ID   A0A0W8AVJ6_KLEPN        Unreviewed;       588 AA.
AC   A0A0W8AVJ6; A0A0J2GHB5; A0A4V0HIQ6;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   02-JUN-2021, entry version 50.
DE   RecName: Full=Peptidoglycan D,D-transpeptidase FtsI {ECO:0000256|HAMAP-Rule:MF_02080};
DE            EC=3.4.16.4 {ECO:0000256|HAMAP-Rule:MF_02080};
DE   AltName: Full=Penicillin-binding protein 3 {ECO:0000256|HAMAP-Rule:MF_02080};
DE            Short=PBP-3 {ECO:0000256|HAMAP-Rule:MF_02080};
GN   Name=ftsI {ECO:0000256|HAMAP-Rule:MF_02080,
GN   ECO:0000313|EMBL:MRD86675.1};
GN   Synonyms=ftsI_1 {ECO:0000313|EMBL:STT52506.1}, ftsI_2
GN   {ECO:0000313|EMBL:SVK72096.1}, ftsI_3 {ECO:0000313|EMBL:SLS44422.1},
GN   ftsI_4 {ECO:0000313|EMBL:SLS77914.1}, ftsI_5
GN   {ECO:0000313|EMBL:STU32598.1}, ftsI_7 {ECO:0000313|EMBL:STV70103.1};
GN   ORFNames=AM386_13995 {ECO:0000313|EMBL:ASC22856.1}, B4U61_00635
GN   {ECO:0000313|EMBL:TEB03799.1}, B5L96_26605
GN   {ECO:0000313|EMBL:OVF65434.1}, BANRA_01934
GN   {ECO:0000313|EMBL:VCZ39830.1}, BANRA_03289
GN   {ECO:0000313|EMBL:VCW58422.1}, BL124_00027960
GN   {ECO:0000313|EMBL:ROG87213.1}, C3F39_10515
GN   {ECO:0000313|EMBL:AUY19176.1}, C4Y50_000535
GN   {ECO:0000313|EMBL:ROG94407.1}, CK508_015405
GN   {ECO:0000313|EMBL:RJS98758.1}, DD581_05120
GN   {ECO:0000313|EMBL:RXY88201.1}, DD583_03315
GN   {ECO:0000313|EMBL:RXZ12446.1}, DM059_00690
GN   {ECO:0000313|EMBL:RCK03275.1}, DM062_00760
GN   {ECO:0000313|EMBL:RCI99793.1}, EAO17_18230
GN   {ECO:0000313|EMBL:RRF08000.1}, EXT45_14640
GN   {ECO:0000313|EMBL:RZG36124.1}, FXN67_14725
GN   {ECO:0000313|EMBL:TYL78263.1}, G5637_15050
GN   {ECO:0000313|EMBL:NGE20071.1}, G7Z27_22825
GN   {ECO:0000313|EMBL:QLI10424.1}, GF489_08905
GN   {ECO:0000313|EMBL:MRD86675.1}, GJI97_022320
GN   {ECO:0000313|EMBL:QOU56428.1}, GJI97_03915
GN   {ECO:0000313|EMBL:MRK04079.1}, GJJ08_022575
GN   {ECO:0000313|EMBL:QOU51083.1}, GJJ08_05355
GN   {ECO:0000313|EMBL:MRK36104.1}, GNE24_10100
GN   {ECO:0000313|EMBL:MTX45539.1}, GNG14_01045
GN   {ECO:0000313|EMBL:MUD50532.1}, GQY16_21990
GN   {ECO:0000313|EMBL:QGZ79391.1}, HJW74_21345
GN   {ECO:0000313|EMBL:QJM33705.1}, NCTC11679_04757
GN   {ECO:0000313|EMBL:STV70103.1}, NCTC13465_04475
GN   {ECO:0000313|EMBL:SQC48283.1}, NCTC13635_05081
GN   {ECO:0000313|EMBL:VEB05243.1}, NCTC1936_01053
GN   {ECO:0000313|EMBL:STT64965.1}, NCTC3279_00263
GN   {ECO:0000313|EMBL:VTR32527.1}, NCTC5052_02861
GN   {ECO:0000313|EMBL:STT94424.1}, NCTC5053_04312
GN   {ECO:0000313|EMBL:STV35655.1}, NCTC8849_01042
GN   {ECO:0000313|EMBL:STT52506.1}, NCTC9637_05624
GN   {ECO:0000313|EMBL:STT50626.1}, NCTC9661_05284
GN   {ECO:0000313|EMBL:STU32598.1}, SAMEA24002668_02916
GN   {ECO:0000313|EMBL:SSF40530.1}, SAMEA3499901_00823
GN   {ECO:0000313|EMBL:SXN29830.1}, SAMEA3515094_03496
GN   {ECO:0000313|EMBL:SXX57950.1}, SAMEA3538546_03489
GN   {ECO:0000313|EMBL:SYB05023.1}, SAMEA3538560_03489
GN   {ECO:0000313|EMBL:SYB62548.1}, SAMEA3649435_01639
GN   {ECO:0000313|EMBL:SVL97485.1}, SAMEA3649466_02055
GN   {ECO:0000313|EMBL:SVM84579.1}, SAMEA3649630_03796
GN   {ECO:0000313|EMBL:SYV13024.1}, SAMEA3649650_01965
GN   {ECO:0000313|EMBL:SVK72096.1}, SAMEA3649733_02927
GN   {ECO:0000313|EMBL:SVS26238.1}, SAMEA3649758_01674
GN   {ECO:0000313|EMBL:SVS92436.1}, SAMEA3673026_02642
GN   {ECO:0000313|EMBL:SVW95007.1}, SAMEA3673122_01923
GN   {ECO:0000313|EMBL:SWE22373.1}, SAMEA3720909_02183
