ID A0A0W8AVJ6_KLEPN Unreviewed; 588 AA. AC A0A0W8AVJ6; A0A0J2GHB5; A0A4V0HIQ6; DT 13-APR-2016, integrated into UniProtKB/TrEMBL. DT 13-APR-2016, sequence version 1. DT 22-APR-2020, entry version 43. DE RecName: Full=Peptidoglycan D,D-transpeptidase FtsI {ECO:0000256|HAMAP-Rule:MF_02080}; DE EC=3.4.16.4 {ECO:0000256|HAMAP-Rule:MF_02080}; DE AltName: Full=Penicillin-binding protein 3 {ECO:0000256|HAMAP-Rule:MF_02080}; DE Short=PBP-3 {ECO:0000256|HAMAP-Rule:MF_02080}; GN Name=ftsI_4 {ECO:0000313|EMBL:SQC48283.1}; GN Synonyms=ftsI {ECO:0000256|HAMAP-Rule:MF_02080, GN ECO:0000313|EMBL:RJS98758.1}, ftsI_1 {ECO:0000313|EMBL:STT52506.1}, GN ftsI_2 {ECO:0000313|EMBL:SVT04628.1}, ftsI_3 GN {ECO:0000313|EMBL:STT50626.1}, ftsI_5 {ECO:0000313|EMBL:STU32598.1}, GN ftsI_7 {ECO:0000313|EMBL:STV70103.1}; GN ORFNames=B4U61_00635 {ECO:0000313|EMBL:TEB03799.1}, B6R99_09600 GN {ECO:0000313|EMBL:OXT03529.1}, BANRA_01934 GN {ECO:0000313|EMBL:VCZ39830.1}, BANRA_03289 GN {ECO:0000313|EMBL:VCW58422.1}, BL124_00027960 GN {ECO:0000313|EMBL:ROG87213.1}, C1459_30435 GN {ECO:0000313|EMBL:TAI74042.1}, C2U49_23915 GN {ECO:0000313|EMBL:AUU97602.1}, C3F39_10515 GN {ECO:0000313|EMBL:AUY19176.1}, C4Y50_000535 GN {ECO:0000313|EMBL:ROG94407.1}, C7V41_14790 GN {ECO:0000313|EMBL:PWF58468.1}, CK508_015405 GN {ECO:0000313|EMBL:RJS98758.1}, DD581_05120 GN {ECO:0000313|EMBL:RXY88201.1}, DD583_03315 GN {ECO:0000313|EMBL:RXZ12446.1}, DM059_00690 GN {ECO:0000313|EMBL:RCK03275.1}, DM062_00760 GN {ECO:0000313|EMBL:RCI99793.1}, DM078_11140 GN {ECO:0000313|EMBL:RBZ23802.1}, EAO17_18230 GN {ECO:0000313|EMBL:RRF08000.1}, EXT45_14640 GN {ECO:0000313|EMBL:RZG36124.1}, F0330_05305 GN {ECO:0000313|EMBL:KAA0487369.1}, F1D54_14890 GN {ECO:0000313|EMBL:KAA1502218.1}, F3G17_17825 GN {ECO:0000313|EMBL:KAA5741965.1}, F3G25_13125 GN {ECO:0000313|EMBL:KAA5734373.1}, FAM29_16680 GN {ECO:0000313|EMBL:THK48054.1}, FAT93_02525 GN {ECO:0000313|EMBL:THS93194.1}, FCH06_005300 GN {ECO:0000313|EMBL:TYY86933.1}, FXN60_14740 GN {ECO:0000313|EMBL:QEI36481.1}, FXN67_14725 GN {ECO:0000313|EMBL:TYL78263.1}, NCTC11679_04757 GN {ECO:0000313|EMBL:STV70103.1}, NCTC13465_04475 GN {ECO:0000313|EMBL:SQC48283.1}, NCTC13635_05081 GN {ECO:0000313|EMBL:VEB05243.1}, NCTC1936_01053 GN {ECO:0000313|EMBL:STT64965.1}, NCTC5052_02861 GN {ECO:0000313|EMBL:STT94424.1}, NCTC5053_04312 GN {ECO:0000313|EMBL:STV35655.1}, NCTC8849_01042 GN {ECO:0000313|EMBL:STT52506.1}, NCTC9637_05624 GN {ECO:0000313|EMBL:STT50626.1}, NCTC9661_05284 GN {ECO:0000313|EMBL:STU32598.1}, SAMEA1712987_02032 GN {ECO:0000313|EMBL:VAP05229.1}, SAMEA24002668_02916 GN {ECO:0000313|EMBL:SSF40530.1}, SAMEA3531867_04079 GN {ECO:0000313|EMBL:VTT47853.1}, SAMEA3649709_01977 GN {ECO:0000313|EMBL:SVT04628.1}, SAMEA3673128_00127 GN {ECO:0000313|EMBL:SWE78326.1}, SAMEA4364603_03511 GN {ECO:0000313|EMBL:SSK45838.1}, SAMEA4873575_04319 GN {ECO:0000313|EMBL:VGI04244.1}, SK89_01947 GN {ECO:0000313|EMBL:KLY18083.1}; OS Klebsiella pneumoniae. OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Klebsiella. OX NCBI_TaxID=573 {ECO:0000313|EMBL:KLY18083.1, ECO:0000313|Proteomes:UP000035995}; RN [1] {ECO:0000313|EMBL:KLY18083.1, ECO:0000313|Proteomes:UP000035995} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CHS153 {ECO:0000313|EMBL:KLY18083.1, RC ECO:0000313|Proteomes:UP000035995}; RG The Broad Institute Genomics Platform; RG The Broad Institute Genome Sequencing Center for Infectious Disease; RA Earl A.M., Onderdonk A.B., Kirby J., Ferraro M.J., Huang S., Spencer M., RA Fodor A., Hooper D., Dekker J., O'Brien T., Quan V., Gombosev A., RA Delaney M., DuBois A., Ernst C., Kim D.S., Rossman W., Gohs F., Petruso H., RA Nozar T., Mougeot F., Manson-McGuire A., Young S., Abouelleil A., Cao P., RA Chapman S.B., Griggs A., Priest M., Shea T., Wortman I., Wortman J.R., RA Nusbaum C., Birren B.; RT "The Genome Sequence of None."; RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:TEB03799.1, ECO:0000313|Proteomes:UP000297943} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=MEC097 {ECO:0000313|EMBL:TEB03799.1, RC ECO:0000313|Proteomes:UP000297943}; RA Arya A.S.; RT "Isolation of Levoglucosan Utilizing Bacteria."; RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:OXT03529.1, ECO:0000313|Proteomes:UP000215430} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=VD412 {ECO:0000313|EMBL:OXT03529.1, RC ECO:0000313|Proteomes:UP000215430}; RA Tran L.D.; RT "Vietnam strains VN412."; RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|EMBL:RRF08000.1, ECO:0000313|Proteomes:UP000275975} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KLPN_104 {ECO:0000313|EMBL:RRF08000.1, RC ECO:0000313|Proteomes:UP000275975}; RX PubMed=30373801; RA Tamma P.D., Fan Y., Bergman Y., Pertea G., Kazmi A., Lewis S., RA Carroll K.C., Schatz M.C., Timp W., Simner P.J.; RT "Applying Rapid Whole Genome Sequencing to Predict Phenotypic Antimicrobial RT Susceptibility Testing Results Among Carbapenem-Resistant Klebsiella RT pneumoniae Clinical Isolates."; RL Antimicrob. Agents Chemother. 0:0-0(2018). RN [5] {ECO:0000313|Proteomes:UP000236255, ECO:0000313|Proteomes:UP000239813} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KPNIH48 {ECO:0000313|Proteomes:UP000239813}, and KPNIH49 RC {ECO:0000313|Proteomes:UP000236255}; RX PubMed=29437920; RG NISC Comparative Sequencing Program; RA Weingarten R.A., Johnson R.C., Conlan S., Ramsburg A.M., Dekker J.P., RA Lau A.F., Khil P., Odom R.T., Deming C., Park M., Thomas P.J., RA Henderson D.K., Palmore T.N., Segre J.A., Frank K.M.; RT "Genomic Analysis of Hospital Plumbing Reveals Diverse Reservoir of RT Bacterial Plasmids Conferring Carbapenem Resistance."; RL MBio 9:e02011-17(2018). RN [6] {ECO:0000313|EMBL:AUY19176.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KPNIH48 {ECO:0000313|EMBL:AUY19176.1}; RA Weingarten R.A., Johnson R.C., Conlan S., Ramsburg A.M., Dekker J.P., RA Lau A.F., Khil P., Odom R.T., Deming C., Park M., Thomas P.J., RA Henderson D.K., Palmore T.N., Segre J.A., Frank K.M.; RT "Genomic Analysis of Hospital Plumbing Reveals Diverse Reservoir of RT Bacterial Plasmids Conferring Carbapenem Resistance."; RL MBio 0:0-0(2018). RN [7] {ECO:0000313|EMBL:AUU97602.