ID   A0A0W8AVJ6_KLEPN        Unreviewed;       588 AA.
AC   A0A0W8AVJ6; A0A0J2GHB5; A0A4V0HIQ6;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   22-FEB-2023, entry version 57.
DE   RecName: Full=Peptidoglycan D,D-transpeptidase FtsI {ECO:0000256|HAMAP-Rule:MF_02080};
DE            EC=3.4.16.4 {ECO:0000256|HAMAP-Rule:MF_02080};
DE   AltName: Full=Penicillin-binding protein 3 {ECO:0000256|HAMAP-Rule:MF_02080};
DE            Short=PBP-3 {ECO:0000256|HAMAP-Rule:MF_02080};
GN   Name=ftsI_3 {ECO:0000313|EMBL:SVS26238.1};
GN   Synonyms=ftsI {ECO:0000256|HAMAP-Rule:MF_02080,
GN   ECO:0000313|EMBL:MTX45539.1}, ftsI_1 {ECO:0000313|EMBL:STT52506.1},
GN   ftsI_2 {ECO:0000313|EMBL:SXN29830.1}, ftsI_4
GN   {ECO:0000313|EMBL:SQC48283.1}, ftsI_5 {ECO:0000313|EMBL:STU32598.1},
GN   ftsI_7 {ECO:0000313|EMBL:STV70103.1};
GN   ORFNames=B5L96_26605 {ECO:0000313|EMBL:OVF65434.1}, BL124_00027960
GN   {ECO:0000313|EMBL:ROG87213.1}, EAO17_18230
GN   {ECO:0000313|EMBL:RRF08000.1}, FXN67_14725
GN   {ECO:0000313|EMBL:TYL78263.1}, G7Z27_22825
GN   {ECO:0000313|EMBL:QLI10424.1}, GJJ08_022575
GN   {ECO:0000313|EMBL:QOU51083.1}, GNE24_10100
GN   {ECO:0000313|EMBL:MTX45539.1}, GNG14_01045
GN   {ECO:0000313|EMBL:MUD50532.1}, HV479_18710
GN   {ECO:0000313|EMBL:NVM14325.1}, KPZU09_40050
GN   {ECO:0000313|EMBL:GHK54269.1}, NCTC11679_04757
GN   {ECO:0000313|EMBL:STV70103.1}, NCTC13465_04475
GN   {ECO:0000313|EMBL:SQC48283.1}, NCTC13635_05081
GN   {ECO:0000313|EMBL:VEB05243.1}, NCTC3279_00263
GN   {ECO:0000313|EMBL:VTR32527.1}, NCTC5052_02861
GN   {ECO:0000313|EMBL:STT94424.1}, NCTC5053_04312
GN   {ECO:0000313|EMBL:STV35655.1}, NCTC8849_01042
GN   {ECO:0000313|EMBL:STT52506.1}, NCTC9637_05624
GN   {ECO:0000313|EMBL:STT50626.1}, NCTC9661_05284
GN   {ECO:0000313|EMBL:STU32598.1}, SAMEA3499874_03070
GN   {ECO:0000313|EMBL:SXG16586.1}, SAMEA3499901_00823
GN   {ECO:0000313|EMBL:SXN29830.1}, SAMEA3512100_03536
GN   {ECO:0000313|EMBL:SXU34073.1}, SAMEA3538828_00863
GN   {ECO:0000313|EMBL:SYR31589.1}, SAMEA3649733_02927
GN   {ECO:0000313|EMBL:SVS26238.1}, SAMEA3720909_02183
GN   {ECO:0000313|EMBL:SWF71742.1}, SAMEA4364603_03511
GN   {ECO:0000313|EMBL:SSK45838.1};
OS   Klebsiella pneumoniae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=573 {ECO:0000313|EMBL:SVS26238.1, ECO:0000313|Proteomes:UP000259497};
RN   [1] {ECO:0000313|EMBL:OVF65434.1, ECO:0000313|Proteomes:UP000196447}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=39383 {ECO:0000313|EMBL:OVF65434.1,
RC   ECO:0000313|Proteomes:UP000196447};
RA   Fouts D., Stalin M.J., Chen L., Wright M., Sutton G., Nguyen K.,
RA   Vanduin D., Rojas L., Hujer A., Hujer K., Bonomo R., Kreiswirth B.,
RA   Adams M.;
RL   Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:RRF08000.1, ECO:0000313|Proteomes:UP000275975}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KLPN_104 {ECO:0000313|EMBL:RRF08000.1,
RC   ECO:0000313|Proteomes:UP000275975};
RX   PubMed=30373801;
RA   Tamma P.D., Fan Y., Bergman Y., Pertea G., Kazmi A., Lewis S.,
RA   Carroll K.C., Schatz M.C., Timp W., Simner P.J.;
RT   "Applying Rapid Whole Genome Sequencing to Predict Phenotypic Antimicrobial
RT   Susceptibility Testing Results Among Carbapenem-Resistant Klebsiella
RT   pneumoniae Clinical Isolates.";
RL   Antimicrob. Agents Chemother. 0:0-0(2018).
