ID A0A0W8AVJ6_KLEPN Unreviewed; 588 AA. AC A0A0W8AVJ6; A0A0J2GHB5; DT 13-APR-2016, integrated into UniProtKB/TrEMBL. DT 13-APR-2016, sequence version 1. DT 08-MAY-2019, entry version 34. DE RecName: Full=Peptidoglycan D,D-transpeptidase FtsI {ECO:0000256|HAMAP-Rule:MF_02080}; DE EC=3.4.16.4 {ECO:0000256|HAMAP-Rule:MF_02080}; DE AltName: Full=Penicillin-binding protein 3 {ECO:0000256|HAMAP-Rule:MF_02080}; DE Short=PBP-3 {ECO:0000256|HAMAP-Rule:MF_02080}; GN Name=ftsI_1 {ECO:0000313|EMBL:AIT01861.1}; GN Synonyms=ftsI {ECO:0000256|HAMAP-Rule:MF_02080, GN ECO:0000313|EMBL:AYW26588.1}, ftsI_3 {ECO:0000313|EMBL:SSW76823.1}, GN ftsI_4 {ECO:0000313|EMBL:SQC48283.1}, ftsI_5 GN {ECO:0000313|EMBL:STU32598.1}, ftsI_7 {ECO:0000313|EMBL:STV70103.1}; GN ORFNames=AXA55_09450 {ECO:0000313|EMBL:RFM50366.1}, BANRA_04461 GN {ECO:0000313|EMBL:VCZ83850.1}, BL124_00027960 GN {ECO:0000313|EMBL:ROG87213.1}, BL146_00006545 GN {ECO:0000313|EMBL:RNO92276.1}, C3483_22070 GN {ECO:0000313|EMBL:AVB73872.1}, C3F39_10515 GN {ECO:0000313|EMBL:AUY19176.1}, C4Y50_000535 GN {ECO:0000313|EMBL:ROG94407.1}, C7V41_14790 GN {ECO:0000313|EMBL:PWF58468.1}, CSC88_14290 GN {ECO:0000313|EMBL:PPK23259.1}, DM059_00690 GN {ECO:0000313|EMBL:RCK03275.1}, DM062_00760 GN {ECO:0000313|EMBL:RCI99793.1}, DPQ49_22785 GN {ECO:0000313|EMBL:AYW26588.1}, DXF97_05380 GN {ECO:0000313|EMBL:RDT68909.1}, DY552_01110 GN {ECO:0000313|EMBL:RFF79036.1}, DZB15_21625 GN {ECO:0000313|EMBL:RFM45447.1}, EAO17_18230 GN {ECO:0000313|EMBL:RRF08000.1}, NCTC11679_04757 GN {ECO:0000313|EMBL:STV70103.1}, NCTC13465_04475 GN {ECO:0000313|EMBL:SQC48283.1}, NCTC13635_05081 GN {ECO:0000313|EMBL:VEB05243.1}, NCTC1936_01053 GN {ECO:0000313|EMBL:STT64965.1}, NCTC5052_02861 GN {ECO:0000313|EMBL:STT94424.1}, NCTC5053_04312 GN {ECO:0000313|EMBL:STV35655.1}, NCTC8849_01042 GN {ECO:0000313|EMBL:STT52506.1}, NCTC9637_05624 GN {ECO:0000313|EMBL:STT50626.1}, NCTC9661_05284 GN {ECO:0000313|EMBL:STU32598.1}, PMK1_02396 GN {ECO:0000313|EMBL:AIT01861.1}, SAMEA104305404_02889 GN {ECO:0000313|EMBL:SSW76823.1}, SAMEA23986918_05501 GN {ECO:0000313|EMBL:SSG22791.1}, SAMEA24002668_02916 GN {ECO:0000313|EMBL:SSF40530.1}, SAMEA4364603_03511 GN {ECO:0000313|EMBL:SSK45838.1}, SAMEA4394730_05373 GN {ECO:0000313|EMBL:SVJ50221.1}, SK89_01947 GN {ECO:0000313|EMBL:KLY18083.1}; OS Klebsiella pneumoniae. OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Klebsiella. OX NCBI_TaxID=573 {ECO:0000313|EMBL:AIT01861.1, ECO:0000313|Proteomes:UP000029666}; RN [1] {ECO:0000313|EMBL:AIT01861.1, ECO:0000313|Proteomes:UP000029666} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=PMK1 {ECO:0000313|EMBL:AIT01861.1, RC ECO:0000313|Proteomes:UP000029666}; RX PubMed=25267672; RA Stoesser N., Giess A., Batty E.M., Sheppard A.E., Walker A.S., RA Wilson D.J., Didelot X., Bashir A., Sebra R., Kasarskis A., RA Sthapit B., Shakya M., Kelly D., Pollard A.J., Peto T.E., Crook D.W., RA Donnelly P., Thorson S., Amatya P., Joshi S.; RT "Genome Sequencing of an Extended Series of NDM-Producing Klebsiella RT pneumoniae Isolates from Neonatal Infections in a Nepali Hospital RT Characterizes the Extent of Community- versus Hospital-Associated RT Transmission in an Endemic Setting."; RL Antimicrob. Agents Chemother. 