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=KPNIH49 {ECO:0000313|EMBL:AUU97602.1}; RG NISC Comparative Sequencing Program; RA Weingarten R.A., Johnson R.C., Conlan S., Ramsburg A.M., Dekker J.P., RA Lau A.F., Khil P., Odom R.T., Deming C., Park M., Thomas P.J., RA Henderson D.K., Palmore T.N., Segre J.A., Frank K.M.; RT "Genomic Analysis of Hospital Plumbing Reveals Diverse Reservoir of RT Bacterial Plasmids Conferring Carbapenem Resistance."; RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases. RN [8] {ECO:0000313|EMBL:TAI74042.1, ECO:0000313|Proteomes:UP000292131} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=G702R2B5 {ECO:0000313|EMBL:TAI74042.1, RC ECO:0000313|Proteomes:UP000292131}; RA Allam M.; RT "Whole Genome Sequencing of Extended Spectrum-Beta-lactamases producing RT Klebsiella pneumoniae: Clonal spread of lineage ST 152."; RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|EMBL:AUU97602.1, ECO:0000313|Proteomes:UP000236255} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KPNIH49 {ECO:0000313|EMBL:AUU97602.1, RC ECO:0000313|Proteomes:UP000236255}; RA Segre J.A., Mullikin J.; RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases. RN [10] {ECO:0000313|EMBL:PWF58468.1, ECO:0000313|Proteomes:UP000245017} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KPL0.2 {ECO:0000313|EMBL:PWF58468.1, RC ECO:0000313|Proteomes:UP000245017}; RA Le Guern R., Grandjean T., Bauduin M., Loquet A., Faure K., Kipnis E., RA Dessein R.; RT "A murine model of gut colonization with Klebsiella pneumoniae NDM."; RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases. RN [11] {ECO:0000313|EMBL:RXY88201.1, ECO:0000313|Proteomes:UP000289252, ECO:0000313|Proteomes:UP000290276} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=3DZ2-3B {ECO:0000313|EMBL:RXY88201.1, RC ECO:0000313|Proteomes:UP000290276}, and 775-DZ2-4B RC {ECO:0000313|EMBL:RXZ12446.1, ECO:0000313|Proteomes:UP000289252}; RA Zhang R., Li J., Wang Y., Shen J., Shen Z., Wang S.; RT "The molecular epidemiology of the NDM positive non-E. coli RT Enterobacteriaceae in poultry production environment."; RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases. RN [12] {ECO:0000313|Proteomes:UP000251721, ECO:0000313|Proteomes:UP000254103, ECO:0000313|Proteomes:UP000254387} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=NCTC11679 {ECO:0000313|EMBL:STV70103.1, RC ECO:0000313|Proteomes:UP000255239}, NCTC13465 RC {ECO:0000313|EMBL:SQC48283.1, ECO:0000313|Proteomes:UP000251721}, RC NCTC1936 {ECO:0000313|EMBL:STT64965.1, RC ECO:0000313|Proteomes:UP000254753}, NCTC5052 RC {ECO:0000313|EMBL:STT94424.1, ECO:0000313|Proteomes:UP000254103}, RC NCTC5053 {ECO:0000313|EMBL:STV35655.1, RC ECO:0000313|Proteomes:UP000254387}, NCTC8849 RC {ECO:0000313|EMBL:STT52506.1, ECO:0000313|Proteomes:UP000254799}, RC NCTC9637 {ECO:0000313|EMBL:STT50626.1, RC ECO:0000313|Proteomes:UP000255099}, and NCTC9661 RC {ECO:0000313|EMBL:STU32598.1, ECO:0000313|Proteomes:UP000255137}; RG Pathogen Informatics; RA Doyle S.; RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases. RN [13] {ECO:0000313|Proteomes:UP000252552, ECO:0000313|Proteomes:UP000253217, ECO:0000313|Proteomes:UP000253559} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BC_4223 {ECO:0000313|EMBL:RCK03275.1, RC ECO:0000313|Proteomes:UP000253217}, BC_4553 