ID A0A0W8AVJ6_KLEPN Unreviewed; 588 AA. AC A0A0W8AVJ6; A0A0J2GHB5; A0A4V0HIQ6; DT 13-APR-2016, integrated into UniProtKB/TrEMBL. DT 13-APR-2016, sequence version 1. DT 02-JUN-2021, entry version 50. DE RecName: Full=Peptidoglycan D,D-transpeptidase FtsI {ECO:0000256|HAMAP-Rule:MF_02080}; DE EC=3.4.16.4 {ECO:0000256|HAMAP-Rule:MF_02080}; DE AltName: Full=Penicillin-binding protein 3 {ECO:0000256|HAMAP-Rule:MF_02080}; DE Short=PBP-3 {ECO:0000256|HAMAP-Rule:MF_02080}; GN Name=ftsI {ECO:0000256|HAMAP-Rule:MF_02080, GN ECO:0000313|EMBL:MRD86675.1}; GN Synonyms=ftsI_1 {ECO:0000313|EMBL:STT52506.1}, ftsI_2 GN {ECO:0000313|EMBL:SVK72096.1}, ftsI_3 {ECO:0000313|EMBL:SLS44422.1}, GN ftsI_4 {ECO:0000313|EMBL:SLS77914.1}, ftsI_5 GN {ECO:0000313|EMBL:STU32598.1}, ftsI_7 {ECO:0000313|EMBL:STV70103.1}; GN ORFNames=AM386_13995 {ECO:0000313|EMBL:ASC22856.1}, B4U61_00635 GN {ECO:0000313|EMBL:TEB03799.1}, B5L96_26605 GN {ECO:0000313|EMBL:OVF65434.1}, BANRA_01934 GN {ECO:0000313|EMBL:VCZ39830.1}, BANRA_03289 GN {ECO:0000313|EMBL:VCW58422.1}, BL124_00027960 GN {ECO:0000313|EMBL:ROG87213.1}, C3F39_10515 GN {ECO:0000313|EMBL:AUY19176.1}, C4Y50_000535 GN {ECO:0000313|EMBL:ROG94407.1}, CK508_015405 GN {ECO:0000313|EMBL:RJS98758.1}, DD581_05120 GN {ECO:0000313|EMBL:RXY88201.1}, DD583_03315 GN {ECO:0000313|EMBL:RXZ12446.1}, DM059_00690 GN {ECO:0000313|EMBL:RCK03275.1}, DM062_00760 GN {ECO:0000313|EMBL:RCI99793.1}, EAO17_18230 GN {ECO:0000313|EMBL:RRF08000.1}, EXT45_14640 GN {ECO:0000313|EMBL:RZG36124.1}, FXN67_14725 GN {ECO:0000313|EMBL:TYL78263.1}, G5637_15050 GN {ECO:0000313|EMBL:NGE20071.1}, G7Z27_22825 GN {ECO:0000313|EMBL:QLI10424.1}, GF489_08905 GN {ECO:0000313|EMBL:MRD86675.1}, GJI97_022320 GN {ECO:0000313|EMBL:QOU56428.1}, GJI97_03915 GN {ECO:0000313|EMBL:MRK04079.1}, GJJ08_022575 GN {ECO:0000313|EMBL:QOU51083.1}, GJJ08_05355 GN {ECO:0000313|EMBL:MRK36104.1}, GNE24_10100 GN {ECO:0000313|EMBL:MTX45539.1}, GNG14_01045 GN {ECO:0000313|EMBL:MUD50532.1}, GQY16_21990 GN {ECO:0000313|EMBL:QGZ79391.1}, HJW74_21345 GN {ECO:0000313|EMBL:QJM33705.1}, NCTC11679_04757 GN {ECO:0000313|EMBL:STV70103.1}, NCTC13465_04475 GN {ECO:0000313|EMBL:SQC48283.1}, NCTC13635_05081 GN {ECO:0000313|EMBL:VEB05243.1}, NCTC1936_01053 GN {ECO:0000313|EMBL:STT64965.1}, NCTC3279_00263 GN {ECO:0000313|EMBL:VTR32527.1}, NCTC5052_02861 GN {ECO:0000313|EMBL:STT94424.1}, NCTC5053_04312 GN {ECO:0000313|EMBL:STV35655.1}, NCTC8849_01042 GN {ECO:0000313|EMBL:STT52506.1}, NCTC9637_05624 GN {ECO:0000313|EMBL:STT50626.1}, NCTC9661_05284 GN {ECO:0000313|EMBL:STU32598.1}, SAMEA24002668_02916 GN {ECO:0000313|EMBL:SSF40530.1}, SAMEA3499901_00823 GN {ECO:0000313|EMBL:SXN29830.1}, SAMEA3515094_03496 GN {ECO:0000313|EMBL:SXX57950.1}, SAMEA3538546_03489 GN {ECO:0000313|EMBL:SYB05023.1}, SAMEA3538560_03489 GN {ECO:0000313|EMBL:SYB62548.1}, SAMEA3649435_01639 GN {ECO:0000313|EMBL:SVL97485.1}, SAMEA3649466_02055 GN {ECO:0000313|EMBL:SVM84579.1}, SAMEA3649630_03796 GN {ECO:0000313|EMBL:SYV13024.1}, SAMEA3649650_01965 GN {ECO:0000313|EMBL:SVK72096.1}, SAMEA3649733_02927 GN {ECO:0000313|EMBL:SVS26238.1}, SAMEA3649758_01674 GN {ECO:0000313|EMBL:SVS92436.1}, SAMEA3673026_02642 GN {ECO:0000313|EMBL:SVW95007.1}, SAMEA3673122_01923 GN {ECO:0000313|EMBL:SWE22373.1}, SAMEA3720909_02183 GN {ECO:0000313|EMBL:SWF71742.1}, SAMEA3721038_01933 GN {ECO:0000313|EMBL:SVX87972.1}, SAMEA3727579_01924 GN {ECO:0000313|EMBL:SWO18854.1}, SAMEA3727651_01170 GN {ECO:0000313|EMBL:SWQ42250.1}, SAMEA3727679_02297 GN {ECO:0000313|EMBL:SWR46557.1}, SAMEA4364603_03511 GN {ECO:0000313|EMBL:SSK45838.1}, SAMEA4370540_04101 GN {ECO:0000313|EMBL:SLS77914.1}, SAMEA4370542_02578 GN {ECO:0000313|EMBL:SLS44422.1}, SAMEA4873581_02889 