ID   A0A0W8AVJ6_KLEPN        Unreviewed;       588 AA.
AC   A0A0W8AVJ6;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   10-OCT-2018, entry version 28.
DE   RecName: Full=Peptidoglycan D,D-transpeptidase FtsI {ECO:0000256|HAMAP-Rule:MF_02080};
DE            EC=3.4.16.4 {ECO:0000256|HAMAP-Rule:MF_02080};
DE   AltName: Full=Penicillin-binding protein 3 {ECO:0000256|HAMAP-Rule:MF_02080};
DE            Short=PBP-3 {ECO:0000256|HAMAP-Rule:MF_02080};
GN   Name=ftsI_1 {ECO:0000313|EMBL:AIT01861.1};
GN   Synonyms=ftsI {ECO:0000256|HAMAP-Rule:MF_02080}, ftsI_3
GN   {ECO:0000313|EMBL:SQC17463.1}, ftsI_4 {ECO:0000313|EMBL:SQC48283.1};
GN   ORFNames=AGG09_09880 {ECO:0000313|EMBL:ALR24543.1}, B1727_29465
GN   {ECO:0000313|EMBL:OXT19880.1}, B4U22_00660
GN   {ECO:0000313|EMBL:OWG10372.1}, B9G35_04985
GN   {ECO:0000313|EMBL:ARS92837.1}, BB785_22940
GN   {ECO:0000313|EMBL:APP60480.1}, C3483_22070
GN   {ECO:0000313|EMBL:AVB73872.1}, C3F39_10515
GN   {ECO:0000313|EMBL:AUY19176.1}, C7V41_14790
GN   {ECO:0000313|EMBL:PWF58468.1}, CPT10_02615
GN   {ECO:0000313|EMBL:PCL83382.1}, CSC88_14290
GN   {ECO:0000313|EMBL:PPK23259.1}, CWQ24_23500
GN   {ECO:0000313|EMBL:AUA52961.1}, DMR37_01965
GN   {ECO:0000313|EMBL:PXK02217.1}, NCTC12463_02035
GN   {ECO:0000313|EMBL:SQC17463.1}, NCTC13465_04475
GN   {ECO:0000313|EMBL:SQC48283.1}, NCTC13687_00165
GN   {ECO:0000313|EMBL:SQC10054.1}, PMK1_02396
GN   {ECO:0000313|EMBL:AIT01861.1}, SM57_00076
GN   {ECO:0000313|EMBL:KMW94783.1};
OS   Klebsiella pneumoniae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella.
OX   NCBI_TaxID=573 {ECO:0000313|EMBL:AIT01861.1, ECO:0000313|Proteomes:UP000029666};
RN   [1] {ECO:0000313|EMBL:AIT01861.1, ECO:0000313|Proteomes:UP000029666}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PMK1 {ECO:0000313|EMBL:AIT01861.1,
RC   ECO:0000313|Proteomes:UP000029666};
RX   PubMed=25267672;
RA   Stoesser N., Giess A., Batty E.M., Sheppard A.E., Walker A.S.,
RA   Wilson D.J., Didelot X., Bashir A., Sebra R., Kasarskis A.,
RA   Sthapit B., Shakya M., Kelly D., Pollard A.J., Peto T.E., Crook D.W.,
RA   Donnelly P., Thorson S., Amatya P., Joshi S.;
RT   "Genome Sequencing of an Extended Series of NDM-Producing Klebsiella
RT   pneumoniae Isolates from Neonatal Infections in a Nepali Hospital
RT   Characterizes the Extent of Community- versus Hospital-Associated
RT   Transmission in an Endemic Setting.";
RL   Antimicrob. Agents Chemother. 58:7347-7357(2014).
