ID A0A0W8AVJ6_KLEPN Unreviewed; 588 AA. AC A0A0W8AVJ6; A0A0J2GHB5; A0A4V0HIQ6; DT 13-APR-2016, integrated into UniProtKB/TrEMBL. DT 13-APR-2016, sequence version 1. DT 19-JAN-2022, entry version 52. DE RecName: Full=Peptidoglycan D,D-transpeptidase FtsI {ECO:0000256|HAMAP-Rule:MF_02080}; DE EC=3.4.16.4 {ECO:0000256|HAMAP-Rule:MF_02080}; DE AltName: Full=Penicillin-binding protein 3 {ECO:0000256|HAMAP-Rule:MF_02080}; DE Short=PBP-3 {ECO:0000256|HAMAP-Rule:MF_02080}; GN Name=ftsI_4 {ECO:0000313|EMBL:SYC61024.1}; GN Synonyms=ftsI {ECO:0000256|HAMAP-Rule:MF_02080, GN ECO:0000313|EMBL:MTX45539.1}, ftsI_1 {ECO:0000313|EMBL:STT52506.1}, GN ftsI_2 {ECO:0000313|EMBL:SWP79314.1}, ftsI_3 GN {ECO:0000313|EMBL:STT50626.1}, ftsI_5 {ECO:0000313|EMBL:STU32598.1}, GN ftsI_7 {ECO:0000313|EMBL:STV70103.1}; GN ORFNames=A7B01_21485 {ECO:0000313|EMBL:ANE72048.1}, B4U61_00635 GN {ECO:0000313|EMBL:TEB03799.1}, B5L96_26605 GN {ECO:0000313|EMBL:OVF65434.1}, BANRA_01934 GN {ECO:0000313|EMBL:VCZ39830.1}, BL124_00027960 GN {ECO:0000313|EMBL:ROG87213.1}, BS595_20550 GN {ECO:0000313|EMBL:ORZ66929.1}, C3F39_10515 GN {ECO:0000313|EMBL:AUY19176.1}, DDJ63_07695 GN {ECO:0000313|EMBL:RFC26594.1}, DRB11_12315 GN {ECO:0000313|EMBL:RBN29387.1}, EAO17_18230 GN {ECO:0000313|EMBL:RRF08000.1}, FXN67_14725 GN {ECO:0000313|EMBL:TYL78263.1}, G5637_15050 GN {ECO:0000313|EMBL:NGE20071.1}, G7Z27_22825 GN {ECO:0000313|EMBL:QLI10424.1}, GJJ08_022575 GN {ECO:0000313|EMBL:QOU51083.1}, GJJ12_021530 GN {ECO:0000313|EMBL:QOU40733.1}, GNE24_10100 GN {ECO:0000313|EMBL:MTX45539.1}, GNG14_01045 GN {ECO:0000313|EMBL:MUD50532.1}, GPZ86_22625 GN {ECO:0000313|EMBL:QID63793.1}, HV479_18710 GN {ECO:0000313|EMBL:NVM14325.1}, NCTC11679_04757 GN {ECO:0000313|EMBL:STV70103.1}, NCTC13465_04475 GN {ECO:0000313|EMBL:SQC48283.1}, NCTC13635_05081 GN {ECO:0000313|EMBL:VEB05243.1}, NCTC3279_00263 GN {ECO:0000313|EMBL:VTR32527.1}, NCTC5052_02861 GN {ECO:0000313|EMBL:STT94424.1}, NCTC5053_04312 GN {ECO:0000313|EMBL:STV35655.1}, NCTC8849_01042 GN {ECO:0000313|EMBL:STT52506.1}, NCTC9637_05624 GN {ECO:0000313|EMBL:STT50626.1}, NCTC9661_05284 GN {ECO:0000313|EMBL:STU32598.1}, SAMEA3499874_03070 GN {ECO:0000313|EMBL:SXG16586.1}, SAMEA3499901_00823 GN {ECO:0000313|EMBL:SXN29830.1}, SAMEA3500057_03149 GN {ECO:0000313|EMBL:SXM18712.1}, SAMEA3512100_03536 GN {ECO:0000313|EMBL:SXU34073.1}, SAMEA3515130_02695 GN {ECO:0000313|EMBL:SYC61024.1}, SAMEA3538828_00863 GN {ECO:0000313|EMBL:SYR31589.1}, SAMEA3649733_02927 GN {ECO:0000313|EMBL:SVS26238.1}, SAMEA3649758_01674 GN {ECO:0000313|EMBL:SVS92436.1}, SAMEA3720909_02183 GN {ECO:0000313|EMBL:SWF71742.1}, SAMEA3727630_03709 GN {ECO:0000313|EMBL:SWP39242.1}, SAMEA3727643_01218 GN {ECO:0000313|EMBL:SWP79314.1}, SAMEA3727679_02297 GN {ECO:0000313|EMBL:SWR46557.1}, SAMEA3729663_01422 GN {ECO:0000313|EMBL:SWU94559.1}, SAMEA4364603_03511 GN {ECO:0000313|EMBL:SSK45838.1}, SAMEA4873619_02565 GN {ECO:0000313|EMBL:VGK16798.1}, SAMEA4873632_03788 