GN {ECO:0000313|EMBL:VGI41983.1}, WP4S18C04_42160 GN {ECO:0000313|EMBL:BBR79630.1}; OS Klebsiella pneumoniae. OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Klebsiella. OX NCBI_TaxID=573 {ECO:0000313|EMBL:MRD86675.1, ECO:0000313|Proteomes:UP000475774}; RN [1] {ECO:0000313|EMBL:TEB03799.1, ECO:0000313|Proteomes:UP000297943} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=MEC097 {ECO:0000313|EMBL:TEB03799.1, RC ECO:0000313|Proteomes:UP000297943}; RA Arya A.S.; RT "Isolation of Levoglucosan Utilizing Bacteria."; RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:OVF65434.1, ECO:0000313|Proteomes:UP000196447} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=39383 {ECO:0000313|EMBL:OVF65434.1, RC ECO:0000313|Proteomes:UP000196447}; RA Fouts D., Stalin M.J., Chen L., Wright M., Sutton G., Nguyen K., RA Vanduin D., Rojas L., Hujer A., Hujer K., Bonomo R., Kreiswirth B., RA Adams M.; RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:ASC22856.1, ECO:0000313|Proteomes:UP000196868} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=AR_0139 {ECO:0000313|EMBL:ASC22856.1, RC ECO:0000313|Proteomes:UP000196868}; RA Conlan S., Thomas P.J., Mullikin J., Frank K.M., Segre J.A.; RT "Whole genome sequencing of Klebsiella pneumoniae AR_0139."; RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|EMBL:RRF08000.1, ECO:0000313|Proteomes:UP000275975} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KLPN_104 {ECO:0000313|EMBL:RRF08000.1, RC ECO:0000313|Proteomes:UP000275975}; RX PubMed=30373801; RA Tamma P.D., Fan Y., Bergman Y., Pertea G., Kazmi A., Lewis S., RA Carroll K.C., Schatz M.C., Timp W., Simner P.J.; RT "Applying Rapid Whole Genome Sequencing to Predict Phenotypic Antimicrobial RT Susceptibility Testing Results Among Carbapenem-Resistant Klebsiella RT pneumoniae Clinical Isolates."; RL Antimicrob. Agents Chemother. 0:0-0(2018). RN [5] {ECO:0000313|Proteomes:UP000239813} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KPNIH48 {ECO:0000313|Proteomes:UP000239813}; RX PubMed=29437920; RG NISC Comparative Sequencing Program; RA Weingarten R.A., Johnson R.C., Conlan S., Ramsburg A.M., Dekker J.P., RA Lau A.F., Khil P., Odom R.T., Deming C., Park M., Thomas P.J., RA Henderson D.K., Palmore T.N., Segre J.A., Frank K.M.; RT "Genomic Analysis of Hospital Plumbing Reveals Diverse Reservoir of RT Bacterial Plasmids Conferring Carbapenem Resistance."; RL MBio 9:e02011-e02017(2018). RN [6] {ECO:0000313|EMBL:AUY19176.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KPNIH48 {ECO:0000313|EMBL:AUY19176.1}; RA Weingarten R.A., Johnson R.C., Conlan S., Ramsburg A.M., Dekker J.P., RA Lau A.F., Khil P., Odom R.T., Deming C., Park M., Thomas P.J., RA Henderson D.K., Palmore T.N., Segre J.A., Frank K.M.; RT "Genomic Analysis of Hospital Plumbing Reveals Diverse Reservoir of RT Bacterial Plasmids Conferring Carbapenem Resistance."; RL MBio 0:0-0(2018). RN [7] {ECO:0000313|Proteomes:UP000289252, ECO:0000313|Proteomes:UP000290276} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=3DZ2-3B {ECO:0000313|EMBL:RXY88201.1, RC ECO:0000313|Proteomes:UP000290276}, and 775-DZ2-4B RC {ECO:0000313|EMBL:RXZ12446.1, ECO:0000313|Proteomes:UP000289252}; RA Zhang R., Li J., Wang Y., Shen J., Shen Z., Wang S.; RT "The molecular epidemiology of the NDM positive non-E. coli RT Enterobacteriaceae in poultry production environment."; RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases. RN [8] {ECO:0000313|Proteomes:UP000251721, ECO:0000313|Proteomes:UP000254103} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=NCTC11679 {ECO:0000313|EMBL:STV70103.1, RC ECO:0000313|Proteomes:UP000255239}, NCTC13465 RC {ECO:0000313|EMBL:SQC48283.1, ECO:0000313|Proteomes:UP000251721}, RC NCTC1936 {ECO:0000313|EMBL:STT64965.1, RC ECO:0000313|Proteomes:UP000254753}, NCTC5052 RC {ECO:0000313|EMBL:STT94424.1, ECO:0000313|Proteomes:UP000254103}, RC NCTC5053 {ECO:0000313|EMBL:STV35655.1, RC ECO:0000313|Proteomes:UP000254387}, NCTC8849 RC {ECO:0000313|EMBL:STT52506.1, ECO:0000313|Proteomes:UP000254799}, RC NCTC9637 {ECO:0000313|EMBL:STT50626.1, RC ECO:0000313|Proteomes:UP000255099}, and NCTC9661 RC {ECO:0000313|EMBL:STU32598.1, ECO:0000313|Proteomes:UP000255137}; RG Pathogen Informatics; RA Doyle S.; RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|Proteomes:UP000252552, ECO:0000313|Proteomes:UP000253217} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BC_4223 {ECO:0000313|EMBL:RCK03275.1, RC ECO:0000313|Proteomes:UP000253217}, and BC_4553 RC {ECO:0000313|EMBL:RCI99793.1, ECO:0000313|Proteomes:UP000252552}; RA Martins R.C.R., Perdigao-Neto L.V., Costa S.F., Levin A.S.S.; RT "Klebsiella pneumoniae genome sequencing and assembly."; RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases. RN [10] {ECO:0000313|Proteomes:UP000252552, ECO:0000313|Proteomes:UP000253217} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BC_4223 {ECO:0000313|EMBL:RCK03275.1, RC ECO:0000313|Proteomes:UP000253217}, and BC_4553 RC {ECO:0000313|EMBL:RCI99793.1, ECO:0000313|Proteomes:UP000252552}; RA Quirk P.G., Krulwich T.A.; RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases. RN [11] {ECO:0000313|Proteomes:UP000257313, ECO:0000313|Proteomes:UP000257762} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=4300STDY6470422 {ECO:0000313|EMBL:SSK45838.1, RC ECO:0000313|Proteomes:UP000252603}, 4300STDY6636959 RC {ECO:0000313|EMBL:SSF40530.1, ECO:0000313|Proteomes:UP000253632}, RC 5012STDY7626380 {ECO:0000313|EMBL:VGI41983.1, RC ECO:0000313|Proteomes:UP000390008}, EuSCAPE_AT029 RC {ECO:0000313|EMBL:SXN29830.1, ECO:0000313|Proteomes:UP000259975}, RC EuSCAPE_BE062 {ECO:0000313|EMBL:SWQ42250.1, RC ECO:0000313|Proteomes:UP000260526}, EuSCAPE_BE092 RC {ECO:0000313|EMBL:SWR46557.1, ECO:0000313|Proteomes:UP000258785}, RC EuSCAPE_ES119 {ECO:0000313|EMBL:SVL97485.1, RC ECO:0000313|Proteomes:UP000258901}, EuSCAPE_ES150 RC {ECO:0000313|EMBL:SVM84579.1, ECO:0000313|Proteomes:UP000260067}, RC EuSCAPE_ES285 {ECO:0000313|EMBL:SYV13024.1, RC ECO:0000313|Proteomes:UP000258898}, EuSCAPE_GR032 RC {ECO:0000313|EMBL:SVK72096.1, ECO:0000313|Proteomes:UP000257762}, RC EuSCAPE_GR114 {ECO:0000313|EMBL:SVS26238.1, RC ECO:0000313|Proteomes:UP000259497}, EuSCAPE_GR139 RC {ECO:0000313|EMBL:SVS92436.1, ECO:0000313|Proteomes:UP000260499}, RC EuSCAPE_IE029 {ECO:0000313|EMBL:SWO18854.1, RC ECO:0000313|Proteomes:UP000257313}, EuSCAPE_IT062 RC {ECO:0000313|EMBL:SXX57950.1, ECO:0000313|Proteomes:UP000259081}, RC EuSCAPE_ME004 {ECO:0000313|EMBL:SYB05023.1, RC ECO:0000313|Proteomes:UP000258893}, EuSCAPE_ME018 RC {ECO:0000313|EMBL:SYB62548.1, ECO:0000313|Proteomes:UP000260135}, RC EuSCAPE_RO021 {ECO:0000313|EMBL:SWE22373.1, RC ECO:0000313|Proteomes:UP000257792}, EuSCAPE_RO112 RC {ECO:0000313|EMBL:SVX87972.1, ECO:0000313|Proteomes:UP000258908}, RC EuSCAPE_SI009 {ECO:0000313|EMBL:SVW95007.1, RC ECO:0000313|Proteomes:UP000259295}, EuSCAPE_UK014 RC {ECO:0000313|EMBL:SWF71742.1, ECO:0000313|Proteomes:UP000259364}, RC NCTC13635 {ECO:0000313|EMBL:VEB05243.1, RC ECO:0000313|Proteomes:UP000282433}, NCTC3279 RC {ECO:0000313|EMBL:VTR32527.1, ECO:0000313|Proteomes:UP000395965}, RC VRES1271 {ECO:0000313|EMBL:SLS77914.1, RC ECO:0000313|Proteomes:UP000191969}, and VRES1272 RC {ECO:0000313|EMBL:SLS44422.1, ECO:0000313|Proteomes:UP000191996}; RG Pathogen