ID   A0A0W8AVJ6_KLEPN        Unreviewed;       588 AA.
AC   A0A0W8AVJ6; A0A0J2GHB5;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   31-JUL-2019, entry version 37.
DE   RecName: Full=Peptidoglycan D,D-transpeptidase FtsI {ECO:0000256|HAMAP-Rule:MF_02080};
DE            EC=3.4.16.4 {ECO:0000256|HAMAP-Rule:MF_02080};
DE   AltName: Full=Penicillin-binding protein 3 {ECO:0000256|HAMAP-Rule:MF_02080};
DE            Short=PBP-3 {ECO:0000256|HAMAP-Rule:MF_02080};
GN   Name=ftsI_1 {ECO:0000313|EMBL:AIT01861.1};
GN   Synonyms=ftsI {ECO:0000256|HAMAP-Rule:MF_02080,
GN   ECO:0000313|EMBL:RJS98758.1}, ftsI_3 {ECO:0000313|EMBL:SSW76823.1},
GN   ftsI_4 {ECO:0000313|EMBL:SQC48283.1}, ftsI_5
GN   {ECO:0000313|EMBL:STU32598.1}, ftsI_7 {ECO:0000313|EMBL:STV70103.1};
GN   ORFNames=BANRA_04461 {ECO:0000313|EMBL:VCZ83850.1}, BL124_00027960
GN   {ECO:0000313|EMBL:ROG87213.1}, C1459_30435
GN   {ECO:0000313|EMBL:TAI74042.1}, C3483_22070
GN   {ECO:0000313|EMBL:AVB73872.1}, C3F39_10515
GN   {ECO:0000313|EMBL:AUY19176.1}, C4Y50_000535
GN   {ECO:0000313|EMBL:ROG94407.1}, C7V41_14790
GN   {ECO:0000313|EMBL:PWF58468.1}, CK508_015405
GN   {ECO:0000313|EMBL:RJS98758.1}, CSC88_14290
GN   {ECO:0000313|EMBL:PPK23259.1}, DD581_05120
GN   {ECO:0000313|EMBL:RXY88201.1}, DD583_03315
GN   {ECO:0000313|EMBL:RXZ12446.1}, DM059_00690
GN   {ECO:0000313|EMBL:RCK03275.1}, DM062_00760
GN   {ECO:0000313|EMBL:RCI99793.1}, DXF97_05380
GN   {ECO:0000313|EMBL:RDT68909.1}, E0760_01080
GN   {ECO:0000313|EMBL:TCZ86898.1}, E1814_01105
GN   {ECO:0000313|EMBL:TDK07127.1}, EAO17_18230
GN   {ECO:0000313|EMBL:RRF08000.1}, EXT45_14640
GN   {ECO:0000313|EMBL:RZG36124.1}, NCTC11679_04757
GN   {ECO:0000313|EMBL:STV70103.1}, NCTC13465_04475
GN   {ECO:0000313|EMBL:SQC48283.1}, NCTC13635_05081
GN   {ECO:0000313|EMBL:VEB05243.1}, NCTC1936_01053
GN   {ECO:0000313|EMBL:STT64965.1}, NCTC5052_02861
GN   {ECO:0000313|EMBL:STT94424.1}, NCTC5053_04312
GN   {ECO:0000313|EMBL:STV35655.1}, NCTC8849_01042
GN   {ECO:0000313|EMBL:STT52506.1}, NCTC9637_05624
GN   {ECO:0000313|EMBL:STT50626.1}, NCTC9661_05284
GN   {ECO:0000313|EMBL:STU32598.1}, PMK1_02396
GN   {ECO:0000313|EMBL:AIT01861.1}, SAMEA104305404_02889
GN   {ECO:0000313|EMBL:SSW76823.1}, SAMEA104567780_03606
GN   {ECO:0000313|EMBL:VGC89642.1}, SAMEA104567818_03247
GN   {ECO:0000313|EMBL:VGD77512.1}, SAMEA23986918_05501
GN   {ECO:0000313|EMBL:SSG22791.1}, SAMEA24002668_02916
GN   {ECO:0000313|EMBL:SSF40530.1}, SAMEA4364603_03511
GN   {ECO:0000313|EMBL:SSK45838.1}, SAMEA4394730_05373
GN   {ECO:0000313|EMBL:SVJ50221.1}, SAMEA4873587_03067
GN   {ECO:0000313|EMBL:VGI77433.1}, SK89_01947
GN   {ECO:0000313|EMBL:KLY18083.1};
OS   Klebsiella pneumoniae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella.
