ID   A0A0W8AVJ6_KLEPN        Unreviewed;       588 AA.
AC   A0A0W8AVJ6; A0A0J2GHB5; A0A4V0HIQ6;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   02-DEC-2020, entry version 47.
DE   RecName: Full=Peptidoglycan D,D-transpeptidase FtsI {ECO:0000256|HAMAP-Rule:MF_02080};
DE            EC=3.4.16.4 {ECO:0000256|HAMAP-Rule:MF_02080};
DE   AltName: Full=Penicillin-binding protein 3 {ECO:0000256|HAMAP-Rule:MF_02080};
DE            Short=PBP-3 {ECO:0000256|HAMAP-Rule:MF_02080};
GN   Name=ftsI_4 {ECO:0000313|EMBL:CAA1289462.1};
GN   Synonyms=ftsI {ECO:0000256|HAMAP-Rule:MF_02080,
GN   ECO:0000313|EMBL:MRD86675.1}, ftsI_1 {ECO:0000313|EMBL:STT52506.1},
GN   ftsI_2 {ECO:0000313|EMBL:SVT04628.1}, ftsI_3
GN   {ECO:0000313|EMBL:STT50626.1}, ftsI_5 {ECO:0000313|EMBL:STU32598.1},
GN   ftsI_7 {ECO:0000313|EMBL:STV70103.1};
GN   ORFNames=B6R99_09600 {ECO:0000313|EMBL:OXT03529.1}, BANRA_01934
GN   {ECO:0000313|EMBL:VCZ39830.1}, BANRA_03289
GN   {ECO:0000313|EMBL:VCW58422.1}, BL124_00027960
GN   {ECO:0000313|EMBL:ROG87213.1}, C2U49_23915
GN   {ECO:0000313|EMBL:AUU97602.1}, C3F39_10515
GN   {ECO:0000313|EMBL:AUY19176.1}, C4Y50_000535
GN   {ECO:0000313|EMBL:ROG94407.1}, C7V41_14790
GN   {ECO:0000313|EMBL:PWF58468.1}, CK508_015405
GN   {ECO:0000313|EMBL:RJS98758.1}, DD581_05120
GN   {ECO:0000313|EMBL:RXY88201.1}, DD583_03315
GN   {ECO:0000313|EMBL:RXZ12446.1}, DM059_00690
GN   {ECO:0000313|EMBL:RCK03275.1}, DM062_00760
GN   {ECO:0000313|EMBL:RCI99793.1}, DM078_11140
GN   {ECO:0000313|EMBL:RBZ23802.1}, EAO17_18230
GN   {ECO:0000313|EMBL:RRF08000.1}, EXT45_14640
GN   {ECO:0000313|EMBL:RZG36124.1}, F0330_05305
GN   {ECO:0000313|EMBL:KAA0487369.1}, F1D54_14890
GN   {ECO:0000313|EMBL:KAA1502218.1}, F3G17_17825
GN   {ECO:0000313|EMBL:KAA5741965.1}, F3G25_13125
GN   {ECO:0000313|EMBL:KAA5734373.1}, FAT93_02525
GN   {ECO:0000313|EMBL:THS93194.1}, FCH06_005300
GN   {ECO:0000313|EMBL:TYY86933.1}, FKC87_04175
GN   {ECO:0000313|EMBL:TQC93342.1}, FXN60_14740
GN   {ECO:0000313|EMBL:QEI36481.1}, FXN67_14725
GN   {ECO:0000313|EMBL:TYL78263.1}, G5637_15050
GN   {ECO:0000313|EMBL:NGE20071.1}, GF489_08905
GN   {ECO:0000313|EMBL:MRD86675.1}, GJJ01_07030
GN   {ECO:0000313|EMBL:MRJ95711.1}, GS419_22700
GN   {ECO:0000313|EMBL:QHD76807.1}, GZH28_04705
GN   {ECO:0000313|EMBL:NER54071.1}, NCTC11679_04757
GN   {ECO:0000313|EMBL:STV70103.1}, NCTC13465_04475
GN   {ECO:0000313|EMBL:SQC48283.1}, NCTC13635_05081
GN   {ECO:0000313|EMBL:VEB05243.1}, NCTC1936_01053
GN   {ECO:0000313|EMBL:STT64965.1}, NCTC5052_02861
GN   {ECO:0000313|EMBL:STT94424.1}, NCTC5053_04312
GN   {ECO:0000313|EMBL:STV35655.1}, NCTC8849_01042
GN   {ECO:0000313|EMBL:STT52506.1}, NCTC9637_05624
GN   {ECO:0000313|EMBL:STT50626.1}, NCTC9661_05284
GN   {ECO:0000313|EMBL:STU32598.1}, SAMEA104567846_04453
GN   {ECO:0000313|EMBL:VGF26171.1}, SAMEA104567853_01838
GN   {ECO:0000313|EMBL:VGF46338.1}, SAMEA104567906_04254
GN   {ECO:0000313|EMBL:VFZ68386.1}, SAMEA104567925_04402
GN   {ECO:0000313|EMBL:VGC10161.1}, SAMEA1712987_02032
GN   {ECO:0000313|EMBL:VAP05229.1}, SAMEA24002668_02916
GN   {ECO:0000313|EMBL:SSF40530.1}, SAMEA3531867_04079
GN   {ECO:0000313|EMBL:VTT47853.1}, SAMEA3538702_02286
GN   {ECO:0000313|EMBL:SYM13347.1}, SAMEA3649466_02055
GN   {ECO:0000313|EMBL:SVM84579.1}, SAMEA3649709_01977
GN   {ECO:0000313|EMBL:SVT04628.1}, SAMEA3649772_04326
GN   {ECO:0000313|EMBL:VUL09924.1}, SAMEA3673122_01923
GN   {ECO:0000313|EMBL:SWE22373.1}, SAMEA3673128_00127
GN   {ECO:0000313|EMBL:SWE78326.1}, SAMEA3727630_03709
GN   {ECO:0000313|EMBL:SWP39242.1}, SAMEA3729660_02009
GN   {ECO:0000313|EMBL:SWU38133.1}, SAMEA3729780_04182
GN   {ECO:0000313|EMBL:CAA1289462.1}, SAMEA4364603_03511
GN   {ECO:0000313|EMBL:SSK45838.1}, SAMEA4873570_02391
GN   {ECO:0000313|EMBL:VGH70929.1}, SAMEA4873575_04319
GN   {ECO:0000313|EMBL:VGI04244.1}, SAMEA4873581_02889
GN   {ECO:0000313|EMBL:VGI41983.1}, SAMEA4873632_03788
GN   {ECO:0000313|EMBL:VGL03660.1}, SK89_01947
GN   {ECO:0000313|EMBL:KLY18083.1};
OS   Klebsiella pneumoniae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella.
