ID   A0A0W8AVJ6_KLEPN        Unreviewed;       588 AA.
AC   A0A0W8AVJ6; A0A0J2GHB5;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   26-FEB-2020, entry version 42.
DE   RecName: Full=Peptidoglycan D,D-transpeptidase FtsI {ECO:0000256|HAMAP-Rule:MF_02080};
DE            EC=3.4.16.4 {ECO:0000256|HAMAP-Rule:MF_02080};
DE   AltName: Full=Penicillin-binding protein 3 {ECO:0000256|HAMAP-Rule:MF_02080};
DE            Short=PBP-3 {ECO:0000256|HAMAP-Rule:MF_02080};
GN   Name=ftsI_1 {ECO:0000313|EMBL:STT52506.1};
GN   Synonyms=ftsI {ECO:0000256|HAMAP-Rule:MF_02080,
GN   ECO:0000313|EMBL:QFU51132.1}, ftsI_2 {ECO:0000313|EMBL:VVK66521.1},
GN   ftsI_3 {ECO:0000313|EMBL:STT50626.1}, ftsI_4
GN   {ECO:0000313|EMBL:SQC48283.1}, ftsI_5 {ECO:0000313|EMBL:STU32598.1},
GN   ftsI_7 {ECO:0000313|EMBL:STV70103.1};
GN   ORFNames=B4U61_00635 {ECO:0000313|EMBL:TEB03799.1}, BANRA_01934
GN   {ECO:0000313|EMBL:VCZ39830.1}, BL124_00027960
GN   {ECO:0000313|EMBL:ROG87213.1}, C1459_30435
GN   {ECO:0000313|EMBL:TAI74042.1}, C2D59_22595
GN   {ECO:0000313|EMBL:QFY35629.1}, C2D61_21725
GN   {ECO:0000313|EMBL:QFY30025.1}, C3F39_10515
GN   {ECO:0000313|EMBL:AUY19176.1}, C4Y50_000535
GN   {ECO:0000313|EMBL:ROG94407.1}, C7V41_14790
GN   {ECO:0000313|EMBL:PWF58468.1}, DD581_05120
GN   {ECO:0000313|EMBL:RXY88201.1}, DD583_03315
GN   {ECO:0000313|EMBL:RXZ12446.1}, DM059_00690
GN   {ECO:0000313|EMBL:RCK03275.1}, DM062_00760
GN   {ECO:0000313|EMBL:RCI99793.1}, EAO17_18230
GN   {ECO:0000313|EMBL:RRF08000.1}, EPO92_18050
GN   {ECO:0000313|EMBL:QFU51132.1}, EQH49_10710
GN   {ECO:0000313|EMBL:QFU59829.1}, EQH51_16115
GN   {ECO:0000313|EMBL:QFU71184.1}, EXT45_14640
GN   {ECO:0000313|EMBL:RZG36124.1}, F0330_05305
GN   {ECO:0000313|EMBL:KAA0487369.1}, F1D54_14890
GN   {ECO:0000313|EMBL:KAA1502218.1}, F2X40_10955
GN   {ECO:0000313|EMBL:QER48071.1}, F3G17_17825
GN   {ECO:0000313|EMBL:KAA5741965.1}, F3G25_13125
GN   {ECO:0000313|EMBL:KAA5734373.1}, F3P37_17625
GN   {ECO:0000313|EMBL:QER82123.1}, F6W81_22800
GN   {ECO:0000313|EMBL:QEW93547.1}, FAT93_02525
GN   {ECO:0000313|EMBL:THS93194.1}, FCH06_005300
GN   {ECO:0000313|EMBL:TYY86933.1}, FJR44_21575
GN   {ECO:0000313|EMBL:QEO72445.1}, FM021_23030
GN   {ECO:0000313|EMBL:QEX44068.1}, FNY87_12775
GN   {ECO:0000313|EMBL:TRW06163.1}, FOB37_03435
GN   {ECO:0000313|EMBL:QET17900.1}, FOB38_16610
GN   {ECO:0000313|EMBL:QET09822.1}, FOB39_02535
GN   {ECO:0000313|EMBL:QET12613.1}, FR744_21290
GN   {ECO:0000313|EMBL:QFH97206.1}, FXN67_14725
GN   {ECO:0000313|EMBL:TYL78263.1}, GFJ44_21935
GN   {ECO:0000313|EMBL:QGA04824.1}, NCTC11679_04757
GN   {ECO:0000313|EMBL:STV70103.1}, NCTC13465_04475
GN   {ECO:0000313|EMBL:SQC48283.1}, NCTC13635_05081
GN   {ECO:0000313|EMBL:VEB05243.1}, NCTC1936_01053
GN   {ECO:0000313|EMBL:STT64965.1}, NCTC5052_02861
GN   {ECO:0000313|EMBL:STT94424.1}, NCTC5053_04312
GN   {ECO:0000313|EMBL:STV35655.1}, NCTC8849_01042
GN   {ECO:0000313|EMBL:STT52506.1}, NCTC9637_05624
GN   {ECO:0000313|EMBL:STT50626.1}, NCTC9661_05284
GN   {ECO:0000313|EMBL:STU32598.1}, SAMEA1712987_02032
GN   {ECO:0000313|EMBL:VAP05229.1}, SAMEA24002668_02916
GN   {ECO:0000313|EMBL:SSF40530.1}, SAMEA3538476_02026
GN   {ECO:0000313|EMBL:VVK66521.1}, SAMEA4364603_03511
GN   {ECO:0000313|EMBL:SSK45838.1}, SK89_01947
GN   {ECO:0000313|EMBL:KLY18083.1};
OS   Klebsiella pneumoniae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella.