Informatics; RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases. RN [12] {ECO:0000313|EMBL:RJS98758.1, ECO:0000313|Proteomes:UP000218552} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=B35 {ECO:0000313|EMBL:RJS98758.1, RC ECO:0000313|Proteomes:UP000218552}; RA Araujo B.F., Campos P.A., Royer S., Ferreira M.L., Goncalves I.R., RA Batistao D.W.F., Cerdeira L.T., Brito C.S., Gontijo-Filho P., Ribas R.M.; RT "Klebsiella pneumoniae KPC-2-producing B35 strain."; RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases. RN [13] {ECO:0000313|EMBL:ROG87213.1, ECO:0000313|Proteomes:UP000283322} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CRK0165 {ECO:0000313|EMBL:ROG87213.1, RC ECO:0000313|Proteomes:UP000283322}; RA Vanduin D., Fouts D., Wright M., Sutton G., Nguyen K., Kreiswirth B., RA Chen L., Rojas L., Hujer A., Hujer K., Bonomo R., Adams M.; RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases. RN [14] {ECO:0000313|Proteomes:UP000269373, ECO:0000313|Proteomes:UP000277476} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Kpneu014 {ECO:0000313|EMBL:VCW58422.1}, and Kpneu037 RC {ECO:0000313|EMBL:VCZ39830.1}; RA Noll B N.; RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases. RN [15] {ECO:0000313|EMBL:ROG94407.1, ECO:0000313|Proteomes:UP000286610} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CRK0390 {ECO:0000313|EMBL:ROG94407.1, RC ECO:0000313|Proteomes:UP000286610}; RA Vanduin D., Fouts D., Sutton G., Nguyen K., Hujer A., Hujer K., Bonomo R.; RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases. RN [16] {ECO:0000313|EMBL:MRD86675.1, ECO:0000313|Proteomes:UP000475774} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=99 {ECO:0000313|EMBL:MRD86675.1, RC ECO:0000313|Proteomes:UP000475774}; RA Paraschiv S., Surleac M., Czobor Barbu I., Popa L.I., Gheorghe I., RA Otelea D., Chifiriuc M.C.; RT "Whole genome sequencing snapshot of multi-drug resistant Klebsiella RT pneumoniae strains from hospitals and receiving wastewater treatment plants RT in Southern Romania."; RL PLoS ONE 0:0-0(2019). RN [17] {ECO:0000313|EMBL:RZG36124.1, ECO:0000313|Proteomes:UP000293472} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=53 {ECO:0000313|EMBL:RZG36124.1, RC ECO:0000313|Proteomes:UP000293472}; RA Newire E., Aydin A., Juma S., Enne V., Roberts A.P.; RT "Identification of a Type IV CRISPR-Cas system located exclusively on RT IncHI1B/ IncFIB plasmids in Enterobacteriaceae."; RL Submitted (FEB-2019) to the EMBL/GenBank/DDBJ databases. RN [18] {ECO:0000313|EMBL:TYL78263.1, ECO:0000313|Proteomes:UP000322977} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=UCO-494 {ECO:0000313|EMBL:TYL78263.1, RC ECO:0000313|Proteomes:UP000322977}; RA Morales-Leon F., Caro C., Opazo-Capurro A., Lincopan N., RA Dominguez-Yevenes M., Lima C., Bello-Toledo H., Gonzalez-Rocha G.; RT "Phenotypic and genetic characterization of extended-spectrum b-lactamase- RT producing hypermucoviscous Klebsiella pneumoniae from Chile."; RL Submitted (AUG-2019) to the EMBL/GenBank/DDBJ databases. RN [19] {ECO:0000313|EMBL:MRK36104.1, ECO:0000313|Proteomes:UP000439817} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CriePir116 {ECO:0000313|EMBL:MRK04079.1, RC ECO:0000313|Proteomes:UP000482635}, and CriePir120 RC {ECO:0000313|EMBL:MRK36104.1, ECO:0000313|Proteomes:UP000439817}; RA Shelenkov A., Mikhaylova Y., Yanushevich Y., Samoilov A., Petrova L., RA Fomina V., Gusarov V., Zamyatin M., Shagin D.; RT "Molecular typing, antibiotic resistance determination and virulence RT profiling for 36 multidrug-resistant clinical Klebsiella pneumoniae RT isolates using second- and third-generation sequencing."; RL Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases. RN [20] {ECO:0000313|Proteomes:UP000470376, ECO:0000313|Proteomes:UP000488995} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KP_10042 {ECO:0000313|EMBL:MUD50532.1, RC ECO:0000313|Proteomes:UP000488995}, and KP_46186 RC {ECO:0000313|EMBL:MTX45539.1, ECO:0000313|Proteomes:UP000470376}; RA Zhou K.; RT "Emergence of a novel subclone of carbapenem-resistant Klebsiella RT pneumoniae ST11 with enhanced virulence and transmissibility: a molecular RT epidemiological, clinical, genomic study."; RL Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases. RN [21] {ECO:0000313|EMBL:QGZ79391.1, ECO:0000313|Proteomes:UP000428800} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BD_DM_914 {ECO:0000313|EMBL:QGZ79391.1, RC ECO:0000313|Proteomes:UP000428800}; RA Farzana R., Walsh T.R.; RT "Colintin resistant K. pneumoniae."; RL Submitted (DEC-2019) to the EMBL/GenBank/DDBJ databases. RN [22] {ECO:0000313|EMBL:BBR79630.1, ECO:0000313|Proteomes:UP000515327} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=WP4-S18-CRE-04 {ECO:0000313|EMBL:BBR79630.1, RC ECO:0000313|Proteomes:UP000515327}; RA Sekizuka T., Itokawa K., Yatsu K., Inamine Y., Kuroda M.; RT "complete genome sequences of Klebsiella pneumoniae str. WP4-S18-CRE-04 RT isolated from wastewater treatment plant effluent."; RL Submitted (DEC-2019) to the EMBL/GenBank/DDBJ databases. RN [23] {ECO:0000313|Proteomes:UP000439817, ECO:0000313|Proteomes:UP000482635} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CriePir116 {ECO:0000313|EMBL:QOU56428.1, RC ECO:0000313|Proteomes:UP000482635}, and CriePir120 RC {ECO:0000313|EMBL:QOU51083.1, ECO:0000313|Proteomes:UP000439817}; RX PubMed=32429555; RA Shelenkov A., Mikhaylova Y., Yanushevich Y., Samoilov A., Petrova L., RA Fomina V., Gusarov V., Zamyatin M., Shagin D., Akimkin V.; RT "Molecular Typing, Characterization of Antimicrobial Resistance, Virulence RT Profiling and Analysis of Whole-Genome Sequence of Clinical Klebsiella RT pneumoniae Isolates."; RL Antibiotics (Basel) 9:0-E261(2020). RN [24] {ECO:0000313|EMBL:NGE20071.1, ECO:0000313|Proteomes:UP000474962} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KPM_60 {ECO:0000313|EMBL:NGE20071.1, RC ECO:0000313|Proteomes:UP000474962}; RA Tokajian S., El Chaar M., El Khoury M.; RT "WGS of Carbapenem-Resistant Entrobacteriaceae."; RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases. RN [25] {ECO:0000313|EMBL:QLI10424.1, ECO:0000313|Proteomes:UP000509467} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=11KM256 {ECO:0000313|EMBL:QLI10424.1, RC ECO:0000313|Proteomes:UP000509467}; RA Brilhante M., Perreten V.; RT "Whole genome sequencing of global problem clones of OXA-48-producing RT Klebsiella pneumoniae from the veterinary setting in Switzerland."; RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases. RN [26] {ECO:0000313|EMBL:QJM33705.1, ECO:0000313|Proteomes:UP000503381} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=A17KP0004 {ECO:0000313|EMBL:QJM33705.1, RC ECO:0000313|Proteomes:UP000503381}; RA Yoon E.-J., Gwon B., Liu C., Kim D., Won D., Park S.G., Choi J.R., RA Jeong S.H.; RT "Built-in CTX-M extended-spectrum beta-lactamase gene in Klebsiella RT pneumoniae ensuring stable propagation of the multidrug-resistant pathogen RT in clinical settings."; RL Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Catalyzes cross-linking of the peptidoglycan cell wall at the CC division septum. {ECO:0000256|HAMAP-Rule:MF_02080}. CC -!