OX   NCBI_TaxID=573 {ECO:0000313|EMBL:KLY18083.1};
RN   [1] {ECO:0000313|EMBL:KLY18083.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CHS153 {ECO:0000313|EMBL:KLY18083.1};
RG   The Broad Institute Genomics Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Earl A.M., Onderdonk A.B., Kirby J., Ferraro M.J., Huang S., Spencer M.,
RA   Fodor A., Hooper D., Dekker J., O'Brien T., Quan V., Gombosev A.,
RA   Delaney M., DuBois A., Ernst C., Kim D.S., Rossman W., Gohs F., Petruso H.,
RA   Nozar T., Mougeot F., Manson-McGuire A., Young S., Abouelleil A., Cao P.,
RA   Chapman S.B., Griggs A., Priest M., Shea T., Wortman I., Wortman J.R.,
RA   Nusbaum C., Birren B.;
RT   "The Genome Sequence of None.";
RL   Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:OXT03529.1, ECO:0000313|Proteomes:UP000215430}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VD412 {ECO:0000313|EMBL:OXT03529.1,
RC   ECO:0000313|Proteomes:UP000215430};
RA   Tran L.D.;
RT   "Vietnam strains VN412.";
RL   Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:RRF08000.1, ECO:0000313|Proteomes:UP000275975}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KLPN_104 {ECO:0000313|EMBL:RRF08000.1,
RC   ECO:0000313|Proteomes:UP000275975};
RX   PubMed=30373801;
RA   Tamma P.D., Fan Y., Bergman Y., Pertea G., Kazmi A., Lewis S.,
RA   Carroll K.C., Schatz M.C., Timp W., Simner P.J.;
RT   "Applying Rapid Whole Genome Sequencing to Predict Phenotypic Antimicrobial
RT   Susceptibility Testing Results Among Carbapenem-Resistant Klebsiella
RT   pneumoniae Clinical Isolates.";
RL   Antimicrob. Agents Chemother. 0:0-0(2018).
RN   [4] {ECO:0000313|Proteomes:UP000236255, ECO:0000313|Proteomes:UP000239813}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KPNIH48 {ECO:0000313|Proteomes:UP000239813}, and KPNIH49
RC   {ECO:0000313|Proteomes:UP000236255};
RX   PubMed=29437920;
RG   NISC Comparative Sequencing Program;
RA   Weingarten R.A., Johnson R.C., Conlan S., Ramsburg A.M., Dekker J.P.,
RA   Lau A.F., Khil P., Odom R.T., Deming C., Park M., Thomas P.J.,
RA   Henderson D.K., Palmore T.N., Segre J.A., Frank K.M.;
RT   "Genomic Analysis of Hospital Plumbing Reveals Diverse Reservoir of
RT   Bacterial Plasmids Conferring Carbapenem Resistance.";
RL   MBio 9:e02011-17(2018).
RN   [5] {ECO:0000313|EMBL:AUY19176.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KPNIH48 {ECO:0000313|EMBL:AUY19176.1};
RA   Weingarten R.A., Johnson R.C., Conlan S., Ramsburg A.M., Dekker J.P.,
RA   Lau A.F., Khil P., Odom R.T., Deming C., Park M., Thomas P.J.,
RA   Henderson D.K., Palmore T.N., Segre J.A., Frank K.M.;
RT   "Genomic Analysis of Hospital Plumbing Reveals Diverse Reservoir of
RT   Bacterial Plasmids Conferring Carbapenem Resistance.";
RL   MBio 0:0-0(2018).