58:7347-7357(2014). RN [2] {ECO:0000313|EMBL:KLY18083.1, ECO:0000313|Proteomes:UP000035995} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CHS153 {ECO:0000313|EMBL:KLY18083.1, RC ECO:0000313|Proteomes:UP000035995}; RG The Broad Institute Genomics Platform; RG The Broad Institute Genome Sequencing Center for Infectious Disease; RA Earl A.M., Onderdonk A.B., Kirby J., Ferraro M.J., Huang S., RA Spencer M., Fodor A., Hooper D., Dekker J., O'Brien T., Quan V., RA Gombosev A., Delaney M., DuBois A., Ernst C., Kim D.S., Rossman W., RA Gohs F., Petruso H., Nozar T., Mougeot F., Manson-McGuire A., RA Young S., Abouelleil A., Cao P., Chapman S.B., Griggs A., Priest M., RA Shea T., Wortman I., Wortman J.R., Nusbaum C., Birren B.; RT "The Genome Sequence of None."; RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:RRF08000.1, ECO:0000313|Proteomes:UP000275975} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KLPN_104 {ECO:0000313|EMBL:RRF08000.1, RC ECO:0000313|Proteomes:UP000275975}; RX PubMed=30373801; RA Tamma P.D., Fan Y., Bergman Y., Pertea G., Kazmi A., Lewis S., RA Carroll K.C., Schatz M.C., Timp W., Simner P.J.; RT "Applying Rapid Whole Genome Sequencing to Predict Phenotypic RT Antimicrobial Susceptibility Testing Results Among Carbapenem- RT Resistant Klebsiella pneumoniae Clinical Isolates."; RL Antimicrob. Agents Chemother. 0:0-0(2018). RN [4] {ECO:0000313|EMBL:PPK23259.1, ECO:0000313|Proteomes:UP000238271} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=PN030E4 {ECO:0000313|EMBL:PPK23259.1, RC ECO:0000313|Proteomes:UP000238271}; RX PubMed=29479347; DOI=10.3389/fmicb.2018.00188; RA Founou L.L., Founou R.C., Allam M., Ismail A., Djoko C.F., RA Essack S.Y.; RT "Genome Sequencing of Extended-Spectrum ?-Lactamase (ESBL)-Producing RT Klebsiella pneumoniae Isolated from Pigs and Abattoir Workers in RT Cameroon."; RL Front. Microbiol. 9:188-188(2018). RN [5] {ECO:0000313|EMBL:AUY19176.1, ECO:0000313|Proteomes:UP000239813} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KPNIH48 {ECO:0000313|EMBL:AUY19176.1, RC ECO:0000313|Proteomes:UP000239813}; RA Weingarten R.A., Johnson R.C., Conlan S., Ramsburg A.M., Dekker J.P., RA Lau A.F., Khil P., Odom R.T., Deming C., Park M., Thomas P.J., RA Henderson D.K., Palmore T.N., Segre J.A., Frank K.M.; RT "Genomic Analysis of Hospital Plumbing Reveals Diverse Reservoir of RT Bacterial Plasmids Conferring Carbapenem Resistance."; RL MBio 0:0-0(2018). RN [6] {ECO:0000313|EMBL:AVB73872.1, ECO:0000313|Proteomes:UP000238332} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=NUHL30457 {ECO:0000313|EMBL:AVB73872.1, RC ECO:0000313|Proteomes:UP000238332}; RA Liu Y.; RT "Genome of Klebsiella pneumoniae NUHL3069."; RL Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases. RN [7] {ECO:0000313|EMBL:PWF58468.1, ECO:0000313|Proteomes:UP000245017} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KPL0.2 {ECO:0000313|EMBL:PWF58468.1, RC ECO:0000313|Proteomes:UP000245017}; RA Le Guern R., Grandjean T., Bauduin M., Loquet A., Faure K., Kipnis E., RA Dessein R.; RT "A murine model of gut colonization with Klebsiella pneumoniae NDM."; RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases. RN [8] {ECO:0000313|Proteomes:UP000251721, ECO:0000313|Proteomes:UP000254103, ECO:0000313|Proteomes:UP000254387} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=NCTC11679 {ECO:0000313|EMBL:STV70103.1, RC ECO:0000313|Proteomes:UP000255239}, NCTC13465 RC {ECO:0000313|EMBL:SQC48283.1, ECO:0000313|Proteomes:UP000251721}, RC NCTC1936 {ECO:0000313|EMBL:STT64965.1, RC ECO:0000313|Proteomes:UP000254753}, NCTC5052 RC {ECO:0000313|EMBL:STT94424.1, ECO:0000313|Proteomes:UP000254103}, RC NCTC5053 {ECO:0000313|EMBL:STV35655.1, RC ECO:0000313|Proteomes:UP000254387}, NCTC8849 RC {ECO:0000313|EMBL:STT52506.1, ECO:0000313|Proteomes:UP000254799}, RC NCTC9637 {ECO:0000313|EMBL:STT50626.1, RC ECO:0000313|Proteomes:UP000255099}, and NCTC9661 RC {ECO:0000313|EMBL:STU32598.1, ECO:0000313|Proteomes:UP000255137}; RG Pathogen Informatics; RA Doyle S.; RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|EMBL:RCI99793.1, ECO:0000313|Proteomes:UP000252552, ECO:0000313|Proteomes:UP000253217} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BC_4223 {ECO:0000313|EMBL:RCK03275.1, RC ECO:0000313|Proteomes:UP000253217}, and BC_4553 RC {ECO:0000313|EMBL:RCI99793.1, ECO:0000313|Proteomes:UP000252552}; RA Martins R.C.R., Perdigao-Neto L.V., Costa S.F., Levin A.S.S.; RT "Klebsiella pneumoniae genome sequencing and assembly."; RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases. RN [10] {ECO:0000313|EMBL:RDT68909.1, ECO:0000313|Proteomes:UP000255489} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=1-RC-17-04409-2 {ECO:0000313|EMBL:RDT68909.1, RC ECO:0000313|Proteomes:UP000255489}; RA Doi Y.; RT "The use of a cohorting ward and systematic surveillance cultures for RT the control of a Klebsiella pneumoniae carbapenemase (KPC)-producing RT Enterobacteriaceae outbreak."; RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases. RN [11] {ECO:0000313|EMBL:RCI99793.1, ECO:0000313|Proteomes:UP000252552, ECO:0000313|Proteomes:UP000253217} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BC_4223 {ECO:0000313|EMBL:RCK03275.1, RC ECO:0000313|Proteomes:UP000253217}, and BC_4553 RC {ECO:0000313|EMBL:RCI99793.1, ECO:0000313|Proteomes:UP000252552}; RA Quirk P.G., Krulwich T.A.; RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases. RN [12] {ECO:0000313|Proteomes:UP000252603, ECO:0000313|Proteomes:UP000253632, ECO:0000313|Proteomes:UP000258067} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=4300STDY6470422 {ECO:0000313|EMBL:SSK45838.1, RC ECO:0000313|Proteomes:UP000252603}, 4300STDY6542360 RC {ECO:0000313|EMBL:SVJ50221.1, ECO:0000313|Proteomes:UP000258067}, RC 4300STDY6636938 {ECO:0000313|EMBL:SSG22791.1, RC ECO:0000313|Proteomes:UP000262540}, 4300STDY6636959 RC {ECO:0000313|EMBL:SSF40530.1, ECO:0000313|Proteomes:UP000253632}, and RC 4300STDY7045912 {ECO:0000313|EMBL:SSW76823.1}; RG Pathogen Informatics; RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases. RN [13] {ECO:0000313|EMBL:RFF79036.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=KP16932 {ECO:0000313|EMBL:RFF79036.1}; RA Zhou K., Shen P., Xiao Y.; RT "Carbapenem-resistance Klebsiella pneumoniae ST11."; RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases. RN [14] {ECO:0000313|EMBL:RFM50366.