ID A0A0W8AVJ6_KLEPN Unreviewed; 588 AA. AC A0A0W8AVJ6; DT 13-APR-2016, integrated into UniProtKB/TrEMBL. DT 13-APR-2016, sequence version 1. DT 20-JUN-2018, entry version 25. DE RecName: Full=Peptidoglycan D,D-transpeptidase FtsI {ECO:0000256|HAMAP-Rule:MF_02080}; DE EC=3.4.16.4 {ECO:0000256|HAMAP-Rule:MF_02080}; DE AltName: Full=Penicillin-binding protein 3 {ECO:0000256|HAMAP-Rule:MF_02080}; DE Short=PBP-3 {ECO:0000256|HAMAP-Rule:MF_02080}; GN Name=ftsI_1 {ECO:0000313|EMBL:AIT01861.1}; GN Synonyms=ftsI {ECO:0000256|HAMAP-Rule:MF_02080}; GN ORFNames=AGG09_09880 {ECO:0000313|EMBL:ALR24543.1}, B1727_29465 GN {ECO:0000313|EMBL:OXT19880.1}, B4U22_00660 GN {ECO:0000313|EMBL:OWG10372.1}, B4U36_00705 GN {ECO:0000313|EMBL:PLB96571.1}, BB785_22940 GN {ECO:0000313|EMBL:APP60480.1}, BKY56_004495 GN {ECO:0000313|EMBL:AUY64082.1}, BL124_0027780 GN {ECO:0000313|EMBL:OSU09320.1}, C3483_22070 GN {ECO:0000313|EMBL:AVB73872.1}, C3F39_10515 GN {ECO:0000313|EMBL:AUY19176.1}, C9J88_23840 GN {ECO:0000313|EMBL:AVS28867.1}, CPT10_02615 GN {ECO:0000313|EMBL:PCL83382.1}, CR230_12620 GN {ECO:0000313|EMBL:ATO23535.1}, CWQ24_23500 GN {ECO:0000313|EMBL:AUA52961.1}, PMK1_02396 GN {ECO:0000313|EMBL:AIT01861.1}, SM57_00076 GN {ECO:0000313|EMBL:KMW94783.1}; OS Klebsiella pneumoniae. OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Klebsiella. OX NCBI_TaxID=573 {ECO:0000313|EMBL:AIT01861.1, ECO:0000313|Proteomes:UP000029666}; RN [1] {ECO:0000313|EMBL:AIT01861.1, ECO:0000313|Proteomes:UP000029666} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=PMK1 {ECO:0000313|EMBL:AIT01861.1, RC ECO:0000313|Proteomes:UP000029666}; RX PubMed=25267672; RA Stoesser N., Giess A., Batty E.M., Sheppard A.E., Walker A.S., RA Wilson D.J., Didelot X., Bashir A., Sebra R., Kasarskis A., RA Sthapit B., Shakya M., Kelly D., Pollard A.J., Peto T.E., Crook D.W., RA Donnelly P., Thorson S., Amatya P., Joshi S.; RT "Genome Sequencing of an Extended Series of NDM-Producing Klebsiella RT pneumoniae Isolates from Neonatal Infections in a Nepali Hospital RT Characterizes the Extent of Community- versus Hospital-Associated RT Transmission in an Endemic Setting."; RL Antimicrob. Agents Chemother. 58:7347-7357(2014). RN [2] {ECO:0000313|EMBL:KMW94783.1, ECO:0000313|Proteomes:UP000037134} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=MGH83 {ECO:0000313|EMBL:KMW94783.1, RC ECO:0000313|Proteomes:UP000037134}; RG The Broad Institute Genomics Platform; RG The Broad Institute Genome Sequencing Center for Infectious Disease; RA Earl A.M., Onderdonk A.B., Kirby J., Ferraro M.J., Huang S., RA Spencer M., Fodor A., Hooper D., Dekker J., O'Brien T., Quan V., RA Gombosev A., Delaney M., Dubois A., Ernst C., Kim D.S., Rossman W., RA Gohs F., Petruso H., Nozar T., Mougeot F., Manson-Mcguire A., RA Young S., Abouelleil A., Cao P., Chapman S.B., Griggs A., Priest M., RA Shea T., Wortman I., Wortman J.R., Nusbaum C., Birren B.; RT "The Genome Sequence of None."; RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Proteomes:UP000067608} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CAV1193 {ECO:0000313|Proteomes:UP000067608}; RA Sheppard A.E., Stoesser N., Sebra R., Kasarskis A., Deikus G., RA Anson L., Walker A.S., Peto T.E., Crook D.W., Mathers A.J.; RT "Complete Genome Sequence of the KPC-producing Klebsiella pneumoniae RT strain CAV1193."; RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|EMBL:AUY64082.1, ECO:0000313|Proteomes:UP000186509} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=GN-2 {ECO:0000313|EMBL:AUY64082.1, RC ECO:0000313|Proteomes:UP000186509}; RX PubMed=27965935; RA Ye M., Tu J., Jiang J., Bi Y., You W., Zhang Y., Ren J., Zhu T., RA Cao Z., Yu Z., Shao C., Shen Z., Ding B., Yuan J., Zhao X., Guo Q., RA Xu X., Huang J., Wang M.; RT "Clinical and Genomic Analysis of Liver Abscess-Causing Klebsiella RT pneumoniae Identifies New Liver Abscess-Associated Virulence Genes."; RL Front. Cell. Infect. Microbiol. 