RN   [2] {ECO:0000313|EMBL:KMW94783.1, ECO:0000313|Proteomes:UP000037134}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGH83 {ECO:0000313|EMBL:KMW94783.1,
RC   ECO:0000313|Proteomes:UP000037134};
RG   The Broad Institute Genomics Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Earl A.M., Onderdonk A.B., Kirby J., Ferraro M.J., Huang S.,
RA   Spencer M., Fodor A., Hooper D., Dekker J., O'Brien T., Quan V.,
RA   Gombosev A., Delaney M., Dubois A., Ernst C., Kim D.S., Rossman W.,
RA   Gohs F., Petruso H., Nozar T., Mougeot F., Manson-Mcguire A.,
RA   Young S., Abouelleil A., Cao P., Chapman S.B., Griggs A., Priest M.,
RA   Shea T., Wortman I., Wortman J.R., Nusbaum C., Birren B.;
RT   "The Genome Sequence of None.";
RL   Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Proteomes:UP000067608}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CAV1193 {ECO:0000313|Proteomes:UP000067608};
RA   Sheppard A.E., Stoesser N., Sebra R., Kasarskis A., Deikus G.,
RA   Anson L., Walker A.S., Peto T.E., Crook D.W., Mathers A.J.;
RT   "Complete Genome Sequence of the KPC-producing Klebsiella pneumoniae
RT   strain CAV1193.";
RL   Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:ALR24543.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CAV1193 {ECO:0000313|EMBL:ALR24543.1};
RX   PubMed=26823590;
RA   Sheppard A.E., Stoesser N., Sebra R., Kasarskis A., Deikus G.,
RA   Anson L., Walker A.S., Peto T.E., Crook D.W., Mathers A.J.;
RT   "Complete Genome Sequence of KPC-Producing Klebsiella pneumoniae
RT   Strain CAV1193.";
RL   Genome Announc. 4:e01649-15(2016).
RN   [5] {ECO:0000313|EMBL:APP60480.1, ECO:0000313|Proteomes:UP000184736}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Kp_Goe_827026 {ECO:0000313|EMBL:APP60480.1,
RC   ECO:0000313|Proteomes:UP000184736};
RA   Bohne W., Bunk B., Overmann J., Gross U., Zautner A.E.;
RT   "A nosocomial outbreak of oxa48-expressing Klebsialla pneumoniae in
RT   Lower Saxony.";
RL   Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|EMBL:ARS92837.1, ECO:0000313|Proteomes:UP000250072}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BK13043 {ECO:0000313|EMBL:ARS92837.1,
RC   ECO:0000313|Proteomes:UP000250072};
RA   Long S.W., Olsen R.J., Eagar T.N., Beres S.B., Zhao P., Davis J.,
RA   Brettin T., Xia F., Musser J.M.;
RT   "Population Genomic Analysis of 1,777 Extended-Spectrum Beta-Lactamase
RT   Producing Klebsiella pneumoniae, Houston, Texas: Unexpected Abundance
RT   of Clonal Group 307.";
RL   MBio 0:0-0(2017).