RC {ECO:0000313|EMBL:RCI99793.1, ECO:0000313|Proteomes:UP000252552}, and RC BC_5001 {ECO:0000313|EMBL:RBZ23802.1, RC ECO:0000313|Proteomes:UP000253559}; RA Martins R.C.R., Perdigao-Neto L.V., Costa S.F., Levin A.S.S.; RT "Klebsiella pneumoniae genome sequencing and assembly."; RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases. RN [14] {ECO:0000313|EMBL:RBZ23802.1, ECO:0000313|Proteomes:UP000253559} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BC_5001 {ECO:0000313|EMBL:RBZ23802.1, RC ECO:0000313|Proteomes:UP000253559}; RA Martins R.C., Perdigao-Neto L.V., Costa S.F., Levin A.S.S.; RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases. RN [15] {ECO:0000313|EMBL:RCI99793.1, ECO:0000313|Proteomes:UP000252552, ECO:0000313|Proteomes:UP000253217} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BC_4223 {ECO:0000313|EMBL:RCK03275.1, RC ECO:0000313|Proteomes:UP000253217}, and BC_4553 RC {ECO:0000313|EMBL:RCI99793.1, ECO:0000313|Proteomes:UP000252552}; RA Quirk P.G., Krulwich T.A.; RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases. RN [16] {ECO:0000313|EMBL:SSF40530.1, ECO:0000313|Proteomes:UP000252603, ECO:0000313|Proteomes:UP000253632} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=2485STDY5438277 {ECO:0000313|EMBL:VAP05229.1, RC ECO:0000313|Proteomes:UP000326261}, 4300STDY6470422 RC {ECO:0000313|EMBL:SSK45838.1, ECO:0000313|Proteomes:UP000252603}, RC 4300STDY6636959 {ECO:0000313|EMBL:SSF40530.1, RC ECO:0000313|Proteomes:UP000253632}, 5012STDY7626374 RC {ECO:0000313|EMBL:VGI04244.1, ECO:0000313|Proteomes:UP000360885}, RC EuSCAPE_GR090 {ECO:0000313|EMBL:SVT04628.1, RC ECO:0000313|Proteomes:UP000259889}, EuSCAPE_RO027 RC {ECO:0000313|EMBL:SWE78326.1, ECO:0000313|Proteomes:UP000258129}, RC F1-8-ERB4 {ECO:0000313|EMBL:VTT47853.1, RC ECO:0000313|Proteomes:UP000095528}, and NCTC13635 RC {ECO:0000313|EMBL:VEB05243.1, ECO:0000313|Proteomes:UP000282433}; RG Pathogen Informatics; RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases. RN [17] {ECO:0000313|EMBL:RJS98758.1, ECO:0000313|Proteomes:UP000218552} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=B35 {ECO:0000313|EMBL:RJS98758.1, RC ECO:0000313|Proteomes:UP000218552}; RA Araujo B.F., Campos P.A., Royer S., Ferreira M.L., Goncalves I.R., RA Batistao D.W.F., Cerdeira L.T., Brito C.S., Gontijo-Filho P., Ribas R.M.; RT "Klebsiella pneumoniae KPC-2-producing B35 strain."; RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases. RN [18] {ECO:0000313|EMBL:ROG94407.1, ECO:0000313|Proteomes:UP000286610} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CRK0390 {ECO:0000313|EMBL:ROG94407.1, RC ECO:0000313|Proteomes:UP000286610}; RA Vanduin D., Fouts D., Sutton G., Nguyen K., Hujer A., Hujer K., Bonomo R.; RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases. RN [19] {ECO:0000313|EMBL:VCW58422.1, ECO:0000313|Proteomes:UP000269373, ECO:0000313|Proteomes:UP000277476} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Kpneu014 {ECO:0000313|EMBL:VCW58422.1}, and Kpneu037 RC {ECO:0000313|EMBL:VCZ39830.1}; RA Noll B N.; RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases. RN [20] {ECO:0000313|EMBL:ROG87213.1, ECO:0000313|Proteomes:UP000283322} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CRK0165 {ECO:0000313|EMBL:ROG87213.1, RC ECO:0000313|Proteomes:UP000283322}; RA Vanduin D., Fouts D., Wright M., Sutton G., Nguyen K., Kreiswirth B., RA Chen L., Rojas L., Hujer A., Hujer K., Bonomo R., Adams M.; RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases. RN [21] {ECO:0000313|EMBL:QEI36481.1, ECO:0000313|Proteomes:UP000322548} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KLP268 {ECO:0000313|EMBL:QEI36481.1, RC ECO:0000313|Proteomes:UP000322548}; RA Marsh J.W., Shields R.K.; RT "Evolution of Outbreak-Causing Carbapenem-Resistant Klebsiella pneumoniae RT ST258 at a Tertiary Care Hospital over 8 Years."; RL MBio 0:0-0(2019). RN [22] {ECO:0000313|EMBL:RZG36124.1, ECO:0000313|Proteomes:UP000293472} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=53 {ECO:0000313|EMBL:RZG36124.1, RC ECO:0000313|Proteomes:UP000293472}; RA Newire E., Aydin A., Juma S., Enne V., Roberts A.P.; RT "Identification of a Type IV CRISPR-Cas system located exclusively on RT IncHI1B/ IncFIB plasmids in Enterobacteriaceae."; RL Submitted (FEB-2019) to the EMBL/GenBank/DDBJ databases. RN [23] {ECO:0000313|EMBL:THK48054.1, ECO:0000313|Proteomes:UP000305572, ECO:0000313|Proteomes:UP000308970} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=SIKP038 {ECO:0000313|EMBL:THK48054.1, RC ECO:0000313|Proteomes:UP000308970}, and SIKP198 RC {ECO:0000313|EMBL:THS93194.1, ECO:0000313|Proteomes:UP000305572}; RA Fouts D., Sutton G., Singh I., Nguyen K.; RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases. RN [24] {ECO:0000313|EMBL:KAA0487369.1, ECO:0000313|Proteomes:UP000323019} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K7 {ECO:0000313|EMBL:KAA0487369.1, RC ECO:0000313|Proteomes:UP000323019}; RA Cho G.-S., Stein M., Fiedler G., Igbinosa E.O., Heuermann L., Brinks E., RA Neve H., Franz C.M.A.P.; RT "Characterization of antibiotic-resistant enterobacteria."; RL Submitted (AUG-2019) to the EMBL/GenBank/DDBJ databases. RN [25] {ECO:0000313|EMBL:TYY86933.1, ECO:0000313|Proteomes:UP000323143} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=AS001328 {ECO:0000313|EMBL:TYY86933.1, RC ECO:0000313|Proteomes:UP000323143}; RA Beisken S.; RT "Evaluating DNBSEQ for clinical isolate sequencing and identification of RT antibiotic resistance."; RL Submitted (AUG-2019) to the EMBL/GenBank/DDBJ databases. RN [26] {ECO:0000313|EMBL:TYL78263.1, ECO:0000313|Proteomes:UP000322977} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=UCO-494 {ECO:0000313|EMBL:TYL78263.1, RC ECO:0000313|Proteomes:UP000322977}; RA Morales-Leon F., Caro C., Opazo-Capurro A., Lincopan N., RA Dominguez-Yevenes M., Lima C., Bello-Toledo H., Gonzalez-Rocha G.; RT "Phenotypic and genetic characterization of extended-spectrum b-lactamase- RT producing hypermucoviscous Klebsiella pneumoniae from Chile."; RL Submitted (AUG-2019) to the EMBL/GenBank/DDBJ databases. RN [27] {ECO:0000313|Proteomes:UP000322675, ECO:0000313|Proteomes:UP000322831} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=P12 {ECO:0000313|Proteomes:UP000322675}, and P23 RC {ECO:0000313|Proteomes:UP000322831}; RA Zhang