ID A0A0W7TX51_9GAMM Unreviewed; 352 AA. AC A0A0W7TX51; DT 16-MAR-2016, integrated into UniProtKB/TrEMBL. DT 16-MAR-2016, sequence version 1. DT 03-MAY-2023, entry version 33. DE SubName: Full=L-asparaginase {ECO:0000313|EMBL:KUE78401.1}; GN Name=ansB {ECO:0000313|EMBL:KUE78401.1}; GN ORFNames=ATO46_10430 {ECO:0000313|EMBL:KUE78401.1}; OS Aeromonas schubertii. OC Bacteria; Pseudomonadota; Gammaproteobacteria; Aeromonadales; OC Aeromonadaceae; Aeromonas. OX NCBI_TaxID=652 {ECO:0000313|EMBL:KUE78401.1, ECO:0000313|Proteomes:UP000054876}; RN [1] {ECO:0000313|EMBL:KUE78401.1, ECO:0000313|Proteomes:UP000054876} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 43700 {ECO:0000313|EMBL:KUE78401.1, RC ECO:0000313|Proteomes:UP000054876}; RA Liu L., Li Q., Zhang F., Shi B.; RT "Complete genome sequence of Aeromonas schubertii strain ATCC43700."; RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the asparaginase 1 family. CC {ECO:0000256|ARBA:ARBA00010518, ECO:0000256|RuleBase:RU004456}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:KUE78401.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; LPUO01000055; KUE78401.1; -; Genomic_DNA. DR RefSeq; WP_050666808.1; NZ_LPUO01000055.1. DR AlphaFoldDB; A0A0W7TX51; -. DR STRING; 652.WL1483_4054; -. DR EnsemblBacteria; KUE78401; KUE78401; ATO46_10430. DR OrthoDB; 9788068at2; -. DR Proteomes; UP000054876; Unassembled WGS sequence. DR GO; GO:0110165; C:cellular anatomical entity; IEA:UniProt. DR GO; GO:0004067; F:asparaginase activity; IEA:UniProtKB-UniRule. DR GO; GO:0006528; P:asparagine metabolic process; IEA:InterPro. DR CDD; cd00411; L-asparaginase_like; 1. DR Gene3D; 3.40.50.40; -; 1. DR Gene3D; 3.40.50.1170; L-asparaginase, N-terminal domain; 1. DR InterPro; IPR004550; AsnASE_II. DR InterPro; IPR036152; Asp/glu_Ase-like_sf. DR InterPro; IPR006034; Asparaginase/glutaminase-like. DR InterPro; IPR020827; Asparaginase/glutaminase_AS1. DR InterPro; IPR027475; Asparaginase/glutaminase_AS2. DR InterPro; IPR040919; Asparaginase_C. DR InterPro; IPR027473; L-asparaginase_C. DR InterPro; IPR027474; L-asparaginase_N. DR InterPro; IPR037152; L-asparaginase_N_sf. DR PANTHER; PTHR11707:SF28; 60 KDA LYSOPHOSPHOLIPASE; 1. DR PANTHER; PTHR11707; L-ASPARAGINASE; 1. DR Pfam; PF00710; Asparaginase; 1. DR Pfam; PF17763; Asparaginase_C; 1. DR PIRSF; PIRSF001220; L-ASNase_gatD; 1. DR PIRSF; PIRSF500176; L_ASNase; 1. DR PRINTS; PR00139; ASNGLNASE. DR SMART; SM00870; Asparaginase; 1. DR SUPFAM; SSF53774; Glutaminase/Asparaginase; 1. DR TIGRFAMs; TIGR00520; asnASE_II; 1. DR PROSITE; PS00144; ASN_GLN_ASE_1; 1. DR PROSITE; PS00917; ASN_GLN_ASE_2; 1. DR PROSITE; PS51732; ASN_GLN_ASE_3; 1. PE 3: Inferred from homology; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1..24 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 25..352 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5006934602" FT DOMAIN 28..220 FT /note="L-asparaginase N-terminal" FT /evidence="ECO:0000259|Pfam:PF00710" FT DOMAIN 239..349 FT /note="Asparaginase/glutaminase C-terminal" FT /evidence="ECO:0000259|Pfam:PF17763" FT ACT_SITE 36 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10099" FT ACT_SITE 36 FT /note="O-isoaspartyl threonine intermediate" FT /evidence="ECO:0000256|PIRSR:PIRSR001220-1" FT ACT_SITE 115 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10100" FT BINDING 82 FT /ligand="substrate" FT /evidence="ECO:0000256|PIRSR:PIRSR001220-2" FT BINDING 115..116 FT /ligand="substrate" FT /evidence="ECO:0000256|PIRSR:PIRSR001220-2" SQ SEQUENCE 352 AA; 37599 MW; 351C0CEF64735AD2 CRC64; MSLPLRKSLI AAVLGMTLSP LAFALPSVHI LATGGTIAGA GQSATQSNYE AGKVAIETLI AAVPEMKKVA DVQGEQVVKI GSQDMNDEVW LKLAKRVNEL LAKDDVDGIV ITHGTDTMEE TAYFLNLTVK SDKPVVLVGA MRPSTAMSAD GPMNLYNAVV TASDPASKGR GVMVAMNDTV LDARDVTKTN TTGVQTFASP NFGPLGYIHN GKIDYQRTPA RLHTSQTPFD VSKLDKLPRV GIVYSYANAS DLPAKALVDA KFDGIVSAGV GNGNLYHTLF DTLAKASEKG IRVVRSARVP TGSTTLDAEI DDAKYGFVAA ESLNPQKARV LLMLSLTQTQ DPKQIQHYFQ QY //