ID   A0A0W8AVJ6_KLEPN        Unreviewed;       588 AA.
AC   A0A0W8AVJ6; A0A0J2GHB5; A0A4V0HIQ6;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   13-SEP-2023, entry version 60.
DE   RecName: Full=Peptidoglycan D,D-transpeptidase FtsI {ECO:0000256|HAMAP-Rule:MF_02080};
DE            EC=3.4.16.4 {ECO:0000256|HAMAP-Rule:MF_02080};
DE   AltName: Full=Penicillin-binding protein 3 {ECO:0000256|HAMAP-Rule:MF_02080};
DE            Short=PBP-3 {ECO:0000256|HAMAP-Rule:MF_02080};
GN   Name=ftsI_3 {ECO:0000313|EMBL:SVS26238.1};
GN   Synonyms=ftsI {ECO:0000256|HAMAP-Rule:MF_02080,
GN   ECO:0000313|EMBL:MRL34674.1}, ftsI_1 {ECO:0000313|EMBL:STT52506.1},
GN   ftsI_2 {ECO:0000313|EMBL:SXN29830.1}, ftsI_4
GN   {ECO:0000313|EMBL:SQC48283.1}, ftsI_5 {ECO:0000313|EMBL:STU32598.1},
GN   ftsI_7 {ECO:0000313|EMBL:STV70103.1};
GN   ORFNames=AGE78_22120 {ECO:0000313|EMBL:APP22148.1}, AI2671V1_4115
GN   {ECO:0000313|EMBL:CAH3882701.1}, B5L96_26605
GN   {ECO:0000313|EMBL:OVF65434.1}, B6I55_13165
GN   {ECO:0000313|EMBL:PLD46453.1}, B6I68_11965
GN   {ECO:0000313|EMBL:PLE27478.1}, BANRA_04330
GN   {ECO:0000313|EMBL:VCX99666.1}, BANRA_04461
GN   {ECO:0000313|EMBL:VCZ83850.1}, BL124_00027960
GN   {ECO:0000313|EMBL:ROG87213.1}, CK244_006335
GN   {ECO:0000313|EMBL:QBH42635.1}, DUW81_15065
GN   {ECO:0000313|EMBL:RCR75314.1}, DW281_06270
GN   {ECO:0000313|EMBL:RDT90881.1}, EAO17_18230
GN   {ECO:0000313|EMBL:RRF08000.1}, FXN67_14725
GN   {ECO:0000313|EMBL:TYL78263.1}, G4V31_07195
GN   {ECO:0000313|EMBL:NGN71919.1}, G5598_14010
GN   {ECO:0000313|EMBL:NGD79872.1}, G7Z27_22825
GN   {ECO:0000313|EMBL:QLI10424.1}, GJD64_02940
GN   {ECO:0000313|EMBL:MTG49769.1}, GJJ08_022575
GN   {ECO:0000313|EMBL:QOU51083.1}, GJJ18_04425
GN   {ECO:0000313|EMBL:MRL34674.1}, GJJ26_021890
GN   {ECO:0000313|EMBL:QOU24876.1}, GNE24_10100
GN   {ECO:0000313|EMBL:MTX45539.1}, GNF00_08110
GN   {ECO:0000313|EMBL:MUA39810.1}, GPZ86_22625
GN   {ECO:0000313|EMBL:QID63793.1}, HC139_02005
GN   {ECO:0000313|EMBL:NJK01873.1}, HJX03_22470
GN   {ECO:0000313|EMBL:QJL31130.1}, HV479_18710
GN   {ECO:0000313|EMBL:NVM14325.1}, KPZU09_40050
GN   {ECO:0000313|EMBL:GHK54269.1}, NCTC11679_04757
GN   {ECO:0000313|EMBL:STV70103.1}, NCTC13465_04475
GN   {ECO:0000313|EMBL:SQC48283.1}, NCTC13635_05081
GN   {ECO:0000313|EMBL:VEB05243.1}, NCTC3279_00263
GN   {ECO:0000313|EMBL:VTR32527.1}, NCTC5052_02861
GN   {ECO:0000313|EMBL:STT94424.1}, NCTC5053_04312
GN   {ECO:0000313|EMBL:STV35655.1}, NCTC8849_01042
GN   {ECO:0000313|EMBL:STT52506.1}, NCTC9637_05624
GN   {ECO:0000313|EMBL:STT50626.1}, NCTC9661_05284
GN   {ECO:0000313|EMBL:STU32598.1}, SAMEA3499874_03070
GN   {ECO:0000313|EMBL:SXG16586.1}, SAMEA3499901_00823
GN   {ECO:0000313|EMBL:SXN29830.1}, SAMEA3512100_03536
GN   {ECO:0000313|EMBL:SXU34073.1}, SAMEA3515122_03018
GN   {ECO:0000313|EMBL:SYH33035.1}, SAMEA3531812_02250
GN   {ECO:0000313|EMBL:SBW58844.1}, SAMEA3538658_00994
GN   {ECO:0000313|EMBL:SYK76929.1}, SAMEA3538828_00863
GN   {ECO:0000313|EMBL:SYR31589.1}, SAMEA3649733_02927