RN   [7] {ECO:0000313|EMBL:OXT19880.1, ECO:0000313|Proteomes:UP000215037}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OK8 {ECO:0000313|EMBL:OXT19880.1,
RC   ECO:0000313|Proteomes:UP000215037};
RA   Nagamalleswari E., Nagaraja V.;
RT   "Draft genome analysis of Klebsiella pneumoniae OK8.";
RL   Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
RN   [8] {ECO:0000313|EMBL:OWG10372.1, ECO:0000313|Proteomes:UP000196744}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1830 {ECO:0000313|EMBL:OWG10372.1,
RC   ECO:0000313|Proteomes:UP000196744};
RA   Martins R.C., Perdigao-Neto L.V., Costa S.F., Levin A.S.;
RT   "Klebsiella pneumoniae genome sequencing and assembly.";
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
RN   [9] {ECO:0000313|EMBL:PCL83382.1, ECO:0000313|Proteomes:UP000218464}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C17 {ECO:0000313|EMBL:PCL83382.1,
RC   ECO:0000313|Proteomes:UP000218464};
RA   Veeraraghavan B., Shankar C., Ghafur A.;
RT   "Colistin resistant K. pneumoniae.";
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
RN   [10] {ECO:0000313|EMBL:AUA52961.1, ECO:0000313|Proteomes:UP000232092}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NU-CRE047 {ECO:0000313|EMBL:AUA52961.1,
RC   ECO:0000313|Proteomes:UP000232092};
RA   Ozer E.A., Krapp F., Qi C., Hauser A.R.;
RT   "Complete genome sequence of Klebsiella pneumoniae strain NU-CRE047.";
RL   Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
RN   [11] {ECO:0000313|EMBL:PPK23259.1, ECO:0000313|Proteomes:UP000238271}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PN030E4 {ECO:0000313|EMBL:PPK23259.1,
RC   ECO:0000313|Proteomes:UP000238271};
RX   PubMed=29479347; DOI=.3389/fmicb.2018.00188;
RA   Founou L., Founou R.C., Allam M., Ismail A., Djoko C.F., Essack S.Y.;
RT   "Genome Sequencing of Extended-Spectrum ?-Lactamase (ESBL)-Producing
RT   Klebsiella pneumoniae Isolated from Pigs and Abattoir Workers in
RT   Cameroon.";
RL   Front. Microbiol. 9:188-188(2018).
RN   [12] {ECO:0000313|EMBL:AUY19176.1, ECO:0000313|Proteomes:UP000239813}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KPNIH48 {ECO:0000313|EMBL:AUY19176.1,
RC   ECO:0000313|Proteomes:UP000239813};
RA   Weingarten R.A., Johnson R.C., Conlan S., Ramsburg A.M., Dekker J.P.,
RA   Lau A.F., Khil P., Odom R.T., Deming C., Park M., Thomas P.J.,
RA   Henderson D.K., Palmore T.N., Segre J.A., Frank K.M.;
RT   "Genomic Analysis of Hospital Plumbing Reveals Diverse Reservoir of
RT   Bacterial Plasmids Conferring Carbapenem Resistance.";
RL   MBio 0:0-0(2018).
RN   [13] {ECO:0000313|EMBL:AVB73872.1, ECO:0000313|Proteomes:UP000238332}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NUHL30457 {ECO:0000313|EMBL:AVB73872.1,
RC   ECO:0000313|Proteomes:UP000238332};
RA   Liu Y.;
RT   "Genome of Klebsiella pneumoniae NUHL3069.";
RL   Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
RN   [14] {ECO:0000313|EMBL:PWF58468.1, ECO:0000313|Proteomes:UP000245017}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KPL0.2 {ECO:0000313|EMBL:PWF58468.1,
RC   ECO:0000313|Proteomes:UP000245017};
RA   Le Guern R., Grandjean T., Bauduin M., Loquet A., Faure K., Kipnis E.,
RA   Dessein R.;
RT   "A murine model of gut colonization with Klebsiella pneumoniae NDM.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [15] {ECO:0000313|EMBL:PXK02217.1, ECO:0000313|Proteomes:UP000248084}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WUSM_KP_56 {ECO:0000313|EMBL:PXK02217.1,
RC   ECO:0000313|Proteomes:UP000248084};
RA   Potter R.F., Lainhart W., Twentyman J., Wallace M., Wang B.,
RA   Burnham C.-A.D., Rosen D.A., Dantas G.;
RT   "Population structure, antibiotic resistance, and uropathogenecity of
RT   Klebsiella variicola.";
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN   [16] {ECO:0000313|Proteomes:UP000251206, ECO:0000313|Proteomes:UP000251721, ECO:0000313|Proteomes:UP000251951}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC12463 {ECO:0000313|EMBL:SQC17463.1,
RC   ECO:0000313|Proteomes:UP000251951}, NCTC13465
RC   {ECO:0000313|EMBL:SQC48283.1, ECO:0000313|Proteomes:UP000251721}, and
RC   NCTC13687 {ECO:0000313|EMBL:SQC10054.1,
RC   ECO:0000313|Proteomes:UP000251206};
RG   Pathogen Informatics;
RA   Doyle S.;
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes cross-linking of the peptidoglycan cell wall
CC       at the division septum. {ECO:0000256|HAMAP-Rule:MF_02080}.