GN {ECO:0000313|EMBL:VGL03660.1}; OS Klebsiella pneumoniae. OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Klebsiella. OX NCBI_TaxID=573 {ECO:0000313|EMBL:SYC61024.1, ECO:0000313|Proteomes:UP000260197}; RN [1] {ECO:0000313|EMBL:ANE72048.1, ECO:0000313|Proteomes:UP000077181} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=SKGH01 {ECO:0000313|EMBL:ANE72048.1, RC ECO:0000313|Proteomes:UP000077181}; RA Alfaresi M.; RT "Complete genome of a pandrug-resistant Klebsiella pneumoniae isolate, RT representing a Carbapenem resistant Enterobacteriaceae (CRE) resistant to RT all commercially available antibiotics in the UAE."; RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:ORZ66929.1, ECO:0000313|Proteomes:UP000193360} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=MNCRE61 {ECO:0000313|EMBL:ORZ66929.1, RC ECO:0000313|Proteomes:UP000193360}; RA Johnson T.J., Hargreaves M., Snippes-Vignone P., Lynfield R.; RT "Comparison of KPC-2 positive Klebsiella pneumoniae."; RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:TEB03799.1, ECO:0000313|Proteomes:UP000297943} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=MEC097 {ECO:0000313|EMBL:TEB03799.1, RC ECO:0000313|Proteomes:UP000297943}; RA Arya A.S.; RT "Isolation of Levoglucosan Utilizing Bacteria."; RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|EMBL:OVF65434.1, ECO:0000313|Proteomes:UP000196447} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=39383 {ECO:0000313|EMBL:OVF65434.1, RC ECO:0000313|Proteomes:UP000196447}; RA Fouts D., Stalin M.J., Chen L., Wright M., Sutton G., Nguyen K., RA Vanduin D., Rojas L., Hujer A., Hujer K., Bonomo R., Kreiswirth B., RA Adams M.; RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases. RN [5] {ECO:0000313|EMBL:RRF08000.1, ECO:0000313|Proteomes:UP000275975} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KLPN_104 {ECO:0000313|EMBL:RRF08000.1, RC ECO:0000313|Proteomes:UP000275975}; RX PubMed=30373801; RA Tamma P.D., Fan Y., Bergman Y., Pertea G., Kazmi A., Lewis S., RA Carroll K.C., Schatz M.C., Timp W., Simner P.J.; RT "Applying Rapid Whole Genome Sequencing to Predict Phenotypic Antimicrobial RT Susceptibility Testing Results Among Carbapenem-Resistant Klebsiella RT pneumoniae Clinical Isolates."; RL Antimicrob. Agents Chemother. 0:0-0(2018). RN [6] {ECO:0000313|Proteomes:UP000239813} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KPNIH48 {ECO:0000313|Proteomes:UP000239813}; RX PubMed=29437920; RG NISC Comparative Sequencing Program; RA Weingarten R.A., Johnson R.C., Conlan S., Ramsburg A.M., Dekker J.P., RA Lau A.F., Khil P., Odom R.T., Deming C., Park M., Thomas P.J., RA Henderson D.K., Palmore T.N., Segre J.A., Frank K.M.; RT "Genomic Analysis of Hospital Plumbing Reveals Diverse Reservoir of RT Bacterial Plasmids Conferring Carbapenem Resistance."; RL MBio 9:e02011-e02017(2018). RN [7] {ECO:0000313|EMBL:AUY19176.