GN   {ECO:0000313|EMBL:SVS26238.1}, SAMEA3720909_02183
GN   {ECO:0000313|EMBL:SWF71742.1}, SAMEA3721197_03463
GN   {ECO:0000313|EMBL:SWJ11095.1}, SAMEA3727667_03609
GN   {ECO:0000313|EMBL:SWQ61710.1}, SAMEA3727687_02229
GN   {ECO:0000313|EMBL:SWR92783.1}, SAMEA3727701_03303
GN   {ECO:0000313|EMBL:SWU60589.1}, SAMEA4364603_03511
GN   {ECO:0000313|EMBL:SSK45838.1}, SAMEA4370542_02578
GN   {ECO:0000313|EMBL:SLS44422.1}, SAMEA4873597_03160
GN   {ECO:0000313|EMBL:VGJ31063.1}, SAMEA4873632_03788
GN   {ECO:0000313|EMBL:VGL03660.1};
OS   Klebsiella pneumoniae.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=573 {ECO:0000313|EMBL:SVS26238.1, ECO:0000313|Proteomes:UP000259497};
RN   [1] {ECO:0000313|EMBL:APP22148.1, ECO:0000313|Proteomes:UP000184661}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CAV1042 {ECO:0000313|EMBL:APP22148.1,
RC   ECO:0000313|Proteomes:UP000184661};
RA   Mathers A.J., Stoesser N., Chai W., Carroll J., Barry K., Cherunvanky A.,
RA   Sebra R., Kasarskis A., Peto T.E., Walker A.S., Sifri C.D., Crook D.W.,
RA   Sheppard A.E.;
RT   "Chromosomal Integration of the Klebsiella pneumoniae carbapenemase gene
RT   (blaKPC) in Klebsiella Species: Elusive but not Rare.";
RL   Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000234439, ECO:0000313|Proteomes:UP000234595}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=COL-Kpn17 {ECO:0000313|EMBL:PLD46453.1,
RC   ECO:0000313|Proteomes:UP000234595}, and COL-Kpn30
RC   {ECO:0000313|EMBL:PLE27478.1, ECO:0000313|Proteomes:UP000234439};
RX   PubMed=29029188; DOI=.1093/infdis/jix524;
RA   Rojas L.J., Weinstock G.M., De La Cadena E., Diaz L., Rios R., Hanson B.M.,
RA   Brown J.S., Vats P., Phillips D.S., Nguyen H., Hujer K.M., Correa A.,
RA   Adams M.D., Perez F., Sodergren E., Narechania A., Planet P.J.,
RA   Villegas M.V., Bonomo R.A., Arias C.A.;
RT   "An Analysis of the Epidemic of Klebsiella pneumoniae Carbapenemase-
RT   Producing K. pneumoniae: Convergence of Two Evolutionary Mechanisms Creates
RT   the "Perfect Storm".";
RL   J. Infect. Dis. 217:82-92(2017).
RN   [3] {ECO:0000313|EMBL:OVF65434.1, ECO:0000313|Proteomes:UP000196447}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=39383 {ECO:0000313|EMBL:OVF65434.1,
RC   ECO:0000313|Proteomes:UP000196447};
RA   Fouts D., Stalin M.J., Chen L., Wright M., Sutton G., Nguyen K.,
RA   Vanduin D., Rojas L., Hujer A., Hujer K., Bonomo R., Kreiswirth B.,
RA   Adams M.;
RL   Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:RRF08000.1, ECO:0000313|Proteomes:UP000275975}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KLPN_104 {ECO:0000313|EMBL:RRF08000.1,
RC   ECO:0000313|Proteomes:UP000275975};
RX   PubMed=30373801;
RA   Tamma P.D., Fan Y., Bergman Y., Pertea G., Kazmi A., Lewis S.,
RA   Carroll K.C., Schatz M.C., Timp W., Simner P.J.;
RT   "Applying Rapid Whole Genome Sequencing to Predict Phenotypic Antimicrobial
RT   Susceptibility Testing Results Among Carbapenem-Resistant Klebsiella
RT   pneumoniae Clinical Isolates.";
RL   Antimicrob. Agents Chemother. 0:0-0(2018).