RN   [6] {ECO:0000313|EMBL:AUU97602.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=KPNIH49 {ECO:0000313|EMBL:AUU97602.1};
RG   NISC Comparative Sequencing Program;
RA   Weingarten R.A., Johnson R.C., Conlan S., Ramsburg A.M., Dekker J.P.,
RA   Lau A.F., Khil P., Odom R.T., Deming C., Park M., Thomas P.J.,
RA   Henderson D.K., Palmore T.N., Segre J.A., Frank K.M.;
RT   "Genomic Analysis of Hospital Plumbing Reveals Diverse Reservoir of
RT   Bacterial Plasmids Conferring Carbapenem Resistance.";
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|EMBL:AUU97602.1, ECO:0000313|Proteomes:UP000236255}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KPNIH49 {ECO:0000313|EMBL:AUU97602.1,
RC   ECO:0000313|Proteomes:UP000236255};
RA   Segre J.A., Mullikin J.;
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [8] {ECO:0000313|EMBL:PWF58468.1, ECO:0000313|Proteomes:UP000245017}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KPL0.2 {ECO:0000313|EMBL:PWF58468.1,
RC   ECO:0000313|Proteomes:UP000245017};
RA   Le Guern R., Grandjean T., Bauduin M., Loquet A., Faure K., Kipnis E.,
RA   Dessein R.;
RT   "A murine model of gut colonization with Klebsiella pneumoniae NDM.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [9] {ECO:0000313|EMBL:RXY88201.1, ECO:0000313|Proteomes:UP000289252, ECO:0000313|Proteomes:UP000290276}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3DZ2-3B {ECO:0000313|EMBL:RXY88201.1,
RC   ECO:0000313|Proteomes:UP000290276}, and 775-DZ2-4B
RC   {ECO:0000313|EMBL:RXZ12446.1, ECO:0000313|Proteomes:UP000289252};
RA   Zhang R., Li J., Wang Y., Shen J., Shen Z., Wang S.;
RT   "The molecular epidemiology of the NDM positive non-E. coli
RT   Enterobacteriaceae in poultry production environment.";
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN   [10] {ECO:0000313|Proteomes:UP000251721, ECO:0000313|Proteomes:UP000254103, ECO:0000313|Proteomes:UP000254387}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC11679 {ECO:0000313|EMBL:STV70103.1,
RC   ECO:0000313|Proteomes:UP000255239}, NCTC13465
RC   {ECO:0000313|EMBL:SQC48283.1, ECO:0000313|Proteomes:UP000251721},
RC   NCTC1936 {ECO:0000313|EMBL:STT64965.1,
RC   ECO:0000313|Proteomes:UP000254753}, NCTC5052
RC   {ECO:0000313|EMBL:STT94424.1, ECO:0000313|Proteomes:UP000254103},
RC   NCTC5053 {ECO:0000313|EMBL:STV35655.1,
RC   ECO:0000313|Proteomes:UP000254387}, NCTC8849
RC   {ECO:0000313|EMBL:STT52506.1, ECO:0000313|Proteomes:UP000254799},
RC   NCTC9637 {ECO:0000313|EMBL:STT50626.1,
RC   ECO:0000313|Proteomes:UP000255099}, and NCTC9661
RC   {ECO:0000313|EMBL:STU32598.1, ECO:0000313|Proteomes:UP000255137};
RG   Pathogen Informatics;
RA   Doyle S.;
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [11] {ECO:0000313|Proteomes:UP000252552, ECO:0000313|Proteomes:UP000253217, ECO:0000313|Proteomes:UP000253559}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BC_4223 {ECO:0000313|EMBL:RCK03275.1,
RC   ECO:0000313|Proteomes:UP000253217}, BC_4553
RC   {ECO:0000313|EMBL:RCI99793.1, ECO:0000313|Proteomes:UP000252552}, and
RC   BC_5001 {ECO:0000313|EMBL:RBZ23802.1,
RC   ECO:0000313|Proteomes:UP000253559};
RA   Martins R.C.R., Perdigao-Neto L.V., Costa S.F., Levin A.S.S.;
RT   "Klebsiella pneumoniae genome sequencing and assembly.";
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN   [12] {ECO:0000313|EMBL:RCI99793.1, ECO:0000313|Proteomes:UP000252552, ECO:0000313|Proteomes:UP000253217}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BC_4223 {ECO:0000313|EMBL:RCK03275.1,
RC   ECO:0000313|Proteomes:UP000253217}, and BC_4553
RC   {ECO:0000313|EMBL:RCI99793.1, ECO:0000313|Proteomes:UP000252552};
RA   Quirk P.G., Krulwich T.A.;
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN   [13] {ECO:0000313|EMBL:RBZ23802.1, ECO:0000313|Proteomes:UP000253559}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BC_5001 {ECO:0000313|EMBL:RBZ23802.1,
RC   ECO:0000313|Proteomes:UP000253559};
RA   Martins R.C., Perdigao-Neto L.V., Costa S.F., Levin A.S.S.;
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN   [14] {ECO:0000313|Proteomes:UP000257792, ECO:0000313|Proteomes:UP000258129, ECO:0000313|Proteomes:UP000258699}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2485STDY5438277 {ECO:0000313|EMBL:VAP05229.1,
RC   ECO:0000313|Proteomes:UP000326261}, 3754STDY6292969