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KPNIH48 {ECO:0000313|EMBL:AUY19176.1}; RA Weingarten R.A., Johnson R.C., Conlan S., Ramsburg A.M., Dekker J.P., RA Lau A.F., Khil P., Odom R.T., Deming C., Park M., Thomas P.J., RA Henderson D.K., Palmore T.N., Segre J.A., Frank K.M.; RT "Genomic Analysis of Hospital Plumbing Reveals Diverse Reservoir of RT Bacterial Plasmids Conferring Carbapenem Resistance."; RL MBio 0:0-0(2018). RN [8] {ECO:0000313|EMBL:RFC26594.1, ECO:0000313|Proteomes:UP000256349} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=H1 {ECO:0000313|EMBL:RFC26594.1, RC ECO:0000313|Proteomes:UP000256349}; RA Khan F.A., Jass J., Soderquist B., Hellmark B., Ehricht R.; RT "Related carbapenemase-producing Klebsiella isolates detected in both a RT hospital and associated aquatic environment in Sweden."; RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|EMBL:RBN29387.1, ECO:0000313|Proteomes:UP000252532} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JZX2124 {ECO:0000313|EMBL:RBN29387.1, RC ECO:0000313|Proteomes:UP000252532}; RA Sun Q., Gu D., Hu Y., Shu L., Hu J., Zhang R., Chen G.; RT "Colonization of different clones of blaKPC-2-bearing Klebsiella pneumoniae RT in the gastrointestinal tract."; RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases. RN [10] {ECO:0000313|Proteomes:UP000251721, ECO:0000313|Proteomes:UP000254103} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=NCTC11679 {ECO:0000313|EMBL:STV70103.1, RC ECO:0000313|Proteomes:UP000255239}, NCTC13465 RC {ECO:0000313|EMBL:SQC48283.1, ECO:0000313|Proteomes:UP000251721}, RC NCTC5052 {ECO:0000313|EMBL:STT94424.1, RC ECO:0000313|Proteomes:UP000254103}, NCTC5053 RC {ECO:0000313|EMBL:STV35655.1, ECO:0000313|Proteomes:UP000254387}, RC NCTC8849 {ECO:0000313|EMBL:STT52506.1, RC ECO:0000313|Proteomes:UP000254799}, NCTC9637 RC {ECO:0000313|EMBL:STT50626.1, ECO:0000313|Proteomes:UP000255099}, and RC NCTC9661 {ECO:0000313|EMBL:STU32598.1, RC ECO:0000313|Proteomes:UP000255137}; RG Pathogen Informatics; RA Doyle S.; RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases. RN [11] {ECO:0000313|Proteomes:UP000257327, ECO:0000313|Proteomes:UP000257447} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=4300STDY6470422 {ECO:0000313|EMBL:SSK45838.1, RC ECO:0000313|Proteomes:UP000252603}, 5012STDY7626418 RC {ECO:0000313|EMBL:VGK16798.1, ECO:0000313|Proteomes:UP000295283}, RC 5012STDY7626430 {ECO:0000313|EMBL:VGL03660.1, RC ECO:0000313|Proteomes:UP000376235}, EuSCAPE_AT002 RC {ECO:0000313|EMBL:SXG16586.1, ECO:0000313|Proteomes:UP000257587}, RC EuSCAPE_AT029 {ECO:0000313|EMBL:SXN29830.1, RC ECO:0000313|Proteomes:UP000259975}, EuSCAPE_BE040 RC {ECO:0000313|EMBL:SWP39242.1, ECO:0000313|Proteomes:UP000258702}, RC EuSCAPE_BE053 {ECO:0000313|EMBL:SWP79314.1, RC ECO:0000313|Proteomes:UP000259594}, EuSCAPE_BE092 RC {ECO:0000313|EMBL:SWR46557.1, ECO:0000313|Proteomes:UP000258785}, RC EuSCAPE_DE072 {ECO:0000313|EMBL:SXU34073.1, RC