GN   {ECO:0000313|EMBL:SWF71742.1}, SAMEA3721038_01933
GN   {ECO:0000313|EMBL:SVX87972.1}, SAMEA3727579_01924
GN   {ECO:0000313|EMBL:SWO18854.1}, SAMEA3727651_01170
GN   {ECO:0000313|EMBL:SWQ42250.1}, SAMEA3727679_02297
GN   {ECO:0000313|EMBL:SWR46557.1}, SAMEA4364603_03511
GN   {ECO:0000313|EMBL:SSK45838.1}, SAMEA4370540_04101
GN   {ECO:0000313|EMBL:SLS77914.1}, SAMEA4370542_02578
GN   {ECO:0000313|EMBL:SLS44422.1}, SAMEA4873581_02889
GN   {ECO:0000313|EMBL:VGI41983.1}, WP4S18C04_42160
GN   {ECO:0000313|EMBL:BBR79630.1};
OS   Klebsiella pneumoniae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella.
OX   NCBI_TaxID=573 {ECO:0000313|EMBL:MRD86675.1, ECO:0000313|Proteomes:UP000475774};
RN   [1] {ECO:0000313|EMBL:TEB03799.1, ECO:0000313|Proteomes:UP000297943}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MEC097 {ECO:0000313|EMBL:TEB03799.1,
RC   ECO:0000313|Proteomes:UP000297943};
RA   Arya A.S.;
RT   "Isolation of Levoglucosan Utilizing Bacteria.";
RL   Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:OVF65434.1, ECO:0000313|Proteomes:UP000196447}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=39383 {ECO:0000313|EMBL:OVF65434.1,
RC   ECO:0000313|Proteomes:UP000196447};
RA   Fouts D., Stalin M.J., Chen L., Wright M., Sutton G., Nguyen K.,
RA   Vanduin D., Rojas L., Hujer A., Hujer K., Bonomo R., Kreiswirth B.,
RA   Adams M.;
RL   Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:ASC22856.1, ECO:0000313|Proteomes:UP000196868}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AR_0139 {ECO:0000313|EMBL:ASC22856.1,
RC   ECO:0000313|Proteomes:UP000196868};
RA   Conlan S., Thomas P.J., Mullikin J., Frank K.M., Segre J.A.;
RT   "Whole genome sequencing of Klebsiella pneumoniae AR_0139.";
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:RRF08000.1, ECO:0000313|Proteomes:UP000275975}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KLPN_104 {ECO:0000313|EMBL:RRF08000.1,
RC   ECO:0000313|Proteomes:UP000275975};
RX   PubMed=30373801;
RA   Tamma P.D., Fan Y., Bergman Y., Pertea G., Kazmi A., Lewis S.,
RA   Carroll K.C., Schatz M.C., Timp W., Simner P.J.;
RT   "Applying Rapid Whole Genome Sequencing to Predict Phenotypic Antimicrobial
RT   Susceptibility Testing Results Among Carbapenem-Resistant Klebsiella
RT   pneumoniae Clinical Isolates.";
RL   Antimicrob. Agents Chemother. 0:0-0(2018).
RN   [5] {ECO:0000313|Proteomes:UP000239813}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KPNIH48 {ECO:0000313|Proteomes:UP000239813};
RX   PubMed=29437920;
RG   NISC Comparative Sequencing Program;
RA   Weingarten R.A., Johnson R.C., Conlan S., Ramsburg A.M., Dekker J.P.,
RA   Lau A.F., Khil P., Odom R.T., Deming C., Park M., Thomas P.J.,
RA   Henderson D.K., Palmore T.N., Segre J.A., Frank K.M.;
RT   "Genomic Analysis of Hospital Plumbing Reveals Diverse Reservoir of
RT   Bacterial Plasmids Conferring Carbapenem Resistance.";
RL   MBio 9:e02011-e02017(2018).
RN   [6] {ECO:0000313|EMBL:AUY19176.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KPNIH48 {ECO:0000313|EMBL:AUY19176.1};
RA   Weingarten R.A., Johnson R.C., Conlan S., Ramsburg A.M., Dekker J.P.,
RA   Lau A.F., Khil P., Odom R.T., Deming C., Park M., Thomas P.J.,
RA   Henderson D.K., Palmore T.N., Segre J.A., Frank K.M.;
RT   "Genomic Analysis of Hospital Plumbing Reveals Diverse Reservoir of
RT   Bacterial Plasmids Conferring Carbapenem Resistance.";
RL   MBio 0:0-0(2018).
