ID   A0A0W8AVJ6_KLEPN        Unreviewed;       588 AA.
AC   A0A0W8AVJ6; A0A0J2GHB5;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   08-MAY-2019, entry version 34.
DE   RecName: Full=Peptidoglycan D,D-transpeptidase FtsI {ECO:0000256|HAMAP-Rule:MF_02080};
DE            EC=3.4.16.4 {ECO:0000256|HAMAP-Rule:MF_02080};
DE   AltName: Full=Penicillin-binding protein 3 {ECO:0000256|HAMAP-Rule:MF_02080};
DE            Short=PBP-3 {ECO:0000256|HAMAP-Rule:MF_02080};
GN   Name=ftsI_1 {ECO:0000313|EMBL:AIT01861.1};
GN   Synonyms=ftsI {ECO:0000256|HAMAP-Rule:MF_02080,
GN   ECO:0000313|EMBL:AYW26588.1}, ftsI_3 {ECO:0000313|EMBL:SSW76823.1},
GN   ftsI_4 {ECO:0000313|EMBL:SQC48283.1}, ftsI_5
GN   {ECO:0000313|EMBL:STU32598.1}, ftsI_7 {ECO:0000313|EMBL:STV70103.1};
GN   ORFNames=AXA55_09450 {ECO:0000313|EMBL:RFM50366.1}, BANRA_04461
GN   {ECO:0000313|EMBL:VCZ83850.1}, BL124_00027960
GN   {ECO:0000313|EMBL:ROG87213.1}, BL146_00006545
GN   {ECO:0000313|EMBL:RNO92276.1}, C3483_22070
GN   {ECO:0000313|EMBL:AVB73872.1}, C3F39_10515
GN   {ECO:0000313|EMBL:AUY19176.1}, C4Y50_000535
GN   {ECO:0000313|EMBL:ROG94407.1}, C7V41_14790
GN   {ECO:0000313|EMBL:PWF58468.1}, CSC88_14290
GN   {ECO:0000313|EMBL:PPK23259.1}, DM059_00690
GN   {ECO:0000313|EMBL:RCK03275.1}, DM062_00760
GN   {ECO:0000313|EMBL:RCI99793.1}, DPQ49_22785
GN   {ECO:0000313|EMBL:AYW26588.1}, DXF97_05380
GN   {ECO:0000313|EMBL:RDT68909.1}, DY552_01110
GN   {ECO:0000313|EMBL:RFF79036.1}, DZB15_21625
GN   {ECO:0000313|EMBL:RFM45447.1}, EAO17_18230
GN   {ECO:0000313|EMBL:RRF08000.1}, NCTC11679_04757
GN   {ECO:0000313|EMBL:STV70103.1}, NCTC13465_04475
GN   {ECO:0000313|EMBL:SQC48283.1}, NCTC13635_05081
GN   {ECO:0000313|EMBL:VEB05243.1}, NCTC1936_01053
GN   {ECO:0000313|EMBL:STT64965.1}, NCTC5052_02861
GN   {ECO:0000313|EMBL:STT94424.1}, NCTC5053_04312
GN   {ECO:0000313|EMBL:STV35655.1}, NCTC8849_01042
GN   {ECO:0000313|EMBL:STT52506.1}, NCTC9637_05624
GN   {ECO:0000313|EMBL:STT50626.1}, NCTC9661_05284
GN   {ECO:0000313|EMBL:STU32598.1}, PMK1_02396
GN   {ECO:0000313|EMBL:AIT01861.1}, SAMEA104305404_02889
GN   {ECO:0000313|EMBL:SSW76823.1}, SAMEA23986918_05501
GN   {ECO:0000313|EMBL:SSG22791.1}, SAMEA24002668_02916
GN   {ECO:0000313|EMBL:SSF40530.1}, SAMEA4364603_03511
GN   {ECO:0000313|EMBL:SSK45838.1}, SAMEA4394730_05373
GN   {ECO:0000313|EMBL:SVJ50221.1}, SK89_01947
GN   {ECO:0000313|EMBL:KLY18083.1};
OS   Klebsiella pneumoniae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella.