ECO:0000313|Proteomes:UP000259753}, EuSCAPE_FR071 RC {ECO:0000313|EMBL:SXM18712.1, ECO:0000313|Proteomes:UP000257447}, RC EuSCAPE_GR114 {ECO:0000313|EMBL:SVS26238.1, RC ECO:0000313|Proteomes:UP000259497}, EuSCAPE_GR139 RC {ECO:0000313|EMBL:SVS92436.1, ECO:0000313|Proteomes:UP000260499}, RC EuSCAPE_HU047 {ECO:0000313|EMBL:SYR31589.1, RC ECO:0000313|Proteomes:UP000258253}, EuSCAPE_IT101 RC {ECO:0000313|EMBL:SYC61024.1, ECO:0000313|Proteomes:UP000260197}, RC EuSCAPE_TR019 {ECO:0000313|EMBL:SWU94559.1, RC ECO:0000313|Proteomes:UP000257327}, EuSCAPE_UK014 RC {ECO:0000313|EMBL:SWF71742.1, ECO:0000313|Proteomes:UP000259364}, RC NCTC13635 {ECO:0000313|EMBL:VEB05243.1, RC ECO:0000313|Proteomes:UP000282433}, and NCTC3279 RC {ECO:0000313|EMBL:VTR32527.1, ECO:0000313|Proteomes:UP000395965}; RG Pathogen Informatics; RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases. RN [12] {ECO:0000313|EMBL:ROG87213.1, ECO:0000313|Proteomes:UP000283322} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CRK0165 {ECO:0000313|EMBL:ROG87213.1, RC ECO:0000313|Proteomes:UP000283322}; RA Vanduin D., Fouts D., Wright M., Sutton G., Nguyen K., Kreiswirth B., RA Chen L., Rojas L., Hujer A., Hujer K., Bonomo R., Adams M.; RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases. RN [13] {ECO:0000313|EMBL:VCZ39830.1, ECO:0000313|Proteomes:UP000269373} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Kpneu037 {ECO:0000313|EMBL:VCZ39830.1}; RA Noll B N.; RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases. RN [14] {ECO:0000313|EMBL:TYL78263.1, ECO:0000313|Proteomes:UP000322977} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=UCO-494 {ECO:0000313|EMBL:TYL78263.1, RC ECO:0000313|Proteomes:UP000322977}; RA Morales-Leon F., Caro C., Opazo-Capurro A., Lincopan N., RA Dominguez-Yevenes M., Lima C., Bello-Toledo H., Gonzalez-Rocha G.; RT "Phenotypic and genetic characterization of extended-spectrum b-lactamase- RT producing hypermucoviscous Klebsiella pneumoniae from Chile."; RL Submitted (AUG-2019) to the EMBL/GenBank/DDBJ databases. RN [15] {ECO:0000313|Proteomes:UP000470376, ECO:0000313|Proteomes:UP000488995} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KP_10042 {ECO:0000313|EMBL:MUD50532.1, RC ECO:0000313|Proteomes:UP000488995}, and KP_46186 RC {ECO:0000313|EMBL:MTX45539.1, ECO:0000313|Proteomes:UP000470376}; RA Zhou K.; RT "Emergence of a novel subclone of carbapenem-resistant Klebsiella RT pneumoniae ST11 with enhanced virulence and transmissibility: a molecular RT epidemiological, clinical, genomic study."; RL Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases. RN [16] {ECO:0000313|Proteomes:UP000434831, ECO:0000313|Proteomes:UP000439817} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CriePir120 {ECO:0000313|EMBL:QOU51083.1, RC ECO:0000313|Proteomes:UP000439817}, and CriePir197 RC {ECO:0000313|EMBL:QOU40733.1, ECO:0000313|Proteomes:UP000434831}; RX PubMed=32429555; RA Shelenkov A., Mikhaylova Y., Yanushevich