RN   [7] {ECO:0000313|Proteomes:UP000289252, ECO:0000313|Proteomes:UP000290276}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3DZ2-3B {ECO:0000313|EMBL:RXY88201.1,
RC   ECO:0000313|Proteomes:UP000290276}, and 775-DZ2-4B
RC   {ECO:0000313|EMBL:RXZ12446.1, ECO:0000313|Proteomes:UP000289252};
RA   Zhang R., Li J., Wang Y., Shen J., Shen Z., Wang S.;
RT   "The molecular epidemiology of the NDM positive non-E. coli
RT   Enterobacteriaceae in poultry production environment.";
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN   [8] {ECO:0000313|Proteomes:UP000251721, ECO:0000313|Proteomes:UP000254103}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC11679 {ECO:0000313|EMBL:STV70103.1,
RC   ECO:0000313|Proteomes:UP000255239}, NCTC13465
RC   {ECO:0000313|EMBL:SQC48283.1, ECO:0000313|Proteomes:UP000251721},
RC   NCTC1936 {ECO:0000313|EMBL:STT64965.1,
RC   ECO:0000313|Proteomes:UP000254753}, NCTC5052
RC   {ECO:0000313|EMBL:STT94424.1, ECO:0000313|Proteomes:UP000254103},
RC   NCTC5053 {ECO:0000313|EMBL:STV35655.1,
RC   ECO:0000313|Proteomes:UP000254387}, NCTC8849
RC   {ECO:0000313|EMBL:STT52506.1, ECO:0000313|Proteomes:UP000254799},
RC   NCTC9637 {ECO:0000313|EMBL:STT50626.1,
RC   ECO:0000313|Proteomes:UP000255099}, and NCTC9661
RC   {ECO:0000313|EMBL:STU32598.1, ECO:0000313|Proteomes:UP000255137};
RG   Pathogen Informatics;
RA   Doyle S.;
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [9] {ECO:0000313|Proteomes:UP000252552, ECO:0000313|Proteomes:UP000253217}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BC_4223 {ECO:0000313|EMBL:RCK03275.1,
RC   ECO:0000313|Proteomes:UP000253217}, and BC_4553
RC   {ECO:0000313|EMBL:RCI99793.1, ECO:0000313|Proteomes:UP000252552};
RA   Martins R.C.R., Perdigao-Neto L.V., Costa S.F., Levin A.S.S.;
RT   "Klebsiella pneumoniae genome sequencing and assembly.";
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN   [10] {ECO:0000313|Proteomes:UP000252552, ECO:0000313|Proteomes:UP000253217}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BC_4223 {ECO:0000313|EMBL:RCK03275.1,
RC   ECO:0000313|Proteomes:UP000253217}, and BC_4553
RC   {ECO:0000313|EMBL:RCI99793.1, ECO:0000313|Proteomes:UP000252552};
RA   Quirk P.G., Krulwich T.A.;
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN   [11] {ECO:0000313|Proteomes:UP000257313, ECO:0000313|Proteomes:UP000257762}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=4300STDY6470422 {ECO:0000313|EMBL:SSK45838.1,
RC   ECO:0000313|Proteomes:UP000252603}, 4300STDY6636959
RC   {ECO:0000313|EMBL:SSF40530.1, ECO:0000313|Proteomes:UP000253632},
RC   5012STDY7626380 {ECO:0000313|EMBL:VGI41983.1,
RC   ECO:0000313|Proteomes:UP000390008}, EuSCAPE_AT029
RC   {ECO:0000313|EMBL:SXN29830.1, ECO:0000313|Proteomes:UP000259975},
RC   EuSCAPE_BE062 {ECO:0000313|EMBL:SWQ42250.1,
RC   ECO:0000313|Proteomes:UP000260526}, EuSCAPE_BE092
RC   {ECO:0000313|EMBL:SWR46557.1, ECO:0000313|Proteomes:UP000258785},
RC   EuSCAPE_ES119 {ECO:0000313|EMBL:SVL97485.1,
RC   ECO:0000313|Proteomes:UP000258901}, EuSCAPE_ES150
RC   {ECO:0000313|EMBL:SVM84579.1, ECO:0000313|Proteomes:UP000260067},
RC   EuSCAPE_ES285 {ECO:0000313|EMBL:SYV13024.1,
RC   ECO:0000313|Proteomes:UP000258898}, EuSCAPE_GR032
RC   {ECO:0000313|EMBL:SVK72096.1, ECO:0000313|Proteomes:UP000257762},
RC   EuSCAPE_GR114 {ECO:0000313|EMBL:SVS26238.1,
RC   ECO:0000313|Proteomes:UP000259497}, EuSCAPE_GR139
RC   {ECO:0000313|EMBL:SVS92436.1, ECO:0000313|Proteomes:UP000260499},
RC   EuSCAPE_IE029 {ECO:0000313|EMBL:SWO18854.1,
RC   ECO:0000313|Proteomes:UP000257313}, EuSCAPE_IT062
RC   {ECO:0000313|EMBL:SXX57950.1, ECO:0000313|Proteomes:UP000259081},
RC   EuSCAPE_ME004 {ECO:0000313|EMBL:SYB05023.1,
RC   ECO:0000313|Proteomes:UP000258893}, EuSCAPE_ME018
RC   {ECO:0000313|EMBL:SYB62548.1, ECO:0000313|Proteomes:UP000260135},