OX   NCBI_TaxID=573 {ECO:0000313|EMBL:AIT01861.1, ECO:0000313|Proteomes:UP000029666};
RN   [1] {ECO:0000313|EMBL:AIT01861.1, ECO:0000313|Proteomes:UP000029666}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PMK1 {ECO:0000313|EMBL:AIT01861.1,
RC   ECO:0000313|Proteomes:UP000029666};
RX   PubMed=25267672;
RA   Stoesser N., Giess A., Batty E.M., Sheppard A.E., Walker A.S.,
RA   Wilson D.J., Didelot X., Bashir A., Sebra R., Kasarskis A.,
RA   Sthapit B., Shakya M., Kelly D., Pollard A.J., Peto T.E., Crook D.W.,
RA   Donnelly P., Thorson S., Amatya P., Joshi S.;
RT   "Genome Sequencing of an Extended Series of NDM-Producing Klebsiella
RT   pneumoniae Isolates from Neonatal Infections in a Nepali Hospital
RT   Characterizes the Extent of Community- versus Hospital-Associated
RT   Transmission in an Endemic Setting.";
RL   Antimicrob. Agents Chemother. 58:7347-7357(2014).
RN   [2] {ECO:0000313|EMBL:KLY18083.1, ECO:0000313|Proteomes:UP000035995}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CHS153 {ECO:0000313|EMBL:KLY18083.1,
RC   ECO:0000313|Proteomes:UP000035995};
RG   The Broad Institute Genomics Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Earl A.M., Onderdonk A.B., Kirby J., Ferraro M.J., Huang S.,
RA   Spencer M., Fodor A., Hooper D., Dekker J., O'Brien T., Quan V.,
RA   Gombosev A., Delaney M., DuBois A., Ernst C., Kim D.S., Rossman W.,
RA   Gohs F., Petruso H., Nozar T., Mougeot F., Manson-McGuire A.,
RA   Young S., Abouelleil A., Cao P., Chapman S.B., Griggs A., Priest M.,
RA   Shea T., Wortman I., Wortman J.R., Nusbaum C., Birren B.;
RT   "The Genome Sequence of None.";
RL   Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:RRF08000.1, ECO:0000313|Proteomes:UP000275975}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KLPN_104 {ECO:0000313|EMBL:RRF08000.1,
RC   ECO:0000313|Proteomes:UP000275975};
RX   PubMed=30373801;
RA   Tamma P.D., Fan Y., Bergman Y., Pertea G., Kazmi A., Lewis S.,
RA   Carroll K.C., Schatz M.C., Timp W., Simner P.J.;
RT   "Applying Rapid Whole Genome Sequencing to Predict Phenotypic
RT   Antimicrobial Susceptibility Testing Results Among Carbapenem-
RT   Resistant Klebsiella pneumoniae Clinical Isolates.";
RL   Antimicrob. Agents Chemother. 0:0-0(2018).
RN   [4] {ECO:0000313|EMBL:PPK23259.1, ECO:0000313|Proteomes:UP000238271}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PN030E4 {ECO:0000313|EMBL:PPK23259.1,
RC   ECO:0000313|Proteomes:UP000238271};
RX   PubMed=29479347; DOI=10.3389/fmicb.2018.00188;
RA   Founou L.L., Founou R.C., Allam M., Ismail A., Djoko C.F.,
RA   Essack S.Y.;
RT   "Genome Sequencing of Extended-Spectrum ?-Lactamase (ESBL)-Producing
RT   Klebsiella pneumoniae Isolated from Pigs and Abattoir Workers in
RT   Cameroon.";
RL   Front. Microbiol. 9:188-188(2018).
RN   [5] {ECO:0000313|EMBL:AUY19176.1, ECO:0000313|Proteomes:UP000239813}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KPNIH48 {ECO:0000313|EMBL:AUY19176.1,
RC   ECO:0000313|Proteomes:UP000239813};
RA   Weingarten R.A., Johnson R.C., Conlan S., Ramsburg A.M., Dekker J.P.,
RA   Lau A.F., Khil P., Odom R.T., Deming C., Park M., Thomas P.J.,
RA   Henderson D.K., Palmore T.N., Segre J.A., Frank K.M.;
RT   "Genomic Analysis of Hospital Plumbing Reveals Diverse Reservoir of
RT   Bacterial Plasmids Conferring Carbapenem Resistance.";
RL   MBio 0:0-0(2018).
