G4V31_07195 GN {ECO:0000313|EMBL:NGN71919.1}, G5598_14010 GN {ECO:0000313|EMBL:NGD79872.1}, G7Z27_22825 GN {ECO:0000313|EMBL:QLI10424.1}, GJD64_02940 GN {ECO:0000313|EMBL:MTG49769.1}, GJJ08_022575 GN {ECO:0000313|EMBL:QOU51083.1}, GJJ18_04425 GN {ECO:0000313|EMBL:MRL34674.1}, GJJ26_021890 GN {ECO:0000313|EMBL:QOU24876.1}, GNE24_10100 GN {ECO:0000313|EMBL:MTX45539.1}, GNF00_08110 GN {ECO:0000313|EMBL:MUA39810.1}, GPZ86_22625 GN {ECO:0000313|EMBL:QID63793.1}, HC139_02005 GN {ECO:0000313|EMBL:NJK01873.1}, HJX03_22470 GN {ECO:0000313|EMBL:QJL31130.1}, HV479_18710 GN {ECO:0000313|EMBL:NVM14325.1}, KPZU09_40050 GN {ECO:0000313|EMBL:GHK54269.1}, NCTC11679_04757 GN {ECO:0000313|EMBL:STV70103.1}, NCTC13465_04475 GN {ECO:0000313|EMBL:SQC48283.1}, NCTC13635_05081 GN {ECO:0000313|EMBL:VEB05243.1}, NCTC3279_00263 GN {ECO:0000313|EMBL:VTR32527.1}, NCTC5052_02861 GN {ECO:0000313|EMBL:STT94424.1}, NCTC5053_04312 GN {ECO:0000313|EMBL:STV35655.1}, NCTC8849_01042 GN {ECO:0000313|EMBL:STT52506.1}, NCTC9637_05624 GN {ECO:0000313|EMBL:STT50626.1}, NCTC9661_05284 GN {ECO:0000313|EMBL:STU32598.1}, SAMEA3499874_03070 GN {ECO:0000313|EMBL:SXG16586.1}, SAMEA3499901_00823 GN {ECO:0000313|EMBL:SXN29830.1}, SAMEA3512100_03536 GN {ECO:0000313|EMBL:SXU34073.1}, SAMEA3515122_03018 GN {ECO:0000313|EMBL:SYH33035.1}, SAMEA3531812_02250 GN {ECO:0000313|EMBL:SBW58844.1}, SAMEA3538658_00994 GN {ECO:0000313|EMBL:SYK76929.1}, SAMEA3538828_00863 GN {ECO:0000313|EMBL:SYR31589.1}, SAMEA3649733_02927 GN {ECO:0000313|EMBL:SVS26238.1}, SAMEA3720909_02183 GN {ECO:0000313|EMBL:SWF71742.1}, SAMEA3721197_03463 GN {ECO:0000313|EMBL:SWJ11095.1}, SAMEA3727667_03609 GN {ECO:0000313|EMBL:SWQ61710.1}, SAMEA3727687_02229 GN {ECO:0000313|EMBL:SWR92783.1}, SAMEA3727701_03303 GN {ECO:0000313|EMBL:SWU60589.1}, SAMEA4364603_03511 GN {ECO:0000313|EMBL:SSK45838.1}, SAMEA4370542_02578 GN {ECO:0000313|EMBL:SLS44422.1}, SAMEA4873597_03160 GN {ECO:0000313|EMBL:VGJ31063.1}, SAMEA4873632_03788 GN {ECO:0000313|EMBL:VGL03660.1}; OS Klebsiella pneumoniae. OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella. OX NCBI_TaxID=573 {ECO:0000313|EMBL:SVS26238.1, ECO:0000313|Proteomes:UP000259497}; RN [1] {ECO:0000313|EMBL:APP22148.1, ECO:0000313|Proteomes:UP000184661} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CAV1042 {ECO:0000313|EMBL:APP22148.1, RC ECO:0000313|Proteomes:UP000184661}; RA Mathers A.J., Stoesser N., Chai W., Carroll J., Barry K., Cherunvanky A., RA Sebra R., Kasarskis A., Peto T.E., Walker A.S., Sifri C.D., Crook D.W., RA Sheppard A.E.; RT "Chromosomal Integration of the Klebsiella pneumoniae carbapenemase gene RT (blaKPC) in Klebsiella Species: Elusive but not Rare."; RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000234439, ECO:0000313|Proteomes:UP000234595} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=COL-Kpn17 {ECO:0000313|EMBL:PLD46453.1, RC ECO:0000313|Proteomes:UP000234595}, and COL-Kpn30 RC {ECO:0000313|EMBL:PLE27478.1, ECO:0000313|Proteomes:UP000234439}; RX PubMed=29029188; DOI=.1093/infdis/jix524; RA Rojas L.J., Weinstock G.M., De La Cadena E., Diaz L., Rios R., Hanson B.M., RA Brown J.S., Vats P., Phillips D.S., Nguyen H., Hujer K.M., Correa A., RA Adams M.D., Perez F., Sodergren E., Narechania A., Planet P.J., RA Villegas M.V., Bonomo R.A., Arias C.A.; RT "An Analysis of the Epidemic of Klebsiella pneumoniae Carbapenemase- RT Producing K. pneumoniae: Convergence of Two Evolutionary Mechanisms Creates RT the "Perfect Storm"."; RL J. Infect. Dis. 217:82-92(2017). RN [3] {ECO:0000313|EMBL:OVF65434.1, ECO:0000313|Proteomes:UP000196447} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=39383 {ECO:0000313|EMBL:OVF65434.1, RC ECO:0000313|Proteomes:UP000196447}; RA Fouts D., Stalin M.J., Chen L., Wright M., Sutton G., Nguyen K., RA Vanduin D., Rojas L., Hujer A., Hujer K., Bonomo R., Kreiswirth B., RA Adams M.; RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|EMBL:RRF08000.1, ECO:0000313|Proteomes:UP000275975} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KLPN_104 {ECO:0000313|EMBL:RRF08000.1, RC ECO:0000313|Proteomes:UP000275975}; RX PubMed=30373801; RA Tamma P.D., Fan Y., Bergman Y., Pertea G., Kazmi A., Lewis S., RA Carroll K.C., Schatz M.C., Timp W., Simner P.J.; RT "Applying Rapid Whole Genome Sequencing to Predict Phenotypic Antimicrobial RT Susceptibility Testing Results Among Carbapenem-Resistant Klebsiella RT pneumoniae Clinical Isolates."; RL Antimicrob. Agents Chemother. 0:0-0(2018). RN [5] {ECO:0000313|EMBL:RCR75314.1, ECO:0000313|Proteomes:UP000253654} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JHTS006 {ECO:0000313|EMBL:RCR75314.1, RC ECO:0000313|Proteomes:UP000253654}; RX PubMed=29648629; RA Simner P.J., Antar A.A., Hao S., Gurtowski J., Tamma P.D., Rock C., RA Opene B.N., Tekle T., Carroll K.C., Schatz M.C., Timp W.; RT "Antibiotic pressure on the acquisition and loss of antibiotic resistance RT genes in Klebsiella pneumoniae."; RL J. Antimicrob. Chemother. 73:1796-1803(2018). RN [6] {ECO:0000313|Proteomes:UP000251721, ECO:0000313|Proteomes:UP000254103} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=NCTC11679 {ECO:0000313|EMBL:STV70103.1, RC ECO:0000313|Proteomes:UP000255239}, NCTC13465 RC {ECO:0000313|EMBL:SQC48283.1, ECO:0000313|Proteomes:UP000251721}, RC NCTC5052 {ECO:0000313|EMBL:STT94424.1, RC ECO:0000313|Proteomes:UP000254103}, NCTC5053 RC {ECO:0000313|EMBL:STV35655.1, ECO:0000313|Proteomes:UP000254387}, RC NCTC8849 {ECO:0000313|EMBL:STT52506.1, RC ECO:0000313|Proteomes:UP000254799}, NCTC9637 RC {ECO:0000313|EMBL:STT50626.1, ECO:0000313|Proteomes:UP000255099}, and RC NCTC9661 {ECO:0000313|EMBL:STU32598.1, RC ECO:0000313|Proteomes:UP000255137}; RG Pathogen Informatics; RA Doyle S.; RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases. RN [7] {ECO:0000313|EMBL:RDT90881.1, ECO:0000313|Proteomes:UP000254680} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K280 {ECO:0000313|EMBL:RDT90881.1, RC ECO:0000313|Proteomes:UP000254680}; RA He F.; RT "Draft genome sequence of Klebsiella pneumoniae K280."; RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases. RN [8] {ECO:0000313|Proteomes:UP000257410, ECO:0000313|Proteomes:UP000257587} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=4300STDY6470422 {ECO:0000313|EMBL:SSK45838.1, RC ECO:0000313|Proteomes:UP000252603}, 5012STDY7626396 RC {ECO:0000313|EMBL:VGJ31063.1, ECO:0000313|Proteomes:UP000295133}, RC 5012STDY7626430 {ECO:0000313|EMBL:VGL03660.1, RC ECO:0000313|Proteomes:UP000376235}, EuSCAPE_AT002 RC {ECO:0000313|EMBL:SXG16586.1, ECO:0000313|Proteomes:UP000257587}, RC EuSCAPE_AT029 {ECO:0000313|EMBL:SXN29830.1, RC ECO:0000313|Proteomes:UP000259975}, EuSCAPE_BE080 RC {ECO:0000313|EMBL:SWQ61710.1, ECO:0000313|Proteomes:UP000260463}, RC EuSCAPE_BE100 {ECO:0000313|EMBL:SWR92783.1, RC ECO:0000313|Proteomes:UP000259946}, EuSCAPE_BE105 RC {ECO:0000313|EMBL:SWU60589.1, ECO:0000313|Proteomes:UP000257410}, RC EuSCAPE_DE072 {ECO:0000313|EMBL:SXU34073.1, RC ECO:0000313|Proteomes:UP000259753}, EuSCAPE_GR114 RC {ECO:0000313|EMBL:SVS26238.1, ECO:0000313|Proteomes:UP000259497}, RC EuSCAPE_HU047 {ECO:0000313|EMBL:SYR31589.1, RC ECO:0000313|Proteomes:UP000258253}, EuSCAPE_IT093 RC {ECO:0000313|EMBL:SYH33035.1, ECO:0000313|Proteomes:UP000258673}, RC EuSCAPE_IT290 {ECO:0000313|EMBL:SYK76929.1, RC ECO:0000313|Proteomes:UP000258808}, EuSCAPE_RS077 RC {ECO:0000313|EMBL:SWJ11095.1, ECO:0000313|Proteomes:UP000259548}, RC EuSCAPE_UK014 {ECO:0000313|EMBL:SWF71742.1, RC ECO:0000313|Proteomes:UP000259364}, NCTC13635 RC {ECO:0000313|EMBL:VEB05243.1, ECO:0000313|Proteomes:UP000282433}, RC NCTC3279 {ECO:0000313|EMBL:VTR32527.1, RC ECO:0000313|Proteomes:UP000395965}, PB173 RC {ECO:0000313|EMBL:SBW58844.1, ECO:0000313|Proteomes:UP000092500}, and RC VRES1272 {ECO:0000313|EMBL:SLS44422.1, RC ECO:0000313|Proteomes:UP000191996}; RG Pathogen Informatics; RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|EMBL:ROG87213.1, ECO:0000313|Proteomes:UP000283322} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CRK0165 {ECO:0000313|EMBL:ROG87213.1, RC ECO:0000313|Proteomes:UP000283322}; RA Vanduin D., Fouts D., Wright M., Sutton G., Nguyen K., Kreiswirth B., RA Chen L., Rojas L., Hujer A., Hujer K., Bonomo R., Adams M.; RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases. RN [10] {ECO:0000313|Proteomes:UP000276286, ECO:0000313|Proteomes:UP000278966} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Kpneu025 {ECO:0000313|EMBL:VCX99666.1}, and Kpneu043 RC {ECO:0000313|EMBL:VCZ83850.1}; RA Noll B N.; RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases. RN [11] {ECO:0000313|EMBL:QBH42635.1, ECO:0000313|Proteomes:UP000218354} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=VBA2172 {ECO:0000313|EMBL:QBH42635.1, RC ECO:0000313|Proteomes:UP000218354}; RA Veeraraghavan B., Shankar C., Vasudevan K., Venkatesan M., Narasimman V.; RT "VBA2172 Klebsiella pneumoniae hybrid assembly."; RL Submitted (FEB-2019) to the EMBL/GenBank/DDBJ databases. RN [12] {ECO:0000313|EMBL:TYL78263.1, ECO:0000313|Proteomes:UP000322977} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=UCO-494 {ECO:0000313|EMBL:TYL78263.1, RC ECO:0000313|Proteomes:UP000322977}; RA Morales-Leon F., Caro C., Opazo-Capurro A., Lincopan N., RA Dominguez-Yevenes M., Lima C., Bello-Toledo H., Gonzalez-Rocha G.; RT "Phenotypic and genetic characterization of extended-spectrum b-lactamase- RT producing hypermucoviscous Klebsiella pneumoniae from Chile."; RL Submitted (AUG-2019) to the EMBL/GenBank/DDBJ databases. RN [13] {ECO:0000313|EMBL:MRL34674.