RC   {ECO:0000313|EMBL:CAA1289462.1, ECO:0000313|Proteomes:UP000257626},
RC   4300STDY6470422 {ECO:0000313|EMBL:SSK45838.1,
RC   ECO:0000313|Proteomes:UP000252603}, 4300STDY6636959
RC   {ECO:0000313|EMBL:SSF40530.1, ECO:0000313|Proteomes:UP000253632},
RC   5012STDY7312664 {ECO:0000313|EMBL:VGF26171.1,
RC   ECO:0000313|Proteomes:UP000337947}, 5012STDY7312671
RC   {ECO:0000313|EMBL:VGF46338.1, ECO:0000313|Proteomes:UP000381540},
RC   5012STDY7312724 {ECO:0000313|EMBL:VFZ68386.1,
RC   ECO:0000313|Proteomes:UP000406376}, 5012STDY7312743
RC   {ECO:0000313|EMBL:VGC10161.1, ECO:0000313|Proteomes:UP000386678},
RC   5012STDY7626369 {ECO:0000313|EMBL:VGH70929.1,
RC   ECO:0000313|Proteomes:UP000343310}, 5012STDY7626374
RC   {ECO:0000313|EMBL:VGI04244.1, ECO:0000313|Proteomes:UP000360885},
RC   5012STDY7626380 {ECO:0000313|EMBL:VGI41983.1,
RC   ECO:0000313|Proteomes:UP000390008}, 5012STDY7626430
RC   {ECO:0000313|EMBL:VGL03660.1, ECO:0000313|Proteomes:UP000376235},
RC   EuSCAPE_BE040 {ECO:0000313|EMBL:SWP39242.1,
RC   ECO:0000313|Proteomes:UP000258702}, EuSCAPE_ES150
RC   {ECO:0000313|EMBL:SVM84579.1, ECO:0000313|Proteomes:UP000260067},
RC   EuSCAPE_GR090 {ECO:0000313|EMBL:SVT04628.1,
RC   ECO:0000313|Proteomes:UP000259889}, EuSCAPE_GR153
RC   {ECO:0000313|EMBL:VUL09924.1, ECO:0000313|Proteomes:UP000443666},
RC   EuSCAPE_IT334 {ECO:0000313|EMBL:SYM13347.1,
RC   ECO:0000313|Proteomes:UP000260565}, EuSCAPE_RO021
RC   {ECO:0000313|EMBL:SWE22373.1, ECO:0000313|Proteomes:UP000257792},
RC   EuSCAPE_RO027 {ECO:0000313|EMBL:SWE78326.1,
RC   ECO:0000313|Proteomes:UP000258129}, EuSCAPE_TR130
RC   {ECO:0000313|EMBL:SWU38133.1, ECO:0000313|Proteomes:UP000258699},
RC   F1-8-ERB4 {ECO:0000313|EMBL:VTT47853.1}, and NCTC13635
RC   {ECO:0000313|EMBL:VEB05243.1, ECO:0000313|Proteomes:UP000282433};
RG   Pathogen Informatics;
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
RN   [15] {ECO:0000313|EMBL:RJS98758.1, ECO:0000313|Proteomes:UP000218552}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B35 {ECO:0000313|EMBL:RJS98758.1,
RC   ECO:0000313|Proteomes:UP000218552};
RA   Araujo B.F., Campos P.A., Royer S., Ferreira M.L., Goncalves I.R.,
RA   Batistao D.W.F., Cerdeira L.T., Brito C.S., Gontijo-Filho P., Ribas R.M.;
RT   "Klebsiella pneumoniae KPC-2-producing B35 strain.";
RL   Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
RN   [16] {ECO:0000313|EMBL:VCW58422.1, ECO:0000313|Proteomes:UP000269373, ECO:0000313|Proteomes:UP000277476}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Kpneu014 {ECO:0000313|EMBL:VCW58422.1}, and Kpneu037
RC   {ECO:0000313|EMBL:VCZ39830.1};
RA   Noll B N.;
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN   [17] {ECO:0000313|EMBL:ROG87213.1, ECO:0000313|Proteomes:UP000283322}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CRK0165 {ECO:0000313|EMBL:ROG87213.1,
RC   ECO:0000313|Proteomes:UP000283322};
RA   Vanduin D., Fouts D., Wright M., Sutton G., Nguyen K., Kreiswirth B.,
RA   Chen L., Rojas L., Hujer A., Hujer K., Bonomo R., Adams M.;
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN   [18] {ECO:0000313|EMBL:ROG94407.1, ECO:0000313|Proteomes:UP000286610}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CRK0390 {ECO:0000313|EMBL:ROG94407.1,
RC   ECO:0000313|Proteomes:UP000286610};
RA   Vanduin D., Fouts D., Sutton G., Nguyen K., Hujer A., Hujer K., Bonomo R.;
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN   [19] {ECO:0000313|EMBL:QEI36481.1, ECO:0000313|Proteomes:UP000322548}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KLP268 {ECO:0000313|EMBL:QEI36481.1,
RC   ECO:0000313|Proteomes:UP000322548};
RA   Marsh J.W., Shields R.K.;
RT   "Evolution of Outbreak-Causing Carbapenem-Resistant Klebsiella pneumoniae
RT   ST258 at a Tertiary Care Hospital over 8 Years.";
RL   MBio 0:0-0(2019).
RN   [20] {ECO:0000313|EMBL:MRD86675.1, ECO:0000313|Proteomes:UP000475774}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=99 {ECO:0000313|EMBL:MRD86675.1,
RC   ECO:0000313|Proteomes:UP000475774};
RA   Paraschiv S., Surleac M., Czobor Barbu I., Popa L.I., Gheorghe I.,
RA   Otelea D., Chifiriuc M.C.;
RT   "Whole genome sequencing snapshot of multi-drug resistant Klebsiella
RT   pneumoniae strains from hospitals and receiving wastewater treatment plants
RT   in Southern Romania.";
RL   PLoS ONE 0:0-0(2019).