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=S9 {ECO:0000313|EMBL:RFM50366.1}; RA de Man T.J.B., Yaffee A.Q., Limbago B.; RT "Multispecies Outbreak of VIM-producing Carbapenem-Resistant RT Enterobacteriaceae Driven by a Promiscuous IncA/C2 Plasmid."; RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases. RN [15] {ECO:0000313|EMBL:RFM45447.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Kp_SE1_NDM_10_2017 {ECO:0000313|EMBL:RFM45447.1}; RA Turton J.F., Turton J.A.; RT "NDM plasmids among nosocomial bacteria in the United Kingdom, RT especially of IncL/M type."; RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases. RN [16] {ECO:0000313|EMBL:VCZ83850.1, ECO:0000313|Proteomes:UP000276286} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Kpneu043 {ECO:0000313|EMBL:VCZ83850.1}; RA Noll B N.; RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases. RN [17] {ECO:0000313|EMBL:ROG94407.1, ECO:0000313|Proteomes:UP000286610} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CRK0390 {ECO:0000313|EMBL:ROG94407.1, RC ECO:0000313|Proteomes:UP000286610}; RA Vanduin D., Fouts D., Sutton G., Nguyen K., Hujer A., Hujer K., RA Bonomo R.; RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases. RN [18] {ECO:0000313|EMBL:RNO92276.1, ECO:0000313|Proteomes:UP000283322, ECO:0000313|Proteomes:UP000283894} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CRK0143 {ECO:0000313|EMBL:RNO92276.1, RC ECO:0000313|Proteomes:UP000283894}, and CRK0165 RC {ECO:0000313|EMBL:ROG87213.1, ECO:0000313|Proteomes:UP000283322}; RA Vanduin D., Fouts D., Wright M., Sutton G., Nguyen K., Kreiswirth B., RA Chen L., Rojas L., Hujer A., Hujer K., Bonomo R., Adams M.; RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases. RN [19] {ECO:0000313|EMBL:AYW26588.1, ECO:0000313|Proteomes:UP000276949} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=4743 {ECO:0000313|EMBL:AYW26588.1, RC ECO:0000313|Proteomes:UP000276949}; RA Sahl J., Zarrilli R.; RT "Diversity, virulence, and antimicrobial resistance in isolates from RT the newly emerging Klebsiella pneumoniae ST101 lineage."; RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases. RN [20] {ECO:0000313|EMBL:VEB05243.1, ECO:0000313|Proteomes:UP000282433} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=NCTC13635 {ECO:0000313|EMBL:VEB05243.1, RC ECO:0000313|Proteomes:UP000282433}; RG Pathogen Informatics; RL Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Catalyzes cross-linking of the peptidoglycan cell wall CC at the division septum. {ECO:0000256|HAMAP-Rule:MF_02080}. CC -!- CATALYTIC ACTIVITY: CC Reaction=Preferential cleavage: (Ac)(2)-L-Lys-D-Ala-|-D-Ala. Also CC transpeptidation of peptidyl-alanyl moieties that are N-acyl CC substituents of D-alanine.; EC=3.4.16.4; CC Evidence={ECO:0000256|HAMAP-Rule:MF_02080}; CC -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis. CC {ECO:0000256|HAMAP-Rule:MF_02080}. CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000256|HAMAP- CC Rule:MF_02080}; Single-pass membrane protein {ECO:0000256|HAMAP- CC Rule:MF_02080}. CC -!