RN   [3] {ECO:0000313|Proteomes:UP000251721, ECO:0000313|Proteomes:UP000254103}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC11679 {ECO:0000313|EMBL:STV70103.1,
RC   ECO:0000313|Proteomes:UP000255239}, NCTC13465
RC   {ECO:0000313|EMBL:SQC48283.1, ECO:0000313|Proteomes:UP000251721},
RC   NCTC5052 {ECO:0000313|EMBL:STT94424.1,
RC   ECO:0000313|Proteomes:UP000254103}, NCTC5053
RC   {ECO:0000313|EMBL:STV35655.1, ECO:0000313|Proteomes:UP000254387},
RC   NCTC8849 {ECO:0000313|EMBL:STT52506.1,
RC   ECO:0000313|Proteomes:UP000254799}, NCTC9637
RC   {ECO:0000313|EMBL:STT50626.1, ECO:0000313|Proteomes:UP000255099}, and
RC   NCTC9661 {ECO:0000313|EMBL:STU32598.1,
RC   ECO:0000313|Proteomes:UP000255137};
RG   Pathogen Informatics;
RA   Doyle S.;
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|Proteomes:UP000257587, ECO:0000313|Proteomes:UP000258253}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=4300STDY6470422 {ECO:0000313|EMBL:SSK45838.1,
RC   ECO:0000313|Proteomes:UP000252603}, EuSCAPE_AT002
RC   {ECO:0000313|EMBL:SXG16586.1, ECO:0000313|Proteomes:UP000257587},
RC   EuSCAPE_AT029 {ECO:0000313|EMBL:SXN29830.1,
RC   ECO:0000313|Proteomes:UP000259975}, EuSCAPE_DE072
RC   {ECO:0000313|EMBL:SXU34073.1, ECO:0000313|Proteomes:UP000259753},
RC   EuSCAPE_GR114 {ECO:0000313|EMBL:SVS26238.1,
RC   ECO:0000313|Proteomes:UP000259497}, EuSCAPE_HU047
RC   {ECO:0000313|EMBL:SYR31589.1, ECO:0000313|Proteomes:UP000258253},
RC   EuSCAPE_UK014 {ECO:0000313|EMBL:SWF71742.1,
RC   ECO:0000313|Proteomes:UP000259364}, NCTC13635
RC   {ECO:0000313|EMBL:VEB05243.1, ECO:0000313|Proteomes:UP000282433}, and
RC   NCTC3279 {ECO:0000313|EMBL:VTR32527.1,
RC   ECO:0000313|Proteomes:UP000395965};
RG   Pathogen Informatics;
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|EMBL:ROG87213.1, ECO:0000313|Proteomes:UP000283322}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CRK0165 {ECO:0000313|EMBL:ROG87213.1,
RC   ECO:0000313|Proteomes:UP000283322};
RA   Vanduin D., Fouts D., Wright M., Sutton G., Nguyen K., Kreiswirth B.,
RA   Chen L., Rojas L., Hujer A., Hujer K., Bonomo R., Adams M.;
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|EMBL:TYL78263.1, ECO:0000313|Proteomes:UP000322977}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UCO-494 {ECO:0000313|EMBL:TYL78263.1,
RC   ECO:0000313|Proteomes:UP000322977};
RA   Morales-Leon F., Caro C., Opazo-Capurro A., Lincopan N.,
RA   Dominguez-Yevenes M., Lima C., Bello-Toledo H., Gonzalez-Rocha G.;
RT   "Phenotypic and genetic characterization of extended-spectrum b-lactamase-
RT   producing hypermucoviscous Klebsiella pneumoniae from Chile.";
RL   Submitted (AUG-2019) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|Proteomes:UP000470376, ECO:0000313|Proteomes:UP000488995}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KP_10042 {ECO:0000313|EMBL:MUD50532.1,
RC   ECO:0000313|Proteomes:UP000488995}, and KP_46186
RC   {ECO:0000313|EMBL:MTX45539.1, ECO:0000313|Proteomes:UP000470376};
RA   Zhou K.;
RT   "Emergence of a novel subclone of carbapenem-resistant Klebsiella
RT   pneumoniae ST11 with enhanced virulence and transmissibility: a molecular
RT   epidemiological, clinical, genomic study.";
RL   Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
RN   [8] {ECO:0000313|EMBL:QOU51083.1, ECO:0000313|Proteomes:UP000439817}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CriePir120 {ECO:0000313|EMBL:QOU51083.1,
RC   ECO:0000313|Proteomes:UP000439817};
RX   PubMed=32429555;
RA   Shelenkov A., Mikhaylova Y., Yanushevich Y., Samoilov A., Petrova L.,
RA   Fomina V., Gusarov V., Zamyatin M., Shagin D., Akimkin V.;
RT   "Molecular Typing, Characterization of Antimicrobial Resistance, Virulence
RT   Profiling and Analysis of Whole-Genome Sequence of Clinical Klebsiella
RT   pneumoniae Isolates.";
RL   Antibiotics 9:0-E261(2020).