OX   NCBI_TaxID=573 {ECO:0000313|EMBL:KLY18083.1, ECO:0000313|Proteomes:UP000035995};
RN   [1] {ECO:0000313|EMBL:KLY18083.1, ECO:0000313|Proteomes:UP000035995}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CHS153 {ECO:0000313|EMBL:KLY18083.1,
RC   ECO:0000313|Proteomes:UP000035995};
RG   The Broad Institute Genomics Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Earl A.M., Onderdonk A.B., Kirby J., Ferraro M.J., Huang S., Spencer M.,
RA   Fodor A., Hooper D., Dekker J., O'Brien T., Quan V., Gombosev A.,
RA   Delaney M., DuBois A., Ernst C., Kim D.S., Rossman W., Gohs F., Petruso H.,
RA   Nozar T., Mougeot F., Manson-McGuire A., Young S., Abouelleil A., Cao P.,
RA   Chapman S.B., Griggs A., Priest M., Shea T., Wortman I., Wortman J.R.,
RA   Nusbaum C., Birren B.;
RT   "The Genome Sequence of None.";
RL   Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:TEB03799.1, ECO:0000313|Proteomes:UP000297943}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MEC097 {ECO:0000313|EMBL:TEB03799.1,
RC   ECO:0000313|Proteomes:UP000297943};
RA   Arya A.S.;
RT   "Isolation of Levoglucosan Utilizing Bacteria.";
RL   Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:RRF08000.1, ECO:0000313|Proteomes:UP000275975}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KLPN_104 {ECO:0000313|EMBL:RRF08000.1,
RC   ECO:0000313|Proteomes:UP000275975};
RX   PubMed=30373801;
RA   Tamma P.D., Fan Y., Bergman Y., Pertea G., Kazmi A., Lewis S.,
RA   Carroll K.C., Schatz M.C., Timp W., Simner P.J.;
RT   "Applying Rapid Whole Genome Sequencing to Predict Phenotypic Antimicrobial
RT   Susceptibility Testing Results Among Carbapenem-Resistant Klebsiella
RT   pneumoniae Clinical Isolates.";
RL   Antimicrob. Agents Chemother. 0:0-0(2018).
RN   [4] {ECO:0000313|Proteomes:UP000239813}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KPNIH48 {ECO:0000313|Proteomes:UP000239813};
RX   PubMed=29437920;
RG   NISC Comparative Sequencing Program;
RA   Weingarten R.A., Johnson R.C., Conlan S., Ramsburg A.M., Dekker J.P.,
RA   Lau A.F., Khil P., Odom R.T., Deming C., Park M., Thomas P.J.,
RA   Henderson D.K., Palmore T.N., Segre J.A., Frank K.M.;
RT   "Genomic Analysis of Hospital Plumbing Reveals Diverse Reservoir of
RT   Bacterial Plasmids Conferring Carbapenem Resistance.";
RL   MBio 9:e02011-17(2018).
RN   [5] {ECO:0000313|EMBL:AUY19176.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KPNIH48 {ECO:0000313|EMBL:AUY19176.1};
RA   Weingarten R.A., Johnson R.C., Conlan S., Ramsburg A.M., Dekker J.P.,
RA   Lau A.F., Khil P., Odom R.T., Deming C., Park M., Thomas P.J.,
RA   Henderson D.K., Palmore T.N., Segre J.A., Frank K.M.;
RT   "Genomic Analysis of Hospital Plumbing Reveals Diverse Reservoir of
RT   Bacterial Plasmids Conferring Carbapenem Resistance.";
RL   MBio 0:0-0(2018).
