ID A0A0V1J984_TRIPS Unreviewed; 397 AA. AC A0A0V1J984; DT 16-MAR-2016, integrated into UniProtKB/TrEMBL. DT 16-MAR-2016, sequence version 1. DT 07-OCT-2020, entry version 15. DE RecName: Full=15-oxoprostaglandin 13-reductase {ECO:0000256|ARBA:ARBA00013509}; DE EC=1.3.1.48 {ECO:0000256|ARBA:ARBA00011981}; DE EC=1.3.1.74 {ECO:0000256|ARBA:ARBA00012410}; DE AltName: Full=NADP-dependent leukotriene B4 12-hydroxydehydrogenase {ECO:0000256|ARBA:ARBA00018667}; DE AltName: Full=Prostaglandin reductase 1 {ECO:0000256|ARBA:ARBA00020651}; DE Flags: Fragment; GN Name=Ptgr1 {ECO:0000313|EMBL:KRZ31513.1}; GN ORFNames=T4B_990 {ECO:0000313|EMBL:KRZ31513.1}; OS Trichinella pseudospiralis (Parasitic roundworm). OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia; OC Trichinellida; Trichinellidae; Trichinella. OX NCBI_TaxID=6337 {ECO:0000313|EMBL:KRZ31513.1, ECO:0000313|Proteomes:UP000054805}; RN [1] {ECO:0000313|EMBL:KRZ31513.1, ECO:0000313|Proteomes:UP000054805} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ISS588 {ECO:0000313|EMBL:KRZ31513.1}; RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.; RT "Evolution of Trichinella species and genotypes."; RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=13,14-dihydro-15-oxo-prostaglandin E2 + NAD(+) = 15- CC oxoprostaglandin E2 + H(+) + NADH; Xref=Rhea:RHEA:11916, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57400, ChEBI:CHEBI:57402, CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.3.1.48; CC Evidence={ECO:0000256|ARBA:ARBA00000916}; CC -!- CATALYTIC ACTIVITY: CC Reaction=13,14-dihydro-15-oxo-prostaglandin E2 + NADP(+) = 15- CC oxoprostaglandin E2 + H(+) + NADPH; Xref=Rhea:RHEA:11912, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57400, ChEBI:CHEBI:57402, CC ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.48; CC Evidence={ECO:0000256|ARBA:ARBA00001800}; CC -!- CATALYTIC ACTIVITY: CC Reaction=an n-alkanal + NAD(+) = an alk-2-enal + H(+) + NADH; CC Xref=Rhea:RHEA:13733, ChEBI:CHEBI:12834, ChEBI:CHEBI:13757, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.3.1.74; CC Evidence={ECO:0000256|ARBA:ARBA00001474}; CC -!- CATALYTIC ACTIVITY: CC Reaction=an n-alkanal + NADP(+) = an alk-2-enal + H(+) + NADPH; CC Xref=Rhea:RHEA:13737, ChEBI:CHEBI:12834, ChEBI:CHEBI:13757, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.74; CC Evidence={ECO:0000256|ARBA:ARBA00000199}; CC -!- SUBUNIT: Monomer or homodimer. {ECO:0000256|ARBA:ARBA00011852}. CC -!- SIMILARITY: Belongs to the NADP-dependent oxidoreductase L4BD family. CC {ECO:0000256|ARBA:ARBA00010460}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:KRZ31513.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JYDS01000024; KRZ31513.1; -; Genomic_DNA. DR Proteomes; UP000054805; Unassembled WGS sequence. DR GO; GO:0005737; C:cytoplasm; IEA:InterPro. DR GO; GO:0036132; F:13-prostaglandin reductase activity; IEA:UniProtKB-EC. DR GO; GO:0047522; F:15-oxoprostaglandin 13-oxidase activity; IEA:UniProtKB-EC. DR GO; GO:0032440; F:2-alkenal reductase [NAD(P)+] activity; IEA:UniProtKB-EC. DR CDD; cd08294; leukotriene_B4_DH_like; 1. DR InterPro; IPR013149; ADH_C. DR InterPro; IPR041694; ADH_N_2. DR InterPro; IPR011032; GroES-like_sf. DR InterPro; IPR036291; NAD(P)-bd_dom_sf. DR InterPro; IPR014190; PTGR1. DR Pfam; PF16884; ADH_N_2; 1. DR Pfam; PF00107; ADH_zinc_N; 1. DR SUPFAM; SSF50129; SSF50129; 1. DR SUPFAM; SSF51735; SSF51735; 1. PE 3: Inferred from homology; FT DOMAIN 15..110 FT /note="ADH_N_2" FT /evidence="ECO:0000259|Pfam:PF16884" FT DOMAIN 164..258 FT /note="ADH_zinc_N" FT /evidence="ECO:0000259|Pfam:PF00107" FT NON_TER 397 FT /evidence="ECO:0000313|EMBL:KRZ31513.1" SQ SEQUENCE 397 AA; 44381 MW; 8A36711F16235F15 CRC64; MTKKEQTPKT VTAQRWIVMK PFDGYPKLSD FAISLTPLRK LQTGEFRCKG LLWSVEPFTR VMDVDLNSKP LVQSLQVAEV VESRNPAFSV GSVVIGYFGW CTDCITNGQE ALCKAYHIGD LHSLPLSASV GAFGLSGIAA YVGFVERCNP QLGSIVVVNA AAGGVGHLVC QMAMFYRCVL IAFVGSDEKV NWLKTFIDAK FVYNYKTVDV GKLLDEIVPD GVDIFFDSVG GEFANKVMVR MKKGGRMCLC GTISDYNDTK SKKDSCVRAD YGLAKRRGFI IRPLSALALR SRWPDLIPKV MELFCKGAMR YREQRYMGFE NLPQALIDQL NGDTFGRVAV YASLHAFVFY YLITVWRNHI LPQTSVPCHL VLKKIKWGVE AKNCECFLQC FKVDQIG //