OX   NCBI_TaxID=573 {ECO:0000313|EMBL:AIT01861.1, ECO:0000313|Proteomes:UP000029666};
RN   [1] {ECO:0000313|EMBL:AIT01861.1, ECO:0000313|Proteomes:UP000029666}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PMK1 {ECO:0000313|EMBL:AIT01861.1,
RC   ECO:0000313|Proteomes:UP000029666};
RX   PubMed=25267672;
RA   Stoesser N., Giess A., Batty E.M., Sheppard A.E., Walker A.S.,
RA   Wilson D.J., Didelot X., Bashir A., Sebra R., Kasarskis A.,
RA   Sthapit B., Shakya M., Kelly D., Pollard A.J., Peto T.E., Crook D.W.,
RA   Donnelly P., Thorson S., Amatya P., Joshi S.;
RT   "Genome Sequencing of an Extended Series of NDM-Producing Klebsiella
RT   pneumoniae Isolates from Neonatal Infections in a Nepali Hospital
RT   Characterizes the Extent of Community- versus Hospital-Associated
RT   Transmission in an Endemic Setting.";
RL   Antimicrob. Agents Chemother. 58:7347-7357(2014).
RN   [2] {ECO:0000313|EMBL:KLY18083.1, ECO:0000313|Proteomes:UP000035995}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CHS153 {ECO:0000313|EMBL:KLY18083.1,
RC   ECO:0000313|Proteomes:UP000035995};
RG   The Broad Institute Genomics Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Earl A.M., Onderdonk A.B., Kirby J., Ferraro M.J., Huang S.,
RA   Spencer M., Fodor A., Hooper D., Dekker J., O'Brien T., Quan V.,
RA   Gombosev A., Delaney M., DuBois A., Ernst C., Kim D.S., Rossman W.,
RA   Gohs F., Petruso H., Nozar T., Mougeot F., Manson-McGuire A.,
RA   Young S., Abouelleil A., Cao P., Chapman S.B., Griggs A., Priest M.,
RA   Shea T., Wortman I., Wortman J.R., Nusbaum C., Birren B.;
RT   "The Genome Sequence of None.";
RL   Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:RRF08000.1, ECO:0000313|Proteomes:UP000275975}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KLPN_104 {ECO:0000313|EMBL:RRF08000.1,
RC   ECO:0000313|Proteomes:UP000275975};
RX   PubMed=30373801;
RA   Tamma P.D., Fan Y., Bergman Y., Pertea G., Kazmi A., Lewis S.,
RA   Carroll K.C., Schatz M.C., Timp W., Simner P.J.;
RT   "Applying Rapid Whole Genome Sequencing to Predict Phenotypic
RT   Antimicrobial Susceptibility Testing Results Among Carbapenem-
RT   Resistant Klebsiella pneumoniae Clinical Isolates.";
RL   Antimicrob. Agents Chemother. 0:0-0(2018).
RN   [4] {ECO:0000313|EMBL:PPK23259.1, ECO:0000313|Proteomes:UP000238271}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PN030E4 {ECO:0000313|EMBL:PPK23259.1,
RC   ECO:0000313|Proteomes:UP000238271};
RX   PubMed=29479347; DOI=10.3389/fmicb.2018.00188;
RA   Founou L.L., Founou R.C., Allam M., Ismail A., Djoko C.F.,
RA   Essack S.Y.;
RT   "Genome Sequencing of Extended-Spectrum ?-Lactamase (ESBL)-Producing
RT   Klebsiella pneumoniae Isolated from Pigs and Abattoir Workers in
RT   Cameroon.";
RL   Front. Microbiol. 9:188-188(2018).
RN   [5] {ECO:0000313|Proteomes:UP000239813}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KPNIH48 {ECO:0000313|Proteomes:UP000239813};
RX   PubMed=29437920;
RG   NISC Comparative Sequencing Program;
RA   Weingarten R.A., Johnson R.C., Conlan S., Ramsburg A.M., Dekker J.P.,
RA   Lau A.F., Khil P., Odom R.T., Deming C., Park M., Thomas P.J.,
RA   Henderson D.K., Palmore T.N., Segre J.A., Frank K.M.;
RT   "Genomic Analysis of Hospital Plumbing Reveals Diverse Reservoir of
RT   Bacterial Plasmids Conferring Carbapenem Resistance.";
RL   MBio 9:e02011-17(2018).