Y., Samoilov A., Petrova L., RA Fomina V., Gusarov V., Zamyatin M., Shagin D., Akimkin V.; RT "Molecular Typing, Characterization of Antimicrobial Resistance, Virulence RT Profiling and Analysis of Whole-Genome Sequence of Clinical Klebsiella RT pneumoniae Isolates."; RL Antibiotics 9:0-E261(2020). RN [17] {ECO:0000313|EMBL:QID63793.1, ECO:0000313|Proteomes:UP000501545} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=20467 {ECO:0000313|EMBL:QID63793.1, RC ECO:0000313|Proteomes:UP000501545}; RA Zhukhovitsky V.G., Shcherbinin D.N., Zubasheva M.V.; RT "De novo genome assembly of Klebsiella pneumoniae clinical strain."; RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases. RN [18] {ECO:0000313|EMBL:NGE20071.1, ECO:0000313|Proteomes:UP000474962} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KPM_60 {ECO:0000313|EMBL:NGE20071.1, RC ECO:0000313|Proteomes:UP000474962}; RA Tokajian S., El Chaar M., El Khoury M.; RT "WGS of Carbapenem-Resistant Entrobacteriaceae."; RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases. RN [19] {ECO:0000313|EMBL:QLI10424.1, ECO:0000313|Proteomes:UP000509467} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=11KM256 {ECO:0000313|EMBL:QLI10424.1, RC ECO:0000313|Proteomes:UP000509467}; RA Brilhante M., Perreten V.; RT "Whole genome sequencing of global problem clones of OXA-48-producing RT Klebsiella pneumoniae from the veterinary setting in Switzerland."; RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases. RN [20] {ECO:0000313|EMBL:NVM14325.1, ECO:0000313|Proteomes:UP000555830} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=LABACER 27 {ECO:0000313|EMBL:NVM14325.1, RC ECO:0000313|Proteomes:UP000555830}; RA Albarracin L., Vargas J.M., Jure M.A., Villena J.; RT "Genomic and immunological characterization of antibiotic-resistant RT Klebsiella pneumoniae isolate from Northwest Argentina."; RL Submitted (JUN-2020) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Catalyzes cross-linking of the peptidoglycan cell wall at the CC division septum. {ECO:0000256|HAMAP-Rule:MF_02080}. CC -!- CATALYTIC ACTIVITY: CC Reaction=Preferential cleavage: (Ac)(2)-L-Lys-D-Ala-|-D-Ala. Also CC transpeptidation of peptidyl-alanyl moieties that are N-acyl CC substituents of D-alanine.; EC=3.4.16.4; Evidence={ECO:0000256|HAMAP- CC Rule:MF_02080}; CC -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis. CC {ECO:0000256|HAMAP-Rule:MF_02080}. CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000256|HAMAP- CC Rule:MF_02080}; Single-pass membrane protein {ECO:0000256|HAMAP- CC Rule:MF_02080}. CC -!