X.; RT "Genome of bacteria."; RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases. RN [28] {ECO:0000313|EMBL:KAA1502218.1, ECO:0000313|Proteomes:UP000322821} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=195D9 {ECO:0000313|EMBL:KAA1502218.1, RC ECO:0000313|Proteomes:UP000322821}; RA Bonnin R.A., Jousset A.B., Chiarelli A., Emeraud C., Glaser P., Naas T., RA Dortet L.; RT "Unexpected genetic diversity among KPC-producing Klebsiella in France."; RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases. RN [29] {ECO:0000313|EMBL:KAA5734373.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=P12 {ECO:0000313|EMBL:KAA5741965.1}, and P23 RC {ECO:0000313|EMBL:KAA5734373.1}; RA Zhang X.; RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Catalyzes cross-linking of the peptidoglycan cell wall at the CC division septum. {ECO:0000256|HAMAP-Rule:MF_02080}. CC -!- CATALYTIC ACTIVITY: CC Reaction=Preferential cleavage: (Ac)(2)-L-Lys-D-Ala-|-D-Ala. Also CC transpeptidation of peptidyl-alanyl moieties that are N-acyl CC substituents of D-alanine.; EC=3.4.16.4; Evidence={ECO:0000256|HAMAP- CC Rule:MF_02080}; CC -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis. CC {ECO:0000256|HAMAP-Rule:MF_02080}. CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000256|HAMAP- CC Rule:MF_02080}; Single-pass membrane protein {ECO:0000256|HAMAP- CC Rule:MF_02080}. CC -!- SIMILARITY: Belongs to the transpeptidase family. FtsI subfamily. CC {ECO:0000256|HAMAP-Rule:MF_02080}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP026178; AUU97602.1; -; Genomic_DNA. DR EMBL; CP026392; AUY19176.1; -; Genomic_DNA. DR EMBL; VTUL01000004; KAA0487369.1; -; Genomic_DNA. DR EMBL; VUBL01000023; KAA1502218.1; -; Genomic_DNA. DR EMBL; VWRA01000013; KAA5734373.1; -; Genomic_DNA. DR EMBL; VWRE01000014; KAA5741965.1; -; Genomic_DNA. DR EMBL; LEUQ01000007; KLY18083.1; -; Genomic_DNA. DR EMBL; NBIK01000006; OXT03529.1; -; Genomic_DNA. DR EMBL; PYBH01000010; PWF58468.1; -; Genomic_DNA. DR EMBL; CP043047; QEI36481.1; -; Genomic_DNA. DR EMBL; QOHW01000006; RBZ23802.1; -; Genomic_DNA. DR EMBL; QORQ01000079; RCI99793.1; -; Genomic_DNA. DR EMBL; QOUG01000039; RCK03275.1; -; Genomic_DNA. DR EMBL; NTHY02000043; RJS98758.1; -; Genomic_DNA. DR EMBL; MPYG04000224; ROG87213.1; -; Genomic_DNA. DR EMBL; PTFF02000003; ROG94407.1; -; Genomic_DNA. DR EMBL; RDAM01000001; RRF08000.1; -; Genomic_DNA. DR EMBL; QFMH01000017; RXY88201.1; -; Genomic_DNA. DR EMBL; QFMF01000002; RXZ12446.1; -; Genomic_DNA. DR EMBL; SGOL01000011; RZG36124.1; -; Genomic_DNA. DR EMBL; UAWQ01000019; SQC48283.1; -; Genomic_DNA. DR EMBL; UFBE01000007; SSF40530.1; -; Genomic_DNA. DR EMBL; UFEU01000009; SSK45838.1; -; Genomic_DNA. DR EMBL; UGLB01000003; STT50626.1; -; Genomic_DNA. DR EMBL; UGLC01000002; STT52506.1; -; Genomic_DNA. DR EMBL; UGLI01000001; STT64965.1; -; Genomic_DNA. DR EMBL; UGLJ01000002; STT94424.1; -; Genomic_DNA. DR EMBL; UGLQ01000003; STU32598.1; -; Genomic_DNA. DR EMBL; UGMN01000004; STV35655.1; -; Genomic_DNA. DR EMBL; UGMG01000001; STV70103.1; -; Genomic_DNA. DR EMBL; UIYB01000005; SVT04628.1; -; Genomic_DNA. DR EMBL; UJGS01000001; SWE78326.1; -; Genomic_DNA. DR