RN   [21] {ECO:0000313|EMBL:RZG36124.1, ECO:0000313|Proteomes:UP000293472}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=53 {ECO:0000313|EMBL:RZG36124.1,
RC   ECO:0000313|Proteomes:UP000293472};
RA   Newire E., Aydin A., Juma S., Enne V., Roberts A.P.;
RT   "Identification of a Type IV CRISPR-Cas system located exclusively on
RT   IncHI1B/ IncFIB plasmids in Enterobacteriaceae.";
RL   Submitted (FEB-2019) to the EMBL/GenBank/DDBJ databases.
RN   [22] {ECO:0000313|EMBL:THS93194.1, ECO:0000313|Proteomes:UP000305572}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SIKP198 {ECO:0000313|EMBL:THS93194.1,
RC   ECO:0000313|Proteomes:UP000305572};
RA   Fouts D., Sutton G., Singh I., Nguyen K.;
RL   Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
RN   [23] {ECO:0000313|EMBL:TQC93342.1, ECO:0000313|Proteomes:UP000316663}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=T38-P35-mcr3-tc {ECO:0000313|EMBL:TQC93342.1,
RC   ECO:0000313|Proteomes:UP000316663};
RA   Yu Y.;
RT   "An mcr-1 and mcr-3 co-harboring Klebsiella pneumoniae strain from human in
RT   Thailand.";
RL   Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases.
RN   [24] {ECO:0000313|EMBL:KAA0487369.1, ECO:0000313|Proteomes:UP000323019}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K7 {ECO:0000313|EMBL:KAA0487369.1,
RC   ECO:0000313|Proteomes:UP000323019};
RA   Cho G.-S., Stein M., Fiedler G., Igbinosa E.O., Heuermann L., Brinks E.,
RA   Neve H., Franz C.M.A.P.;
RT   "Characterization of antibiotic-resistant enterobacteria.";
RL   Submitted (AUG-2019) to the EMBL/GenBank/DDBJ databases.
RN   [25] {ECO:0000313|EMBL:TYY86933.1, ECO:0000313|Proteomes:UP000323143}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AS001328 {ECO:0000313|EMBL:TYY86933.1,
RC   ECO:0000313|Proteomes:UP000323143};
RA   Beisken S.;
RT   "Evaluating DNBSEQ for clinical isolate sequencing and identification of
RT   antibiotic resistance.";
RL   Submitted (AUG-2019) to the EMBL/GenBank/DDBJ databases.
RN   [26] {ECO:0000313|EMBL:TYL78263.1, ECO:0000313|Proteomes:UP000322977}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UCO-494 {ECO:0000313|EMBL:TYL78263.1,
RC   ECO:0000313|Proteomes:UP000322977};
RA   Morales-Leon F., Caro C., Opazo-Capurro A., Lincopan N.,
RA   Dominguez-Yevenes M., Lima C., Bello-Toledo H., Gonzalez-Rocha G.;
RT   "Phenotypic and genetic characterization of extended-spectrum b-lactamase-
RT   producing hypermucoviscous Klebsiella pneumoniae from Chile.";
RL   Submitted (AUG-2019) to the EMBL/GenBank/DDBJ databases.
RN   [27] {ECO:0000313|Proteomes:UP000322675, ECO:0000313|Proteomes:UP000322831}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=P12 {ECO:0000313|Proteomes:UP000322675}, and P23
RC   {ECO:0000313|Proteomes:UP000322831};
RA   Zhang X.;
RT   "Genome of bacteria.";
RL   Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
RN   [28] {ECO:0000313|EMBL:KAA1502218.1, ECO:0000313|Proteomes:UP000322821}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=195D9 {ECO:0000313|EMBL:KAA1502218.1,
RC   ECO:0000313|Proteomes:UP000322821};
RA   Bonnin R.A., Jousset A.B., Chiarelli A., Emeraud C., Glaser P., Naas T.,
RA   Dortet L.;
RT   "Unexpected genetic diversity among KPC-producing Klebsiella in France.";
RL   Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
RN   [29] {ECO:0000313|EMBL:KAA5734373.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=P12 {ECO:0000313|EMBL:KAA5741965.1}, and P23
RC   {ECO:0000313|EMBL:KAA5734373.1};
RA   Zhang X.;
RL   Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
RN   [30] {ECO:0000313|EMBL:MRJ95711.1, ECO:0000313|Proteomes:UP000441029}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CriePir226 {ECO:0000313|EMBL:MRJ95711.1,
RC   ECO:0000313|Proteomes:UP000441029};
RA   Shelenkov A., Mikhaylova Y., Yanushevich Y., Samoilov A., Petrova L.,
RA   Fomina V., Gusarov V., Zamyatin M., Shagin D.;
RT   "Molecular typing, antibiotic resistance determination and virulence
RT   profiling for 36 multidrug-resistant clinical Klebsiella pneumoniae
RT   isolates using second- and third-generation sequencing.";
RL   Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
RN   [31] {ECO:0000313|EMBL:QHD76807.1, ECO:0000313|Proteomes:UP000464108}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Kp36 {ECO:0000313|EMBL:QHD76807.1,
RC   ECO:0000313|Proteomes:UP000464108};
RA   Tan D.;
RT   "Mobile Genetic Element-Mediated Frameshifting in wcaJ Provides Phage
RT   Resistance in Klebsiella pneumoniae.";
RL   Submitted (DEC-2019) to the EMBL/GenBank/DDBJ databases.