RC   EuSCAPE_RO021 {ECO:0000313|EMBL:SWE22373.1,
RC   ECO:0000313|Proteomes:UP000257792}, EuSCAPE_RO112
RC   {ECO:0000313|EMBL:SVX87972.1, ECO:0000313|Proteomes:UP000258908},
RC   EuSCAPE_SI009 {ECO:0000313|EMBL:SVW95007.1,
RC   ECO:0000313|Proteomes:UP000259295}, EuSCAPE_UK014
RC   {ECO:0000313|EMBL:SWF71742.1, ECO:0000313|Proteomes:UP000259364},
RC   NCTC13635 {ECO:0000313|EMBL:VEB05243.1,
RC   ECO:0000313|Proteomes:UP000282433}, NCTC3279
RC   {ECO:0000313|EMBL:VTR32527.1, ECO:0000313|Proteomes:UP000395965},
RC   VRES1271 {ECO:0000313|EMBL:SLS77914.1,
RC   ECO:0000313|Proteomes:UP000191969}, and VRES1272
RC   {ECO:0000313|EMBL:SLS44422.1, ECO:0000313|Proteomes:UP000191996};
RG   Pathogen Informatics;
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
RN   [12] {ECO:0000313|EMBL:RJS98758.1, ECO:0000313|Proteomes:UP000218552}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B35 {ECO:0000313|EMBL:RJS98758.1,
RC   ECO:0000313|Proteomes:UP000218552};
RA   Araujo B.F., Campos P.A., Royer S., Ferreira M.L., Goncalves I.R.,
RA   Batistao D.W.F., Cerdeira L.T., Brito C.S., Gontijo-Filho P., Ribas R.M.;
RT   "Klebsiella pneumoniae KPC-2-producing B35 strain.";
RL   Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
RN   [13] {ECO:0000313|EMBL:ROG87213.1, ECO:0000313|Proteomes:UP000283322}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CRK0165 {ECO:0000313|EMBL:ROG87213.1,
RC   ECO:0000313|Proteomes:UP000283322};
RA   Vanduin D., Fouts D., Wright M., Sutton G., Nguyen K., Kreiswirth B.,
RA   Chen L., Rojas L., Hujer A., Hujer K., Bonomo R., Adams M.;
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN   [14] {ECO:0000313|Proteomes:UP000269373, ECO:0000313|Proteomes:UP000277476}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Kpneu014 {ECO:0000313|EMBL:VCW58422.1}, and Kpneu037
RC   {ECO:0000313|EMBL:VCZ39830.1};
RA   Noll B N.;
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN   [15] {ECO:0000313|EMBL:ROG94407.1, ECO:0000313|Proteomes:UP000286610}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CRK0390 {ECO:0000313|EMBL:ROG94407.1,
RC   ECO:0000313|Proteomes:UP000286610};
RA   Vanduin D., Fouts D., Sutton G., Nguyen K., Hujer A., Hujer K., Bonomo R.;
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN   [16] {ECO:0000313|EMBL:MRD86675.1, ECO:0000313|Proteomes:UP000475774}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=99 {ECO:0000313|EMBL:MRD86675.1,
RC   ECO:0000313|Proteomes:UP000475774};
RA   Paraschiv S., Surleac M., Czobor Barbu I., Popa L.I., Gheorghe I.,
RA   Otelea D., Chifiriuc M.C.;
RT   "Whole genome sequencing snapshot of multi-drug resistant Klebsiella
RT   pneumoniae strains from hospitals and receiving wastewater treatment plants
RT   in Southern Romania.";
RL   PLoS ONE 0:0-0(2019).
RN   [17] {ECO:0000313|EMBL:RZG36124.1, ECO:0000313|Proteomes:UP000293472}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=53 {ECO:0000313|EMBL:RZG36124.1,
RC   ECO:0000313|Proteomes:UP000293472};
RA   Newire E., Aydin A., Juma S., Enne V., Roberts A.P.;
RT   "Identification of a Type IV CRISPR-Cas system located exclusively on
RT   IncHI1B/ IncFIB plasmids in Enterobacteriaceae.";
RL   Submitted (FEB-2019) to the EMBL/GenBank/DDBJ databases.
RN   [18] {ECO:0000313|EMBL:TYL78263.1, ECO:0000313|Proteomes:UP000322977}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UCO-494 {ECO:0000313|EMBL:TYL78263.1,
RC   ECO:0000313|Proteomes:UP000322977};
RA   Morales-Leon F., Caro C., Opazo-Capurro A., Lincopan N.,
RA   Dominguez-Yevenes M., Lima C., Bello-Toledo H., Gonzalez-Rocha G.;
RT   "Phenotypic and genetic characterization of extended-spectrum b-lactamase-
RT   producing hypermucoviscous Klebsiella pneumoniae from Chile.";
RL   Submitted (AUG-2019) to the EMBL/GenBank/DDBJ databases.