CC   -!- CATALYTIC ACTIVITY: Preferential cleavage: (Ac)(2)-L-Lys-D-Ala-|-
CC       D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are
CC       N-acyl substituents of D-alanine. {ECO:0000256|HAMAP-
CC       Rule:MF_02080}.
CC   -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC       {ECO:0000256|HAMAP-Rule:MF_02080}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000256|HAMAP-
CC       Rule:MF_02080}; Single-pass membrane protein {ECO:0000256|HAMAP-
CC       Rule:MF_02080}.
CC   -!- SIMILARITY: Belongs to the transpeptidase family. FtsI subfamily.
CC       {ECO:0000256|HAMAP-Rule:MF_02080}.
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DR   EMBL; CP008929; AIT01861.1; -; Genomic_DNA.
DR   EMBL; CP013322; ALR24543.1; -; Genomic_DNA.
DR   EMBL; CP018707; APP60480.1; -; Genomic_DNA.
DR   EMBL; CP020837; ARS92837.1; -; Genomic_DNA.
DR   EMBL; CP025037; AUA52961.1; -; Genomic_DNA.
DR   EMBL; CP026392; AUY19176.1; -; Genomic_DNA.
DR   EMBL; CP026586; AVB73872.1; -; Genomic_DNA.
DR   EMBL; LGJJ01000001; KMW94783.1; -; Genomic_DNA.
DR   EMBL; NBSB01000037; OWG10372.1; -; Genomic_DNA.
DR   EMBL; MZXR01000064; OXT19880.1; -; Genomic_DNA.
DR   EMBL; NXFM01000002; PCL83382.1; -; Genomic_DNA.
DR   EMBL; PDVM01000046; PPK23259.1; -; Genomic_DNA.
DR   EMBL; PYBH01000010; PWF58468.1; -; Genomic_DNA.
DR   EMBL; QIWS01000002; PXK02217.1; -; Genomic_DNA.
DR   EMBL; UAWP01000001; SQC10054.1; -; Genomic_DNA.
DR   EMBL; UASL01000006; SQC17463.1; -; Genomic_DNA.
DR   EMBL; UAWQ01000019; SQC48283.1; -; Genomic_DNA.
DR   RefSeq; WP_002888559.1; NZ_QKRK01000005.1.
DR   EnsemblBacteria; AIT01861; AIT01861; PMK1_02396.
DR   EnsemblBacteria; ALR24543; ALR24543; AGG09_09880.
DR   EnsemblBacteria; ODN12518; ODN12518; BCB67_07340.
DR   EnsemblBacteria; SBZ45450; SBZ45450; SAMEA3531778_04411.
DR   KEGG; kpb:FH42_21260; -.
DR   KEGG; kpne:KU54_022460; -.
DR   KEGG; kpnu:LI86_22300; -.
DR   KEGG; kpx:PMK1_02396; -.
DR   PATRIC; fig|573.1346.peg.1085; -.
DR   eggNOG; ENOG4105CJN; Bacteria.
DR   eggNOG; COG0768; LUCA.
DR   KO; K03587; -.
DR   UniPathway; UPA00219; -.
DR   Proteomes; UP000029666; Chromosome.
DR   Proteomes; UP000037134; Unassembled WGS sequence.
DR   Proteomes; UP000067608; Chromosome.
DR   Proteomes; UP000184736; Chromosome.
DR   Proteomes; UP000196744; Unassembled WGS sequence.
DR   Proteomes; UP000215037; Unassembled WGS sequence.
DR   Proteomes; UP000218464; Unassembled WGS sequence.
DR   Proteomes; UP000232092; Chromosome.
DR   Proteomes; UP000238271; Unassembled WGS sequence.
DR   Proteomes; UP000238332; Chromosome.