RN   [6] {ECO:0000313|EMBL:QFY30025.1, ECO:0000313|Proteomes:UP000325416, ECO:0000313|Proteomes:UP000326098}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=11420 {ECO:0000313|EMBL:QFY35629.1,
RC   ECO:0000313|Proteomes:UP000325416}, and 13190
RC   {ECO:0000313|EMBL:QFY30025.1, ECO:0000313|Proteomes:UP000326098};
RA   Jia X., Ma G., Zhan Z., Zhou D., Chen F.;
RT   "Hypervirulent and multidrug-resistant Klebsiella pneumoniae.";
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|EMBL:TAI74042.1, ECO:0000313|Proteomes:UP000292131}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=G702R2B5 {ECO:0000313|EMBL:TAI74042.1,
RC   ECO:0000313|Proteomes:UP000292131};
RA   Allam M.;
RT   "Whole Genome Sequencing of Extended Spectrum-Beta-lactamases producing
RT   Klebsiella pneumoniae: Clonal spread of lineage ST 152.";
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [8] {ECO:0000313|EMBL:PWF58468.1, ECO:0000313|Proteomes:UP000245017}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KPL0.2 {ECO:0000313|EMBL:PWF58468.1,
RC   ECO:0000313|Proteomes:UP000245017};
RA   Le Guern R., Grandjean T., Bauduin M., Loquet A., Faure K., Kipnis E.,
RA   Dessein R.;
RT   "A murine model of gut colonization with Klebsiella pneumoniae NDM.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [9] {ECO:0000313|EMBL:RXY88201.1, ECO:0000313|Proteomes:UP000289252, ECO:0000313|Proteomes:UP000290276}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3DZ2-3B {ECO:0000313|EMBL:RXY88201.1,
RC   ECO:0000313|Proteomes:UP000290276}, and 775-DZ2-4B
RC   {ECO:0000313|EMBL:RXZ12446.1, ECO:0000313|Proteomes:UP000289252};
RA   Zhang R., Li J., Wang Y., Shen J., Shen Z., Wang S.;
RT   "The molecular epidemiology of the NDM positive non-E. coli
RT   Enterobacteriaceae in poultry production environment.";
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN   [10] {ECO:0000313|Proteomes:UP000251721, ECO:0000313|Proteomes:UP000254103, ECO:0000313|Proteomes:UP000254387}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC11679 {ECO:0000313|EMBL:STV70103.1,
RC   ECO:0000313|Proteomes:UP000255239}, NCTC13465
RC   {ECO:0000313|EMBL:SQC48283.1, ECO:0000313|Proteomes:UP000251721},
RC   NCTC1936 {ECO:0000313|EMBL:STT64965.1,
RC   ECO:0000313|Proteomes:UP000254753}, NCTC5052
RC   {ECO:0000313|EMBL:STT94424.1, ECO:0000313|Proteomes:UP000254103},
RC   NCTC5053 {ECO:0000313|EMBL:STV35655.1,
RC   ECO:0000313|Proteomes:UP000254387}, NCTC8849
RC   {ECO:0000313|EMBL:STT52506.1, ECO:0000313|Proteomes:UP000254799},
RC   NCTC9637 {ECO:0000313|EMBL:STT50626.1,
RC   ECO:0000313|Proteomes:UP000255099}, and NCTC9661
RC   {ECO:0000313|EMBL:STU32598.1, ECO:0000313|Proteomes:UP000255137};
RG   Pathogen Informatics;
RA   Doyle S.;
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [11] {ECO:0000313|EMBL:RCI99793.1, ECO:0000313|Proteomes:UP000252552, ECO:0000313|Proteomes:UP000253217}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BC_4223 {ECO:0000313|EMBL:RCK03275.1,
RC   ECO:0000313|Proteomes:UP000253217}, and BC_4553
RC   {ECO:0000313|EMBL:RCI99793.1, ECO:0000313|Proteomes:UP000252552};
RA   Martins R.C.R., Perdigao-Neto L.V., Costa S.F., Levin A.S.S.;
RT   "Klebsiella pneumoniae genome sequencing and assembly.";
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN   [12] {ECO:0000313|EMBL:RCI99793.1, ECO:0000313|Proteomes:UP000252552, ECO:0000313|Proteomes:UP000253217}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BC_4223 {ECO:0000313|EMBL:RCK03275.1,
RC   ECO:0000313|Proteomes:UP000253217}, and BC_4553
RC   {ECO:0000313|EMBL:RCI99793.1, ECO:0000313|Proteomes:UP000252552};
RA   Quirk P.G., Krulwich T.A.;
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN   [13] {ECO:0000313|EMBL:VCZ39830.1, ECO:0000313|Proteomes:UP000269373}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Kpneu037 {ECO:0000313|EMBL:VCZ39830.1};
RA   Noll B N.;
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN   [14] {ECO:0000313|EMBL:ROG94407.1, ECO:0000313|Proteomes:UP000286610}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CRK0390 {ECO:0000313|EMBL:ROG94407.1,
RC   ECO:0000313|Proteomes:UP000286610};
RA   Vanduin D., Fouts D., Sutton G., Nguyen K., Hujer A., Hujer K., Bonomo R.;