RN   [32] {ECO:0000313|EMBL:NER54071.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UCO505 {ECO:0000313|EMBL:NER54071.1};
RA   Morales-Leon F., Opazo-Capurro A., Gonzalez-Rocha G., Bello-Toledo H.;
RT   "Colistin-heteroresistance in extended-spectrum -lactamase producing
RT   Klebsiella pneumoniae from Chile.";
RL   Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
RN   [33] {ECO:0000313|EMBL:NGE20071.1, ECO:0000313|Proteomes:UP000474962}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KPM_60 {ECO:0000313|EMBL:NGE20071.1,
RC   ECO:0000313|Proteomes:UP000474962};
RA   Tokajian S., El Chaar M., El Khoury M.;
RT   "WGS of Carbapenem-Resistant Entrobacteriaceae.";
RL   Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes cross-linking of the peptidoglycan cell wall at the
CC       division septum. {ECO:0000256|HAMAP-Rule:MF_02080}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Preferential cleavage: (Ac)(2)-L-Lys-D-Ala-|-D-Ala. Also
CC         transpeptidation of peptidyl-alanyl moieties that are N-acyl
CC         substituents of D-alanine.; EC=3.4.16.4; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_02080};
CC   -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC       {ECO:0000256|HAMAP-Rule:MF_02080}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000256|HAMAP-
CC       Rule:MF_02080}; Single-pass membrane protein {ECO:0000256|HAMAP-
CC       Rule:MF_02080}.
CC   -!- SIMILARITY: Belongs to the transpeptidase family. FtsI subfamily.
CC       {ECO:0000256|HAMAP-Rule:MF_02080}.
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DR   EMBL; CP026178; AUU97602.1; -; Genomic_DNA.
DR   EMBL; CP026392; AUY19176.1; -; Genomic_DNA.
DR   EMBL; UJWM02000001; CAA1289462.1; -; Genomic_DNA.
DR   EMBL; VTUL01000004; KAA0487369.1; -; Genomic_DNA.
DR   EMBL; VUBL01000023; KAA1502218.1; -; Genomic_DNA.
DR   EMBL; VWRA01000013; KAA5734373.1; -; Genomic_DNA.
DR   EMBL; VWRE01000014; KAA5741965.1; -; Genomic_DNA.
DR   EMBL; LEUQ01000007; KLY18083.1; -; Genomic_DNA.
DR   EMBL; WJBQ01000005; MRD86675.1; -; Genomic_DNA.
DR   EMBL; WJVL01000004; MRJ95711.1; -; Genomic_DNA.
DR   EMBL; JAAFZD010000003; NER54071.1; -; Genomic_DNA.
DR   EMBL; JAAJRV010000009; NGE20071.1; -; Genomic_DNA.
DR   EMBL; NBIK01000006; OXT03529.1; -; Genomic_DNA.
DR   EMBL; PYBH01000010; PWF58468.1; -; Genomic_DNA.
DR   EMBL; CP043047; QEI36481.1; -; Genomic_DNA.
DR   EMBL; CP047192; QHD76807.1; -; Genomic_DNA.
DR   EMBL; QOHW01000006; RBZ23802.1; -; Genomic_DNA.
DR   EMBL; QORQ01000079; RCI99793.1; -; Genomic_DNA.
DR   EMBL; QOUG01000039; RCK03275.1; -; Genomic_DNA.
DR   EMBL; NTHY02000043; RJS98758.1; -; Genomic_DNA.
DR   EMBL; MPYG04000224; ROG87213.1; -; Genomic_DNA.
DR   EMBL; PTFF02000003; ROG94407.1; -; Genomic_DNA.
DR   EMBL; RDAM01000001; RRF08000.1; -; Genomic_DNA.
DR   EMBL; QFMH01000017; RXY88201.1; -; Genomic_DNA.
DR   EMBL; QFMF01000002; RXZ12446.1; -; Genomic_DNA.
DR   EMBL; SGOL01000011; RZG36124.1; -; Genomic_DNA.
DR   EMBL; UAWQ01000019; SQC48283.1; -; Genomic_DNA.
DR   EMBL; UFBE01000007; SSF40530.1; -; Genomic_DNA.
DR   EMBL; UFEU01000009; SSK45838.1; -; Genomic_DNA.
DR   EMBL; UGLB01000003; STT50626.1; -; Genomic_DNA.
DR   EMBL; UGLC01000002; STT52506.1; -; Genomic_DNA.
DR   EMBL; UGLI01000001; STT64965.1; -; Genomic_DNA.
DR   EMBL; UGLJ01000002; STT94424.1; -; Genomic_DNA.
DR   EMBL; UGLQ01000003; STU32598.1; -; Genomic_DNA.
DR   EMBL; UGMN01000004; STV35655.1; -; Genomic_DNA.
DR   EMBL; UGMG01000001; STV70103.1; -; Genomic_DNA.
DR   EMBL; UITM01000005; SVM84579.1; -; Genomic_DNA.