RN   [6] {ECO:0000313|EMBL:AUY19176.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KPNIH48 {ECO:0000313|EMBL:AUY19176.1};
RA   Weingarten R.A., Johnson R.C., Conlan S., Ramsburg A.M., Dekker J.P.,
RA   Lau A.F., Khil P., Odom R.T., Deming C., Park M., Thomas P.J.,
RA   Henderson D.K., Palmore T.N., Segre J.A., Frank K.M.;
RT   "Genomic Analysis of Hospital Plumbing Reveals Diverse Reservoir of
RT   Bacterial Plasmids Conferring Carbapenem Resistance.";
RL   MBio 0:0-0(2018).
RN   [7] {ECO:0000313|EMBL:TAI74042.1, ECO:0000313|Proteomes:UP000292131}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=G702R2B5 {ECO:0000313|EMBL:TAI74042.1,
RC   ECO:0000313|Proteomes:UP000292131};
RA   Allam M.;
RT   "Whole Genome Sequencing of Extended Spectrum-Beta-lactamases
RT   producing Klebsiella pneumoniae: Clonal spread of lineage ST 152.";
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [8] {ECO:0000313|EMBL:AVB73872.1, ECO:0000313|Proteomes:UP000238332}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NUHL30457 {ECO:0000313|EMBL:AVB73872.1,
RC   ECO:0000313|Proteomes:UP000238332};
RA   Liu Y.;
RT   "Genome of Klebsiella pneumoniae NUHL3069.";
RL   Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
RN   [9] {ECO:0000313|EMBL:PWF58468.1, ECO:0000313|Proteomes:UP000245017}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KPL0.2 {ECO:0000313|EMBL:PWF58468.1,
RC   ECO:0000313|Proteomes:UP000245017};
RA   Le Guern R., Grandjean T., Bauduin M., Loquet A., Faure K., Kipnis E.,
RA   Dessein R.;
RT   "A murine model of gut colonization with Klebsiella pneumoniae NDM.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [10] {ECO:0000313|EMBL:RXY88201.1, ECO:0000313|Proteomes:UP000289252, ECO:0000313|Proteomes:UP000290276}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3DZ2-3B {ECO:0000313|EMBL:RXY88201.1,
RC   ECO:0000313|Proteomes:UP000290276}, and 775-DZ2-4B
RC   {ECO:0000313|EMBL:RXZ12446.1, ECO:0000313|Proteomes:UP000289252};
RA   Zhang R., Li J., Wang Y., Shen J., Shen Z., Wang S.;
RT   "The molecular epidemiology of the NDM positive non-E. coli
RT   Enterobacteriaceae in poultry production environment.";
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN   [11] {ECO:0000313|Proteomes:UP000251721, ECO:0000313|Proteomes:UP000254103, ECO:0000313|Proteomes:UP000254387}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC11679 {ECO:0000313|EMBL:STV70103.1,
RC   ECO:0000313|Proteomes:UP000255239}, NCTC13465
RC   {ECO:0000313|EMBL:SQC48283.1, ECO:0000313|Proteomes:UP000251721},
RC   NCTC1936 {ECO:0000313|EMBL:STT64965.1,
RC   ECO:0000313|Proteomes:UP000254753}, NCTC5052
RC   {ECO:0000313|EMBL:STT94424.1, ECO:0000313|Proteomes:UP000254103},
RC   NCTC5053 {ECO:0000313|EMBL:STV35655.1,
RC   ECO:0000313|Proteomes:UP000254387}, NCTC8849
RC   {ECO:0000313|EMBL:STT52506.1, ECO:0000313|Proteomes:UP000254799},
RC   NCTC9637 {ECO:0000313|EMBL:STT50626.1,
RC   ECO:0000313|Proteomes:UP000255099}, and NCTC9661
RC   {ECO:0000313|EMBL:STU32598.1, ECO:0000313|Proteomes:UP000255137};
RG   Pathogen Informatics;
RA   Doyle S.;
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [12] {ECO:0000313|EMBL:RCI99793.1, ECO:0000313|Proteomes:UP000252552, ECO:0000313|Proteomes:UP000253217}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BC_4223 {ECO:0000313|EMBL:RCK03275.1,
RC   ECO:0000313|Proteomes:UP000253217}, and BC_4553
RC   {ECO:0000313|EMBL:RCI99793.1, ECO:0000313|Proteomes:UP000252552};
RA   Martins R.C.R., Perdigao-Neto L.V., Costa S.F., Levin A.S.S.;
RT   "Klebsiella pneumoniae genome sequencing and assembly.";
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN   [13] {ECO:0000313|EMBL:RDT68909.1, ECO:0000313|Proteomes:UP000255489}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1-RC-17-04409-2 {ECO:0000313|EMBL:RDT68909.1,