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN   [15] {ECO:0000313|EMBL:ROG87213.1, ECO:0000313|Proteomes:UP000283322}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CRK0165 {ECO:0000313|EMBL:ROG87213.1,
RC   ECO:0000313|Proteomes:UP000283322};
RA   Vanduin D., Fouts D., Wright M., Sutton G., Nguyen K., Kreiswirth B.,
RA   Chen L., Rojas L., Hujer A., Hujer K., Bonomo R., Adams M.;
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN   [16] {ECO:0000313|EMBL:VEB05243.1, ECO:0000313|Proteomes:UP000282433}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2485STDY5438277 {ECO:0000313|EMBL:VAP05229.1,
RC   ECO:0000313|Proteomes:UP000326261}, 4300STDY6470422
RC   {ECO:0000313|EMBL:SSK45838.1, ECO:0000313|Proteomes:UP000252603},
RC   4300STDY6636959 {ECO:0000313|EMBL:SSF40530.1,
RC   ECO:0000313|Proteomes:UP000253632}, EuSCAPE_IL018
RC   {ECO:0000313|EMBL:VVK66521.1, ECO:0000313|Proteomes:UP000259433}, and
RC   NCTC13635 {ECO:0000313|EMBL:VEB05243.1,
RC   ECO:0000313|Proteomes:UP000282433};
RG   Pathogen Informatics;
RL   Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
RN   [17] {ECO:0000313|EMBL:QFU51132.1, ECO:0000313|Proteomes:UP000325692}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LH102-A {ECO:0000313|EMBL:QFU51132.1,
RC   ECO:0000313|Proteomes:UP000325692};
RA   Hadjadj L., Rolain J.-M.;
RT   "Genome of KpLH102-A.";
RL   Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
RN   [18] {ECO:0000313|EMBL:QFU59829.1, ECO:0000313|Proteomes:UP000326754}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LH94 {ECO:0000313|EMBL:QFU59829.1,
RC   ECO:0000313|Proteomes:UP000326754};
RA   Hadjadj L., Rolain J.-M.;
RT   "Genome of KpLH94.";
RL   Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
RN   [19] {ECO:0000313|EMBL:QFU71184.1, ECO:0000313|Proteomes:UP000326148}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TH164 {ECO:0000313|EMBL:QFU71184.1,
RC   ECO:0000313|Proteomes:UP000326148};
RA   Hadjadj L., Rolain J.-M.;
RT   "Genome of KpTH164.";
RL   Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
RN   [20] {ECO:0000313|EMBL:RZG36124.1, ECO:0000313|Proteomes:UP000293472}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=53 {ECO:0000313|EMBL:RZG36124.1,
RC   ECO:0000313|Proteomes:UP000293472};
RA   Newire E., Aydin A., Juma S., Enne V., Roberts A.P.;
RT   "Identification of a Type IV CRISPR-Cas system located exclusively on
RT   IncHI1B/ IncFIB plasmids in Enterobacteriaceae.";
RL   Submitted (FEB-2019) to the EMBL/GenBank/DDBJ databases.
RN   [21] {ECO:0000313|EMBL:THS93194.1, ECO:0000313|Proteomes:UP000305572}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SIKP198 {ECO:0000313|EMBL:THS93194.1,
RC   ECO:0000313|Proteomes:UP000305572};
RA   Fouts D., Sutton G., Singh I., Nguyen K.;
RL   Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
RN   [22] {ECO:0000313|EMBL:QEX44068.1, ECO:0000313|Proteomes:UP000326156}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KP58 {ECO:0000313|EMBL:QEX44068.1,
RC   ECO:0000313|Proteomes:UP000326156};
RA   Ruan Z., He F.;
RT   "Emergence of a pandrug resistant hypervirulent Klebsiella pneumoniae
RT   isolate in China.";
RL   Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
RN   [23] {ECO:0000313|Proteomes:UP000320855}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=szkp201906 {ECO:0000313|Proteomes:UP000320855};
RA   Shen Z., Gao Q., Li M.;
RT   "Emergence of NDM-5-producing hypervirulent Klebsiella pneumoniae from
RT   clinical infections.";
RL   Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
RN   [24] {ECO:0000313|EMBL:TRW06163.1, ECO:0000313|Proteomes:UP000317393}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SCPM-O-B-8658 {ECO:0000313|EMBL:TRW06163.1}, and SCPM-O-B-8658
RC   (KPB536) {ECO:0000313|Proteomes:UP000317393};
RA   Myakinina V., Fursova N., Volozhantsev N., Sizova A., Kislichkina A.,
RA   Bogun A., Mukhina T., Mayskaya N.;
RL   Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
RN   [25] {ECO:0000313|EMBL:KAA0487369.1, ECO:0000313|Proteomes:UP000323019}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K7 {ECO:0000313|EMBL:KAA0487369.1,
RC   ECO:0000313|Proteomes:UP000323019};
RA   Cho G.-S., Stein M., Fiedler G., Igbinosa E.O., Heuermann L., Brinks E.,
RA   Neve H., Franz C.M.A.P.;
RT   "Characterization of antibiotic-resistant enterobacteria.";
RL   Submitted (AUG-2019) to the EMBL/GenBank/DDBJ databases.