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CriePir115 {ECO:0000313|EMBL:MRL34674.1}; RA Shelenkov A., Mikhaylova Y., Yanushevich Y., Samoilov A., Petrova L., RA Fomina V., Gusarov V., Zamyatin M., Shagin D.; RT "Molecular typing, antibiotic resistance determination and virulence RT profiling for 36 multidrug-resistant clinical Klebsiella pneumoniae RT isolates using second- and third-generation sequencing."; RL Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases. RN [14] {ECO:0000313|EMBL:MTX45539.1, ECO:0000313|Proteomes:UP000485085} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KP_38044 {ECO:0000313|EMBL:MUA39810.1, RC ECO:0000313|Proteomes:UP000485085}, and KP_46186 RC {ECO:0000313|EMBL:MTX45539.1}; RA Zhou K.; RT "Emergence of a novel subclone of carbapenem-resistant Klebsiella RT pneumoniae ST11 with enhanced virulence and transmissibility: a molecular RT epidemiological, clinical, genomic study."; RL Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases. RN [15] {ECO:0000313|EMBL:MTG49769.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=RADAR27 {ECO:0000313|EMBL:MTG49769.1}; RA Surleac M., Paraschiv S., Czobor Barbu I., Popa L.I., Gheorghe I., RA Otelea D., Chifiriuc M.C.; RL Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases. RN [16] {ECO:0000313|Proteomes:UP000439817, ECO:0000313|Proteomes:UP000487173} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CriePir120 {ECO:0000313|EMBL:QOU51083.1, RC ECO:0000313|Proteomes:UP000439817}, and CriePir26 RC {ECO:0000313|EMBL:QOU24876.1}; RX PubMed=32429555; RA Shelenkov A., Mikhaylova Y., Yanushevich Y., Samoilov A., Petrova L., RA Fomina V., Gusarov V., Zamyatin M., Shagin D., Akimkin V.; RT "Molecular Typing, Characterization of Antimicrobial Resistance, Virulence RT Profiling and Analysis of Whole-Genome Sequence of Clinical Klebsiella RT pneumoniae Isolates."; RL Antibiotics 9:E261-E261(2020). RN [17] {ECO:0000313|EMBL:MTG49769.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=RADAR27 {ECO:0000313|EMBL:MTG49769.1}; RA Surleac M., Paraschiv S., Czobor Barbu I., Popa L.I., Gheorghe I., RA Otelea D., Chifiriuc M.C.; RT "Whole genome sequencing snapshot of multi-drug resistant Klebsiella RT pneumoniae strains from hospitals and receiving wastewater treatment plants RT in Southern Romania."; RL PLoS ONE 0:0-0(2020). RN [18] {ECO:0000313|EMBL:QID63793.1, ECO:0000313|Proteomes:UP000501545} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=20467 {ECO:0000313|EMBL:QID63793.1, RC ECO:0000313|Proteomes:UP000501545}; RA Zhukhovitsky V.G., Shcherbinin D.N., Zubasheva M.V.; RT "De novo genome assembly of Klebsiella pneumoniae clinical strain."; RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases. RN [19] {ECO:0000313|EMBL:NGN71919.1, ECO:0000313|Proteomes:UP000479475} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=2429 {ECO:0000313|EMBL:NGN71919.1, RC ECO:0000313|Proteomes:UP000479475}; RA Starkova P.S., Sulyan O.S., Likholetova D.V., Ageevets V.A., Lazareva I.V., RA Sopova J.V., Sidorenko S.V.; RT "Klebsiella pneumoniae genome sequencing and assembly."; RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases. RN [20] {ECO:0000313|EMBL:NGD79872.1, ECO:0000313|Proteomes:UP000472401} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KPM_42 {ECO:0000313|EMBL:NGD79872.1, RC ECO:0000313|Proteomes:UP000472401}; RA Tokajian S., El Chaar M., El Khoury M.; RT "WGS of Carbapenem-Resistant Entrobacteriaceae."; RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases. RN [21] {ECO:0000313|EMBL:QLI10424.1, ECO:0000313|Proteomes:UP000509467} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=11KM256 {ECO:0000313|EMBL:QLI10424.1, RC ECO:0000313|Proteomes:UP000509467}; RA Brilhante M., Perreten V.; RT "Whole genome sequencing of global problem clones of OXA-48-producing RT Klebsiella pneumoniae from the veterinary setting in Switzerland."; RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases. RN [22] {ECO:0000313|EMBL:NJK01873.1, ECO:0000313|Proteomes:UP000551791} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=UMB8492 {ECO:0000313|EMBL:NJK01873.1, RC ECO:0000313|Proteomes:UP000551791}; RA Miller-Ensminger T., Wolfe A.J., Putonti C.; RT "Draft genome sequences of bacterial isolates from the female urobiome."; RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases. RN [23] {ECO:0000313|EMBL:QJL31130.1, ECO:0000313|Proteomes:UP000503203} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C16KP0122 {ECO:0000313|EMBL:QJL31130.1, RC ECO:0000313|Proteomes:UP000503203}; RA Yoon E.-J., Gwon B., Liu C., Kim D., Won D., Park S.G., Choi J.R., RA Jeong S.H.; RT "Built-in CTX-M extended-spectrum beta-lactamase gene in Klebsiella RT pneumoniae ensuring stable propagation of the multidrug-resistant pathogen RT in clinical settings."; RL Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases. RN [24] {ECO:0000313|EMBL:NVM14325.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=LABACER 27 {ECO:0000313|EMBL:NVM14325.1}; RA Albarracin L., Vargas J.M., Jure M.A., Villena J.; RT "Genomic and immunological characterization of antibiotic-resistant RT Klebsiella pneumoniae isolate from Northwest Argentina."; RL Submitted (JUN-2020) to the EMBL/GenBank/DDBJ databases. RN [25] {ECO:0000313|EMBL:GHK54269.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Zam_UTH_09 {ECO:0000313|EMBL:GHK54269.1}; RA Shawa M., Furuta Y., Simbotwe M., Mulenga E., Mubanga M., Mulenga G., RA Kaile C., Zorigt T., Hang'ombe B., Higashi H.; RT "Genome Sequence of ESBL Producing Zambian Clinical Strains."; RL Submitted (OCT-2020) to the EMBL/GenBank/DDBJ databases. RN [26] {ECO:0000313|EMBL:CAH3882701.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=147 {ECO:0000313|EMBL:CAH3882701.1}; RA Alioto T., Alioto T., Gomez Garrido J.; RL Submitted (MAY-2022) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Catalyzes cross-linking of the peptidoglycan cell wall at the CC division septum. {ECO:0000256|HAMAP-Rule:MF_02080}. CC -!- CATALYTIC ACTIVITY: CC Reaction=Preferential cleavage: (Ac)2-L-Lys-D-Ala-|-D-Ala. Also CC transpeptidation of peptidyl-alanyl moieties that are N-acyl CC substituents of D-alanine.; EC=3.4.16.4; Evidence={ECO:0000256|HAMAP- CC Rule:MF_02080}; CC -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis. CC {ECO:0000256|HAMAP-Rule:MF_02080}. CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000256|HAMAP- CC Rule:MF_02080}; Single-pass membrane protein {ECO:0000256|HAMAP- CC Rule:MF_02080}. CC -!