6:165-165(2016). RN [5] {ECO:0000313|EMBL:ALR24543.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=CAV1193 {ECO:0000313|EMBL:ALR24543.1}; RX PubMed=26823590; RA Sheppard A.E., Stoesser N., Sebra R., Kasarskis A., Deikus G., RA Anson L., Walker A.S., Peto T.E., Crook D.W., Mathers A.J.; RT "Complete Genome Sequence of KPC-Producing Klebsiella pneumoniae RT Strain CAV1193."; RL Genome Announc. 4:e01649-15(2016). RN [6] {ECO:0000313|EMBL:APP60480.1, ECO:0000313|Proteomes:UP000184736} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Kp_Goe_827026 {ECO:0000313|EMBL:APP60480.1, RC ECO:0000313|Proteomes:UP000184736}; RA Bohne W., Bunk B., Overmann J., Gross U., Zautner A.E.; RT "A nosocomial outbreak of oxa48-expressing Klebsialla pneumoniae in RT Lower Saxony."; RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases. RN [7] {ECO:0000313|EMBL:AUY64082.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=GN-2 {ECO:0000313|EMBL:AUY64082.1}; RA Mah S.A., Swanson W.J., Moy G.W., Vacquier V.D.; RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases. RN [8] {ECO:0000313|EMBL:OXT19880.1, ECO:0000313|Proteomes:UP000215037} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=OK8 {ECO:0000313|EMBL:OXT19880.1, RC ECO:0000313|Proteomes:UP000215037}; RA Nagamalleswari E., Nagaraja V.; RT "Draft genome analysis of Klebsiella pneumoniae OK8."; RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|EMBL:OWG10372.1, ECO:0000313|Proteomes:UP000196744} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=1830 {ECO:0000313|EMBL:OWG10372.1, RC ECO:0000313|Proteomes:UP000196744}; RA Martins R.C., Perdigao-Neto L.V., Costa S.F., Levin A.S.; RT "Klebsiella pneumoniae genome sequencing and assembly."; RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases. RN [10] {ECO:0000313|EMBL:OSU09320.1, ECO:0000313|Proteomes:UP000186691} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=1163_2046 {ECO:0000313|EMBL:OSU09320.1, RC ECO:0000313|Proteomes:UP000186691}; RA Afonso C.L., Miller P.J., Scott M.A., Spackman E., Goraichik I., RA Dimitrov K.M., Suarez D.L., Swayne D.E.; RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases. RN [11] {ECO:0000313|EMBL:PCL83382.1, ECO:0000313|Proteomes:UP000218464} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C17 {ECO:0000313|EMBL:PCL83382.1, RC ECO:0000313|Proteomes:UP000218464}; RA Veeraraghavan B., Shankar C., Ghafur A.; RT "Colistin resistant K. pneumoniae."; RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases. RN [12] {ECO:0000313|EMBL:ATO23535.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=QS17-0029 {ECO:0000313|EMBL:ATO23535.1}; RA Snesrud E.; RT "Sequencing of mcr-1 carrying Escherichia coli from Thailand."; RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases. RN [13] {ECO:0000313|EMBL:AUA52961.1, ECO:0000313|Proteomes:UP000232092} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=NU-CRE047 {ECO:0000313|EMBL:AUA52961.1, RC ECO:0000313|Proteomes:UP000232092}; RA Ozer E.A., Krapp F., Qi C., Hauser A.R.; RT "Complete genome sequence of Klebsiella pneumoniae strain NU-CRE047."; RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases. RN [14] {ECO:0000313|EMBL:PLB96571.1, ECO:0000313|Proteomes:UP000234277} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=LIM1499 {ECO:0000313|EMBL:PLB96571.1, RC ECO:0000313|Proteomes:UP000234277}; RA Martins R.C.R., Perdigao-Neto L.V., Costa S.F., Levin A.S.S.; RT "Klebsiella pneumoniae genome sequencing and assembly."; RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases. RN [15] {ECO:0000313|EMBL:AUY19176.1, ECO:0000313|Proteomes:UP000239813} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KPNIH48 {ECO:0000313|EMBL:AUY19176.1, RC ECO:0000313|Proteomes:UP000239813}; RA Weingarten R.A., Johnson R.C., Conlan S., Ramsburg A.M., Dekker J.P., RA Lau A.F., Khil P., Odom R.T., Deming C., Park M., Thomas P.J., RA Henderson D.K., Palmore T.N., Segre J.A., Frank K.M.; RT "Genomic Analysis of Hospital Plumbing Reveals Diverse Reservoir of RT Bacterial Plasmids Conferring Carbapenem Resistance."; RL MBio 0:0-0(2018). RN [16] {ECO:0000313|EMBL:AVB73872.1, ECO:0000313|Proteomes:UP000238332} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=NUHL30457 {ECO:0000313|EMBL:AVB73872.1, RC ECO:0000313|Proteomes:UP000238332}; RA Liu Y.; RT "Genome of Klebsiella pneumoniae NUHL3069."; RL Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases. RN [17] {ECO:0000313|EMBL:AVS28867.1, ECO:0000313|Proteomes:UP000241666} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CFSAN054110 {ECO:0000313|EMBL:AVS28867.1, RC ECO:0000313|Proteomes:UP000241666}; RA Hoffmann M., Pedersen S.K., Sanchez M., Pettengill J.B., RA Hendriksen R.S.; RT "Genome assemblies for Global Microbial Identifier (GMI) Proficiency RT Testing reference strains."; RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Catalyzes cross-linking of the peptidoglycan cell wall CC at the division septum. {ECO:0000256|HAMAP-Rule:MF_02080}. CC -!- CATALYTIC ACTIVITY: Preferential cleavage: (Ac)(2)-L-Lys-D-Ala-|- CC D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are CC N-acyl substituents of D-alanine. {ECO:0000256|HAMAP- CC Rule:MF_02080}. CC -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis. CC {ECO:0000256|HAMAP-Rule:MF_02080}. CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000256|HAMAP- CC Rule:MF_02080}; Single-pass membrane protein {ECO:0000256|HAMAP- CC Rule:MF_02080}. CC -!- SIMILARITY: Belongs to the transpeptidase family. FtsI subfamily. CC {ECO:0000256|HAMAP-Rule:MF_02080}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP008929; AIT01861.1; -; Genomic_DNA. DR EMBL; CP013322; ALR24543.1; -; Genomic_DNA. DR EMBL; CP018707; APP60480.1; -; Genomic_DNA. DR EMBL; CP024038; ATO23535.1; -; Genomic_DNA. DR EMBL; CP025037; AUA52961.1; -; Genomic_DNA. DR EMBL; CP026392; AUY19176.1; -; Genomic_DNA. DR EMBL; CP019160; AUY64082.1; -; Genomic_DNA. DR EMBL; CP026586; AVB73872.1; -; Genomic_DNA. DR EMBL; CP028180; AVS28867.1; -; Genomic_DNA. DR EMBL; LGJJ01000001; KMW94783.1; -; Genomic_DNA. DR EMBL; MPYG03000224; OSU09320.1; -; Genomic_DNA. DR EMBL; NBSB01000037; OWG10372.1; -; Genomic_DNA. DR EMBL; MZXR01000064; OXT19880.1; -; Genomic_DNA. DR EMBL; NXFM01000002; PCL83382.1; -; Genomic_DNA. DR EMBL; PKRL01000049; PLB96571.1; -; Genomic_DNA. DR RefSeq; WP_002888559.1; NZ_PTMB01000006.1. DR EnsemblBacteria; AIT01861; AIT01861; PMK1_02396. DR EnsemblBacteria; ALR24543; ALR24543; AGG09_09880. DR EnsemblBacteria; ODN12518; ODN12518; BCB67_07340. DR EnsemblBacteria; SBZ45450; SBZ45450; SAMEA3531778_04411. DR KEGG; kpb:FH42_21260; -. DR KEGG; kpne:KU54_022460; -. DR KEGG; kpnu:LI86_22300; -. DR KEGG; kpx:PMK1_02396; -. DR PATRIC; fig|573.1346.peg.1085; -. DR eggNOG; ENOG4105CJN; Bacteria. DR eggNOG; COG0768; LUCA. DR KO; K03587; -. DR UniPathway; UPA00219; -. DR