RN   [26] {ECO:0000313|EMBL:TYY86933.1, ECO:0000313|Proteomes:UP000323143}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AS001328 {ECO:0000313|EMBL:TYY86933.1,
RC   ECO:0000313|Proteomes:UP000323143};
RA   Beisken S.;
RT   "Evaluating DNBSEQ for clinical isolate sequencing and identification of
RT   antibiotic resistance.";
RL   Submitted (AUG-2019) to the EMBL/GenBank/DDBJ databases.
RN   [27] {ECO:0000313|EMBL:QFH97206.1, ECO:0000313|Proteomes:UP000325644}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C2 {ECO:0000313|EMBL:QFH97206.1,
RC   ECO:0000313|Proteomes:UP000325644};
RA   Phan H.T.T., Stoesser N., Gordon K.A., Crook D., Walker S.A., Mathers A.J.,
RA   Peto T.E.A., George S., Lipworth S.I.;
RT   "Genomic Dynamics of Species and Mobile Genetic Elements in a Prolonged
RT   blaIMP-4-associated Carbapenemase Outbreak in an Australian Hospital.";
RL   Submitted (AUG-2019) to the EMBL/GenBank/DDBJ databases.
RN   [28] {ECO:0000313|EMBL:TYL78263.1, ECO:0000313|Proteomes:UP000322977}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UCO-494 {ECO:0000313|EMBL:TYL78263.1,
RC   ECO:0000313|Proteomes:UP000322977};
RA   Morales-Leon F., Caro C., Opazo-Capurro A., Lincopan N.,
RA   Dominguez-Yevenes M., Lima C., Bello-Toledo H., Gonzalez-Rocha G.;
RT   "Phenotypic and genetic characterization of extended-spectrum b-lactamase-
RT   producing hypermucoviscous Klebsiella pneumoniae from Chile.";
RL   Submitted (AUG-2019) to the EMBL/GenBank/DDBJ databases.
RN   [29] {ECO:0000313|EMBL:QER82123.1, ECO:0000313|Proteomes:UP000323986}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=D1 {ECO:0000313|EMBL:QER82123.1,
RC   ECO:0000313|Proteomes:UP000323986};
RA   Jousset A.B., Bonnin R.A., Takissian J., Glaser P., Dortet L., Naas T.;
RT   "Concomitant carriage of KPC-producing and non-KPC-producing Klebsiella
RT   pneumoniae ST512 due to in vivo lost of pKPC.";
RL   Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
RN   [30] {ECO:0000313|EMBL:QEO72445.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=RJY9645 {ECO:0000313|EMBL:QEO72445.1};
RA   Shen Z., Gao Q., Li M.;
RT   "Emergence of NDM-5-producing hypervirulent Klebsiella pneumoniae from
RT   clinical infections.";
RL   Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
RN   [31] {ECO:0000313|Proteomes:UP000322263, ECO:0000313|Proteomes:UP000324565, ECO:0000313|Proteomes:UP000324621}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FDAARGOS_629 {ECO:0000313|EMBL:QET17900.1,
RC   ECO:0000313|Proteomes:UP000322263}, FDAARGOS_630
RC   {ECO:0000313|EMBL:QET09822.1, ECO:0000313|Proteomes:UP000324621}, and
RC   FDAARGOS_631 {ECO:0000313|EMBL:QET12613.1,
RC   ECO:0000313|Proteomes:UP000324565};
RA   Bachman M., Young C., Tallon L., Sadzewicz L., Vavikolanu K., Mehta A.,
RA   Aluvathingal J., Nadendla S., Nandy P., Geyer C., Yan Y., Sichtig H.;
RT   "FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS):
RT   Supporting development and validation of Infectious Disease Dx tests.";
RL   Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
RN   [32] {ECO:0000313|Proteomes:UP000322675, ECO:0000313|Proteomes:UP000322831}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=P12 {ECO:0000313|Proteomes:UP000322675}, and P23
RC   {ECO:0000313|Proteomes:UP000322831};
RA   Zhang X.;
RT   "Genome of bacteria.";
RL   Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
RN   [33] {ECO:0000313|EMBL:QEW93547.1, ECO:0000313|Proteomes:UP000326210}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KP65 {ECO:0000313|EMBL:QEW93547.1,
RC   ECO:0000313|Proteomes:UP000326210};
RA   He F.;
RT   "Genome sequence of Klebsiella pneumoniae KP65.";
RL   Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