RC   ECO:0000313|Proteomes:UP000255489};
RA   Doi Y.;
RT   "The use of a cohorting ward and systematic surveillance cultures for
RT   the control of a Klebsiella pneumoniae carbapenemase (KPC)-producing
RT   Enterobacteriaceae outbreak.";
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN   [14] {ECO:0000313|EMBL:RCI99793.1, ECO:0000313|Proteomes:UP000252552, ECO:0000313|Proteomes:UP000253217}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BC_4223 {ECO:0000313|EMBL:RCK03275.1,
RC   ECO:0000313|Proteomes:UP000253217}, and BC_4553
RC   {ECO:0000313|EMBL:RCI99793.1, ECO:0000313|Proteomes:UP000252552};
RA   Quirk P.G., Krulwich T.A.;
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN   [15] {ECO:0000313|Proteomes:UP000252603, ECO:0000313|Proteomes:UP000253632, ECO:0000313|Proteomes:UP000258067}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=4300STDY6470422 {ECO:0000313|EMBL:SSK45838.1,
RC   ECO:0000313|Proteomes:UP000252603}, 4300STDY6542360
RC   {ECO:0000313|EMBL:SVJ50221.1, ECO:0000313|Proteomes:UP000258067},
RC   4300STDY6636938 {ECO:0000313|EMBL:SSG22791.1,
RC   ECO:0000313|Proteomes:UP000262540}, 4300STDY6636959
RC   {ECO:0000313|EMBL:SSF40530.1, ECO:0000313|Proteomes:UP000253632},
RC   4300STDY7045912 {ECO:0000313|EMBL:SSW76823.1}, 5012STDY7312565
RC   {ECO:0000313|EMBL:VGC89642.1, ECO:0000313|Proteomes:UP000295619},
RC   5012STDY7312603 {ECO:0000313|EMBL:VGD77512.1,
RC   ECO:0000313|Proteomes:UP000295037}, 5012STDY7626386
RC   {ECO:0000313|EMBL:VGI77433.1, ECO:0000313|Proteomes:UP000294936}, and
RC   NCTC13635 {ECO:0000313|EMBL:VEB05243.1,
RC   ECO:0000313|Proteomes:UP000282433};
RG   Pathogen Informatics;
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN   [16] {ECO:0000313|EMBL:RJS98758.1, ECO:0000313|Proteomes:UP000218552}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B35 {ECO:0000313|EMBL:RJS98758.1,
RC   ECO:0000313|Proteomes:UP000218552};
RA   Araujo B.F., Campos P.A., Royer S., Ferreira M.L., Goncalves I.R.,
RA   Batistao D.W.F., Cerdeira L.T., Brito C.S., Gontijo-Filho P.,
RA   Ribas R.M.;
RT   "Klebsiella pneumoniae KPC-2-producing B35 strain.";
RL   Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
RN   [17] {ECO:0000313|EMBL:ROG94407.1, ECO:0000313|Proteomes:UP000286610}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CRK0390 {ECO:0000313|EMBL:ROG94407.1,
RC   ECO:0000313|Proteomes:UP000286610};
RA   Vanduin D., Fouts D., Sutton G., Nguyen K., Hujer A., Hujer K.,
RA   Bonomo R.;
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN   [18] {ECO:0000313|EMBL:ROG87213.1, ECO:0000313|Proteomes:UP000283322}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CRK0165 {ECO:0000313|EMBL:ROG87213.1,
RC   ECO:0000313|Proteomes:UP000283322};
RA   Vanduin D., Fouts D., Wright M., Sutton G., Nguyen K., Kreiswirth B.,
RA   Chen L., Rojas L., Hujer A., Hujer K., Bonomo R., Adams M.;
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN   [19] {ECO:0000313|EMBL:VCZ83850.1, ECO:0000313|Proteomes:UP000276286}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Kpneu043 {ECO:0000313|EMBL:VCZ83850.1};
RA   Noll B N.;
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN   [20] {ECO:0000313|EMBL:RZG36124.1, ECO:0000313|Proteomes:UP000293472}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=53 {ECO:0000313|EMBL:RZG36124.1,
RC   ECO:0000313|Proteomes:UP000293472};
RA   Newire E., Aydin A., Juma S., Enne V., Roberts A.P.;
RT   "Identification of a Type IV CRISPR-Cas system located exclusively on
RT   IncHI1B/ IncFIB plasmids in Enterobacteriaceae.";
RL   Submitted (FEB-2019) to the EMBL/GenBank/DDBJ databases.