EMBL; POWO01000503; TAI74042.1; -; Genomic_DNA. DR EMBL; MWQX01000001; TEB03799.1; -; Genomic_DNA. DR EMBL; SSYE01000013; THK48054.1; -; Genomic_DNA. DR EMBL; STEC01000003; THS93194.1; -; Genomic_DNA. DR EMBL; VSSY01000011; TYL78263.1; -; Genomic_DNA. DR EMBL; SUOY02000004; TYY86933.1; -; Genomic_DNA. DR EMBL; UNZU01000006; VAP05229.1; -; Genomic_DNA. DR EMBL; UWVV01000001; VCW58422.1; -; Genomic_DNA. DR EMBL; UWXT01000001; VCZ39830.1; -; Genomic_DNA. DR EMBL; LR134162; VEB05243.1; -; Genomic_DNA. DR EMBL; CAAGZV010000010; VGI04244.1; -; Genomic_DNA. DR EMBL; FLXF02000005; VTT47853.1; -; Genomic_DNA. DR RefSeq; WP_002888559.1; NZ_WHSH01000003.1. DR EnsemblBacteria; AIT01861; AIT01861; PMK1_02396. DR EnsemblBacteria; ALR24543; ALR24543; AGG09_09880. DR EnsemblBacteria; ODN12518; ODN12518; BCB67_07340. DR EnsemblBacteria; SBZ45450; SBZ45450; SAMEA3531778_04411. DR KEGG; kpb:FH42_21260; -. DR KEGG; kpne:KU54_022460; -. DR KEGG; kpnu:LI86_22300; -. DR KEGG; kpx:PMK1_02396; -. DR PATRIC; fig|571.67.peg.2011; -. DR KO; K03587; -. DR OrthoDB; 213680at2; -. DR UniPathway; UPA00219; -. DR Proteomes; UP000035995; Unassembled WGS sequence. DR Proteomes; UP000095528; Unassembled WGS sequence. DR Proteomes; UP000215430; Unassembled WGS sequence. DR Proteomes; UP000218552; Unassembled WGS sequence. DR Proteomes; UP000236255; Chromosome. DR Proteomes; UP000239813; Chromosome. DR Proteomes; UP000245017; Unassembled WGS sequence. DR Proteomes; UP000251721; Unassembled WGS sequence. DR Proteomes; UP000252552; Unassembled WGS sequence. DR Proteomes; UP000252603; Unassembled WGS sequence. DR Proteomes; UP000253217; Unassembled WGS sequence. DR Proteomes; UP000253559; Unassembled WGS sequence. DR Proteomes; UP000253632; Unassembled WGS sequence. DR Proteomes; UP000254103; Unassembled WGS sequence. DR Proteomes; UP000254387; Unassembled WGS sequence. DR Proteomes; UP000254753; Unassembled WGS sequence. DR Proteomes; UP000254799; Unassembled WGS sequence. DR Proteomes; UP000255099; Unassembled WGS sequence. DR Proteomes; UP000255137; Unassembled WGS sequence. DR Proteomes; UP000255239; Unassembled WGS sequence. DR Proteomes; UP000258129; Unassembled WGS sequence. DR Proteomes; UP000259889; Unassembled WGS sequence. DR Proteomes; UP000269373; Unassembled WGS sequence. DR Proteomes; UP000275975; Unassembled WGS sequence. DR Proteomes; UP000277476; Unassembled WGS sequence. DR Proteomes; UP000282433; Chromosome 1. DR Proteomes; UP000283322; Unassembled WGS sequence. DR Proteomes; UP000286610; Unassembled WGS sequence. DR Proteomes; UP000289252; Unassembled WGS sequence. DR Proteomes; UP000290276; Unassembled WGS sequence. DR Proteomes; UP000292131; Unassembled WGS sequence. DR Proteomes; UP000293472; Unassembled WGS sequence. DR Proteomes; UP000297943; Unassembled WGS sequence. DR Proteomes; UP000305572; Unassembled WGS sequence. DR Proteomes; UP000308970; Unassembled WGS sequence. DR Proteomes; UP000322548; Chromosome. DR Proteomes; UP000322675; Unassembled WGS sequence. DR Proteomes; UP000322821; Unassembled WGS sequence. DR Proteomes; UP000322831; Unassembled WGS sequence. DR Proteomes; UP000322977; Unassembled WGS sequence. DR