RN   [34] {ECO:0000313|EMBL:QER48071.1, ECO:0000313|Proteomes:UP000324100}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=555 {ECO:0000313|EMBL:QER48071.1,
RC   ECO:0000313|Proteomes:UP000324100};
RA   Rong X.;
RT   "Klebsiella pneumoniae 555 carrying blaNDM-5 gene isolated from chicken
RT   farms in China.";
RL   Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
RN   [35] {ECO:0000313|EMBL:KAA1502218.1, ECO:0000313|Proteomes:UP000322821}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=195D9 {ECO:0000313|EMBL:KAA1502218.1,
RC   ECO:0000313|Proteomes:UP000322821};
RA   Bonnin R.A., Jousset A.B., Chiarelli A., Emeraud C., Glaser P., Naas T.,
RA   Dortet L.;
RT   "Unexpected genetic diversity among KPC-producing Klebsiella in France.";
RL   Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
RN   [36] {ECO:0000313|EMBL:KAA5734373.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=P12 {ECO:0000313|EMBL:KAA5741965.1}, and P23
RC   {ECO:0000313|EMBL:KAA5734373.1};
RA   Zhang X.;
RL   Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
RN   [37] {ECO:0000313|EMBL:QGA04824.1, ECO:0000313|Proteomes:UP000325646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SMU18037509 {ECO:0000313|EMBL:QGA04824.1,
RC   ECO:0000313|Proteomes:UP000325646};
RA   Imai K.;
RT   "A Case with Community-Acquired Emphysematous Osteomyelitis Caused by
RT   Serotype K2 - ST25 Klebsiella pneumoniae, Japan.";
RL   Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes cross-linking of the peptidoglycan cell wall at the
CC       division septum. {ECO:0000256|HAMAP-Rule:MF_02080}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Preferential cleavage: (Ac)(2)-L-Lys-D-Ala-|-D-Ala. Also
CC         transpeptidation of peptidyl-alanyl moieties that are N-acyl
CC         substituents of D-alanine.; EC=3.4.16.4; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_02080};
CC   -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC       {ECO:0000256|HAMAP-Rule:MF_02080}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000256|HAMAP-
CC       Rule:MF_02080}; Single-pass membrane protein {ECO:0000256|HAMAP-
CC       Rule:MF_02080}.
CC   -!- SIMILARITY: Belongs to the transpeptidase family. FtsI subfamily.
CC       {ECO:0000256|HAMAP-Rule:MF_02080}.
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DR   EMBL; CP026392; AUY19176.1; -; Genomic_DNA.
DR   EMBL; VTUL01000004; KAA0487369.1; -; Genomic_DNA.
DR   EMBL; VUBL01000023; KAA1502218.1; -; Genomic_DNA.
DR   EMBL; VWRA01000013; KAA5734373.1; -; Genomic_DNA.
DR   EMBL; VWRE01000014; KAA5741965.1; -; Genomic_DNA.
DR   EMBL; LEUQ01000007; KLY18083.1; -; Genomic_DNA.
DR   EMBL; PYBH01000010; PWF58468.1; -; Genomic_DNA.
DR   EMBL; CP041353; QEO72445.1; -; Genomic_DNA.
DR   EMBL; CP043932; QER48071.1; -; Genomic_DNA.
DR   EMBL; CP043969; QER82123.1; -; Genomic_DNA.
DR   EMBL; CP044039; QET09822.1; -; Genomic_DNA.
DR   EMBL; CP044033; QET12613.1; -; Genomic_DNA.
DR   EMBL; CP044047; QET17900.1; -; Genomic_DNA.
DR   EMBL; CP044258; QEW93547.1; -; Genomic_DNA.
DR   EMBL; CP041373; QEX44068.1; -; Genomic_DNA.
DR   EMBL; CP042520; QFH97206.1; -; Genomic_DNA.
DR   EMBL; CP035194; QFU51132.1; -; Genomic_DNA.
DR   EMBL; CP035202; QFU59829.1; -; Genomic_DNA.
DR   EMBL; CP035210; QFU71184.1; -; Genomic_DNA.
DR   EMBL; CP026017; QFY30025.1; -; Genomic_DNA.
DR   EMBL; CP026023; QFY35629.1; -; Genomic_DNA.
DR   EMBL; CP045661; QGA04824.1; -; Genomic_DNA.
DR   EMBL; QORQ01000079; RCI99793.1; -; Genomic_DNA.
DR   EMBL; QOUG01000039; RCK03275.1; -; Genomic_DNA.
DR   EMBL; MPYG04000224; ROG87213.1; -; Genomic_DNA.
DR   EMBL; PTFF02000003; ROG94407.1; -; Genomic_DNA.
DR   EMBL; RDAM01000001; RRF08000.1; -; Genomic_DNA.