DR   EMBL; UIYB01000005; SVT04628.1; -; Genomic_DNA.
DR   EMBL; UJGH01000005; SWE22373.1; -; Genomic_DNA.
DR   EMBL; UJGS01000001; SWE78326.1; -; Genomic_DNA.
DR   EMBL; UJOM01000007; SWP39242.1; -; Genomic_DNA.
DR   EMBL; UJRJ01000005; SWU38133.1; -; Genomic_DNA.
DR   EMBL; UKYO01000007; SYM13347.1; -; Genomic_DNA.
DR   EMBL; STEC01000003; THS93194.1; -; Genomic_DNA.
DR   EMBL; VIAJ01000002; TQC93342.1; -; Genomic_DNA.
DR   EMBL; VSSY01000011; TYL78263.1; -; Genomic_DNA.
DR   EMBL; SUOY02000004; TYY86933.1; -; Genomic_DNA.
DR   EMBL; UNZU01000006; VAP05229.1; -; Genomic_DNA.
DR   EMBL; UWVV01000001; VCW58422.1; -; Genomic_DNA.
DR   EMBL; UWXT01000001; VCZ39830.1; -; Genomic_DNA.
DR   EMBL; LR134162; VEB05243.1; -; Genomic_DNA.
DR   EMBL; CAAGTI010000006; VFZ68386.1; -; Genomic_DNA.
DR   EMBL; CAAGVF010000014; VGC10161.1; -; Genomic_DNA.
DR   EMBL; CAAGXU010000006; VGF26171.1; -; Genomic_DNA.
DR   EMBL; CAAGXW010000005; VGF46338.1; -; Genomic_DNA.
DR   EMBL; CAAGZQ010000006; VGH70929.1; -; Genomic_DNA.
DR   EMBL; CAAGZV010000010; VGI04244.1; -; Genomic_DNA.
DR   EMBL; CAAHAF010000005; VGI41983.1; -; Genomic_DNA.
DR   EMBL; CAAHCC010000007; VGL03660.1; -; Genomic_DNA.
DR   EMBL; FLXF02000005; VTT47853.1; -; Genomic_DNA.
DR   EMBL; CABGAI010000001; VUL09924.1; -; Genomic_DNA.
DR   RefSeq; WP_002888559.1; NZ_WYAM01000022.1.
DR   EnsemblBacteria; AIT01861; AIT01861; PMK1_02396.
DR   EnsemblBacteria; ALR24543; ALR24543; AGG09_09880.
DR   EnsemblBacteria; ODN12518; ODN12518; BCB67_07340.
DR   EnsemblBacteria; SBZ45450; SBZ45450; SAMEA3531778_04411.
DR   KEGG; kpb:FH42_21260; -.
DR   KEGG; kpne:KU54_022460; -.
DR   KEGG; kpnu:LI86_22300; -.
DR   KEGG; kpx:PMK1_02396; -.
DR   PATRIC; fig|571.67.peg.2011; -.
DR   OrthoDB; 213680at2; -.
DR   UniPathway; UPA00219; -.
DR   Proteomes; UP000215430; Unassembled WGS sequence.
DR   Proteomes; UP000218552; Unassembled WGS sequence.
DR   Proteomes; UP000236255; Chromosome.
DR   Proteomes; UP000239813; Chromosome.
DR   Proteomes; UP000245017; Unassembled WGS sequence.
DR   Proteomes; UP000251721; Unassembled WGS sequence.
DR   Proteomes; UP000252552; Unassembled WGS sequence.
DR   Proteomes; UP000252603; Unassembled WGS sequence.
DR   Proteomes; UP000253217; Unassembled WGS sequence.
DR   Proteomes; UP000253559; Unassembled WGS sequence.
DR   Proteomes; UP000253632; Unassembled WGS sequence.
DR   Proteomes; UP000254103; Unassembled WGS sequence.
DR   Proteomes; UP000254387; Unassembled WGS sequence.
DR   Proteomes; UP000254753; Unassembled WGS sequence.
DR   Proteomes; UP000254799; Unassembled WGS sequence.
DR   Proteomes; UP000255099; Unassembled WGS sequence.
DR   Proteomes; UP000255137; Unassembled WGS sequence.
DR   Proteomes; UP000255239; Unassembled WGS sequence.
DR   Proteomes; UP000257626; Unassembled WGS sequence.
DR   Proteomes; UP000257792; Unassembled WGS sequence.
DR   Proteomes; UP000258129; Unassembled WGS sequence.
DR   Proteomes; UP000258699; Unassembled WGS sequence.
DR   Proteomes; UP000258702; Unassembled WGS sequence.
DR   Proteomes; UP000259889; Unassembled WGS sequence.
DR   Proteomes; UP000260067; Unassembled WGS sequence.
DR   Proteomes; UP000260565; Unassembled WGS sequence.
DR   Proteomes; UP000269373; Unassembled WGS sequence.
DR   Proteomes; UP000275975; Unassembled WGS sequence.
DR   Proteomes; UP000277476; Unassembled WGS sequence.
DR   Proteomes; UP000282433; Chromosome 1.
DR   Proteomes; UP000283322; Unassembled WGS sequence.
DR   Proteomes; UP000286610; Unassembled WGS sequence.
DR   Proteomes; UP000289252; Unassembled WGS sequence.
