ID A0A0U3D483_HUMAN Unreviewed; 362 AA. AC A0A0U3D483; DT 16-MAR-2016, integrated into UniProtKB/TrEMBL. DT 16-MAR-2016, sequence version 1. DT 29-MAY-2024, entry version 47. DE SubName: Full=MHC class I antigen {ECO:0000313|EMBL:ALT45948.1}; GN Name=HLA-B {ECO:0000313|EMBL:ALT45948.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:ALT45948.1}; RN [1] {ECO:0000313|EMBL:ALT45948.1} RP NUCLEOTIDE SEQUENCE. RA Lazaro A.M., Masaberg C., Hou L., Hurley C.K.; RT "Novel HLA class I allele."; RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:SBL08934.1} RP NUCLEOTIDE SEQUENCE. RA Lavstsen T., Jespersen J.S.; RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:SFV42107.1} RP NUCLEOTIDE SEQUENCE. RA Capua I., De Benedictis P., Joannis T., Lombin L.H., Cattoli G.; RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|EMBL:SBV08728.1} RP NUCLEOTIDE SEQUENCE. RA Marsh S.G.E.; RT "Full-length genomic HLA sequences."; RL Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases. RN [5] {ECO:0000313|EMBL:SOF03614.1} RP NUCLEOTIDE SEQUENCE. RA Marsh GE S.; RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases. RN [6] {ECO:0000313|EMBL:AUT12117.1} RP NUCLEOTIDE SEQUENCE. RA Lazaro A.M., Hou L., Enriquez E., Persaud M., Hurley C.K.; RT "Novel HLA Class I alleles."; RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases. RN [7] {ECO:0000313|EMBL:AUT12117.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=29405566; DOI=.1111/iji.12357; RA Marsh S.G.; RT "Nomenclature for factors of the HLA system, update December 2017."; RL Int. J. Immunogenet. 45:88-93(2018). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|ARBA:ARBA00002297}. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single- CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|ARBA:ARBA00006909, ECO:0000256|RuleBase:RU004439}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KT363117; ALT45948.1; -; Genomic_DNA. DR EMBL; MG680156; AUT12117.1; -; Genomic_DNA. DR EMBL; LT575622; SBL08934.1; -; Genomic_DNA. DR EMBL; LT596624; SBV08728.1; -; Genomic_DNA. DR EMBL; LT627678; SFV42107.1; -; Genomic_DNA. DR EMBL; LT908326; SOF03614.1; -; Genomic_DNA. DR AlphaFoldDB; A0A0U3D483; -. DR SMR; A0A0U3D483; -. DR PeptideAtlas; A0A0U3D483; -. DR ChiTaRS; HLA-B; human. DR GO; GO:0031901; C:early endosome membrane; IEA:UniProt. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:UniProt. DR GO; GO:0009897; C:external side of plasma membrane; IEA:TreeGrafter. DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter. DR GO; GO:0098553; C:lumenal side of endoplasmic reticulum membrane; IEA:UniProt. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0030670; C:phagocytic vesicle membrane; IEA:UniProt. DR GO; GO:0055038; C:recycling endosome membrane; IEA:UniProt. DR GO; GO:0042605; F:peptide antigen binding; IEA:TreeGrafter. DR GO; GO:0005102; F:signaling receptor binding; IEA:TreeGrafter. DR GO; GO:0002486; P:antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; IEA:TreeGrafter. DR GO; GO:0002476; P:antigen processing and presentation of endogenous peptide antigen via MHC class Ib; IEA:TreeGrafter. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IEA:TreeGrafter. DR CDD; cd21026; IgC1_MHC_Ia_HLA-B; 1. DR Gene3D; 2.60.40.10; Immunoglobulins; 1. DR Gene3D; 3.30.500.10; MHC class I-like antigen recognition-like; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR PANTHER; PTHR16675:SF242; CLASS IB MHC ANTIGEN QA-2-RELATED; 1. DR PANTHER; PTHR16675; MHC CLASS I-RELATED; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; Immunoglobulin; 1. DR SUPFAM; SSF54452; MHC antigen-recognition domain; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Immunity {ECO:0000256|ARBA:ARBA00022451}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|ARBA:ARBA00022451}; KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1..24 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 25..362 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5015048924" FT TRANSMEM 306..330 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 209..295 FT /note="Ig-like" FT /evidence="ECO:0000259|PROSITE:PS50835" FT REGION 335..362 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 339..362 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 362 AA; 40536 MW; D11DCCF8460EC551 CRC64; MRVTAPRTVL LLLWGAVALT ETWAGSHSMR YFYTAMSRPG RGEPRFIAVG YVDDTQFVRF DSDAASPRTE PRAPWIEQEG PEYWDRNTQI FKTNTQTYRE NLRIALRYYN QSEAGSHTWQ TMYGCDVGPD GRLLRGHNQY AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAARVAEQL RAYLEGLCVE WLRRHLENGK ETLQRADPPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP SSQSTIPIVG IVAGLAVLAV VVIGAVVATV MCRRKSSGGK GGSYSQAASS DSAQGSDVSL TA //