RN   [6] {ECO:0000313|EMBL:AVB73872.1, ECO:0000313|Proteomes:UP000238332}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NUHL30457 {ECO:0000313|EMBL:AVB73872.1,
RC   ECO:0000313|Proteomes:UP000238332};
RA   Liu Y.;
RT   "Genome of Klebsiella pneumoniae NUHL3069.";
RL   Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|EMBL:PWF58468.1, ECO:0000313|Proteomes:UP000245017}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KPL0.2 {ECO:0000313|EMBL:PWF58468.1,
RC   ECO:0000313|Proteomes:UP000245017};
RA   Le Guern R., Grandjean T., Bauduin M., Loquet A., Faure K., Kipnis E.,
RA   Dessein R.;
RT   "A murine model of gut colonization with Klebsiella pneumoniae NDM.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [8] {ECO:0000313|Proteomes:UP000251721, ECO:0000313|Proteomes:UP000254103, ECO:0000313|Proteomes:UP000254387}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC11679 {ECO:0000313|EMBL:STV70103.1,
RC   ECO:0000313|Proteomes:UP000255239}, NCTC13465
RC   {ECO:0000313|EMBL:SQC48283.1, ECO:0000313|Proteomes:UP000251721},
RC   NCTC1936 {ECO:0000313|EMBL:STT64965.1,
RC   ECO:0000313|Proteomes:UP000254753}, NCTC5052
RC   {ECO:0000313|EMBL:STT94424.1, ECO:0000313|Proteomes:UP000254103},
RC   NCTC5053 {ECO:0000313|EMBL:STV35655.1,
RC   ECO:0000313|Proteomes:UP000254387}, NCTC8849
RC   {ECO:0000313|EMBL:STT52506.1, ECO:0000313|Proteomes:UP000254799},
RC   NCTC9637 {ECO:0000313|EMBL:STT50626.1,
RC   ECO:0000313|Proteomes:UP000255099}, and NCTC9661
RC   {ECO:0000313|EMBL:STU32598.1, ECO:0000313|Proteomes:UP000255137};
RG   Pathogen Informatics;
RA   Doyle S.;
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [9] {ECO:0000313|EMBL:RCI99793.1, ECO:0000313|Proteomes:UP000252552, ECO:0000313|Proteomes:UP000253217}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BC_4223 {ECO:0000313|EMBL:RCK03275.1,
RC   ECO:0000313|Proteomes:UP000253217}, and BC_4553
RC   {ECO:0000313|EMBL:RCI99793.1, ECO:0000313|Proteomes:UP000252552};
RA   Martins R.C.R., Perdigao-Neto L.V., Costa S.F., Levin A.S.S.;
RT   "Klebsiella pneumoniae genome sequencing and assembly.";
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN   [10] {ECO:0000313|EMBL:RDT68909.1, ECO:0000313|Proteomes:UP000255489}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1-RC-17-04409-2 {ECO:0000313|EMBL:RDT68909.1,
RC   ECO:0000313|Proteomes:UP000255489};
RA   Doi Y.;
RT   "The use of a cohorting ward and systematic surveillance cultures for
RT   the control of a Klebsiella pneumoniae carbapenemase (KPC)-producing
RT   Enterobacteriaceae outbreak.";
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN   [11] {ECO:0000313|EMBL:RCI99793.1, ECO:0000313|Proteomes:UP000252552, ECO:0000313|Proteomes:UP000253217}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BC_4223 {ECO:0000313|EMBL:RCK03275.1,
RC   ECO:0000313|Proteomes:UP000253217}, and BC_4553
RC   {ECO:0000313|EMBL:RCI99793.1, ECO:0000313|Proteomes:UP000252552};
RA   Quirk P.G., Krulwich T.A.;
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN   [12] {ECO:0000313|Proteomes:UP000252603, ECO:0000313|Proteomes:UP000253632, ECO:0000313|Proteomes:UP000258067}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=4300STDY6470422 {ECO:0000313|EMBL:SSK45838.1,
RC   ECO:0000313|Proteomes:UP000252603}, 4300STDY6542360
RC   {ECO:0000313|EMBL:SVJ50221.1, ECO:0000313|Proteomes:UP000258067},
RC   4300STDY6636938 {ECO:0000313|EMBL:SSG22791.1,
RC   ECO:0000313|Proteomes:UP000262540}, 4300STDY6636959
RC   {ECO:0000313|EMBL:SSF40530.1, ECO:0000313|Proteomes:UP000253632}, and
RC   4300STDY7045912 {ECO:0000313|EMBL:SSW76823.1};
RG   Pathogen Informatics;
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN   [13] {ECO:0000313|EMBL:RFF79036.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=KP16932 {ECO:0000313|EMBL:RFF79036.1};