- CATALYTIC ACTIVITY: CC Reaction=Preferential cleavage: (Ac)(2)-L-Lys-D-Ala-|-D-Ala. Also CC transpeptidation of peptidyl-alanyl moieties that are N-acyl CC substituents of D-alanine.; EC=3.4.16.4; Evidence={ECO:0000256|HAMAP- CC Rule:MF_02080}; CC -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis. CC {ECO:0000256|HAMAP-Rule:MF_02080}. CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000256|HAMAP- CC Rule:MF_02080}; Single-pass membrane protein {ECO:0000256|HAMAP- CC Rule:MF_02080}. CC -!- SIMILARITY: Belongs to the transpeptidase family. FtsI subfamily. CC {ECO:0000256|HAMAP-Rule:MF_02080}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP021960; ASC22856.1; -; Genomic_DNA. DR EMBL; CP026392; AUY19176.1; -; Genomic_DNA. DR EMBL; AP022078; BBR79630.1; -; Genomic_DNA. DR EMBL; WJBQ01000005; MRD86675.1; -; Genomic_DNA. DR EMBL; WJWE01000002; MRK04079.1; -; Genomic_DNA. DR EMBL; WJWD01000003; MRK36104.1; -; Genomic_DNA. DR EMBL; WNOE01000015; MTX45539.1; -; Genomic_DNA. DR EMBL; WNSY01000001; MUD50532.1; -; Genomic_DNA. DR EMBL; JAAJRV010000009; NGE20071.1; -; Genomic_DNA. DR EMBL; NDBK01000112; OVF65434.1; -; Genomic_DNA. DR EMBL; CP046949; QGZ79391.1; -; Genomic_DNA. DR EMBL; CP052560; QJM33705.1; -; Genomic_DNA. DR EMBL; CP049716; QLI10424.1; -; Genomic_DNA. DR EMBL; CP063008; QOU51083.1; -; Genomic_DNA. DR EMBL; CP063011; QOU56428.1; -; Genomic_DNA. DR EMBL; QORQ01000079; RCI99793.1; -; Genomic_DNA. DR EMBL; QOUG01000039; RCK03275.1; -; Genomic_DNA. DR EMBL; NTHY02000043; RJS98758.1; -; Genomic_DNA. DR EMBL; MPYG04000224; ROG87213.1; -; Genomic_DNA. DR EMBL; PTFF02000003; ROG94407.1; -; Genomic_DNA. DR EMBL; RDAM01000001; RRF08000.1; -; Genomic_DNA. DR EMBL; QFMH01000017; RXY88201.1; -; Genomic_DNA. DR EMBL; QFMF01000002; RXZ12446.1; -; Genomic_DNA. DR EMBL; SGOL01000011; RZG36124.1; -; Genomic_DNA. DR EMBL; FWJM01000007; SLS44422.1; -; Genomic_DNA. DR EMBL; FWJN01000015; SLS77914.1; -; Genomic_DNA. DR EMBL; UAWQ01000019; SQC48283.1; -; Genomic_DNA. DR EMBL; UFBE01000007; SSF40530.1; -; Genomic_DNA. DR EMBL; UFEU01000009; SSK45838.1; -; Genomic_DNA. DR EMBL; UGLB01000003; STT50626.1; -; Genomic_DNA. DR EMBL; UGLC01000002; STT52506.1; -; Genomic_DNA. DR EMBL; UGLI01000001; STT64965.1; -; Genomic_DNA. DR EMBL; UGLJ01000002; STT94424.1; -; Genomic_DNA. DR EMBL; UGLQ01000003; STU32598.1; -; Genomic_DNA. DR EMBL; UGMN01000004; STV35655.1; -; Genomic_DNA. DR EMBL; UGMG01000001; STV70103.1; -; Genomic_DNA. DR EMBL; UIRX01000006; SVK72096.1; -; Genomic_DNA. DR EMBL; UISV01000004; SVL97485.1; -; Genomic_DNA. DR EMBL; UITM01000005; SVM84579.1; -; Genomic_DNA. DR EMBL; UIXM01000008; SVS26238.1; -; Genomic_DNA. DR EMBL; UIYA01000005; SVS92436.1; -; Genomic_DNA. DR EMBL; UJAY01000009; SVW95007.1; -; Genomic_DNA. DR EMBL; UJBS01000005; SVX87972.1; -; Genomic_DNA. DR EMBL; UJGH01000005; SWE22373.1; -; Genomic_DNA. DR EMBL; UJHH01000008; SWF71742.1; -; Genomic_DNA. DR EMBL; UJNP01000005; SWO18854.1; -; Genomic_DNA. DR EMBL; UJPD01000003; SWQ42250.1; -; Genomic_DNA. DR EMBL; UJPY01000006; SWR46557.1; -; Genomic_DNA. DR EMBL; UKGE01000003; SXN29830.1; -; Genomic_DNA. DR EMBL; UKNV01000007; SXX57950.1; -; Genomic_DNA. DR EMBL; UKQI01000007; SYB05023.1; -; Genomic_DNA. DR EMBL; UKQT01000007; SYB62548.1; -; Genomic_DNA. DR EMBL; ULFB01000011; SYV13024.1; -; Genomic_DNA. DR EMBL; MWQX01000001; TEB03799.1; -; Genomic_DNA. DR EMBL; VSSY01000011; TYL78263.1; -; Genomic_DNA. DR EMBL; UWVV01000001; VCW58422.1; -; Genomic_DNA. DR EMBL; UWXT01000001; VCZ39830.1; -; Genomic_DNA. DR EMBL; LR134162; VEB05243.1; -; Genomic_DNA. DR EMBL; CAAHAF010000005; VGI41983.1; -; Genomic_DNA. DR EMBL; CABEFC010000002; VTR32527.1; -; Genomic_DNA. DR RefSeq; WP_002888559.1; NZ_WYAM01000022.1. DR EnsemblBacteria; AIT01861; AIT01861; PMK1_02396. DR EnsemblBacteria; AUY19176; AUY19176; C3F39_10515. DR EnsemblBacteria; AVB73872; AVB73872; C3483_22070. DR