RN   [5] {ECO:0000313|EMBL:RCR75314.1, ECO:0000313|Proteomes:UP000253654}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JHTS006 {ECO:0000313|EMBL:RCR75314.1,
RC   ECO:0000313|Proteomes:UP000253654};
RX   PubMed=29648629;
RA   Simner P.J., Antar A.A., Hao S., Gurtowski J., Tamma P.D., Rock C.,
RA   Opene B.N., Tekle T., Carroll K.C., Schatz M.C., Timp W.;
RT   "Antibiotic pressure on the acquisition and loss of antibiotic resistance
RT   genes in Klebsiella pneumoniae.";
RL   J. Antimicrob. Chemother. 73:1796-1803(2018).
RN   [6] {ECO:0000313|Proteomes:UP000251721, ECO:0000313|Proteomes:UP000254103}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC11679 {ECO:0000313|EMBL:STV70103.1,
RC   ECO:0000313|Proteomes:UP000255239}, NCTC13465
RC   {ECO:0000313|EMBL:SQC48283.1, ECO:0000313|Proteomes:UP000251721},
RC   NCTC5052 {ECO:0000313|EMBL:STT94424.1,
RC   ECO:0000313|Proteomes:UP000254103}, NCTC5053
RC   {ECO:0000313|EMBL:STV35655.1, ECO:0000313|Proteomes:UP000254387},
RC   NCTC8849 {ECO:0000313|EMBL:STT52506.1,
RC   ECO:0000313|Proteomes:UP000254799}, NCTC9637
RC   {ECO:0000313|EMBL:STT50626.1, ECO:0000313|Proteomes:UP000255099}, and
RC   NCTC9661 {ECO:0000313|EMBL:STU32598.1,
RC   ECO:0000313|Proteomes:UP000255137};
RG   Pathogen Informatics;
RA   Doyle S.;
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|EMBL:RDT90881.1, ECO:0000313|Proteomes:UP000254680}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K280 {ECO:0000313|EMBL:RDT90881.1,
RC   ECO:0000313|Proteomes:UP000254680};
RA   He F.;
RT   "Draft genome sequence of Klebsiella pneumoniae K280.";
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN   [8] {ECO:0000313|Proteomes:UP000257410, ECO:0000313|Proteomes:UP000257587}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=4300STDY6470422 {ECO:0000313|EMBL:SSK45838.1,
RC   ECO:0000313|Proteomes:UP000252603}, 5012STDY7626396
RC   {ECO:0000313|EMBL:VGJ31063.1, ECO:0000313|Proteomes:UP000295133},
RC   5012STDY7626430 {ECO:0000313|EMBL:VGL03660.1,
RC   ECO:0000313|Proteomes:UP000376235}, EuSCAPE_AT002
RC   {ECO:0000313|EMBL:SXG16586.1, ECO:0000313|Proteomes:UP000257587},
RC   EuSCAPE_AT029 {ECO:0000313|EMBL:SXN29830.1,
RC   ECO:0000313|Proteomes:UP000259975}, EuSCAPE_BE080
RC   {ECO:0000313|EMBL:SWQ61710.1, ECO:0000313|Proteomes:UP000260463},
RC   EuSCAPE_BE100 {ECO:0000313|EMBL:SWR92783.1,
RC   ECO:0000313|Proteomes:UP000259946}, EuSCAPE_BE105
RC   {ECO:0000313|EMBL:SWU60589.1, ECO:0000313|Proteomes:UP000257410},
RC   EuSCAPE_DE072 {ECO:0000313|EMBL:SXU34073.1,
RC   ECO:0000313|Proteomes:UP000259753}, EuSCAPE_GR114
RC   {ECO:0000313|EMBL:SVS26238.1, ECO:0000313|Proteomes:UP000259497},
RC   EuSCAPE_HU047 {ECO:0000313|EMBL:SYR31589.1,
RC   ECO:0000313|Proteomes:UP000258253}, EuSCAPE_IT093
RC   {ECO:0000313|EMBL:SYH33035.1, ECO:0000313|Proteomes:UP000258673},
RC   EuSCAPE_IT290 {ECO:0000313|EMBL:SYK76929.1,
RC   ECO:0000313|Proteomes:UP000258808}, EuSCAPE_RS077
RC   {ECO:0000313|EMBL:SWJ11095.1, ECO:0000313|Proteomes:UP000259548},
RC   EuSCAPE_UK014 {ECO:0000313|EMBL:SWF71742.1,
RC   ECO:0000313|Proteomes:UP000259364}, NCTC13635
RC   {ECO:0000313|EMBL:VEB05243.1, ECO:0000313|Proteomes:UP000282433},
RC   NCTC3279 {ECO:0000313|EMBL:VTR32527.1,
RC   ECO:0000313|Proteomes:UP000395965}, PB173
RC   {ECO:0000313|EMBL:SBW58844.1, ECO:0000313|Proteomes:UP000092500}, and
RC   VRES1272 {ECO:0000313|EMBL:SLS44422.1,
RC   ECO:0000313|Proteomes:UP000191996};
RG   Pathogen Informatics;
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