RA   Zhou K., Shen P., Xiao Y.;
RT   "Carbapenem-resistance Klebsiella pneumoniae ST11.";
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
RN   [14] {ECO:0000313|EMBL:RFM50366.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=S9 {ECO:0000313|EMBL:RFM50366.1};
RA   de Man T.J.B., Yaffee A.Q., Limbago B.;
RT   "Multispecies Outbreak of VIM-producing Carbapenem-Resistant
RT   Enterobacteriaceae Driven by a Promiscuous IncA/C2 Plasmid.";
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
RN   [15] {ECO:0000313|EMBL:RFM45447.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Kp_SE1_NDM_10_2017 {ECO:0000313|EMBL:RFM45447.1};
RA   Turton J.F., Turton J.A.;
RT   "NDM plasmids among nosocomial bacteria in the United Kingdom,
RT   especially of IncL/M type.";
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
RN   [16] {ECO:0000313|EMBL:VCZ83850.1, ECO:0000313|Proteomes:UP000276286}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Kpneu043 {ECO:0000313|EMBL:VCZ83850.1};
RA   Noll B N.;
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN   [17] {ECO:0000313|EMBL:ROG94407.1, ECO:0000313|Proteomes:UP000286610}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CRK0390 {ECO:0000313|EMBL:ROG94407.1,
RC   ECO:0000313|Proteomes:UP000286610};
RA   Vanduin D., Fouts D., Sutton G., Nguyen K., Hujer A., Hujer K.,
RA   Bonomo R.;
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN   [18] {ECO:0000313|EMBL:RNO92276.1, ECO:0000313|Proteomes:UP000283322, ECO:0000313|Proteomes:UP000283894}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CRK0143 {ECO:0000313|EMBL:RNO92276.1,
RC   ECO:0000313|Proteomes:UP000283894}, and CRK0165
RC   {ECO:0000313|EMBL:ROG87213.1, ECO:0000313|Proteomes:UP000283322};
RA   Vanduin D., Fouts D., Wright M., Sutton G., Nguyen K., Kreiswirth B.,
RA   Chen L., Rojas L., Hujer A., Hujer K., Bonomo R., Adams M.;
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN   [19] {ECO:0000313|EMBL:AYW26588.1, ECO:0000313|Proteomes:UP000276949}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=4743 {ECO:0000313|EMBL:AYW26588.1,
RC   ECO:0000313|Proteomes:UP000276949};
RA   Sahl J., Zarrilli R.;
RT   "Diversity, virulence, and antimicrobial resistance in isolates from
RT   the newly emerging Klebsiella pneumoniae ST101 lineage.";
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
RN   [20] {ECO:0000313|EMBL:VEB05243.1, ECO:0000313|Proteomes:UP000282433}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC13635 {ECO:0000313|EMBL:VEB05243.1,
RC   ECO:0000313|Proteomes:UP000282433};
RG   Pathogen Informatics;
RL   Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes cross-linking of the peptidoglycan cell wall
CC       at the division septum. {ECO:0000256|HAMAP-Rule:MF_02080}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Preferential cleavage: (Ac)(2)-L-Lys-D-Ala-|-D-Ala. Also
CC         transpeptidation of peptidyl-alanyl moieties that are N-acyl
CC         substituents of D-alanine.; EC=3.4.16.4;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_02080};
CC   -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC       {ECO:0000256|HAMAP-Rule:MF_02080}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000256|HAMAP-
CC       Rule:MF_02080}; Single-pass membrane protein {ECO:0000256|HAMAP-
CC       Rule:MF_02080}.
CC   -!- SIMILARITY: Belongs to the transpeptidase family. FtsI subfamily.
CC       {ECO:0000256|HAMAP-Rule:MF_02080}.
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DR   EMBL; CP008929; AIT01861.1; -; Genomic_DNA.
DR   EMBL; CP026392; AUY19176.1; -; Genomic_DNA.
DR   EMBL; CP026586; AVB73872.1; -; Genomic_DNA.
DR   EMBL; CP033625; AYW26588.1; -; Genomic_DNA.
DR   EMBL; LEUQ01000007; KLY18083.1; -; Genomic_DNA.
DR   EMBL; PDVM01000046; PPK23259.1; -; Genomic_DNA.