RN   [19] {ECO:0000313|EMBL:MRK36104.1, ECO:0000313|Proteomes:UP000439817}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CriePir116 {ECO:0000313|EMBL:MRK04079.1,
RC   ECO:0000313|Proteomes:UP000482635}, and CriePir120
RC   {ECO:0000313|EMBL:MRK36104.1, ECO:0000313|Proteomes:UP000439817};
RA   Shelenkov A., Mikhaylova Y., Yanushevich Y., Samoilov A., Petrova L.,
RA   Fomina V., Gusarov V., Zamyatin M., Shagin D.;
RT   "Molecular typing, antibiotic resistance determination and virulence
RT   profiling for 36 multidrug-resistant clinical Klebsiella pneumoniae
RT   isolates using second- and third-generation sequencing.";
RL   Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases.
RN   [20] {ECO:0000313|Proteomes:UP000470376, ECO:0000313|Proteomes:UP000488995}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KP_10042 {ECO:0000313|EMBL:MUD50532.1,
RC   ECO:0000313|Proteomes:UP000488995}, and KP_46186
RC   {ECO:0000313|EMBL:MTX45539.1, ECO:0000313|Proteomes:UP000470376};
RA   Zhou K.;
RT   "Emergence of a novel subclone of carbapenem-resistant Klebsiella
RT   pneumoniae ST11 with enhanced virulence and transmissibility: a molecular
RT   epidemiological, clinical, genomic study.";
RL   Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
RN   [21] {ECO:0000313|EMBL:QGZ79391.1, ECO:0000313|Proteomes:UP000428800}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BD_DM_914 {ECO:0000313|EMBL:QGZ79391.1,
RC   ECO:0000313|Proteomes:UP000428800};
RA   Farzana R., Walsh T.R.;
RT   "Colintin resistant K. pneumoniae.";
RL   Submitted (DEC-2019) to the EMBL/GenBank/DDBJ databases.
RN   [22] {ECO:0000313|EMBL:BBR79630.1, ECO:0000313|Proteomes:UP000515327}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WP4-S18-CRE-04 {ECO:0000313|EMBL:BBR79630.1,
RC   ECO:0000313|Proteomes:UP000515327};
RA   Sekizuka T., Itokawa K., Yatsu K., Inamine Y., Kuroda M.;
RT   "complete genome sequences of Klebsiella pneumoniae str. WP4-S18-CRE-04
RT   isolated from wastewater treatment plant effluent.";
RL   Submitted (DEC-2019) to the EMBL/GenBank/DDBJ databases.
RN   [23] {ECO:0000313|Proteomes:UP000439817, ECO:0000313|Proteomes:UP000482635}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CriePir116 {ECO:0000313|EMBL:QOU56428.1,
RC   ECO:0000313|Proteomes:UP000482635}, and CriePir120
RC   {ECO:0000313|EMBL:QOU51083.1, ECO:0000313|Proteomes:UP000439817};
RX   PubMed=32429555;
RA   Shelenkov A., Mikhaylova Y., Yanushevich Y., Samoilov A., Petrova L.,
RA   Fomina V., Gusarov V., Zamyatin M., Shagin D., Akimkin V.;
RT   "Molecular Typing, Characterization of Antimicrobial Resistance, Virulence
RT   Profiling and Analysis of Whole-Genome Sequence of Clinical Klebsiella
RT   pneumoniae Isolates.";
RL   Antibiotics (Basel) 9:0-E261(2020).
RN   [24] {ECO:0000313|EMBL:NGE20071.1, ECO:0000313|Proteomes:UP000474962}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KPM_60 {ECO:0000313|EMBL:NGE20071.1,
RC   ECO:0000313|Proteomes:UP000474962};
RA   Tokajian S., El Chaar M., El Khoury M.;
RT   "WGS of Carbapenem-Resistant Entrobacteriaceae.";
RL   Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
RN   [25] {ECO:0000313|EMBL:QLI10424.1, ECO:0000313|Proteomes:UP000509467}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=11KM256 {ECO:0000313|EMBL:QLI10424.1,
RC   ECO:0000313|Proteomes:UP000509467};
RA   Brilhante M., Perreten V.;
RT   "Whole genome sequencing of global problem clones of OXA-48-producing
RT   Klebsiella pneumoniae from the veterinary setting in Switzerland.";
RL   Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
RN   [26] {ECO:0000313|EMBL:QJM33705.1, ECO:0000313|Proteomes:UP000503381}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=A17KP0004 {ECO:0000313|EMBL:QJM33705.1,
RC   ECO:0000313|Proteomes:UP000503381};
RA   Yoon E.-J., Gwon B., Liu C., Kim D., Won D., Park S.G., Choi J.R.,
RA   Jeong S.H.;
RT   "Built-in CTX-M extended-spectrum beta-lactamase gene in Klebsiella
RT   pneumoniae ensuring stable propagation of the multidrug-resistant pathogen
RT   in clinical settings.";
RL   Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes cross-linking of the peptidoglycan cell wall at the
CC       division septum. {ECO:0000256|HAMAP-Rule:MF_02080}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Preferential cleavage: (Ac)(2)-L-Lys-D-Ala-|-D-Ala. Also
CC         transpeptidation of peptidyl-alanyl moieties that are N-acyl
CC         substituents of D-alanine.; EC=3.4.16.4; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_02080};
CC   -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC       {ECO:0000256|HAMAP-Rule:MF_02080}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000256|HAMAP-
CC       Rule:MF_02080}; Single-pass membrane protein {ECO:0000256|HAMAP-
CC       Rule:MF_02080}.