DR   EMBL; QFMH01000017; RXY88201.1; -; Genomic_DNA.
DR   EMBL; QFMF01000002; RXZ12446.1; -; Genomic_DNA.
DR   EMBL; SGOL01000011; RZG36124.1; -; Genomic_DNA.
DR   EMBL; UAWQ01000019; SQC48283.1; -; Genomic_DNA.
DR   EMBL; UFBE01000007; SSF40530.1; -; Genomic_DNA.
DR   EMBL; UFEU01000009; SSK45838.1; -; Genomic_DNA.
DR   EMBL; UGLB01000003; STT50626.1; -; Genomic_DNA.
DR   EMBL; UGLC01000002; STT52506.1; -; Genomic_DNA.
DR   EMBL; UGLI01000001; STT64965.1; -; Genomic_DNA.
DR   EMBL; UGLJ01000002; STT94424.1; -; Genomic_DNA.
DR   EMBL; UGLQ01000003; STU32598.1; -; Genomic_DNA.
DR   EMBL; UGMN01000004; STV35655.1; -; Genomic_DNA.
DR   EMBL; UGMG01000001; STV70103.1; -; Genomic_DNA.
DR   EMBL; POWO01000503; TAI74042.1; -; Genomic_DNA.
DR   EMBL; MWQX01000001; TEB03799.1; -; Genomic_DNA.
DR   EMBL; STEC01000003; THS93194.1; -; Genomic_DNA.
DR   EMBL; VKCR01000013; TRW06163.1; -; Genomic_DNA.
DR   EMBL; VSSY01000011; TYL78263.1; -; Genomic_DNA.
DR   EMBL; SUOY02000004; TYY86933.1; -; Genomic_DNA.
DR   EMBL; UNZU01000006; VAP05229.1; -; Genomic_DNA.
DR   EMBL; UWXT01000001; VCZ39830.1; -; Genomic_DNA.
DR   EMBL; LR134162; VEB05243.1; -; Genomic_DNA.
DR   EMBL; UKJU02000006; VVK66521.1; -; Genomic_DNA.
DR   RefSeq; WP_002888559.1; NZ_WHSH01000003.1.
DR   EnsemblBacteria; AIT01861; AIT01861; PMK1_02396.
DR   EnsemblBacteria; ALR24543; ALR24543; AGG09_09880.
DR   EnsemblBacteria; KLY18083; KLY18083; SK89_01947.
DR   EnsemblBacteria; ODN12518; ODN12518; BCB67_07340.
DR   EnsemblBacteria; SBZ45450; SBZ45450; SAMEA3531778_04411.
DR   KEGG; kpb:FH42_21260; -.
DR   KEGG; kpne:KU54_022460; -.
DR   KEGG; kpnu:LI86_22300; -.
DR   KEGG; kpx:PMK1_02396; -.
DR   PATRIC; fig|571.67.peg.2011; -.
DR   KO; K03587; -.
DR   OrthoDB; 213680at2; -.
DR   UniPathway; UPA00219; -.
DR   Proteomes; UP000035995; Unassembled WGS sequence.
DR   Proteomes; UP000239813; Chromosome.
DR   Proteomes; UP000245017; Unassembled WGS sequence.
DR   Proteomes; UP000251721; Unassembled WGS sequence.
DR   Proteomes; UP000252552; Unassembled WGS sequence.
DR   Proteomes; UP000252603; Unassembled WGS sequence.
DR   Proteomes; UP000253217; Unassembled WGS sequence.
DR   Proteomes; UP000253632; Unassembled WGS sequence.
DR   Proteomes; UP000254103; Unassembled WGS sequence.
DR   Proteomes; UP000254387; Unassembled WGS sequence.
DR   Proteomes; UP000254753; Unassembled WGS sequence.
DR   Proteomes; UP000254799; Unassembled WGS sequence.
DR   Proteomes; UP000255099; Unassembled WGS sequence.
DR   Proteomes; UP000255137; Unassembled WGS sequence.
DR   Proteomes; UP000255239; Unassembled WGS sequence.
DR   Proteomes; UP000259433; Unassembled WGS sequence.
DR   Proteomes; UP000269373; Unassembled WGS sequence.
DR   Proteomes; UP000275975; Unassembled WGS sequence.
DR   Proteomes; UP000282433; Chromosome 1.
DR   Proteomes; UP000283322; Unassembled WGS sequence.
DR   Proteomes; UP000286610; Unassembled WGS sequence.
DR   Proteomes; UP000289252; Unassembled WGS sequence.
DR   Proteomes; UP000290276; Unassembled WGS sequence.
DR   Proteomes; UP000292131; Unassembled WGS sequence.
DR   Proteomes; UP000293472; Unassembled WGS sequence.
DR   Proteomes; UP000297943; Unassembled WGS sequence.