- SIMILARITY: Belongs to the transpeptidase family. FtsI subfamily. CC {ECO:0000256|HAMAP-Rule:MF_02080}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP015500; ANE72048.1; -; Genomic_DNA. DR EMBL; CP026392; AUY19176.1; -; Genomic_DNA. DR EMBL; WNOE01000015; MTX45539.1; -; Genomic_DNA. DR EMBL; WNSY01000001; MUD50532.1; -; Genomic_DNA. DR EMBL; JAAJRV010000009; NGE20071.1; -; Genomic_DNA. DR EMBL; JABXNZ010000009; NVM14325.1; -; Genomic_DNA. DR EMBL; MSLG01000044; ORZ66929.1; -; Genomic_DNA. DR EMBL; NDBK01000112; OVF65434.1; -; Genomic_DNA. DR EMBL; CP048937; QID63793.1; -; Genomic_DNA. DR EMBL; CP049716; QLI10424.1; -; Genomic_DNA. DR EMBL; CP062997; QOU40733.1; -; Genomic_DNA. DR EMBL; CP063008; QOU51083.1; -; Genomic_DNA. DR EMBL; QMKE01000009; RBN29387.1; -; Genomic_DNA. DR EMBL; QDDZ01000004; RFC26594.1; -; Genomic_DNA. DR EMBL; MPYG04000224; ROG87213.1; -; Genomic_DNA. DR EMBL; RDAM01000001; RRF08000.1; -; Genomic_DNA. DR EMBL; UAWQ01000019; SQC48283.1; -; Genomic_DNA. DR EMBL; UFEU01000009; SSK45838.1; -; Genomic_DNA. DR EMBL; UGLB01000003; STT50626.1; -; Genomic_DNA. DR EMBL; UGLC01000002; STT52506.1; -; Genomic_DNA. DR EMBL; UGLJ01000002; STT94424.1; -; Genomic_DNA. DR EMBL; UGLQ01000003; STU32598.1; -; Genomic_DNA. DR EMBL; UGMN01000004; STV35655.1; -; Genomic_DNA. DR EMBL; UGMG01000001; STV70103.1; -; Genomic_DNA. DR EMBL; UIXM01000008; SVS26238.1; -; Genomic_DNA. DR EMBL; UIYA01000005; SVS92436.1; -; Genomic_DNA. DR EMBL; UJHH01000008; SWF71742.1; -; Genomic_DNA. DR EMBL; UJOM01000007; SWP39242.1; -; Genomic_DNA. DR EMBL; UJOV01000003; SWP79314.1; -; Genomic_DNA. DR EMBL; UJPY01000006; SWR46557.1; -; Genomic_DNA. DR EMBL; UJSO01000004; SWU94559.1; -; Genomic_DNA. DR EMBL; UKAW01000007; SXG16586.1; -; Genomic_DNA. DR EMBL; UKFJ01000008; SXM18712.1; -; Genomic_DNA. DR EMBL; UKGE01000003; SXN29830.1; -; Genomic_DNA. DR EMBL; UKLK01000007; SXU34073.1; -; Genomic_DNA. DR EMBL; UKRN01000006; SYC61024.1; -; Genomic_DNA. DR EMBL; ULCI01000003; SYR31589.1; -; Genomic_DNA. DR EMBL; MWQX01000001; TEB03799.1; -; Genomic_DNA. DR EMBL; VSSY01000011; TYL78263.1; -; Genomic_DNA. DR EMBL; UWXT01000001; VCZ39830.1; -; Genomic_DNA. DR EMBL; LR134162; VEB05243.1; -; Genomic_DNA. DR EMBL; CAAHBN010000006; VGK16798.1; -; Genomic_DNA. DR EMBL; CAAHCC010000007; VGL03660.1; -; Genomic_DNA. DR EMBL; CABEFC010000002; VTR32527.1; -; Genomic_DNA. DR RefSeq; WP_002888559.1; NZ_WYAM01000022.1. DR EnsemblBacteria; AIT01861; AIT01861; PMK1_02396. DR EnsemblBacteria; AUY19176; AUY19176; C3F39_10515. DR EnsemblBacteria; AVB73872; AVB73872; C3483_22070. DR EnsemblBacteria; KLY18083; KLY18083; SK89_01947. DR EnsemblBacteria; PPK23259; PPK23259; CSC88_14290. DR EnsemblBacteria; PWF58468; PWF58468; C7V41_14790. DR EnsemblBacteria; RCI99793; RCI99793; DM062_00760. DR EnsemblBacteria; RCK03275; RCK03275; DM059_00690. DR EnsemblBacteria; RDT68909; RDT68909; DXF97_05380. DR EnsemblBacteria; SQC48283; SQC48283; NCTC13465_04475. DR EnsemblBacteria; SSF40530; SSF40530; SAMEA24002668_02916. DR EnsemblBacteria; SSG22791; SSG22791; SAMEA23986918_05501. DR EnsemblBacteria; SSK45838; SSK45838; SAMEA4364603_03511. DR EnsemblBacteria; STT50626; STT50626; NCTC9637_05624. DR EnsemblBacteria; STT52506; STT52506; NCTC8849_01042. DR EnsemblBacteria; STT64965; STT64965; NCTC1936_01053. DR