CC   -!- SIMILARITY: Belongs to the transpeptidase family. FtsI subfamily.
CC       {ECO:0000256|HAMAP-Rule:MF_02080}.
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DR   EMBL; CP021960; ASC22856.1; -; Genomic_DNA.
DR   EMBL; CP026392; AUY19176.1; -; Genomic_DNA.
DR   EMBL; AP022078; BBR79630.1; -; Genomic_DNA.
DR   EMBL; WJBQ01000005; MRD86675.1; -; Genomic_DNA.
DR   EMBL; WJWE01000002; MRK04079.1; -; Genomic_DNA.
DR   EMBL; WJWD01000003; MRK36104.1; -; Genomic_DNA.
DR   EMBL; WNOE01000015; MTX45539.1; -; Genomic_DNA.
DR   EMBL; WNSY01000001; MUD50532.1; -; Genomic_DNA.
DR   EMBL; JAAJRV010000009; NGE20071.1; -; Genomic_DNA.
DR   EMBL; NDBK01000112; OVF65434.1; -; Genomic_DNA.
DR   EMBL; CP046949; QGZ79391.1; -; Genomic_DNA.
DR   EMBL; CP052560; QJM33705.1; -; Genomic_DNA.
DR   EMBL; CP049716; QLI10424.1; -; Genomic_DNA.
DR   EMBL; CP063008; QOU51083.1; -; Genomic_DNA.
DR   EMBL; CP063011; QOU56428.1; -; Genomic_DNA.
DR   EMBL; QORQ01000079; RCI99793.1; -; Genomic_DNA.
DR   EMBL; QOUG01000039; RCK03275.1; -; Genomic_DNA.
DR   EMBL; NTHY02000043; RJS98758.1; -; Genomic_DNA.
DR   EMBL; MPYG04000224; ROG87213.1; -; Genomic_DNA.
DR   EMBL; PTFF02000003; ROG94407.1; -; Genomic_DNA.
DR   EMBL; RDAM01000001; RRF08000.1; -; Genomic_DNA.
DR   EMBL; QFMH01000017; RXY88201.1; -; Genomic_DNA.
DR   EMBL; QFMF01000002; RXZ12446.1; -; Genomic_DNA.
DR   EMBL; SGOL01000011; RZG36124.1; -; Genomic_DNA.
DR   EMBL; FWJM01000007; SLS44422.1; -; Genomic_DNA.
DR   EMBL; FWJN01000015; SLS77914.1; -; Genomic_DNA.
DR   EMBL; UAWQ01000019; SQC48283.1; -; Genomic_DNA.
DR   EMBL; UFBE01000007; SSF40530.1; -; Genomic_DNA.
DR   EMBL; UFEU01000009; SSK45838.1; -; Genomic_DNA.
DR   EMBL; UGLB01000003; STT50626.1; -; Genomic_DNA.
DR   EMBL; UGLC01000002; STT52506.1; -; Genomic_DNA.
DR   EMBL; UGLI01000001; STT64965.1; -; Genomic_DNA.
DR   EMBL; UGLJ01000002; STT94424.1; -; Genomic_DNA.
DR   EMBL; UGLQ01000003; STU32598.1; -; Genomic_DNA.
DR   EMBL; UGMN01000004; STV35655.1; -; Genomic_DNA.
DR   EMBL; UGMG01000001; STV70103.1; -; Genomic_DNA.
DR   EMBL; UIRX01000006; SVK72096.1; -; Genomic_DNA.
DR   EMBL; UISV01000004; SVL97485.1; -; Genomic_DNA.
DR   EMBL; UITM01000005; SVM84579.1; -; Genomic_DNA.
DR   EMBL; UIXM01000008; SVS26238.1; -; Genomic_DNA.
DR   EMBL; UIYA01000005; SVS92436.1; -; Genomic_DNA.
DR   EMBL; UJAY01000009; SVW95007.1; -; Genomic_DNA.
DR   EMBL; UJBS01000005; SVX87972.1; -; Genomic_DNA.
DR   EMBL; UJGH01000005; SWE22373.1; -; Genomic_DNA.
DR   EMBL; UJHH01000008; SWF71742.1; -; Genomic_DNA.
DR   EMBL; UJNP01000005; SWO18854.1; -; Genomic_DNA.
DR   EMBL; UJPD01000003; SWQ42250.1; -; Genomic_DNA.
DR   EMBL; UJPY01000006; SWR46557.1; -; Genomic_DNA.
DR   EMBL; UKGE01000003; SXN29830.1; -; Genomic_DNA.
DR   EMBL; UKNV01000007; SXX57950.1; -; Genomic_DNA.
DR   EMBL; UKQI01000007; SYB05023.1; -; Genomic_DNA.
DR   EMBL; UKQT01000007; SYB62548.1; -; Genomic_DNA.
DR   EMBL; ULFB01000011; SYV13024.1; -; Genomic_DNA.