RN   [9] {ECO:0000313|EMBL:ROG87213.1, ECO:0000313|Proteomes:UP000283322}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CRK0165 {ECO:0000313|EMBL:ROG87213.1,
RC   ECO:0000313|Proteomes:UP000283322};
RA   Vanduin D., Fouts D., Wright M., Sutton G., Nguyen K., Kreiswirth B.,
RA   Chen L., Rojas L., Hujer A., Hujer K., Bonomo R., Adams M.;
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN   [10] {ECO:0000313|Proteomes:UP000276286, ECO:0000313|Proteomes:UP000278966}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Kpneu025 {ECO:0000313|EMBL:VCX99666.1}, and Kpneu043
RC   {ECO:0000313|EMBL:VCZ83850.1};
RA   Noll B N.;
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN   [11] {ECO:0000313|EMBL:QBH42635.1, ECO:0000313|Proteomes:UP000218354}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VBA2172 {ECO:0000313|EMBL:QBH42635.1,
RC   ECO:0000313|Proteomes:UP000218354};
RA   Veeraraghavan B., Shankar C., Vasudevan K., Venkatesan M., Narasimman V.;
RT   "VBA2172 Klebsiella pneumoniae hybrid assembly.";
RL   Submitted (FEB-2019) to the EMBL/GenBank/DDBJ databases.
RN   [12] {ECO:0000313|EMBL:TYL78263.1, ECO:0000313|Proteomes:UP000322977}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UCO-494 {ECO:0000313|EMBL:TYL78263.1,
RC   ECO:0000313|Proteomes:UP000322977};
RA   Morales-Leon F., Caro C., Opazo-Capurro A., Lincopan N.,
RA   Dominguez-Yevenes M., Lima C., Bello-Toledo H., Gonzalez-Rocha G.;
RT   "Phenotypic and genetic characterization of extended-spectrum b-lactamase-
RT   producing hypermucoviscous Klebsiella pneumoniae from Chile.";
RL   Submitted (AUG-2019) to the EMBL/GenBank/DDBJ databases.
RN   [13] {ECO:0000313|EMBL:MRL34674.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CriePir115 {ECO:0000313|EMBL:MRL34674.1};
RA   Shelenkov A., Mikhaylova Y., Yanushevich Y., Samoilov A., Petrova L.,
RA   Fomina V., Gusarov V., Zamyatin M., Shagin D.;
RT   "Molecular typing, antibiotic resistance determination and virulence
RT   profiling for 36 multidrug-resistant clinical Klebsiella pneumoniae
RT   isolates using second- and third-generation sequencing.";
RL   Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases.
RN   [14] {ECO:0000313|EMBL:MTX45539.1, ECO:0000313|Proteomes:UP000485085}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KP_38044 {ECO:0000313|EMBL:MUA39810.1,
RC   ECO:0000313|Proteomes:UP000485085}, and KP_46186
RC   {ECO:0000313|EMBL:MTX45539.1};
RA   Zhou K.;
RT   "Emergence of a novel subclone of carbapenem-resistant Klebsiella
RT   pneumoniae ST11 with enhanced virulence and transmissibility: a molecular
RT   epidemiological, clinical, genomic study.";
RL   Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
RN   [15] {ECO:0000313|EMBL:MTG49769.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=RADAR27 {ECO:0000313|EMBL:MTG49769.1};
RA   Surleac M., Paraschiv S., Czobor Barbu I., Popa L.I., Gheorghe I.,
RA   Otelea D., Chifiriuc M.C.;
RL   Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
RN   [16] {ECO:0000313|Proteomes:UP000439817, ECO:0000313|Proteomes:UP000487173}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CriePir120 {ECO:0000313|EMBL:QOU51083.1,
RC   ECO:0000313|Proteomes:UP000439817}, and CriePir26
RC   {ECO:0000313|EMBL:QOU24876.1};
RX   PubMed=32429555;
RA   Shelenkov A., Mikhaylova Y., Yanushevich Y., Samoilov A., Petrova L.,
RA   Fomina V., Gusarov V., Zamyatin M., Shagin D., Akimkin V.;
RT   "Molecular Typing, Characterization of Antimicrobial Resistance, Virulence
RT   Profiling and Analysis of Whole-Genome Sequence of Clinical Klebsiella
RT   pneumoniae Isolates.";
RL   Antibiotics 9:E261-E261(2020).