EnsemblBacteria; STT94424; STT94424; NCTC5052_02861. DR EnsemblBacteria; STU32598; STU32598; NCTC9661_05284. DR EnsemblBacteria; STV35655; STV35655; NCTC5053_04312. DR EnsemblBacteria; STV70103; STV70103; NCTC11679_04757. DR EnsemblBacteria; SVJ50221; SVJ50221; SAMEA4394730_05373. DR EnsemblBacteria; VEB05243; VEB05243; NCTC13635_05081. DR KEGG; kpb:FH42_21260; -. DR KEGG; kpne:KU54_022460; -. DR KEGG; kpnu:LI86_22300; -. DR KEGG; kpx:PMK1_02396; -. DR OrthoDB; 213680at2; -. DR UniPathway; UPA00219; -. DR Proteomes; UP000077181; Chromosome. DR Proteomes; UP000193360; Unassembled WGS sequence. DR Proteomes; UP000196447; Unassembled WGS sequence. DR Proteomes; UP000239813; Chromosome. DR Proteomes; UP000251721; Unassembled WGS sequence. DR Proteomes; UP000252532; Unassembled WGS sequence. DR Proteomes; UP000252603; Unassembled WGS sequence. DR Proteomes; UP000254103; Unassembled WGS sequence. DR Proteomes; UP000254387; Unassembled WGS sequence. DR Proteomes; UP000254799; Unassembled WGS sequence. DR Proteomes; UP000255099; Unassembled WGS sequence. DR Proteomes; UP000255137; Unassembled WGS sequence. DR Proteomes; UP000255239; Unassembled WGS sequence. DR Proteomes; UP000256349; Unassembled WGS sequence. DR Proteomes; UP000257327; Unassembled WGS sequence. DR Proteomes; UP000257447; Unassembled WGS sequence. DR Proteomes; UP000257587; Unassembled WGS sequence. DR Proteomes; UP000258253; Unassembled WGS sequence. DR Proteomes; UP000258702; Unassembled WGS sequence. DR Proteomes; UP000258785; Unassembled WGS sequence. DR Proteomes; UP000259364; Unassembled WGS sequence. DR Proteomes; UP000259497; Unassembled WGS sequence. DR Proteomes; UP000259594; Unassembled WGS sequence. DR Proteomes; UP000259753; Unassembled WGS sequence. DR Proteomes; UP000259975; Unassembled WGS sequence. DR Proteomes; UP000260197; Unassembled WGS sequence. DR Proteomes; UP000260499; Unassembled WGS sequence. DR Proteomes; UP000269373; Unassembled WGS sequence. DR Proteomes; UP000275975; Unassembled WGS sequence. DR Proteomes; UP000282433; Chromosome 1. DR Proteomes; UP000283322; Unassembled WGS sequence. DR Proteomes; UP000295283; Unassembled WGS sequence. DR Proteomes; UP000297943; Unassembled WGS sequence. DR Proteomes; UP000322977; Unassembled WGS sequence. DR Proteomes; UP000376235; Unassembled WGS sequence. DR Proteomes; UP000395965; Unassembled WGS sequence. DR Proteomes; UP000434831; Chromosome. DR Proteomes; UP000439817; Chromosome. DR Proteomes; UP000470376; Unassembled WGS sequence. DR Proteomes; UP000474962; Unassembled WGS sequence. DR Proteomes; UP000488995; Unassembled WGS sequence. DR Proteomes; UP000501545; Chromosome. DR Proteomes; UP000509467; Chromosome. DR Proteomes; UP000555830; Unassembled WGS sequence. DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule. DR GO; GO:0008658; F:penicillin binding; IEA:InterPro. DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:InterPro. DR