DR   EMBL; MWQX01000001; TEB03799.1; -; Genomic_DNA.
DR   EMBL; VSSY01000011; TYL78263.1; -; Genomic_DNA.
DR   EMBL; UWVV01000001; VCW58422.1; -; Genomic_DNA.
DR   EMBL; UWXT01000001; VCZ39830.1; -; Genomic_DNA.
DR   EMBL; LR134162; VEB05243.1; -; Genomic_DNA.
DR   EMBL; CAAHAF010000005; VGI41983.1; -; Genomic_DNA.
DR   EMBL; CABEFC010000002; VTR32527.1; -; Genomic_DNA.
DR   RefSeq; WP_002888559.1; NZ_WYAM01000022.1.
DR   EnsemblBacteria; AIT01861; AIT01861; PMK1_02396.
DR   EnsemblBacteria; AUY19176; AUY19176; C3F39_10515.
DR   EnsemblBacteria; AVB73872; AVB73872; C3483_22070.
DR   EnsemblBacteria; KLY18083; KLY18083; SK89_01947.
DR   EnsemblBacteria; PPK23259; PPK23259; CSC88_14290.
DR   EnsemblBacteria; PWF58468; PWF58468; C7V41_14790.
DR   EnsemblBacteria; RCI99793; RCI99793; DM062_00760.
DR   EnsemblBacteria; RCK03275; RCK03275; DM059_00690.
DR   EnsemblBacteria; RDT68909; RDT68909; DXF97_05380.
DR   EnsemblBacteria; SQC48283; SQC48283; NCTC13465_04475.
DR   EnsemblBacteria; SSF40530; SSF40530; SAMEA24002668_02916.
DR   EnsemblBacteria; SSG22791; SSG22791; SAMEA23986918_05501.
DR   EnsemblBacteria; SSK45838; SSK45838; SAMEA4364603_03511.
DR   EnsemblBacteria; STT50626; STT50626; NCTC9637_05624.
DR   EnsemblBacteria; STT52506; STT52506; NCTC8849_01042.
DR   EnsemblBacteria; STT64965; STT64965; NCTC1936_01053.
DR   EnsemblBacteria; STT94424; STT94424; NCTC5052_02861.
DR   EnsemblBacteria; STU32598; STU32598; NCTC9661_05284.
DR   EnsemblBacteria; STV35655; STV35655; NCTC5053_04312.
DR   EnsemblBacteria; STV70103; STV70103; NCTC11679_04757.
DR   EnsemblBacteria; SVJ50221; SVJ50221; SAMEA4394730_05373.
DR   EnsemblBacteria; VEB05243; VEB05243; NCTC13635_05081.
DR   KEGG; kpb:FH42_21260; -.
DR   KEGG; kpne:KU54_022460; -.
DR   KEGG; kpnu:LI86_22300; -.
DR   KEGG; kpx:PMK1_02396; -.
DR   OrthoDB; 213680at2; -.
DR   UniPathway; UPA00219; -.
DR   Proteomes; UP000191969; Unassembled WGS sequence.
DR   Proteomes; UP000191996; Unassembled WGS sequence.
DR   Proteomes; UP000196447; Unassembled WGS sequence.
DR   Proteomes; UP000196868; Chromosome.
DR   Proteomes; UP000218552; Unassembled WGS sequence.
DR   Proteomes; UP000239813; Chromosome.
DR   Proteomes; UP000251721; Unassembled WGS sequence.
DR   Proteomes; UP000252552; Unassembled WGS sequence.
DR   Proteomes; UP000252603; Unassembled WGS sequence.
DR   Proteomes; UP000253217; Unassembled WGS sequence.
DR   Proteomes; UP000253632; Unassembled WGS sequence.
DR   Proteomes; UP000254103; Unassembled WGS sequence.
DR   Proteomes; UP000254387; Unassembled WGS sequence.
DR   Proteomes; UP000254753; Unassembled WGS sequence.
DR   Proteomes; UP000254799; Unassembled WGS sequence.
DR   Proteomes; UP000255099; Unassembled WGS sequence.
DR   Proteomes; UP000255137; Unassembled WGS sequence.
DR   Proteomes; UP000255239; Unassembled WGS sequence.
DR   Proteomes; UP000257313; Unassembled WGS sequence.
DR   Proteomes; UP000257762; Unassembled WGS sequence.
DR   Proteomes; UP000257792; Unassembled WGS sequence.
DR   Proteomes; UP000258785; Unassembled WGS sequence.
DR   Proteomes; UP000258893; Unassembled WGS sequence.
DR   Proteomes; UP000258898; Unassembled WGS sequence.
DR   Proteomes; UP000258901; Unassembled WGS sequence.
DR   Proteomes; UP000258908; Unassembled WGS sequence.
DR   Proteomes; UP000259081; Unassembled WGS sequence.
DR   Proteomes; UP000259295; Unassembled WGS sequence.
DR   Proteomes; UP000259364; Unassembled WGS sequence.
DR   Proteomes; UP000259497; Unassembled WGS sequence.
DR   Proteomes; UP000259975; Unassembled WGS sequence.
DR   Proteomes; UP000260067; Unassembled WGS sequence.