Proteomes; UP000029666; Chromosome. DR Proteomes; UP000037134; Unassembled WGS sequence. DR Proteomes; UP000067608; Chromosome. DR Proteomes; UP000184736; Chromosome. DR Proteomes; UP000186509; Chromosome. DR Proteomes; UP000186691; Unassembled WGS sequence. DR Proteomes; UP000196744; Unassembled WGS sequence. DR Proteomes; UP000215037; Unassembled WGS sequence. DR Proteomes; UP000218464; Unassembled WGS sequence. DR Proteomes; UP000232092; Chromosome. DR Proteomes; UP000234277; Unassembled WGS sequence. DR Proteomes; UP000238332; Chromosome. DR Proteomes; UP000239813; Chromosome. DR Proteomes; UP000241666; Chromosome. DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule. DR GO; GO:0008658; F:penicillin binding; IEA:InterPro. DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:InterPro. DR GO; GO:0009002; F:serine-type D-Ala-D-Ala carboxypeptidase activity; IEA:UniProtKB-UniRule. DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW. DR GO; GO:0043093; P:FtsZ-dependent cytokinesis; IEA:UniProtKB-UniRule. DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-UniRule. DR GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW. DR HAMAP; MF_02080; FtsI_transpept; 1. DR InterPro; IPR012338; Beta-lactam/transpept-like. DR InterPro; IPR037532; FtsI_transpept. DR InterPro; IPR005311; PBP_dimer. DR InterPro; IPR036138; PBP_dimer_sf. DR InterPro; IPR001460; PCN-bd_Tpept. DR Pfam; PF03717; PBP_dimer; 1. DR Pfam; PF00905; Transpeptidase; 1. DR SUPFAM; SSF56519; SSF56519; 1. DR SUPFAM; SSF56601; SSF56601; 1. PE 3: Inferred from homology; KW Carboxypeptidase {ECO:0000256|HAMAP-Rule:MF_02080}; KW Cell cycle {ECO:0000256|HAMAP-Rule:MF_02080}; KW Cell division {ECO:0000256|HAMAP-Rule:MF_02080, KW ECO:0000313|EMBL:ALR24543.1}; KW Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_02080}; KW Cell membrane {ECO:0000256|HAMAP-Rule:MF_02080}; KW Cell shape {ECO:0000256|HAMAP-Rule:MF_02080}; KW Cell wall biogenesis/degradation {ECO:0000256|HAMAP-Rule:MF_02080}; KW Complete proteome {ECO:0000313|Proteomes:UP000029666, KW ECO:0000313|Proteomes:UP000037134, ECO:0000313|Proteomes:UP000067608, KW ECO:0000313|Proteomes:UP000184736}; KW Glycosyltransferase {ECO:0000313|EMBL:AIT01861.1}; KW Hydrolase {ECO:0000256|HAMAP-Rule:MF_02080}; KW Membrane {ECO:0000256|HAMAP-Rule:MF_02080}; KW Peptidoglycan synthesis {ECO:0000256|HAMAP-Rule:MF_02080}; KW Protease {ECO:0000256|HAMAP-Rule:MF_02080}; KW Septation {ECO:0000256|HAMAP-Rule:MF_02080}; KW Transferase {ECO:0000313|EMBL:AIT01861.1}; KW Transmembrane {ECO:0000256|HAMAP-Rule:MF_02080}; KW Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_02080}. FT TRANSMEM 20 44 Helical. {ECO:0000256|HAMAP-Rule: FT MF_02080}. FT DOMAIN 70 220 PBP_dimer. {ECO:0000259|Pfam:PF03717}. FT DOMAIN 260 554 Transpeptidase. {ECO:0000259|Pfam: FT PF00905}. FT ACT_SITE 307 307 Acyl-ester intermediate. FT {ECO:0000256|HAMAP-Rule:MF_02080}. SQ SEQUENCE 588 AA; 64003 MW; 2FE4408506D51A55 CRC64; MKAAPKTPKA KRQEEQANFI SWRFALLCGC ILLALAFLLG RVAWLQVISP DMLVRQGDMR SLRVQEVSTA RGMITDRSGR PLAVSVPVKA IWADPKELHD AGGVTLDTRW KALADALNMP LDQLATRINT NPRMRFIYLA RQVNPDMADY IKKLKLPGIH LREESRRYYP SGEVTAHLIG FTNVDSQGIE GVEKSFDKWL TGQPGERIVR KDRYGRVIED ISSTDSQAAH NLALSIDERL QALVYRELNN AVAFNKAESG SAVLVDVNTG EVLAMANSPS YNPNNFAGTA KDTMRNRAIT DVFEPGSTVK PMVVMTALQR GIVNENTVLN TVPYRINGHE IKDVARYSEL TLTGVLQKSS NVGVSKLALA MPSSALVDTY SRFGLGKATN LGLVGERSGL YPQKQRWSDI ERATFSFGYG LMVTPLQLAR VYATIGSYGI YRPLSITKVD PPVPGERVFP ESLVRTVVHM MESVALPGGG GVKAAIKGYR IAIKTGTAKK VGPDGRYINK YIAYTAGVAP ASHPRFALVV VINDPQAGKY YGGAVSAPVF GAIMGGVLRT MNIEPDALAT GEKSEFVINQ GEGTGGRS //