- SIMILARITY: Belongs to the transpeptidase family. FtsI subfamily. CC {ECO:0000256|HAMAP-Rule:MF_02080}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP018671; APP22148.1; -; Genomic_DNA. DR EMBL; OW849316; CAH3882701.1; -; Genomic_DNA. DR EMBL; BNFF01000001; GHK54269.1; -; Genomic_DNA. DR EMBL; WJWF01000003; MRL34674.1; -; Genomic_DNA. DR EMBL; WMJH01000002; MTG49769.1; -; Genomic_DNA. DR EMBL; WNOE01000015; MTX45539.1; -; Genomic_DNA. DR EMBL; WNPO01000011; MUA39810.1; -; Genomic_DNA. DR EMBL; JAAJSK010000007; NGD79872.1; -; Genomic_DNA. DR EMBL; JAAKYD010000005; NGN71919.1; -; Genomic_DNA. DR EMBL; JAAUVU010000002; NJK01873.1; -; Genomic_DNA. DR EMBL; JABXNZ010000009; NVM14325.1; -; Genomic_DNA. DR EMBL; NDBK01000112; OVF65434.1; -; Genomic_DNA. DR EMBL; NCLW01000021; PLD46453.1; -; Genomic_DNA. DR EMBL; NCMJ01000062; PLE27478.1; -; Genomic_DNA. DR EMBL; CP036320; QBH42635.1; -; Genomic_DNA. DR EMBL; CP048937; QID63793.1; -; Genomic_DNA. DR EMBL; CP052431; QJL31130.1; -; Genomic_DNA. DR EMBL; CP049716; QLI10424.1; -; Genomic_DNA. DR EMBL; CP062986; QOU24876.1; -; Genomic_DNA. DR EMBL; CP063008; QOU51083.1; -; Genomic_DNA. DR EMBL; QPAF01000006; RCR75314.1; -; Genomic_DNA. DR EMBL; QRCD01000005; RDT90881.1; -; Genomic_DNA. DR EMBL; MPYG04000224; ROG87213.1; -; Genomic_DNA. DR EMBL; RDAM01000001; RRF08000.1; -; Genomic_DNA. DR EMBL; FLVI01000006; SBW58844.1; -; Genomic_DNA. DR EMBL; FWJM01000007; SLS44422.1; -; Genomic_DNA. DR EMBL; UAWQ01000019; SQC48283.1; -; Genomic_DNA. DR EMBL; UFEU01000009; SSK45838.1; -; Genomic_DNA. DR EMBL; UGLB01000003; STT50626.1; -; Genomic_DNA. DR EMBL; UGLC01000002; STT52506.1; -; Genomic_DNA. DR EMBL; UGLJ01000002; STT94424.1; -; Genomic_DNA. DR EMBL; UGLQ01000003; STU32598.1; -; Genomic_DNA. DR EMBL; UGMN01000004; STV35655.1; -; Genomic_DNA. DR EMBL; UGMG01000001; STV70103.1; -; Genomic_DNA. DR EMBL; UIXM01000008; SVS26238.1; -; Genomic_DNA. DR EMBL; UJHH01000008; SWF71742.1; -; Genomic_DNA. DR EMBL; UJJV01000009; SWJ11095.1; -; Genomic_DNA. DR EMBL; UJPJ01000011; SWQ61710.1; -; Genomic_DNA. DR EMBL; UJQI01000008; SWR92783.1; -; Genomic_DNA. DR EMBL; UJSE01000008; SWU60589.1; -; Genomic_DNA. DR EMBL; UKAW01000007; SXG16586.1; -; Genomic_DNA. DR EMBL; UKGE01000003; SXN29830.1; -; Genomic_DNA. DR EMBL; UKLK01000007; SXU34073.1; -; Genomic_DNA. DR EMBL; UKUT01000006; SYH33035.1; -; Genomic_DNA. DR EMBL; UKXO01000003; SYK76929.1; -; Genomic_DNA. DR EMBL; ULCI01000003; SYR31589.1; -; Genomic_DNA. DR EMBL; VSSY01000011; TYL78263.1; -; Genomic_DNA. DR EMBL; UWWS01000001; VCX99666.1; -; Genomic_DNA. DR EMBL; UWYB01000001; VCZ83850.1; -; Genomic_DNA. DR EMBL; LR134162; VEB05243.1; -; Genomic_DNA. DR EMBL; CAAHAW010000008; VGJ31063.1; -; Genomic_DNA. DR EMBL; CAAHCC010000007; VGL03660.1; -; Genomic_DNA. DR EMBL; CABEFC010000002; VTR32527.1; -; Genomic_DNA. DR RefSeq; WP_002888559.1; NZ_WYAM01000022.1. DR EnsemblBacteria; AIT01861; AIT01861; PMK1_02396. DR EnsemblBacteria; AUY19176; AUY19176; C3F39_10515. DR EnsemblBacteria; AVB73872; AVB73872; C3483_22070. DR EnsemblBacteria; KLY18083; KLY18083; SK89_01947. DR EnsemblBacteria; PPK23259; PPK23259; CSC88_14290. DR EnsemblBacteria; PWF58468; PWF58468; C7V41_14790. DR EnsemblBacteria; RCI99793; RCI99793; DM062_00760. DR EnsemblBacteria; RCK03275; RCK03275; DM059_00690. DR EnsemblBacteria; RDT68909; RDT68909; DXF97_05380. DR EnsemblBacteria; SQC48283; SQC48283; NCTC13465_04475. DR EnsemblBacteria; SSF40530; SSF40530; SAMEA24002668_02916. DR EnsemblBacteria; SSG22791; SSG22791; SAMEA23986918_05501. DR EnsemblBacteria; SSK45838; SSK45838; SAMEA4364603_03511. DR EnsemblBacteria; STT50626; STT50626; NCTC9637_05624. DR EnsemblBacteria; STT52506; STT52506; NCTC8849_01042. DR