DR   Proteomes; UP000305572; Unassembled WGS sequence.
DR   Proteomes; UP000317393; Unassembled WGS sequence.
DR   Proteomes; UP000320855; Chromosome.
DR   Proteomes; UP000322263; Chromosome.
DR   Proteomes; UP000322675; Unassembled WGS sequence.
DR   Proteomes; UP000322821; Unassembled WGS sequence.
DR   Proteomes; UP000322831; Unassembled WGS sequence.
DR   Proteomes; UP000322977; Unassembled WGS sequence.
DR   Proteomes; UP000323019; Unassembled WGS sequence.
DR   Proteomes; UP000323143; Unassembled WGS sequence.
DR   Proteomes; UP000323986; Chromosome.
DR   Proteomes; UP000324100; Chromosome.
DR   Proteomes; UP000324565; Chromosome 1.
DR   Proteomes; UP000324621; Chromosome.
DR   Proteomes; UP000325416; Chromosome.
DR   Proteomes; UP000325644; Chromosome.
DR   Proteomes; UP000325646; Chromosome.
DR   Proteomes; UP000325692; Chromosome.
DR   Proteomes; UP000326098; Chromosome.
DR   Proteomes; UP000326148; Chromosome.
DR   Proteomes; UP000326156; Chromosome.
DR   Proteomes; UP000326210; Chromosome.
DR   Proteomes; UP000326261; Unassembled WGS sequence.
DR   Proteomes; UP000326754; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:InterPro.
DR   GO; GO:0009002; F:serine-type D-Ala-D-Ala carboxypeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR   GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR   GO; GO:0043093; P:FtsZ-dependent cytokinesis; IEA:UniProtKB-UniRule.
DR   GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.710.10; -; 1.
DR   HAMAP; MF_02080; FtsI_transpept; 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR037532; FtsI_transpept.
DR   InterPro; IPR005311; PBP_dimer.
DR   InterPro; IPR036138; PBP_dimer_sf.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   Pfam; PF03717; PBP_dimer; 1.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SUPFAM; SSF56519; SSF56519; 1.
DR   SUPFAM; SSF56601; SSF56601; 1.
PE   3: Inferred from homology;
KW   Carboxypeptidase {ECO:0000256|HAMAP-Rule:MF_02080,
KW   ECO:0000313|EMBL:QGA04824.1}; Cell cycle {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Cell division {ECO:0000256|HAMAP-Rule:MF_02080,
KW   ECO:0000313|EMBL:SQC48283.1};
KW   Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Cell membrane {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Cell shape {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Cell wall biogenesis/degradation {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Glycosyltransferase {ECO:0000313|EMBL:SQC48283.1};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_02080, ECO:0000313|EMBL:QGA04824.1};
KW   Membrane {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Peptidoglycan synthesis {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Protease {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Septation {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Transferase {ECO:0000313|EMBL:AUY19176.1};
KW   Transmembrane {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_02080}.
FT   TRANSMEM        20..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_02080"
FT   DOMAIN          70..220
FT                   /note="PBP_dimer"
FT                   /evidence="ECO:0000259|Pfam:PF03717"
FT   DOMAIN          260..554
FT                   /note="Transpeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF00905"
FT   ACT_SITE        307
FT                   /note="Acyl-ester intermediate"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_02080"
SQ   SEQUENCE   588 AA;  64003 MW;  2FE4408506D51A55 CRC64;
     MKAAPKTPKA KRQEEQANFI SWRFALLCGC ILLALAFLLG RVAWLQVISP DMLVRQGDMR
     SLRVQEVSTA RGMITDRSGR PLAVSVPVKA IWADPKELHD AGGVTLDTRW KALADALNMP
     LDQLATRINT NPRMRFIYLA RQVNPDMADY IKKLKLPGIH LREESRRYYP SGEVTAHLIG
     FTNVDSQGIE GVEKSFDKWL TGQPGERIVR KDRYGRVIED ISSTDSQAAH NLALSIDERL
     QALVYRELNN AVAFNKAESG SAVLVDVNTG EVLAMANSPS YNPNNFAGTA KDTMRNRAIT
     DVFEPGSTVK PMVVMTALQR GIVNENTVLN TVPYRINGHE IKDVARYSEL TLTGVLQKSS
     NVGVSKLALA MPSSALVDTY SRFGLGKATN LGLVGERSGL YPQKQRWSDI ERATFSFGYG
     LMVTPLQLAR VYATIGSYGI YRPLSITKVD PPVPGERVFP ESLVRTVVHM MESVALPGGG
     GVKAAIKGYR IAIKTGTAKK VGPDGRYINK YIAYTAGVAP ASHPRFALVV VINDPQAGKY
     YGGAVSAPVF GAIMGGVLRT MNIEPDALAT GEKSEFVINQ GEGTGGRS
//