RN   [21] {ECO:0000313|EMBL:TDK07127.1, ECO:0000313|Proteomes:UP000294951}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RJ1071 {ECO:0000313|EMBL:TDK07127.1,
RC   ECO:0000313|Proteomes:UP000294951};
RA   Wang S.;
RT   "Multidrug-Resistant Klebsiella pneumoniae Clinical Bloodstream
RT   Isolates in Shanghai, China.";
RL   Submitted (MAR-2019) to the EMBL/GenBank/DDBJ databases.
RN   [22] {ECO:0000313|EMBL:TCZ86898.1, ECO:0000313|Proteomes:UP000294891}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Y17 tetA {ECO:0000313|EMBL:TCZ86898.1,
RC   ECO:0000313|Proteomes:UP000294891};
RA   Sun Q., Wang Y., Dong N., Shen L., Zhou H., Hu Y., Gu D., Chen S.,
RA   Zhang R., Ji Q.;
RT   "The application of CRISPR/Cas9-based genome editing in studying the
RT   mechanism of pandrug resistance in Klebsiella pneumoniae.";
RL   Submitted (MAR-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes cross-linking of the peptidoglycan cell wall
CC       at the division septum. {ECO:0000256|HAMAP-Rule:MF_02080}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Preferential cleavage: (Ac)(2)-L-Lys-D-Ala-|-D-Ala. Also
CC         transpeptidation of peptidyl-alanyl moieties that are N-acyl
CC         substituents of D-alanine.; EC=3.4.16.4;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_02080};
CC   -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC       {ECO:0000256|HAMAP-Rule:MF_02080}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000256|HAMAP-
CC       Rule:MF_02080}; Single-pass membrane protein {ECO:0000256|HAMAP-
CC       Rule:MF_02080}.
CC   -!- SIMILARITY: Belongs to the transpeptidase family. FtsI subfamily.
CC       {ECO:0000256|HAMAP-Rule:MF_02080}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP008929; AIT01861.1; -; Genomic_DNA.
DR   EMBL; CP026392; AUY19176.1; -; Genomic_DNA.
DR   EMBL; CP026586; AVB73872.1; -; Genomic_DNA.
DR   EMBL; LEUQ01000007; KLY18083.1; -; Genomic_DNA.
DR   EMBL; PDVM01000046; PPK23259.1; -; Genomic_DNA.
DR   EMBL; PYBH01000010; PWF58468.1; -; Genomic_DNA.
DR   EMBL; QORQ01000079; RCI99793.1; -; Genomic_DNA.
DR   EMBL; QOUG01000039; RCK03275.1; -; Genomic_DNA.
DR   EMBL; QRBO01000007; RDT68909.1; -; Genomic_DNA.
DR   EMBL; NTHY02000043; RJS98758.1; -; Genomic_DNA.
DR   EMBL; MPYG04000224; ROG87213.1; -; Genomic_DNA.
DR   EMBL; PTFF02000003; ROG94407.1; -; Genomic_DNA.
DR   EMBL; RDAM01000001; RRF08000.1; -; Genomic_DNA.
DR   EMBL; QFMH01000017; RXY88201.1; -; Genomic_DNA.
DR   EMBL; QFMF01000002; RXZ12446.1; -; Genomic_DNA.
DR   EMBL; SGOL01000011; RZG36124.1; -; Genomic_DNA.
DR   EMBL; UAWQ01000019; SQC48283.1; -; Genomic_DNA.
DR   EMBL; UFBE01000007; SSF40530.1; -; Genomic_DNA.