RN   [17] {ECO:0000313|EMBL:MTG49769.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=RADAR27 {ECO:0000313|EMBL:MTG49769.1};
RA   Surleac M., Paraschiv S., Czobor Barbu I., Popa L.I., Gheorghe I.,
RA   Otelea D., Chifiriuc M.C.;
RT   "Whole genome sequencing snapshot of multi-drug resistant Klebsiella
RT   pneumoniae strains from hospitals and receiving wastewater treatment plants
RT   in Southern Romania.";
RL   PLoS ONE 0:0-0(2020).
RN   [18] {ECO:0000313|EMBL:QID63793.1, ECO:0000313|Proteomes:UP000501545}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=20467 {ECO:0000313|EMBL:QID63793.1,
RC   ECO:0000313|Proteomes:UP000501545};
RA   Zhukhovitsky V.G., Shcherbinin D.N., Zubasheva M.V.;
RT   "De novo genome assembly of Klebsiella pneumoniae clinical strain.";
RL   Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
RN   [19] {ECO:0000313|EMBL:NGN71919.1, ECO:0000313|Proteomes:UP000479475}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2429 {ECO:0000313|EMBL:NGN71919.1,
RC   ECO:0000313|Proteomes:UP000479475};
RA   Starkova P.S., Sulyan O.S., Likholetova D.V., Ageevets V.A., Lazareva I.V.,
RA   Sopova J.V., Sidorenko S.V.;
RT   "Klebsiella pneumoniae genome sequencing and assembly.";
RL   Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
RN   [20] {ECO:0000313|EMBL:NGD79872.1, ECO:0000313|Proteomes:UP000472401}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KPM_42 {ECO:0000313|EMBL:NGD79872.1,
RC   ECO:0000313|Proteomes:UP000472401};
RA   Tokajian S., El Chaar M., El Khoury M.;
RT   "WGS of Carbapenem-Resistant Entrobacteriaceae.";
RL   Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
RN   [21] {ECO:0000313|EMBL:QLI10424.1, ECO:0000313|Proteomes:UP000509467}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=11KM256 {ECO:0000313|EMBL:QLI10424.1,
RC   ECO:0000313|Proteomes:UP000509467};
RA   Brilhante M., Perreten V.;
RT   "Whole genome sequencing of global problem clones of OXA-48-producing
RT   Klebsiella pneumoniae from the veterinary setting in Switzerland.";
RL   Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
RN   [22] {ECO:0000313|EMBL:NJK01873.1, ECO:0000313|Proteomes:UP000551791}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UMB8492 {ECO:0000313|EMBL:NJK01873.1,
RC   ECO:0000313|Proteomes:UP000551791};
RA   Miller-Ensminger T., Wolfe A.J., Putonti C.;
RT   "Draft genome sequences of bacterial isolates from the female urobiome.";
RL   Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
RN   [23] {ECO:0000313|EMBL:QJL31130.1, ECO:0000313|Proteomes:UP000503203}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C16KP0122 {ECO:0000313|EMBL:QJL31130.1,
RC   ECO:0000313|Proteomes:UP000503203};
RA   Yoon E.-J., Gwon B., Liu C., Kim D., Won D., Park S.G., Choi J.R.,
RA   Jeong S.H.;
RT   "Built-in CTX-M extended-spectrum beta-lactamase gene in Klebsiella
RT   pneumoniae ensuring stable propagation of the multidrug-resistant pathogen
RT   in clinical settings.";
RL   Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases.
RN   [24] {ECO:0000313|EMBL:NVM14325.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LABACER 27 {ECO:0000313|EMBL:NVM14325.1};
RA   Albarracin L., Vargas J.M., Jure M.A., Villena J.;
RT   "Genomic and immunological characterization of antibiotic-resistant
RT   Klebsiella pneumoniae isolate from Northwest Argentina.";
RL   Submitted (JUN-2020) to the EMBL/GenBank/DDBJ databases.
RN   [25] {ECO:0000313|EMBL:GHK54269.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Zam_UTH_09 {ECO:0000313|EMBL:GHK54269.1};
RA   Shawa M., Furuta Y., Simbotwe M., Mulenga E., Mubanga M., Mulenga G.,
RA   Kaile C., Zorigt T., Hang'ombe B., Higashi H.;
RT   "Genome Sequence of ESBL Producing Zambian Clinical Strains.";
RL   Submitted (OCT-2020) to the EMBL/GenBank/DDBJ databases.
RN   [26] {ECO:0000313|EMBL:CAH3882701.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=147 {ECO:0000313|EMBL:CAH3882701.1};
RA   Alioto T., Alioto T., Gomez Garrido J.;
RL   Submitted (MAY-2022) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes cross-linking of the peptidoglycan cell wall at the
CC       division septum. {ECO:0000256|HAMAP-Rule:MF_02080}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Preferential cleavage: (Ac)2-L-Lys-D-Ala-|-D-Ala. Also
CC         transpeptidation of peptidyl-alanyl moieties that are N-acyl
CC         substituents of D-alanine.; EC=3.4.16.4; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_02080};
CC   -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC       {ECO:0000256|HAMAP-Rule:MF_02080}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000256|HAMAP-
CC       Rule:MF_02080}; Single-pass membrane protein {ECO:0000256|HAMAP-
CC       Rule:MF_02080}.