RN   [9] {ECO:0000313|EMBL:QLI10424.1, ECO:0000313|Proteomes:UP000509467}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=11KM256 {ECO:0000313|EMBL:QLI10424.1,
RC   ECO:0000313|Proteomes:UP000509467};
RA   Brilhante M., Perreten V.;
RT   "Whole genome sequencing of global problem clones of OXA-48-producing
RT   Klebsiella pneumoniae from the veterinary setting in Switzerland.";
RL   Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
RN   [10] {ECO:0000313|EMBL:NVM14325.1, ECO:0000313|Proteomes:UP000555830}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LABACER 27 {ECO:0000313|EMBL:NVM14325.1,
RC   ECO:0000313|Proteomes:UP000555830};
RA   Albarracin L., Vargas J.M., Jure M.A., Villena J.;
RT   "Genomic and immunological characterization of antibiotic-resistant
RT   Klebsiella pneumoniae isolate from Northwest Argentina.";
RL   Submitted (JUN-2020) to the EMBL/GenBank/DDBJ databases.
RN   [11] {ECO:0000313|EMBL:GHK54269.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Zam_UTH_09 {ECO:0000313|EMBL:GHK54269.1};
RA   Shawa M., Furuta Y., Simbotwe M., Mulenga E., Mubanga M., Mulenga G.,
RA   Kaile C., Zorigt T., Hang'ombe B., Higashi H.;
RT   "Genome Sequence of ESBL Producing Zambian Clinical Strains.";
RL   Submitted (OCT-2020) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes cross-linking of the peptidoglycan cell wall at the
CC       division septum. {ECO:0000256|HAMAP-Rule:MF_02080}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Preferential cleavage: (Ac)2-L-Lys-D-Ala-|-D-Ala. Also
CC         transpeptidation of peptidyl-alanyl moieties that are N-acyl
CC         substituents of D-alanine.; EC=3.4.16.4; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_02080};
CC   -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC       {ECO:0000256|HAMAP-Rule:MF_02080}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000256|HAMAP-
CC       Rule:MF_02080}; Single-pass membrane protein {ECO:0000256|HAMAP-
CC       Rule:MF_02080}.
CC   -!- SIMILARITY: Belongs to the transpeptidase family. FtsI subfamily.
CC       {ECO:0000256|HAMAP-Rule:MF_02080}.
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DR   EMBL; BNFF01000001; GHK54269.1; -; Genomic_DNA.
DR   EMBL; WNOE01000015; MTX45539.1; -; Genomic_DNA.
DR   EMBL; WNSY01000001; MUD50532.1; -; Genomic_DNA.
DR   EMBL; JABXNZ010000009; NVM14325.1; -; Genomic_DNA.
DR   EMBL; NDBK01000112; OVF65434.1; -; Genomic_DNA.
DR   EMBL; CP049716; QLI10424.1; -; Genomic_DNA.
DR   EMBL; CP063008; QOU51083.1; -; Genomic_DNA.
DR   EMBL; MPYG04000224; ROG87213.1; -; Genomic_DNA.
DR   EMBL; RDAM01000001; RRF08000.1; -; Genomic_DNA.
DR   EMBL; UAWQ01000019; SQC48283.1; -; Genomic_DNA.