DR   EMBL; UFBK01000018; SSG22791.1; -; Genomic_DNA.
DR   EMBL; UFEU01000009; SSK45838.1; -; Genomic_DNA.
DR   EMBL; UFQE01000045; SSW76823.1; -; Genomic_DNA.
DR   EMBL; UGLB01000003; STT50626.1; -; Genomic_DNA.
DR   EMBL; UGLC01000002; STT52506.1; -; Genomic_DNA.
DR   EMBL; UGLI01000001; STT64965.1; -; Genomic_DNA.
DR   EMBL; UGLJ01000002; STT94424.1; -; Genomic_DNA.
DR   EMBL; UGLQ01000003; STU32598.1; -; Genomic_DNA.
DR   EMBL; UGMN01000004; STV35655.1; -; Genomic_DNA.
DR   EMBL; UGMG01000001; STV70103.1; -; Genomic_DNA.
DR   EMBL; UIRA01000014; SVJ50221.1; -; Genomic_DNA.
DR   EMBL; POWO01000503; TAI74042.1; -; Genomic_DNA.
DR   EMBL; SKFD01000001; TCZ86898.1; -; Genomic_DNA.
DR   EMBL; SMTN01000001; TDK07127.1; -; Genomic_DNA.
DR   EMBL; UWYB01000001; VCZ83850.1; -; Genomic_DNA.
DR   EMBL; LR134162; VEB05243.1; -; Genomic_DNA.
DR   EMBL; CAAGVV010000008; VGC89642.1; -; Genomic_DNA.
DR   EMBL; CAAGWQ010000008; VGD77512.1; -; Genomic_DNA.
DR   EMBL; CAAHAK010000005; VGI77433.1; -; Genomic_DNA.
DR   RefSeq; WP_002888559.1; NZ_UWZM01000001.1.
DR   EnsemblBacteria; AIT01861; AIT01861; PMK1_02396.
DR   EnsemblBacteria; ALR24543; ALR24543; AGG09_09880.
DR   EnsemblBacteria; KLY18083; KLY18083; SK89_01947.
DR   EnsemblBacteria; ODN12518; ODN12518; BCB67_07340.
DR   EnsemblBacteria; SBZ45450; SBZ45450; SAMEA3531778_04411.
DR   KEGG; kpb:FH42_21260; -.
DR   KEGG; kpne:KU54_022460; -.
DR   KEGG; kpnu:LI86_22300; -.
DR   KEGG; kpx:PMK1_02396; -.
DR   PATRIC; fig|571.67.peg.2011; -.
DR   PATRIC; fig|573.1346.peg.1085; -.
DR   KO; K03587; -.
DR   OrthoDB; 213680at2; -.
DR   UniPathway; UPA00219; -.
DR   Proteomes; UP000029666; Chromosome.
DR   Proteomes; UP000035995; Unassembled WGS sequence.
DR   Proteomes; UP000218552; Unassembled WGS sequence.
DR   Proteomes; UP000238271; Unassembled WGS sequence.
DR   Proteomes; UP000238332; Chromosome.
DR   Proteomes; UP000239813; Chromosome.
DR   Proteomes; UP000245017; Unassembled WGS sequence.
DR   Proteomes; UP000251721; Unassembled WGS sequence.
DR   Proteomes; UP000252552; Unassembled WGS sequence.
DR   Proteomes; UP000252603; Unassembled WGS sequence.
DR   Proteomes; UP000253217; Unassembled WGS sequence.
DR   Proteomes; UP000253632; Unassembled WGS sequence.
DR   Proteomes; UP000254103; Unassembled WGS sequence.
DR   Proteomes; UP000254387; Unassembled WGS sequence.
DR   Proteomes; UP000254753; Unassembled WGS sequence.
DR   Proteomes; UP000254799; Unassembled WGS sequence.
DR   Proteomes; UP000255099; Unassembled WGS sequence.
DR   Proteomes; UP000255137; Unassembled WGS sequence.
DR   Proteomes; UP000255239; Unassembled WGS sequence.
DR   Proteomes; UP000255489; Unassembled WGS sequence.
DR   Proteomes; UP000258067; Unassembled WGS sequence.
DR   Proteomes; UP000262540; Unassembled WGS sequence.
DR   Proteomes; UP000275975; Unassembled WGS sequence.