- SIMILARITY: Belongs to the transpeptidase family. FtsI subfamily. CC {ECO:0000256|HAMAP-Rule:MF_02080}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP008929; AIT01861.1; -; Genomic_DNA. DR EMBL; CP026392; AUY19176.1; -; Genomic_DNA. DR EMBL; CP026586; AVB73872.1; -; Genomic_DNA. DR EMBL; CP033625; AYW26588.1; -; Genomic_DNA. DR EMBL; LEUQ01000007; KLY18083.1; -; Genomic_DNA. DR EMBL; PDVM01000046; PPK23259.1; -; Genomic_DNA. DR EMBL; PYBH01000010; PWF58468.1; -; Genomic_DNA. DR EMBL; QORQ01000079; RCI99793.1; -; Genomic_DNA. DR EMBL; QOUG01000039; RCK03275.1; -; Genomic_DNA. DR EMBL; QRBO01000007; RDT68909.1; -; Genomic_DNA. DR EMBL; QVAN01000001; RFF79036.1; -; Genomic_DNA. DR EMBL; QVGE01000001; RFM45447.1; -; Genomic_DNA. DR EMBL; QVFZ01000001; RFM50366.1; -; Genomic_DNA. DR EMBL; MPWU04000033; RNO92276.1; -; Genomic_DNA. DR EMBL; MPYG04000224; ROG87213.1; -; Genomic_DNA. DR EMBL; PTFF02000003; ROG94407.1; -; Genomic_DNA. DR EMBL; RDAM01000001; RRF08000.1; -; Genomic_DNA. DR EMBL; UAWQ01000019; SQC48283.1; -; Genomic_DNA. DR EMBL; UFBE01000007; SSF40530.1; -; Genomic_DNA. DR EMBL; UFBK01000018; SSG22791.1; -; Genomic_DNA. DR EMBL; UFEU01000009; SSK45838.1; -; Genomic_DNA. DR EMBL; UFQE01000045; SSW76823.1; -; Genomic_DNA. DR EMBL; UGLB01000003; STT50626.1; -; Genomic_DNA. DR EMBL; UGLC01000002; STT52506.1; -; Genomic_DNA. DR EMBL; UGLI01000001; STT64965.1; -; Genomic_DNA. DR EMBL; UGLJ01000002; STT94424.1; -; Genomic_DNA. DR EMBL; UGLQ01000003; STU32598.1; -; Genomic_DNA. DR EMBL; UGMN01000004; STV35655.1; -; Genomic_DNA. DR EMBL; UGMG01000001; STV70103.1; -; Genomic_DNA. DR EMBL; UIRA01000014; SVJ50221.1; -; Genomic_DNA. DR EMBL; UWYB01000001; VCZ83850.1; -; Genomic_DNA. DR EMBL; LR134162; VEB05243.1; -; Genomic_DNA. DR RefSeq; WP_002888559.1; NZ_UWYQ01000001.1. DR EnsemblBacteria; AIT01861; AIT01861; PMK1_02396. DR EnsemblBacteria; ALR24543; ALR24543; AGG09_09880. DR EnsemblBacteria; KLY18083; KLY18083; SK89_01947. DR EnsemblBacteria; ODN12518; ODN12518; BCB67_07340. DR EnsemblBacteria; SBZ45450; SBZ45450; SAMEA3531778_04411. DR KEGG; kpb:FH42_21260; -. DR KEGG; kpne:KU54_022460; -. DR KEGG; kpnu:LI86_22300; -. DR KEGG; kpx:PMK1_02396; -. DR PATRIC; fig|571.67.peg.2011; -. DR PATRIC; fig|573.1346.peg.1085; -. DR eggNOG; ENOG4105CJN; Bacteria. DR eggNOG; COG0768; LUCA. DR KO; K03587; -. DR OrthoDB; 213680at2; -. DR UniPathway; UPA00219; -. DR Proteomes; UP000029666; Chromosome. DR Proteomes; UP000035995; Unassembled WGS sequence. DR Proteomes; UP000238271; Unassembled WGS sequence. DR Proteomes; UP000238332; Chromosome. DR Proteomes; UP000239813; Chromosome. DR Proteomes; UP000245017; Unassembled WGS sequence. DR Proteomes; UP000251721; Unassembled WGS sequence. DR Proteomes; UP000252552; Unassembled WGS sequence. DR Proteomes; UP000252603; Unassembled WGS sequence. DR Proteomes; UP000253217; Unassembled WGS sequence. DR Proteomes; UP000253632; Unassembled WGS sequence. DR Proteomes; UP000254103; Unassembled WGS sequence. DR Proteomes; UP000254387; Unassembled WGS sequence. DR Proteomes; UP000254753; Unassembled WGS sequence. DR Proteomes; UP000254799; Unassembled WGS sequence. DR Proteomes; UP000255099; Unassembled WGS sequence. DR Proteomes; UP000255137; Unassembled WGS sequence. DR Proteomes; UP000255239; Unassembled WGS sequence. DR Proteomes; UP000255489; Unassembled WGS sequence. DR Proteomes; UP000258067; Unassembled WGS sequence. DR Proteomes; UP000262540; Unassembled WGS sequence. DR Proteomes; UP000275975; Unassembled WGS sequence. DR Proteomes; UP000276286; Unassembled WGS sequence. DR