CC   -!- SIMILARITY: Belongs to the transpeptidase family. FtsI subfamily.
CC       {ECO:0000256|HAMAP-Rule:MF_02080}.
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DR   EMBL; CP018671; APP22148.1; -; Genomic_DNA.
DR   EMBL; OW849316; CAH3882701.1; -; Genomic_DNA.
DR   EMBL; BNFF01000001; GHK54269.1; -; Genomic_DNA.
DR   EMBL; WJWF01000003; MRL34674.1; -; Genomic_DNA.
DR   EMBL; WMJH01000002; MTG49769.1; -; Genomic_DNA.
DR   EMBL; WNOE01000015; MTX45539.1; -; Genomic_DNA.
DR   EMBL; WNPO01000011; MUA39810.1; -; Genomic_DNA.
DR   EMBL; JAAJSK010000007; NGD79872.1; -; Genomic_DNA.
DR   EMBL; JAAKYD010000005; NGN71919.1; -; Genomic_DNA.
DR   EMBL; JAAUVU010000002; NJK01873.1; -; Genomic_DNA.
DR   EMBL; JABXNZ010000009; NVM14325.1; -; Genomic_DNA.
DR   EMBL; NDBK01000112; OVF65434.1; -; Genomic_DNA.
DR   EMBL; NCLW01000021; PLD46453.1; -; Genomic_DNA.
DR   EMBL; NCMJ01000062; PLE27478.1; -; Genomic_DNA.
DR   EMBL; CP036320; QBH42635.1; -; Genomic_DNA.
DR   EMBL; CP048937; QID63793.1; -; Genomic_DNA.
DR   EMBL; CP052431; QJL31130.1; -; Genomic_DNA.
DR   EMBL; CP049716; QLI10424.1; -; Genomic_DNA.
DR   EMBL; CP062986; QOU24876.1; -; Genomic_DNA.
DR   EMBL; CP063008; QOU51083.1; -; Genomic_DNA.
DR   EMBL; QPAF01000006; RCR75314.1; -; Genomic_DNA.
DR   EMBL; QRCD01000005; RDT90881.1; -; Genomic_DNA.
DR   EMBL; MPYG04000224; ROG87213.1; -; Genomic_DNA.
DR   EMBL; RDAM01000001; RRF08000.1; -; Genomic_DNA.
DR   EMBL; FLVI01000006; SBW58844.1; -; Genomic_DNA.
DR   EMBL; FWJM01000007; SLS44422.1; -; Genomic_DNA.
DR   EMBL; UAWQ01000019; SQC48283.1; -; Genomic_DNA.
DR   EMBL; UFEU01000009; SSK45838.1; -; Genomic_DNA.
DR   EMBL; UGLB01000003; STT50626.1; -; Genomic_DNA.
DR   EMBL; UGLC01000002; STT52506.1; -; Genomic_DNA.
DR   EMBL; UGLJ01000002; STT94424.1; -; Genomic_DNA.
DR   EMBL; UGLQ01000003; STU32598.1; -; Genomic_DNA.
DR   EMBL; UGMN01000004; STV35655.1; -; Genomic_DNA.
DR   EMBL; UGMG01000001; STV70103.1; -; Genomic_DNA.
DR   EMBL; UIXM01000008; SVS26238.1; -; Genomic_DNA.
DR   EMBL; UJHH01000008; SWF71742.1; -; Genomic_DNA.
DR   EMBL; UJJV01000009; SWJ11095.1; -; Genomic_DNA.
DR   EMBL; UJPJ01000011; SWQ61710.1; -; Genomic_DNA.
DR   EMBL; UJQI01000008; SWR92783.1; -; Genomic_DNA.
DR   EMBL; UJSE01000008; SWU60589.1; -; Genomic_DNA.
DR   EMBL; UKAW01000007; SXG16586.1; -; Genomic_DNA.
DR   EMBL; UKGE01000003; SXN29830.1; -; Genomic_DNA.
DR   EMBL; UKLK01000007; SXU34073.1; -; Genomic_DNA.
DR   EMBL; UKUT01000006; SYH33035.1; -; Genomic_DNA.
DR   EMBL; UKXO01000003; SYK76929.1; -; Genomic_DNA.
DR   EMBL; ULCI01000003; SYR31589.1; -; Genomic_DNA.
DR   EMBL; VSSY01000011; TYL78263.1; -; Genomic_DNA.
DR   EMBL; UWWS01000001; VCX99666.1; -; Genomic_DNA.