DR   EMBL; PYBH01000010; PWF58468.1; -; Genomic_DNA.
DR   EMBL; QORQ01000079; RCI99793.1; -; Genomic_DNA.
DR   EMBL; QOUG01000039; RCK03275.1; -; Genomic_DNA.
DR   EMBL; QRBO01000007; RDT68909.1; -; Genomic_DNA.
DR   EMBL; QVAN01000001; RFF79036.1; -; Genomic_DNA.
DR   EMBL; QVGE01000001; RFM45447.1; -; Genomic_DNA.
DR   EMBL; QVFZ01000001; RFM50366.1; -; Genomic_DNA.
DR   EMBL; MPWU04000033; RNO92276.1; -; Genomic_DNA.
DR   EMBL; MPYG04000224; ROG87213.1; -; Genomic_DNA.
DR   EMBL; PTFF02000003; ROG94407.1; -; Genomic_DNA.
DR   EMBL; RDAM01000001; RRF08000.1; -; Genomic_DNA.
DR   EMBL; UAWQ01000019; SQC48283.1; -; Genomic_DNA.
DR   EMBL; UFBE01000007; SSF40530.1; -; Genomic_DNA.
DR   EMBL; UFBK01000018; SSG22791.1; -; Genomic_DNA.
DR   EMBL; UFEU01000009; SSK45838.1; -; Genomic_DNA.
DR   EMBL; UFQE01000045; SSW76823.1; -; Genomic_DNA.
DR   EMBL; UGLB01000003; STT50626.1; -; Genomic_DNA.
DR   EMBL; UGLC01000002; STT52506.1; -; Genomic_DNA.
DR   EMBL; UGLI01000001; STT64965.1; -; Genomic_DNA.
DR   EMBL; UGLJ01000002; STT94424.1; -; Genomic_DNA.
DR   EMBL; UGLQ01000003; STU32598.1; -; Genomic_DNA.
DR   EMBL; UGMN01000004; STV35655.1; -; Genomic_DNA.
DR   EMBL; UGMG01000001; STV70103.1; -; Genomic_DNA.
DR   EMBL; UIRA01000014; SVJ50221.1; -; Genomic_DNA.
DR   EMBL; UWYB01000001; VCZ83850.1; -; Genomic_DNA.
DR   EMBL; LR134162; VEB05243.1; -; Genomic_DNA.
DR   RefSeq; WP_002888559.1; NZ_UWYQ01000001.1.
DR   EnsemblBacteria; AIT01861; AIT01861; PMK1_02396.
DR   EnsemblBacteria; ALR24543; ALR24543; AGG09_09880.
DR   EnsemblBacteria; KLY18083; KLY18083; SK89_01947.
DR   EnsemblBacteria; ODN12518; ODN12518; BCB67_07340.
DR   EnsemblBacteria; SBZ45450; SBZ45450; SAMEA3531778_04411.
DR   KEGG; kpb:FH42_21260; -.
DR   KEGG; kpne:KU54_022460; -.
DR   KEGG; kpnu:LI86_22300; -.
DR   KEGG; kpx:PMK1_02396; -.
DR   PATRIC; fig|571.67.peg.2011; -.
DR   PATRIC; fig|573.1346.peg.1085; -.
DR   eggNOG; ENOG4105CJN; Bacteria.
DR   eggNOG; COG0768; LUCA.
DR   KO; K03587; -.
DR   OrthoDB; 213680at2; -.
DR   UniPathway; UPA00219; -.
DR   Proteomes; UP000029666; Chromosome.
DR   Proteomes; UP000035995; Unassembled WGS sequence.
DR   Proteomes; UP000238271; Unassembled WGS sequence.
DR   Proteomes; UP000238332; Chromosome.
DR   Proteomes; UP000239813; Chromosome.
DR   Proteomes; UP000245017; Unassembled WGS sequence.
DR   Proteomes; UP000251721; Unassembled WGS sequence.
DR   Proteomes; UP000252552; Unassembled WGS sequence.
DR   Proteomes; UP000252603; Unassembled WGS sequence.
DR   Proteomes; UP000253217; Unassembled WGS sequence.
DR   Proteomes; UP000253632; Unassembled WGS sequence.
DR   Proteomes; UP000254103; Unassembled WGS sequence.
DR   Proteomes; UP000254387; Unassembled WGS sequence.
DR   Proteomes; UP000254753; Unassembled WGS sequence.