Proteomes; UP000276949; Chromosome. DR Proteomes; UP000282433; Chromosome 1. DR Proteomes; UP000283322; Unassembled WGS sequence. DR Proteomes; UP000283894; Unassembled WGS sequence. DR Proteomes; UP000286610; Unassembled WGS sequence. DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule. DR GO; GO:0008658; F:penicillin binding; IEA:InterPro. DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:InterPro. DR GO; GO:0009002; F:serine-type D-Ala-D-Ala carboxypeptidase activity; IEA:UniProtKB-UniRule. DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW. DR GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW. DR GO; GO:0043093; P:FtsZ-dependent cytokinesis; IEA:UniProtKB-UniRule. DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-UniRule. DR GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW. DR HAMAP; MF_02080; FtsI_transpept; 1. DR InterPro; IPR012338; Beta-lactam/transpept-like. DR InterPro; IPR037532; FtsI_transpept. DR InterPro; IPR005311; PBP_dimer. DR InterPro; IPR036138; PBP_dimer_sf. DR InterPro; IPR001460; PCN-bd_Tpept. DR Pfam; PF03717; PBP_dimer; 1. DR Pfam; PF00905; Transpeptidase; 1. DR SUPFAM; SSF56519; SSF56519; 1. DR SUPFAM; SSF56601; SSF56601; 1. PE 3: Inferred from homology; KW Carboxypeptidase {ECO:0000256|HAMAP-Rule:MF_02080}; KW Cell cycle {ECO:0000256|HAMAP-Rule:MF_02080}; KW Cell division {ECO:0000256|HAMAP-Rule:MF_02080, KW ECO:0000313|EMBL:SQC48283.1}; KW Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_02080}; KW Cell membrane {ECO:0000256|HAMAP-Rule:MF_02080}; KW Cell shape {ECO:0000256|HAMAP-Rule:MF_02080}; KW Cell wall biogenesis/degradation {ECO:0000256|HAMAP-Rule:MF_02080}; KW Complete proteome {ECO:0000313|Proteomes:UP000029666, KW ECO:0000313|Proteomes:UP000035995, ECO:0000313|Proteomes:UP000238271, KW ECO:0000313|Proteomes:UP000238332}; KW Glycosyltransferase {ECO:0000313|EMBL:AIT01861.1}; KW Hydrolase {ECO:0000256|HAMAP-Rule:MF_02080}; KW Membrane {ECO:0000256|HAMAP-Rule:MF_02080}; KW Peptidoglycan synthesis {ECO:0000256|HAMAP-Rule:MF_02080}; KW Protease {ECO:0000256|HAMAP-Rule:MF_02080}; KW Septation {ECO:0000256|HAMAP-Rule:MF_02080}; KW Transferase {ECO:0000313|EMBL:AIT01861.1}; KW Transmembrane {ECO:0000256|HAMAP-Rule:MF_02080}; KW Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_02080}. FT TRANSMEM 20 44 Helical. {ECO:0000256|HAMAP-Rule: FT MF_02080}. FT DOMAIN 70 220 PBP_dimer. {ECO:0000259|Pfam:PF03717}. FT DOMAIN 260 554 Transpeptidase. {ECO:0000259|Pfam: FT PF00905}. FT ACT_SITE 307 307 Acyl-ester intermediate. FT {ECO:0000256|HAMAP-Rule:MF_02080}. SQ SEQUENCE 588 AA; 64003 MW; 2FE4408506D51A55 CRC64; MKAAPKTPKA KRQEEQANFI SWRFALLCGC ILLALAFLLG RVAWLQVISP DMLVRQGDMR SLRVQEVSTA RGMITDRSGR PLAVSVPVKA IWADPKELHD AGGVTLDTRW KALADALNMP LDQLATRINT NPRMRFIYLA RQVNPDMADY IKKLKLPGIH LREESRRYYP SGEVTAHLIG FTNVDSQGIE GVEKSFDKWL TGQPGERIVR KDRYGRVIED ISSTDSQAAH NLALSIDERL QALVYRELNN AVAFNKAESG SAVLVDVNTG EVLAMANSPS YNPNNFAGTA KDTMRNRAIT DVFEPGSTVK PMVVMTALQR GIVNENTVLN TVPYRINGHE IKDVARYSEL TLTGVLQKSS NVGVSKLALA MPSSALVDTY SRFGLGKATN LGLVGERSGL YPQKQRWSDI ERATFSFGYG LMVTPLQLAR VYATIGSYGI YRPLSITKVD PPVPGERVFP ESLVRTVVHM MESVALPGGG GVKAAIKGYR IAIKTGTAKK VGPDGRYINK YIAYTAGVAP ASHPRFALVV VINDPQAGKY YGGAVSAPVF GAIMGGVLRT MNIEPDALAT GEKSEFVINQ GEGTGGRS //