EnsemblBacteria; KLY18083; KLY18083; SK89_01947. DR EnsemblBacteria; PPK23259; PPK23259; CSC88_14290. DR EnsemblBacteria; PWF58468; PWF58468; C7V41_14790. DR EnsemblBacteria; RCI99793; RCI99793; DM062_00760. DR EnsemblBacteria; RCK03275; RCK03275; DM059_00690. DR EnsemblBacteria; RDT68909; RDT68909; DXF97_05380. DR EnsemblBacteria; SQC48283; SQC48283; NCTC13465_04475. DR EnsemblBacteria; SSF40530; SSF40530; SAMEA24002668_02916. DR EnsemblBacteria; SSG22791; SSG22791; SAMEA23986918_05501. DR EnsemblBacteria; SSK45838; SSK45838; SAMEA4364603_03511. DR EnsemblBacteria; STT50626; STT50626; NCTC9637_05624. DR EnsemblBacteria; STT52506; STT52506; NCTC8849_01042. DR EnsemblBacteria; STT64965; STT64965; NCTC1936_01053. DR EnsemblBacteria; STT94424; STT94424; NCTC5052_02861. DR EnsemblBacteria; STU32598; STU32598; NCTC9661_05284. DR EnsemblBacteria; STV35655; STV35655; NCTC5053_04312. DR EnsemblBacteria; STV70103; STV70103; NCTC11679_04757. DR EnsemblBacteria; SVJ50221; SVJ50221; SAMEA4394730_05373. DR EnsemblBacteria; VEB05243; VEB05243; NCTC13635_05081. DR KEGG; kpb:FH42_21260; -. DR KEGG; kpne:KU54_022460; -. DR KEGG; kpnu:LI86_22300; -. DR KEGG; kpx:PMK1_02396; -. DR OrthoDB; 213680at2; -. DR UniPathway; UPA00219; -. DR Proteomes; UP000191969; Unassembled WGS sequence. DR Proteomes; UP000191996; Unassembled WGS sequence. DR Proteomes; UP000196447; Unassembled WGS sequence. DR Proteomes; UP000196868; Chromosome. DR Proteomes; UP000218552; Unassembled WGS sequence. DR Proteomes; UP000239813; Chromosome. DR Proteomes; UP000251721; Unassembled WGS sequence. DR Proteomes; UP000252552; Unassembled WGS sequence. DR Proteomes; UP000252603; Unassembled WGS sequence. DR Proteomes; UP000253217; Unassembled WGS sequence. DR Proteomes; UP000253632; Unassembled WGS sequence. DR Proteomes; UP000254103; Unassembled WGS sequence. DR Proteomes; UP000254387; Unassembled WGS sequence. DR Proteomes; UP000254753; Unassembled WGS sequence. DR Proteomes; UP000254799; Unassembled WGS sequence. DR Proteomes; UP000255099; Unassembled WGS sequence. DR Proteomes; UP000255137; Unassembled WGS sequence. DR Proteomes; UP000255239; Unassembled WGS sequence. DR Proteomes; UP000257313; Unassembled WGS sequence. DR Proteomes; UP000257762; Unassembled WGS sequence. DR Proteomes; UP000257792; Unassembled WGS sequence. DR Proteomes; UP000258785; Unassembled WGS sequence. DR Proteomes; UP000258893; Unassembled WGS sequence. DR Proteomes; UP000258898; Unassembled WGS sequence. DR Proteomes; UP000258901; Unassembled WGS sequence. DR Proteomes; UP000258908; Unassembled WGS sequence. DR Proteomes; UP000259081; Unassembled WGS sequence. DR Proteomes; UP000259295; Unassembled WGS sequence. DR Proteomes; UP000259364; Unassembled WGS sequence. DR Proteomes; UP000259497; Unassembled WGS sequence. DR Proteomes; UP000259975; Unassembled WGS sequence. DR Proteomes; UP000260067; Unassembled WGS sequence. DR Proteomes; UP000260135; Unassembled WGS sequence. DR Proteomes; UP000260499; Unassembled WGS sequence. DR Proteomes; UP000260526; Unassembled WGS sequence. DR Proteomes; UP000269373; Unassembled WGS sequence. DR Proteomes; UP000275975; Unassembled WGS sequence. DR Proteomes; UP000277476; Unassembled WGS sequence. DR Proteomes; UP000282433; Chromosome 1. DR Proteomes; UP000283322; Unassembled WGS sequence. DR Proteomes; UP000286610; Unassembled WGS sequence. DR Proteomes; UP000289252; Unassembled WGS sequence. DR Proteomes; UP000290276; Unassembled WGS sequence. DR Proteomes; UP000293472; Unassembled WGS sequence. DR Proteomes; UP000297943; Unassembled WGS sequence. DR Proteomes; UP000322977; Unassembled WGS sequence. DR