EnsemblBacteria; STT64965; STT64965; NCTC1936_01053. DR EnsemblBacteria; STT94424; STT94424; NCTC5052_02861. DR EnsemblBacteria; STU32598; STU32598; NCTC9661_05284. DR EnsemblBacteria; STV35655; STV35655; NCTC5053_04312. DR EnsemblBacteria; STV70103; STV70103; NCTC11679_04757. DR EnsemblBacteria; SVJ50221; SVJ50221; SAMEA4394730_05373. DR EnsemblBacteria; VEB05243; VEB05243; NCTC13635_05081. DR KEGG; kpb:FH42_21260; -. DR KEGG; kpne:KU54_022460; -. DR KEGG; kpnu:LI86_22300; -. DR KEGG; kpx:PMK1_02396; -. DR OMA; QDNYSLA; -. DR UniPathway; UPA00219; -. DR Proteomes; UP000092500; Unassembled WGS sequence. DR Proteomes; UP000184661; Chromosome. DR Proteomes; UP000191996; Unassembled WGS sequence. DR Proteomes; UP000196447; Unassembled WGS sequence. DR Proteomes; UP000218354; Chromosome. DR Proteomes; UP000234439; Unassembled WGS sequence. DR Proteomes; UP000234595; Unassembled WGS sequence. DR Proteomes; UP000251721; Unassembled WGS sequence. DR Proteomes; UP000252603; Unassembled WGS sequence. DR Proteomes; UP000253654; Unassembled WGS sequence. DR Proteomes; UP000254103; Unassembled WGS sequence. DR Proteomes; UP000254387; Unassembled WGS sequence. DR Proteomes; UP000254680; Unassembled WGS sequence. DR Proteomes; UP000254799; Unassembled WGS sequence. DR Proteomes; UP000255099; Unassembled WGS sequence. DR Proteomes; UP000255137; Unassembled WGS sequence. DR Proteomes; UP000255239; Unassembled WGS sequence. DR Proteomes; UP000257410; Unassembled WGS sequence. DR Proteomes; UP000257587; Unassembled WGS sequence. DR Proteomes; UP000258253; Unassembled WGS sequence. DR Proteomes; UP000258673; Unassembled WGS sequence. DR Proteomes; UP000258808; Unassembled WGS sequence. DR Proteomes; UP000259364; Unassembled WGS sequence. DR Proteomes; UP000259497; Unassembled WGS sequence. DR Proteomes; UP000259548; Unassembled WGS sequence. DR Proteomes; UP000259753; Unassembled WGS sequence. DR Proteomes; UP000259946; Unassembled WGS sequence. DR Proteomes; UP000259975; Unassembled WGS sequence. DR Proteomes; UP000260463; Unassembled WGS sequence. DR Proteomes; UP000275975; Unassembled WGS sequence. DR Proteomes; UP000276286; Unassembled WGS sequence. DR Proteomes; UP000278966; Unassembled WGS sequence. DR Proteomes; UP000282433; Chromosome 1. DR Proteomes; UP000283322; Unassembled WGS sequence. DR Proteomes; UP000295133; Unassembled WGS sequence. DR Proteomes; UP000322977; Unassembled WGS sequence. DR Proteomes; UP000376235; Unassembled WGS sequence. DR Proteomes; UP000395965; Unassembled WGS sequence. DR Proteomes; UP000435249; Unassembled WGS sequence. DR Proteomes; UP000439817; Chromosome. DR Proteomes; UP000472401; Unassembled WGS sequence. DR Proteomes; UP000479475; Unassembled WGS sequence. DR Proteomes; UP000485085; Unassembled WGS sequence. DR Proteomes; UP000487173; Chromosome. DR Proteomes; UP000501545; Chromosome. DR Proteomes; UP000503203; Chromosome. DR Proteomes; UP000509467; Chromosome. DR Proteomes; UP000551791; Unassembled WGS sequence. DR Proteomes; UP000655094; Unassembled WGS sequence. DR Proteomes; UP000789542; Chromosome. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0008658; F:penicillin binding; IEA:InterPro. DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:InterPro. DR GO; GO:0009002; F:serine-type D-Ala-D-Ala carboxypeptidase activity; IEA:UniProtKB-UniRule. DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW. DR GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW. DR GO; GO:0043093; P:FtsZ-dependent cytokinesis; IEA:UniProtKB-UniRule. DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-UniRule. DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW. DR GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW. DR Gene3D; 1.10.150.770; -; 1. DR Gene3D; 3.30.450.330; -; 1. DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1. DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1. DR HAMAP; MF_02080; FtsI_transpept; 1. DR InterPro; IPR012338; Beta-lactam/transpept-like. DR InterPro; IPR037532; FtsI_transpept. DR InterPro; IPR005311; PBP_dimer. DR InterPro; IPR036138; PBP_dimer_sf. DR InterPro; IPR001460; PCN-bd_Tpept. DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1. DR PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1. DR Pfam; PF03717; PBP_dimer; 1. DR Pfam; PF00905; Transpeptidase; 1. DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1. DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1. PE 3: Inferred from homology; KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645, ECO:0000256|HAMAP- KW Rule:MF_02080}; KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|HAMAP- KW Rule:MF_02080}; KW Cell division {ECO:0000256|ARBA:ARBA00022618, ECO:0000256|HAMAP- KW Rule:MF_02080}; Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_02080}; KW Cell membrane {ECO:0000256|HAMAP-Rule:MF_02080}; KW Cell shape {ECO:0000256|HAMAP-Rule:MF_02080}; KW Cell wall biogenesis/degradation {ECO:0000256|HAMAP-Rule:MF_02080}; KW Glycosyltransferase {ECO:0000313|EMBL:SVS26238.1}; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_02080}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_02080}; KW Peptidoglycan synthesis {ECO:0000256|HAMAP-Rule:MF_02080}; KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|HAMAP-Rule:MF_02080}; KW Septation {ECO:0000256|ARBA:ARBA00023210, ECO:0000256|HAMAP-Rule:MF_02080}; KW Transferase {ECO:0000313|EMBL:SVS26238.1}; KW Transmembrane {ECO:0000256|HAMAP-Rule:MF_02080}; KW Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_02080}. FT TRANSMEM 20..44 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_02080" FT DOMAIN 70..220 FT /note="Penicillin-binding protein dimerisation" FT /evidence="ECO:0000259|Pfam:PF03717" FT DOMAIN 260..554 FT /note="Penicillin-binding protein transpeptidase" FT /evidence="ECO:0000259|Pfam:PF00905" FT ACT_SITE 307 FT /note="Acyl-ester intermediate" FT /evidence="ECO:0000256|HAMAP-Rule:MF_02080" SQ SEQUENCE 588 AA; 64003 MW; 2FE4408506D51A55 CRC64; MKAAPKTPKA KRQEEQANFI SWRFALLCGC ILLALAFLLG RVAWLQVISP DMLVRQGDMR SLRVQEVSTA RGMITDRSGR PLAVSVPVKA IWADPKELHD AGGVTLDTRW KALADALNMP LDQLATRINT NPRMRFIYLA RQVNPDMADY IKKLKLPGIH LREESRRYYP SGEVTAHLIG FTNVDSQGIE GVEKSFDKWL TGQPGERIVR KDRYGRVIED ISSTDSQAAH NLALSIDERL QALVYRELNN AVAFNKAESG SAVLVDVNTG EVLAMANSPS YNPNNFAGTA KDTMRNRAIT DVFEPGSTVK PMVVMTALQR GIVNENTVLN TVPYRINGHE IKDVARYSEL TLTGVLQKSS NVGVSKLALA MPSSALVDTY SRFGLGKATN LGLVGERSGL YPQKQRWSDI ERATFSFGYG LMVTPLQLAR VYATIGSYGI YRPLSITKVD PPVPGERVFP ESLVRTVVHM MESVALPGGG GVKAAIKGYR IAIKTGTAKK VGPDGRYINK YIAYTAGVAP ASHPRFALVV VINDPQAGKY YGGAVSAPVF GAIMGGVLRT MNIEPDALAT GEKSEFVINQ GEGTGGRS //