ID   A0A0W7TX51_9GAMM        Unreviewed;       352 AA.
AC   A0A0W7TX51;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   03-AUG-2022, entry version 29.
DE   SubName: Full=L-asparaginase {ECO:0000313|EMBL:KUE78401.1};
GN   Name=ansB {ECO:0000313|EMBL:KUE78401.1};
GN   ORFNames=ATO46_10430 {ECO:0000313|EMBL:KUE78401.1};
OS   Aeromonas schubertii.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Aeromonas.
OX   NCBI_TaxID=652 {ECO:0000313|EMBL:KUE78401.1, ECO:0000313|Proteomes:UP000054876};
RN   [1] {ECO:0000313|EMBL:KUE78401.1, ECO:0000313|Proteomes:UP000054876}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43700 {ECO:0000313|EMBL:KUE78401.1,
RC   ECO:0000313|Proteomes:UP000054876};
RA   Liu L., Li Q., Zhang F., Shi B.;
RT   "Complete genome sequence of Aeromonas schubertii strain ATCC43700.";
RL   Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the asparaginase 1 family.
CC       {ECO:0000256|ARBA:ARBA00010518, ECO:0000256|RuleBase:RU004456}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KUE78401.1}.
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DR   EMBL; LPUO01000055; KUE78401.1; -; Genomic_DNA.
DR   RefSeq; WP_050666808.1; NZ_LPUO01000055.1.
DR   STRING; 652.WL1483_4054; -.
DR   EnsemblBacteria; KUE78401; KUE78401; ATO46_10430.
DR   Proteomes; UP000054876; Unassembled WGS sequence.
DR   GO; GO:0110165; C:cellular anatomical entity; IEA:UniProt.
DR   GO; GO:0004067; F:asparaginase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006528; P:asparagine metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.1170; -; 1.
DR   Gene3D; 3.40.50.40; -; 1.
DR   InterPro; IPR004550; AsnASE_II.
DR   InterPro; IPR036152; Asp/glu_Ase-like_sf.
DR   InterPro; IPR006034; Asparaginase/glutaminase-like.
DR   InterPro; IPR020827; Asparaginase/glutaminase_AS1.
DR   InterPro; IPR027475; Asparaginase/glutaminase_AS2.
DR   InterPro; IPR040919; Asparaginase_C.
DR   InterPro; IPR027473; L-asparaginase_C.
DR   InterPro; IPR027474; L-asparaginase_N.
DR   InterPro; IPR037152; L-asparaginase_N_sf.
DR   Pfam; PF00710; Asparaginase; 1.
DR   Pfam; PF17763; Asparaginase_C; 1.
DR   PIRSF; PIRSF001220; L-ASNase_gatD; 1.
DR   PRINTS; PR00139; ASNGLNASE.
DR   SMART; SM00870; Asparaginase; 1.
DR   SUPFAM; SSF53774; SSF53774; 1.
DR   TIGRFAMs; TIGR00520; asnASE_II; 1.
DR   PROSITE; PS00144; ASN_GLN_ASE_1; 1.
DR   PROSITE; PS00917; ASN_GLN_ASE_2; 1.
DR   PROSITE; PS51732; ASN_GLN_ASE_3; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           25..352
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5006934602"
FT   DOMAIN          28..220
FT                   /note="Asparaginase"
FT                   /evidence="ECO:0000259|Pfam:PF00710"
FT   DOMAIN          239..349
FT                   /note="Asparaginase_C"
FT                   /evidence="ECO:0000259|Pfam:PF17763"
FT   REGION          115..116
FT                   /note="Substrate binding"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001220-2"
FT   ACT_SITE        36
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10099"
FT   ACT_SITE        36
FT                   /note="Acyl-ester intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR604550-50"
FT   ACT_SITE        36
FT                   /note="O-isoaspartyl threonine intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001220-1"
FT   ACT_SITE        115
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10100"
FT   BINDING         82
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001220-2"
SQ   SEQUENCE   352 AA;  37599 MW;  351C0CEF64735AD2 CRC64;
     MSLPLRKSLI AAVLGMTLSP LAFALPSVHI LATGGTIAGA GQSATQSNYE AGKVAIETLI
     AAVPEMKKVA DVQGEQVVKI GSQDMNDEVW LKLAKRVNEL LAKDDVDGIV ITHGTDTMEE
     TAYFLNLTVK SDKPVVLVGA MRPSTAMSAD GPMNLYNAVV TASDPASKGR GVMVAMNDTV
     LDARDVTKTN TTGVQTFASP NFGPLGYIHN GKIDYQRTPA RLHTSQTPFD VSKLDKLPRV
     GIVYSYANAS DLPAKALVDA KFDGIVSAGV GNGNLYHTLF DTLAKASEKG IRVVRSARVP
     TGSTTLDAEI DDAKYGFVAA ESLNPQKARV LLMLSLTQTQ DPKQIQHYFQ QY
//