DR   Proteomes; UP000290276; Unassembled WGS sequence.
DR   Proteomes; UP000293472; Unassembled WGS sequence.
DR   Proteomes; UP000305572; Unassembled WGS sequence.
DR   Proteomes; UP000316663; Unassembled WGS sequence.
DR   Proteomes; UP000322548; Chromosome.
DR   Proteomes; UP000322675; Unassembled WGS sequence.
DR   Proteomes; UP000322821; Unassembled WGS sequence.
DR   Proteomes; UP000322831; Unassembled WGS sequence.
DR   Proteomes; UP000322977; Unassembled WGS sequence.
DR   Proteomes; UP000323019; Unassembled WGS sequence.
DR   Proteomes; UP000323143; Unassembled WGS sequence.
DR   Proteomes; UP000326261; Unassembled WGS sequence.
DR   Proteomes; UP000337947; Unassembled WGS sequence.
DR   Proteomes; UP000343310; Unassembled WGS sequence.
DR   Proteomes; UP000360885; Unassembled WGS sequence.
DR   Proteomes; UP000376235; Unassembled WGS sequence.
DR   Proteomes; UP000381540; Unassembled WGS sequence.
DR   Proteomes; UP000386678; Unassembled WGS sequence.
DR   Proteomes; UP000390008; Unassembled WGS sequence.
DR   Proteomes; UP000406376; Unassembled WGS sequence.
DR   Proteomes; UP000441029; Unassembled WGS sequence.
DR   Proteomes; UP000443666; Unassembled WGS sequence.
DR   Proteomes; UP000464108; Chromosome.
DR   Proteomes; UP000474962; Unassembled WGS sequence.
DR   Proteomes; UP000475774; Unassembled WGS sequence.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:InterPro.
DR   GO; GO:0009002; F:serine-type D-Ala-D-Ala carboxypeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR   GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR   GO; GO:0043093; P:FtsZ-dependent cytokinesis; IEA:UniProtKB-UniRule.
DR   GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.710.10; -; 1.
DR   HAMAP; MF_02080; FtsI_transpept; 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR037532; FtsI_transpept.
DR   InterPro; IPR005311; PBP_dimer.
DR   InterPro; IPR036138; PBP_dimer_sf.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   Pfam; PF03717; PBP_dimer; 1.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SUPFAM; SSF56519; SSF56519; 1.
DR   SUPFAM; SSF56601; SSF56601; 1.
PE   3: Inferred from homology;
KW   Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645, ECO:0000256|HAMAP-
KW   Rule:MF_02080, ECO:0000313|EMBL:MRD86675.1};
KW   Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|HAMAP-
KW   Rule:MF_02080};
KW   Cell division {ECO:0000256|ARBA:ARBA00022618, ECO:0000256|HAMAP-
KW   Rule:MF_02080, ECO:0000313|EMBL:SQC48283.1};
KW   Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Cell membrane {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Cell shape {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Cell wall biogenesis/degradation {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Glycosyltransferase {ECO:0000313|EMBL:CAA1289462.1};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_02080,
KW   ECO:0000313|EMBL:MRD86675.1};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_02080};
KW   Peptidoglycan synthesis {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|HAMAP-Rule:MF_02080};
KW   Septation {ECO:0000256|ARBA:ARBA00023210, ECO:0000256|HAMAP-Rule:MF_02080};
KW   Transferase {ECO:0000313|EMBL:AUU97602.1};
KW   Transmembrane {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_02080}.
FT   TRANSMEM        20..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_02080"
FT   DOMAIN          70..220
FT                   /note="PBP_dimer"
FT                   /evidence="ECO:0000259|Pfam:PF03717"
FT   DOMAIN          260..554
FT                   /note="Transpeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF00905"
FT   ACT_SITE        307
FT                   /note="Acyl-ester intermediate"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_02080"
SQ   SEQUENCE   588 AA;  64003 MW;  2FE4408506D51A55 CRC64;
     MKAAPKTPKA KRQEEQANFI SWRFALLCGC ILLALAFLLG RVAWLQVISP DMLVRQGDMR
     SLRVQEVSTA RGMITDRSGR PLAVSVPVKA IWADPKELHD AGGVTLDTRW KALADALNMP
     LDQLATRINT NPRMRFIYLA RQVNPDMADY IKKLKLPGIH LREESRRYYP SGEVTAHLIG
     FTNVDSQGIE GVEKSFDKWL TGQPGERIVR KDRYGRVIED ISSTDSQAAH NLALSIDERL
     QALVYRELNN AVAFNKAESG SAVLVDVNTG EVLAMANSPS YNPNNFAGTA KDTMRNRAIT
     DVFEPGSTVK PMVVMTALQR GIVNENTVLN TVPYRINGHE IKDVARYSEL TLTGVLQKSS
     NVGVSKLALA MPSSALVDTY SRFGLGKATN LGLVGERSGL YPQKQRWSDI ERATFSFGYG
     LMVTPLQLAR VYATIGSYGI YRPLSITKVD PPVPGERVFP ESLVRTVVHM MESVALPGGG
     GVKAAIKGYR IAIKTGTAKK VGPDGRYINK YIAYTAGVAP ASHPRFALVV VINDPQAGKY
     YGGAVSAPVF GAIMGGVLRT MNIEPDALAT GEKSEFVINQ GEGTGGRS
//