GO; GO:0009002; F:serine-type D-Ala-D-Ala carboxypeptidase activity; IEA:UniProtKB-UniRule. DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW. DR GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW. DR GO; GO:0043093; P:FtsZ-dependent cytokinesis; IEA:UniProtKB-UniRule. DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-UniRule. DR GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW. DR Gene3D; 3.40.710.10; -; 1. DR HAMAP; MF_02080; FtsI_transpept; 1. DR InterPro; IPR012338; Beta-lactam/transpept-like. DR InterPro; IPR037532; FtsI_transpept. DR InterPro; IPR005311; PBP_dimer. DR InterPro; IPR036138; PBP_dimer_sf. DR InterPro; IPR001460; PCN-bd_Tpept. DR Pfam; PF03717; PBP_dimer; 1. DR Pfam; PF00905; Transpeptidase; 1. DR SUPFAM; SSF56519; SSF56519; 1. DR SUPFAM; SSF56601; SSF56601; 1. PE 3: Inferred from homology; KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645, ECO:0000256|HAMAP- KW Rule:MF_02080}; KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|HAMAP- KW Rule:MF_02080}; KW Cell division {ECO:0000256|ARBA:ARBA00022618, ECO:0000256|HAMAP- KW Rule:MF_02080}; Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_02080}; KW Cell membrane {ECO:0000256|HAMAP-Rule:MF_02080}; KW Cell shape {ECO:0000256|HAMAP-Rule:MF_02080}; KW Cell wall biogenesis/degradation {ECO:0000256|HAMAP-Rule:MF_02080}; KW Glycosyltransferase {ECO:0000313|EMBL:SYC61024.1}; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_02080}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_02080}; KW Peptidoglycan synthesis {ECO:0000256|HAMAP-Rule:MF_02080}; KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|HAMAP-Rule:MF_02080}; KW Septation {ECO:0000256|ARBA:ARBA00023210, ECO:0000256|HAMAP-Rule:MF_02080}; KW Transferase {ECO:0000313|EMBL:SYC61024.1}; KW Transmembrane {ECO:0000256|HAMAP-Rule:MF_02080}; KW Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_02080}. FT TRANSMEM 20..44 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_02080" FT DOMAIN 70..220 FT /note="PBP_dimer" FT /evidence="ECO:0000259|Pfam:PF03717" FT DOMAIN 260..554 FT /note="Transpeptidase" FT /evidence="ECO:0000259|Pfam:PF00905" FT ACT_SITE 307 FT /note="Acyl-ester intermediate" FT /evidence="ECO:0000256|HAMAP-Rule:MF_02080" SQ SEQUENCE 588 AA; 64003 MW; 2FE4408506D51A55 CRC64; MKAAPKTPKA KRQEEQANFI SWRFALLCGC ILLALAFLLG RVAWLQVISP DMLVRQGDMR SLRVQEVSTA RGMITDRSGR PLAVSVPVKA IWADPKELHD AGGVTLDTRW KALADALNMP LDQLATRINT NPRMRFIYLA RQVNPDMADY IKKLKLPGIH LREESRRYYP SGEVTAHLIG FTNVDSQGIE GVEKSFDKWL TGQPGERIVR KDRYGRVIED ISSTDSQAAH NLALSIDERL QALVYRELNN AVAFNKAESG SAVLVDVNTG EVLAMANSPS YNPNNFAGTA KDTMRNRAIT DVFEPGSTVK PMVVMTALQR GIVNENTVLN TVPYRINGHE IKDVARYSEL TLTGVLQKSS NVGVSKLALA MPSSALVDTY SRFGLGKATN LGLVGERSGL YPQKQRWSDI ERATFSFGYG LMVTPLQLAR VYATIGSYGI YRPLSITKVD PPVPGERVFP ESLVRTVVHM MESVALPGGG GVKAAIKGYR IAIKTGTAKK VGPDGRYINK YIAYTAGVAP ASHPRFALVV VINDPQAGKY YGGAVSAPVF GAIMGGVLRT MNIEPDALAT GEKSEFVINQ GEGTGGRS //