DR   EMBL; UWYB01000001; VCZ83850.1; -; Genomic_DNA.
DR   EMBL; LR134162; VEB05243.1; -; Genomic_DNA.
DR   EMBL; CAAHAW010000008; VGJ31063.1; -; Genomic_DNA.
DR   EMBL; CAAHCC010000007; VGL03660.1; -; Genomic_DNA.
DR   EMBL; CABEFC010000002; VTR32527.1; -; Genomic_DNA.
DR   RefSeq; WP_002888559.1; NZ_WYAM01000022.1.
DR   EnsemblBacteria; AIT01861; AIT01861; PMK1_02396.
DR   EnsemblBacteria; AUY19176; AUY19176; C3F39_10515.
DR   EnsemblBacteria; AVB73872; AVB73872; C3483_22070.
DR   EnsemblBacteria; KLY18083; KLY18083; SK89_01947.
DR   EnsemblBacteria; PPK23259; PPK23259; CSC88_14290.
DR   EnsemblBacteria; PWF58468; PWF58468; C7V41_14790.
DR   EnsemblBacteria; RCI99793; RCI99793; DM062_00760.
DR   EnsemblBacteria; RCK03275; RCK03275; DM059_00690.
DR   EnsemblBacteria; RDT68909; RDT68909; DXF97_05380.
DR   EnsemblBacteria; SQC48283; SQC48283; NCTC13465_04475.
DR   EnsemblBacteria; SSF40530; SSF40530; SAMEA24002668_02916.
DR   EnsemblBacteria; SSG22791; SSG22791; SAMEA23986918_05501.
DR   EnsemblBacteria; SSK45838; SSK45838; SAMEA4364603_03511.
DR   EnsemblBacteria; STT50626; STT50626; NCTC9637_05624.
DR   EnsemblBacteria; STT52506; STT52506; NCTC8849_01042.
DR   EnsemblBacteria; STT64965; STT64965; NCTC1936_01053.
DR   EnsemblBacteria; STT94424; STT94424; NCTC5052_02861.
DR   EnsemblBacteria; STU32598; STU32598; NCTC9661_05284.
DR   EnsemblBacteria; STV35655; STV35655; NCTC5053_04312.
DR   EnsemblBacteria; STV70103; STV70103; NCTC11679_04757.
DR   EnsemblBacteria; SVJ50221; SVJ50221; SAMEA4394730_05373.
DR   EnsemblBacteria; VEB05243; VEB05243; NCTC13635_05081.
DR   KEGG; kpb:FH42_21260; -.
DR   KEGG; kpne:KU54_022460; -.
DR   KEGG; kpnu:LI86_22300; -.
DR   KEGG; kpx:PMK1_02396; -.
DR   OMA; QDNYSLA; -.
DR   UniPathway; UPA00219; -.
DR   Proteomes; UP000092500; Unassembled WGS sequence.
DR   Proteomes; UP000184661; Chromosome.
DR   Proteomes; UP000191996; Unassembled WGS sequence.
DR   Proteomes; UP000196447; Unassembled WGS sequence.
DR   Proteomes; UP000218354; Chromosome.
DR   Proteomes; UP000234439; Unassembled WGS sequence.
DR   Proteomes; UP000234595; Unassembled WGS sequence.
DR   Proteomes; UP000251721; Unassembled WGS sequence.
DR   Proteomes; UP000252603; Unassembled WGS sequence.
DR   Proteomes; UP000253654; Unassembled WGS sequence.
DR   Proteomes; UP000254103; Unassembled WGS sequence.
DR   Proteomes; UP000254387; Unassembled WGS sequence.
DR   Proteomes; UP000254680; Unassembled WGS sequence.
DR   Proteomes; UP000254799; Unassembled WGS sequence.
DR   Proteomes; UP000255099; Unassembled WGS sequence.
DR   Proteomes; UP000255137; Unassembled WGS sequence.
DR   Proteomes; UP000255239; Unassembled WGS sequence.
DR   Proteomes; UP000257410; Unassembled WGS sequence.
DR   Proteomes; UP000257587; Unassembled WGS sequence.
DR   Proteomes; UP000258253; Unassembled WGS sequence.
DR   Proteomes; UP000258673; Unassembled WGS sequence.
DR   Proteomes; UP000258808; Unassembled WGS sequence.
DR   Proteomes; UP000259364; Unassembled WGS sequence.
DR   Proteomes; UP000259497; Unassembled WGS sequence.
DR   Proteomes; UP000259548; Unassembled WGS sequence.
DR   Proteomes; UP000259753; Unassembled WGS sequence.
DR   Proteomes; UP000259946; Unassembled WGS sequence.
DR   Proteomes; UP000259975; Unassembled WGS sequence.
DR   Proteomes; UP000260463; Unassembled WGS sequence.