DR   EMBL; UFEU01000009; SSK45838.1; -; Genomic_DNA.
DR   EMBL; UGLB01000003; STT50626.1; -; Genomic_DNA.
DR   EMBL; UGLC01000002; STT52506.1; -; Genomic_DNA.
DR   EMBL; UGLJ01000002; STT94424.1; -; Genomic_DNA.
DR   EMBL; UGLQ01000003; STU32598.1; -; Genomic_DNA.
DR   EMBL; UGMN01000004; STV35655.1; -; Genomic_DNA.
DR   EMBL; UGMG01000001; STV70103.1; -; Genomic_DNA.
DR   EMBL; UIXM01000008; SVS26238.1; -; Genomic_DNA.
DR   EMBL; UJHH01000008; SWF71742.1; -; Genomic_DNA.
DR   EMBL; UKAW01000007; SXG16586.1; -; Genomic_DNA.
DR   EMBL; UKGE01000003; SXN29830.1; -; Genomic_DNA.
DR   EMBL; UKLK01000007; SXU34073.1; -; Genomic_DNA.
DR   EMBL; ULCI01000003; SYR31589.1; -; Genomic_DNA.
DR   EMBL; VSSY01000011; TYL78263.1; -; Genomic_DNA.
DR   EMBL; LR134162; VEB05243.1; -; Genomic_DNA.
DR   EMBL; CABEFC010000002; VTR32527.1; -; Genomic_DNA.
DR   RefSeq; WP_002888559.1; NZ_WYAM01000022.1.
DR   EnsemblBacteria; AIT01861; AIT01861; PMK1_02396.
DR   EnsemblBacteria; AUY19176; AUY19176; C3F39_10515.
DR   EnsemblBacteria; AVB73872; AVB73872; C3483_22070.
DR   EnsemblBacteria; KLY18083; KLY18083; SK89_01947.
DR   EnsemblBacteria; PPK23259; PPK23259; CSC88_14290.
DR   EnsemblBacteria; PWF58468; PWF58468; C7V41_14790.
DR   EnsemblBacteria; RCI99793; RCI99793; DM062_00760.
DR   EnsemblBacteria; RCK03275; RCK03275; DM059_00690.
DR   EnsemblBacteria; RDT68909; RDT68909; DXF97_05380.
DR   EnsemblBacteria; SQC48283; SQC48283; NCTC13465_04475.
DR   EnsemblBacteria; SSF40530; SSF40530; SAMEA24002668_02916.
DR   EnsemblBacteria; SSG22791; SSG22791; SAMEA23986918_05501.
DR   EnsemblBacteria; SSK45838; SSK45838; SAMEA4364603_03511.
DR   EnsemblBacteria; STT50626; STT50626; NCTC9637_05624.
DR   EnsemblBacteria; STT52506; STT52506; NCTC8849_01042.
DR   EnsemblBacteria; STT64965; STT64965; NCTC1936_01053.
DR   EnsemblBacteria; STT94424; STT94424; NCTC5052_02861.
DR   EnsemblBacteria; STU32598; STU32598; NCTC9661_05284.
DR   EnsemblBacteria; STV35655; STV35655; NCTC5053_04312.
DR   EnsemblBacteria; STV70103; STV70103; NCTC11679_04757.
DR   EnsemblBacteria; SVJ50221; SVJ50221; SAMEA4394730_05373.
DR   EnsemblBacteria; VEB05243; VEB05243; NCTC13635_05081.
DR   KEGG; kpb:FH42_21260; -.
DR   KEGG; kpne:KU54_022460; -.
DR   KEGG; kpnu:LI86_22300; -.
DR   KEGG; kpx:PMK1_02396; -.
DR   OMA; HGKEEYY; -.
DR   UniPathway; UPA00219; -.
DR   Proteomes; UP000196447; Unassembled WGS sequence.
DR   Proteomes; UP000251721; Unassembled WGS sequence.
DR   Proteomes; UP000252603; Unassembled WGS sequence.
DR   Proteomes; UP000254103; Unassembled WGS sequence.
DR   Proteomes; UP000254387; Unassembled WGS sequence.
DR   Proteomes; UP000254799; Unassembled WGS sequence.
DR   Proteomes; UP000255099; Unassembled WGS sequence.
DR   Proteomes; UP000255137; Unassembled WGS sequence.
DR   Proteomes; UP000255239; Unassembled WGS sequence.
DR   Proteomes; UP000257587; Unassembled WGS sequence.