DR   Proteomes; UP000239813; Chromosome.
DR   Proteomes; UP000245017; Unassembled WGS sequence.
DR   Proteomes; UP000248084; Unassembled WGS sequence.
DR   Proteomes; UP000250072; Chromosome.
DR   Proteomes; UP000251206; Unassembled WGS sequence.
DR   Proteomes; UP000251721; Unassembled WGS sequence.
DR   Proteomes; UP000251951; Unassembled WGS sequence.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:InterPro.
DR   GO; GO:0009002; F:serine-type D-Ala-D-Ala carboxypeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR   GO; GO:0043093; P:FtsZ-dependent cytokinesis; IEA:UniProtKB-UniRule.
DR   GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR   HAMAP; MF_02080; FtsI_transpept; 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR037532; FtsI_transpept.
DR   InterPro; IPR005311; PBP_dimer.
DR   InterPro; IPR036138; PBP_dimer_sf.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   Pfam; PF03717; PBP_dimer; 1.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SUPFAM; SSF56519; SSF56519; 1.
DR   SUPFAM; SSF56601; SSF56601; 1.
PE   3: Inferred from homology;
KW   Carboxypeptidase {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Cell cycle {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Cell division {ECO:0000256|HAMAP-Rule:MF_02080,
KW   ECO:0000313|EMBL:ALR24543.1};
KW   Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Cell membrane {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Cell shape {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Cell wall biogenesis/degradation {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Complete proteome {ECO:0000313|Proteomes:UP000029666,
KW   ECO:0000313|Proteomes:UP000037134, ECO:0000313|Proteomes:UP000067608,
KW   ECO:0000313|Proteomes:UP000184736};
KW   Glycosyltransferase {ECO:0000313|EMBL:AIT01861.1};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Membrane {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Peptidoglycan synthesis {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Protease {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Septation {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Transferase {ECO:0000313|EMBL:AIT01861.1};
KW   Transmembrane {ECO:0000256|HAMAP-Rule:MF_02080};
KW   Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_02080}.
FT   TRANSMEM     20     44       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_02080}.
FT   DOMAIN       70    220       PBP_dimer. {ECO:0000259|Pfam:PF03717}.
FT   DOMAIN      260    554       Transpeptidase. {ECO:0000259|Pfam:
FT                                PF00905}.
FT   ACT_SITE    307    307       Acyl-ester intermediate.
FT                                {ECO:0000256|HAMAP-Rule:MF_02080}.
SQ   SEQUENCE   588 AA;  64003 MW;  2FE4408506D51A55 CRC64;
     MKAAPKTPKA KRQEEQANFI SWRFALLCGC ILLALAFLLG RVAWLQVISP DMLVRQGDMR
     SLRVQEVSTA RGMITDRSGR PLAVSVPVKA IWADPKELHD AGGVTLDTRW KALADALNMP
     LDQLATRINT NPRMRFIYLA RQVNPDMADY IKKLKLPGIH LREESRRYYP SGEVTAHLIG
     FTNVDSQGIE GVEKSFDKWL TGQPGERIVR KDRYGRVIED ISSTDSQAAH NLALSIDERL
     QALVYRELNN AVAFNKAESG SAVLVDVNTG EVLAMANSPS YNPNNFAGTA KDTMRNRAIT
     DVFEPGSTVK PMVVMTALQR GIVNENTVLN TVPYRINGHE IKDVARYSEL TLTGVLQKSS
     NVGVSKLALA MPSSALVDTY SRFGLGKATN LGLVGERSGL YPQKQRWSDI ERATFSFGYG
     LMVTPLQLAR VYATIGSYGI YRPLSITKVD PPVPGERVFP ESLVRTVVHM MESVALPGGG
     GVKAAIKGYR IAIKTGTAKK VGPDGRYINK YIAYTAGVAP ASHPRFALVV VINDPQAGKY
     YGGAVSAPVF GAIMGGVLRT MNIEPDALAT GEKSEFVINQ GEGTGGRS
//