DR   Proteomes; UP000275975; Unassembled WGS sequence.
DR   Proteomes; UP000276286; Unassembled WGS sequence.
DR   Proteomes; UP000278966; Unassembled WGS sequence.
DR   Proteomes; UP000282433; Chromosome 1.
DR   Proteomes; UP000283322; Unassembled WGS sequence.
DR   Proteomes; UP000295133; Unassembled WGS sequence.
DR   Proteomes; UP000322977; Unassembled WGS sequence.
DR   Proteomes; UP000376235; Unassembled WGS sequence.
DR   Proteomes; UP000395965; Unassembled WGS sequence.
DR   Proteomes; UP000435249; Unassembled WGS sequence.
DR   Proteomes; UP000439817; Chromosome.
DR   Proteomes; UP000472401; Unassembled WGS sequence.
DR   Proteomes; UP000479475; Unassembled WGS sequence.
DR   Proteomes; UP000485085; Unassembled WGS sequence.
DR   Proteomes; UP000487173; Chromosome.
DR   Proteomes; UP000501545; Chromosome.
DR   Proteomes; UP000503203; Chromosome.
DR   Proteomes; UP000509467; Chromosome.
DR   Proteomes; UP000551791; Unassembled WGS sequence.
DR   Proteomes; UP000655094; Unassembled WGS sequence.
DR   Proteomes; UP000789542; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:InterPro.
DR   GO; GO:0009002; F:serine-type D-Ala-D-Ala carboxypeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR   GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR   GO; GO:0043093; P:FtsZ-dependent cytokinesis; IEA:UniProtKB-UniRule.
DR   GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.150.770; -; 1.
DR   Gene3D; 3.30.450.330; -; 1.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR   HAMAP; MF_02080; FtsI_transpept; 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR037532; FtsI_transpept.
DR   InterPro; IPR005311; PBP_dimer.
DR   InterPro; IPR036138; PBP_dimer_sf.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR   PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1.
DR   Pfam; PF03717; PBP_dimer; 1.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR   SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE   3: Inferred from homology;
KW   Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645, ECO:0000256|HAMAP-
KW   Rule:MF_02080};
KW   Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|HAMAP-
KW   Rule:MF_02080};
KW   Cell division {ECO:0000256|ARBA:ARBA00022618, ECO:0000256|HAMAP-
KW   Rule:MF_02080}; Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Cell membrane {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Cell shape {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Cell wall biogenesis/degradation {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Glycosyltransferase {ECO:0000313|EMBL:SVS26238.1};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_02080};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_02080};
KW   Peptidoglycan synthesis {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|HAMAP-Rule:MF_02080};
KW   Septation {ECO:0000256|ARBA:ARBA00023210, ECO:0000256|HAMAP-Rule:MF_02080};
KW   Transferase {ECO:0000313|EMBL:SVS26238.1};
KW   Transmembrane {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_02080}.
FT   TRANSMEM        20..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_02080"
FT   DOMAIN          70..220
FT                   /note="Penicillin-binding protein dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF03717"
FT   DOMAIN          260..554
FT                   /note="Penicillin-binding protein transpeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF00905"
FT   ACT_SITE        307
FT                   /note="Acyl-ester intermediate"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_02080"
SQ   SEQUENCE   588 AA;  64003 MW;  2FE4408506D51A55 CRC64;
     MKAAPKTPKA KRQEEQANFI SWRFALLCGC ILLALAFLLG RVAWLQVISP DMLVRQGDMR
     SLRVQEVSTA RGMITDRSGR PLAVSVPVKA IWADPKELHD AGGVTLDTRW KALADALNMP
     LDQLATRINT NPRMRFIYLA RQVNPDMADY IKKLKLPGIH LREESRRYYP SGEVTAHLIG
     FTNVDSQGIE GVEKSFDKWL TGQPGERIVR KDRYGRVIED ISSTDSQAAH NLALSIDERL
     QALVYRELNN AVAFNKAESG SAVLVDVNTG EVLAMANSPS YNPNNFAGTA KDTMRNRAIT
     DVFEPGSTVK PMVVMTALQR GIVNENTVLN TVPYRINGHE IKDVARYSEL TLTGVLQKSS
     NVGVSKLALA MPSSALVDTY SRFGLGKATN LGLVGERSGL YPQKQRWSDI ERATFSFGYG
     LMVTPLQLAR VYATIGSYGI YRPLSITKVD PPVPGERVFP ESLVRTVVHM MESVALPGGG
     GVKAAIKGYR IAIKTGTAKK VGPDGRYINK YIAYTAGVAP ASHPRFALVV VINDPQAGKY
     YGGAVSAPVF GAIMGGVLRT MNIEPDALAT GEKSEFVINQ GEGTGGRS
//