DR   Proteomes; UP000260135; Unassembled WGS sequence.
DR   Proteomes; UP000260499; Unassembled WGS sequence.
DR   Proteomes; UP000260526; Unassembled WGS sequence.
DR   Proteomes; UP000269373; Unassembled WGS sequence.
DR   Proteomes; UP000275975; Unassembled WGS sequence.
DR   Proteomes; UP000277476; Unassembled WGS sequence.
DR   Proteomes; UP000282433; Chromosome 1.
DR   Proteomes; UP000283322; Unassembled WGS sequence.
DR   Proteomes; UP000286610; Unassembled WGS sequence.
DR   Proteomes; UP000289252; Unassembled WGS sequence.
DR   Proteomes; UP000290276; Unassembled WGS sequence.
DR   Proteomes; UP000293472; Unassembled WGS sequence.
DR   Proteomes; UP000297943; Unassembled WGS sequence.
DR   Proteomes; UP000322977; Unassembled WGS sequence.
DR   Proteomes; UP000390008; Unassembled WGS sequence.
DR   Proteomes; UP000395965; Unassembled WGS sequence.
DR   Proteomes; UP000428800; Chromosome.
DR   Proteomes; UP000439817; Unassembled WGS sequence.
DR   Proteomes; UP000470376; Unassembled WGS sequence.
DR   Proteomes; UP000474962; Unassembled WGS sequence.
DR   Proteomes; UP000475774; Unassembled WGS sequence.
DR   Proteomes; UP000482635; Chromosome.
DR   Proteomes; UP000488995; Unassembled WGS sequence.
DR   Proteomes; UP000503381; Chromosome.
DR   Proteomes; UP000509467; Chromosome.
DR   Proteomes; UP000515327; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:InterPro.
DR   GO; GO:0009002; F:serine-type D-Ala-D-Ala carboxypeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR   GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR   GO; GO:0043093; P:FtsZ-dependent cytokinesis; IEA:UniProtKB-UniRule.
DR   GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.710.10; -; 1.
DR   HAMAP; MF_02080; FtsI_transpept; 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR037532; FtsI_transpept.
DR   InterPro; IPR005311; PBP_dimer.
DR   InterPro; IPR036138; PBP_dimer_sf.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   Pfam; PF03717; PBP_dimer; 1.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SUPFAM; SSF56519; SSF56519; 1.
DR   SUPFAM; SSF56601; SSF56601; 1.
PE   3: Inferred from homology;
KW   Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645, ECO:0000256|HAMAP-
KW   Rule:MF_02080};
KW   Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|HAMAP-
KW   Rule:MF_02080};
KW   Cell division {ECO:0000256|ARBA:ARBA00022618, ECO:0000256|HAMAP-
KW   Rule:MF_02080}; Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Cell membrane {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Cell shape {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Cell wall biogenesis/degradation {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Glycosyltransferase {ECO:0000313|EMBL:SLS44422.1};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_02080};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_02080};
KW   Peptidoglycan synthesis {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|HAMAP-Rule:MF_02080};
KW   Septation {ECO:0000256|ARBA:ARBA00023210, ECO:0000256|HAMAP-Rule:MF_02080};
KW   Transferase {ECO:0000313|EMBL:MRD86675.1};
KW   Transmembrane {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_02080}.
FT   TRANSMEM        20..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_02080"
FT   DOMAIN          70..220
FT                   /note="PBP_dimer"
FT                   /evidence="ECO:0000259|Pfam:PF03717"
FT   DOMAIN          260..554
FT                   /note="Transpeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF00905"
FT   ACT_SITE        307
FT                   /note="Acyl-ester intermediate"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_02080"
SQ   SEQUENCE   588 AA;  64003 MW;  2FE4408506D51A55 CRC64;
     MKAAPKTPKA KRQEEQANFI SWRFALLCGC ILLALAFLLG RVAWLQVISP DMLVRQGDMR
     SLRVQEVSTA RGMITDRSGR PLAVSVPVKA IWADPKELHD AGGVTLDTRW KALADALNMP
     LDQLATRINT NPRMRFIYLA RQVNPDMADY IKKLKLPGIH LREESRRYYP SGEVTAHLIG
     FTNVDSQGIE GVEKSFDKWL TGQPGERIVR KDRYGRVIED ISSTDSQAAH NLALSIDERL
     QALVYRELNN AVAFNKAESG SAVLVDVNTG EVLAMANSPS YNPNNFAGTA KDTMRNRAIT
     DVFEPGSTVK PMVVMTALQR GIVNENTVLN TVPYRINGHE IKDVARYSEL TLTGVLQKSS
     NVGVSKLALA MPSSALVDTY SRFGLGKATN LGLVGERSGL YPQKQRWSDI ERATFSFGYG
     LMVTPLQLAR VYATIGSYGI YRPLSITKVD PPVPGERVFP ESLVRTVVHM MESVALPGGG
     GVKAAIKGYR IAIKTGTAKK VGPDGRYINK YIAYTAGVAP ASHPRFALVV VINDPQAGKY
     YGGAVSAPVF GAIMGGVLRT MNIEPDALAT GEKSEFVINQ GEGTGGRS
//