DR   Proteomes; UP000258253; Unassembled WGS sequence.
DR   Proteomes; UP000259364; Unassembled WGS sequence.
DR   Proteomes; UP000259497; Unassembled WGS sequence.
DR   Proteomes; UP000259753; Unassembled WGS sequence.
DR   Proteomes; UP000259975; Unassembled WGS sequence.
DR   Proteomes; UP000275975; Unassembled WGS sequence.
DR   Proteomes; UP000282433; Chromosome 1.
DR   Proteomes; UP000283322; Unassembled WGS sequence.
DR   Proteomes; UP000322977; Unassembled WGS sequence.
DR   Proteomes; UP000395965; Unassembled WGS sequence.
DR   Proteomes; UP000439817; Chromosome.
DR   Proteomes; UP000470376; Unassembled WGS sequence.
DR   Proteomes; UP000488995; Unassembled WGS sequence.
DR   Proteomes; UP000509467; Chromosome.
DR   Proteomes; UP000555830; Unassembled WGS sequence.
DR   Proteomes; UP000655094; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:InterPro.
DR   GO; GO:0009002; F:serine-type D-Ala-D-Ala carboxypeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR   GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR   GO; GO:0043093; P:FtsZ-dependent cytokinesis; IEA:UniProtKB-UniRule.
DR   GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.150.770; -; 1.
DR   Gene3D; 3.30.450.330; -; 1.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR   HAMAP; MF_02080; FtsI_transpept; 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR037532; FtsI_transpept.
DR   InterPro; IPR005311; PBP_dimer.
DR   InterPro; IPR036138; PBP_dimer_sf.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR   PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1.
DR   Pfam; PF03717; PBP_dimer; 1.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR   SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE   3: Inferred from homology;
KW   Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645, ECO:0000256|HAMAP-
KW   Rule:MF_02080};
KW   Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|HAMAP-
KW   Rule:MF_02080};
KW   Cell division {ECO:0000256|ARBA:ARBA00022618, ECO:0000256|HAMAP-
KW   Rule:MF_02080}; Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Cell membrane {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Cell shape {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Cell wall biogenesis/degradation {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Glycosyltransferase {ECO:0000313|EMBL:SVS26238.1};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_02080};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_02080};
KW   Peptidoglycan synthesis {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|HAMAP-Rule:MF_02080};
KW   Septation {ECO:0000256|ARBA:ARBA00023210, ECO:0000256|HAMAP-Rule:MF_02080};
KW   Transferase {ECO:0000313|EMBL:SVS26238.1};
KW   Transmembrane {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_02080}.
FT   TRANSMEM        20..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_02080"
FT   DOMAIN          70..220
FT                   /note="Penicillin-binding protein dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF03717"
FT   DOMAIN          260..554
FT                   /note="Penicillin-binding protein transpeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF00905"
FT   ACT_SITE        307
FT                   /note="Acyl-ester intermediate"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_02080"
SQ   SEQUENCE   588 AA;  64003 MW;  2FE4408506D51A55 CRC64;
     MKAAPKTPKA KRQEEQANFI SWRFALLCGC ILLALAFLLG RVAWLQVISP DMLVRQGDMR
     SLRVQEVSTA RGMITDRSGR PLAVSVPVKA IWADPKELHD AGGVTLDTRW KALADALNMP
     LDQLATRINT NPRMRFIYLA RQVNPDMADY IKKLKLPGIH LREESRRYYP SGEVTAHLIG
     FTNVDSQGIE GVEKSFDKWL TGQPGERIVR KDRYGRVIED ISSTDSQAAH NLALSIDERL
     QALVYRELNN AVAFNKAESG SAVLVDVNTG EVLAMANSPS YNPNNFAGTA KDTMRNRAIT
     DVFEPGSTVK PMVVMTALQR GIVNENTVLN TVPYRINGHE IKDVARYSEL TLTGVLQKSS
     NVGVSKLALA MPSSALVDTY SRFGLGKATN LGLVGERSGL YPQKQRWSDI ERATFSFGYG
     LMVTPLQLAR VYATIGSYGI YRPLSITKVD PPVPGERVFP ESLVRTVVHM MESVALPGGG
     GVKAAIKGYR IAIKTGTAKK VGPDGRYINK YIAYTAGVAP ASHPRFALVV VINDPQAGKY
     YGGAVSAPVF GAIMGGVLRT MNIEPDALAT GEKSEFVINQ GEGTGGRS
//