Proteomes; UP000323019; Unassembled WGS sequence. DR Proteomes; UP000323143; Unassembled WGS sequence. DR Proteomes; UP000326261; Unassembled WGS sequence. DR Proteomes; UP000360885; Unassembled WGS sequence. DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule. DR GO; GO:0008658; F:penicillin binding; IEA:InterPro. DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:InterPro. DR GO; GO:0009002; F:serine-type D-Ala-D-Ala carboxypeptidase activity; IEA:UniProtKB-UniRule. DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW. DR GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW. DR GO; GO:0043093; P:FtsZ-dependent cytokinesis; IEA:UniProtKB-UniRule. DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-UniRule. DR GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW. DR Gene3D; 3.40.710.10; -; 1. DR HAMAP; MF_02080; FtsI_transpept; 1. DR InterPro; IPR012338; Beta-lactam/transpept-like. DR InterPro; IPR037532; FtsI_transpept. DR InterPro; IPR005311; PBP_dimer. DR InterPro; IPR036138; PBP_dimer_sf. DR InterPro; IPR001460; PCN-bd_Tpept. DR Pfam; PF03717; PBP_dimer; 1. DR Pfam; PF00905; Transpeptidase; 1. DR SUPFAM; SSF56519; SSF56519; 1. DR SUPFAM; SSF56601; SSF56601; 1. PE 3: Inferred from homology; KW Carboxypeptidase {ECO:0000256|HAMAP-Rule:MF_02080}; KW Cell cycle {ECO:0000256|HAMAP-Rule:MF_02080}; KW Cell division {ECO:0000256|HAMAP-Rule:MF_02080, KW ECO:0000313|EMBL:SQC48283.1}; KW Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_02080}; KW Cell membrane {ECO:0000256|HAMAP-Rule:MF_02080}; KW Cell shape {ECO:0000256|HAMAP-Rule:MF_02080}; KW Cell wall biogenesis/degradation {ECO:0000256|HAMAP-Rule:MF_02080}; KW Glycosyltransferase {ECO:0000313|EMBL:SQC48283.1}; KW Hydrolase {ECO:0000256|HAMAP-Rule:MF_02080}; KW Membrane {ECO:0000256|HAMAP-Rule:MF_02080}; KW Peptidoglycan synthesis {ECO:0000256|HAMAP-Rule:MF_02080}; KW Protease {ECO:0000256|HAMAP-Rule:MF_02080}; KW Septation {ECO:0000256|HAMAP-Rule:MF_02080}; KW Transferase {ECO:0000313|EMBL:AUU97602.1}; KW Transmembrane {ECO:0000256|HAMAP-Rule:MF_02080}; KW Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_02080}. FT TRANSMEM 20..44 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_02080" FT DOMAIN 70..220 FT /note="PBP_dimer" FT /evidence="ECO:0000259|Pfam:PF03717" FT DOMAIN 260..554 FT /note="Transpeptidase" FT /evidence="ECO:0000259|Pfam:PF00905" FT ACT_SITE 307 FT /note="Acyl-ester intermediate" FT /evidence="ECO:0000256|HAMAP-Rule:MF_02080" SQ SEQUENCE 588 AA; 64003 MW; 2FE4408506D51A55 CRC64; MKAAPKTPKA KRQEEQANFI SWRFALLCGC ILLALAFLLG RVAWLQVISP DMLVRQGDMR SLRVQEVSTA RGMITDRSGR PLAVSVPVKA IWADPKELHD AGGVTLDTRW KALADALNMP LDQLATRINT NPRMRFIYLA RQVNPDMADY IKKLKLPGIH LREESRRYYP SGEVTAHLIG FTNVDSQGIE GVEKSFDKWL TGQPGERIVR KDRYGRVIED ISSTDSQAAH NLALSIDERL QALVYRELNN AVAFNKAESG SAVLVDVNTG EVLAMANSPS YNPNNFAGTA KDTMRNRAIT DVFEPGSTVK PMVVMTALQR GIVNENTVLN TVPYRINGHE IKDVARYSEL TLTGVLQKSS NVGVSKLALA MPSSALVDTY SRFGLGKATN LGLVGERSGL YPQKQRWSDI ERATFSFGYG LMVTPLQLAR VYATIGSYGI YRPLSITKVD PPVPGERVFP ESLVRTVVHM MESVALPGGG GVKAAIKGYR IAIKTGTAKK VGPDGRYINK YIAYTAGVAP ASHPRFALVV VINDPQAGKY YGGAVSAPVF GAIMGGVLRT MNIEPDALAT GEKSEFVINQ GEGTGGRS //