Proteomes; UP000390008; Unassembled WGS sequence. DR Proteomes; UP000395965; Unassembled WGS sequence. DR Proteomes; UP000428800; Chromosome. DR Proteomes; UP000439817; Unassembled WGS sequence. DR Proteomes; UP000470376; Unassembled WGS sequence. DR Proteomes; UP000474962; Unassembled WGS sequence. DR Proteomes; UP000475774; Unassembled WGS sequence. DR Proteomes; UP000482635; Chromosome. DR Proteomes; UP000488995; Unassembled WGS sequence. DR Proteomes; UP000503381; Chromosome. DR Proteomes; UP000509467; Chromosome. DR Proteomes; UP000515327; Chromosome. DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule. DR GO; GO:0008658; F:penicillin binding; IEA:InterPro. DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:InterPro. DR GO; GO:0009002; F:serine-type D-Ala-D-Ala carboxypeptidase activity; IEA:UniProtKB-UniRule. DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW. DR GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW. DR GO; GO:0043093; P:FtsZ-dependent cytokinesis; IEA:UniProtKB-UniRule. DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-UniRule. DR GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW. DR Gene3D; 3.40.710.10; -; 1. DR HAMAP; MF_02080; FtsI_transpept; 1. DR InterPro; IPR012338; Beta-lactam/transpept-like. DR InterPro; IPR037532; FtsI_transpept. DR InterPro; IPR005311; PBP_dimer. DR InterPro; IPR036138; PBP_dimer_sf. DR InterPro; IPR001460; PCN-bd_Tpept. DR Pfam; PF03717; PBP_dimer; 1. DR Pfam; PF00905; Transpeptidase; 1. DR SUPFAM; SSF56519; SSF56519; 1. DR SUPFAM; SSF56601; SSF56601; 1. PE 3: Inferred from homology; KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645, ECO:0000256|HAMAP- KW Rule:MF_02080}; KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|HAMAP- KW Rule:MF_02080}; KW Cell division {ECO:0000256|ARBA:ARBA00022618, ECO:0000256|HAMAP- KW Rule:MF_02080}; Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_02080}; KW Cell membrane {ECO:0000256|HAMAP-Rule:MF_02080}; KW Cell shape {ECO:0000256|HAMAP-Rule:MF_02080}; KW Cell wall biogenesis/degradation {ECO:0000256|HAMAP-Rule:MF_02080}; KW Glycosyltransferase {ECO:0000313|EMBL:SLS44422.1}; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_02080}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_02080}; KW Peptidoglycan synthesis {ECO:0000256|HAMAP-Rule:MF_02080}; KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|HAMAP-Rule:MF_02080}; KW Septation {ECO:0000256|ARBA:ARBA00023210, ECO:0000256|HAMAP-Rule:MF_02080}; KW Transferase {ECO:0000313|EMBL:MRD86675.1}; KW Transmembrane {ECO:0000256|HAMAP-Rule:MF_02080}; KW Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_02080}. FT TRANSMEM 20..44 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_02080" FT DOMAIN 70..220 FT /note="PBP_dimer" FT /evidence="ECO:0000259|Pfam:PF03717" FT DOMAIN 260..554 FT /note="Transpeptidase" FT /evidence="ECO:0000259|Pfam:PF00905" FT ACT_SITE 307 FT /note="Acyl-ester intermediate" FT /evidence="ECO:0000256|HAMAP-Rule:MF_02080" SQ SEQUENCE 588 AA; 64003 MW; 2FE4408506D51A55 CRC64; MKAAPKTPKA KRQEEQANFI SWRFALLCGC ILLALAFLLG RVAWLQVISP DMLVRQGDMR SLRVQEVSTA RGMITDRSGR PLAVSVPVKA IWADPKELHD AGGVTLDTRW KALADALNMP LDQLATRINT NPRMRFIYLA RQVNPDMADY IKKLKLPGIH LREESRRYYP SGEVTAHLIG FTNVDSQGIE GVEKSFDKWL TGQPGERIVR KDRYGRVIED ISSTDSQAAH NLALSIDERL QALVYRELNN AVAFNKAESG SAVLVDVNTG EVLAMANSPS YNPNNFAGTA KDTMRNRAIT DVFEPGSTVK PMVVMTALQR GIVNENTVLN TVPYRINGHE IKDVARYSEL TLTGVLQKSS NVGVSKLALA MPSSALVDTY SRFGLGKATN LGLVGERSGL YPQKQRWSDI ERATFSFGYG LMVTPLQLAR VYATIGSYGI YRPLSITKVD PPVPGERVFP ESLVRTVVHM MESVALPGGG GVKAAIKGYR IAIKTGTAKK VGPDGRYINK YIAYTAGVAP ASHPRFALVV VINDPQAGKY YGGAVSAPVF GAIMGGVLRT MNIEPDALAT GEKSEFVINQ GEGTGGRS //