DR   Proteomes; UP000254799; Unassembled WGS sequence.
DR   Proteomes; UP000255099; Unassembled WGS sequence.
DR   Proteomes; UP000255137; Unassembled WGS sequence.
DR   Proteomes; UP000255239; Unassembled WGS sequence.
DR   Proteomes; UP000255489; Unassembled WGS sequence.
DR   Proteomes; UP000258067; Unassembled WGS sequence.
DR   Proteomes; UP000262540; Unassembled WGS sequence.
DR   Proteomes; UP000275975; Unassembled WGS sequence.
DR   Proteomes; UP000276286; Unassembled WGS sequence.
DR   Proteomes; UP000276949; Chromosome.
DR   Proteomes; UP000282433; Chromosome 1.
DR   Proteomes; UP000283322; Unassembled WGS sequence.
DR   Proteomes; UP000283894; Unassembled WGS sequence.
DR   Proteomes; UP000286610; Unassembled WGS sequence.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:InterPro.
DR   GO; GO:0009002; F:serine-type D-Ala-D-Ala carboxypeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR   GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR   GO; GO:0043093; P:FtsZ-dependent cytokinesis; IEA:UniProtKB-UniRule.
DR   GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR   HAMAP; MF_02080; FtsI_transpept; 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR037532; FtsI_transpept.
DR   InterPro; IPR005311; PBP_dimer.
DR   InterPro; IPR036138; PBP_dimer_sf.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   Pfam; PF03717; PBP_dimer; 1.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SUPFAM; SSF56519; SSF56519; 1.
DR   SUPFAM; SSF56601; SSF56601; 1.
PE   3: Inferred from homology;
KW   Carboxypeptidase {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Cell cycle {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Cell division {ECO:0000256|HAMAP-Rule:MF_02080,
KW   ECO:0000313|EMBL:SQC48283.1};
KW   Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Cell membrane {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Cell shape {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Cell wall biogenesis/degradation {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Complete proteome {ECO:0000313|Proteomes:UP000029666,
KW   ECO:0000313|Proteomes:UP000035995, ECO:0000313|Proteomes:UP000238271,
KW   ECO:0000313|Proteomes:UP000238332};
KW   Glycosyltransferase {ECO:0000313|EMBL:AIT01861.1};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Membrane {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Peptidoglycan synthesis {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Protease {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Septation {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Transferase {ECO:0000313|EMBL:AIT01861.1};
KW   Transmembrane {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_02080}.
FT   TRANSMEM     20     44       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_02080}.
FT   DOMAIN       70    220       PBP_dimer. {ECO:0000259|Pfam:PF03717}.
FT   DOMAIN      260    554       Transpeptidase. {ECO:0000259|Pfam:
FT                                PF00905}.
FT   ACT_SITE    307    307       Acyl-ester intermediate.
FT                                {ECO:0000256|HAMAP-Rule:MF_02080}.
SQ   SEQUENCE   588 AA;  64003 MW;  2FE4408506D51A55 CRC64;
     MKAAPKTPKA KRQEEQANFI SWRFALLCGC ILLALAFLLG RVAWLQVISP DMLVRQGDMR
     SLRVQEVSTA RGMITDRSGR PLAVSVPVKA IWADPKELHD AGGVTLDTRW KALADALNMP
     LDQLATRINT NPRMRFIYLA RQVNPDMADY IKKLKLPGIH LREESRRYYP SGEVTAHLIG
     FTNVDSQGIE GVEKSFDKWL TGQPGERIVR KDRYGRVIED ISSTDSQAAH NLALSIDERL
     QALVYRELNN AVAFNKAESG SAVLVDVNTG EVLAMANSPS YNPNNFAGTA KDTMRNRAIT
     DVFEPGSTVK PMVVMTALQR GIVNENTVLN TVPYRINGHE IKDVARYSEL TLTGVLQKSS
     NVGVSKLALA MPSSALVDTY SRFGLGKATN LGLVGERSGL YPQKQRWSDI ERATFSFGYG
     LMVTPLQLAR VYATIGSYGI YRPLSITKVD PPVPGERVFP ESLVRTVVHM MESVALPGGG
     GVKAAIKGYR IAIKTGTAKK VGPDGRYINK YIAYTAGVAP ASHPRFALVV VINDPQAGKY
     YGGAVSAPVF GAIMGGVLRT MNIEPDALAT GEKSEFVINQ GEGTGGRS
//