DR   Proteomes; UP000276286; Unassembled WGS sequence.
DR   Proteomes; UP000282433; Chromosome 1.
DR   Proteomes; UP000283322; Unassembled WGS sequence.
DR   Proteomes; UP000286610; Unassembled WGS sequence.
DR   Proteomes; UP000289252; Unassembled WGS sequence.
DR   Proteomes; UP000290276; Unassembled WGS sequence.
DR   Proteomes; UP000292131; Unassembled WGS sequence.
DR   Proteomes; UP000293472; Unassembled WGS sequence.
DR   Proteomes; UP000294891; Unassembled WGS sequence.
DR   Proteomes; UP000294936; Unassembled WGS sequence.
DR   Proteomes; UP000294951; Unassembled WGS sequence.
DR   Proteomes; UP000295037; Unassembled WGS sequence.
DR   Proteomes; UP000295619; Unassembled WGS sequence.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:InterPro.
DR   GO; GO:0009002; F:serine-type D-Ala-D-Ala carboxypeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR   GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR   GO; GO:0043093; P:FtsZ-dependent cytokinesis; IEA:UniProtKB-UniRule.
DR   GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR   HAMAP; MF_02080; FtsI_transpept; 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR037532; FtsI_transpept.
DR   InterPro; IPR005311; PBP_dimer.
DR   InterPro; IPR036138; PBP_dimer_sf.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   Pfam; PF03717; PBP_dimer; 1.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SUPFAM; SSF56519; SSF56519; 1.
DR   SUPFAM; SSF56601; SSF56601; 1.
PE   3: Inferred from homology;
KW   Carboxypeptidase {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Cell cycle {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Cell division {ECO:0000256|HAMAP-Rule:MF_02080,
KW   ECO:0000313|EMBL:SQC48283.1};
KW   Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Cell membrane {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Cell shape {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Cell wall biogenesis/degradation {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Complete proteome {ECO:0000313|Proteomes:UP000029666,
KW   ECO:0000313|Proteomes:UP000035995, ECO:0000313|Proteomes:UP000218552,
KW   ECO:0000313|Proteomes:UP000238271};
KW   Glycosyltransferase {ECO:0000313|EMBL:AIT01861.1};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Membrane {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Peptidoglycan synthesis {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Protease {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Septation {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Transferase {ECO:0000313|EMBL:AIT01861.1};
KW   Transmembrane {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_02080}.
FT   TRANSMEM     20     44       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_02080}.
FT   DOMAIN       70    220       PBP_dimer. {ECO:0000259|Pfam:PF03717}.
FT   DOMAIN      260    554       Transpeptidase. {ECO:0000259|Pfam:
FT                                PF00905}.
FT   ACT_SITE    307    307       Acyl-ester intermediate.
FT                                {ECO:0000256|HAMAP-Rule:MF_02080}.
SQ   SEQUENCE   588 AA;  64003 MW;  2FE4408506D51A55 CRC64;
     MKAAPKTPKA KRQEEQANFI SWRFALLCGC ILLALAFLLG RVAWLQVISP DMLVRQGDMR
     SLRVQEVSTA RGMITDRSGR PLAVSVPVKA IWADPKELHD AGGVTLDTRW KALADALNMP
     LDQLATRINT NPRMRFIYLA RQVNPDMADY IKKLKLPGIH LREESRRYYP SGEVTAHLIG
     FTNVDSQGIE GVEKSFDKWL TGQPGERIVR KDRYGRVIED ISSTDSQAAH NLALSIDERL
     QALVYRELNN AVAFNKAESG SAVLVDVNTG EVLAMANSPS YNPNNFAGTA KDTMRNRAIT
     DVFEPGSTVK PMVVMTALQR GIVNENTVLN TVPYRINGHE IKDVARYSEL TLTGVLQKSS
     NVGVSKLALA MPSSALVDTY SRFGLGKATN LGLVGERSGL YPQKQRWSDI ERATFSFGYG
     LMVTPLQLAR VYATIGSYGI YRPLSITKVD PPVPGERVFP ESLVRTVVHM MESVALPGGG
     GVKAAIKGYR IAIKTGTAKK VGPDGRYINK YIAYTAGVAP ASHPRFALVV VINDPQAGKY
     YGGAVSAPVF GAIMGGVLRT MNIEPDALAT GEKSEFVINQ GEGTGGRS
//