ID A0A0U3D483_HUMAN Unreviewed; 362 AA. AC A0A0U3D483; DT 16-MAR-2016, integrated into UniProtKB/TrEMBL. DT 16-MAR-2016, sequence version 1. DT 14-DEC-2022, entry version 41. DE SubName: Full=MHC class I antigen {ECO:0000313|EMBL:ALT45948.1}; GN Name=HLA-B {ECO:0000313|EMBL:ALT45948.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:ALT45948.1}; RN [1] {ECO:0000313|EMBL:ALT45948.1} RP NUCLEOTIDE SEQUENCE. RA Lazaro A.M., Masaberg C., Hou L., Hurley C.K.; RT "Novel HLA class I allele."; RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:SBL08934.1} RP NUCLEOTIDE SEQUENCE. RA Lavstsen T., Jespersen J.S.; RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:SFV42107.1} RP NUCLEOTIDE SEQUENCE. RA Capua I., De Benedictis P., Joannis T., Lombin L.H., Cattoli G.; RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|EMBL:SBV08728.1} RP NUCLEOTIDE SEQUENCE. RA Marsh S.G.E.; RT "Full-length genomic HLA sequences."; RL Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases. RN [5] {ECO:0000313|EMBL:SOF03614.1} RP NUCLEOTIDE SEQUENCE. RA Marsh GE S.; RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases. RN [6] {ECO:0000313|EMBL:AUT12117.1} RP NUCLEOTIDE SEQUENCE. RA Lazaro A.M., Hou L., Enriquez E., Persaud M., Hurley C.K.; RT "Novel HLA Class I alleles."; RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases. RN [7] {ECO:0000313|EMBL:AUT12117.1} RP NUCLEOTIDE SEQUENCE. RA Marsh S.G.E.; RT "Nomenclature for factors of the HLA system, update December 2017."; RL Int. J. Immunogenet. 0:0-0(2018). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KT363117; ALT45948.1; -; Genomic_DNA. DR EMBL; MG680156; AUT12117.1; -; Genomic_DNA. DR EMBL; LT575622; SBL08934.1; -; Genomic_DNA. DR EMBL; LT596624; SBV08728.1; -; Genomic_DNA. DR EMBL; LT627678; SFV42107.1; -; Genomic_DNA. DR EMBL; LT908326; SOF03614.1; -; Genomic_DNA. DR AlphaFoldDB; A0A0U3D483; -. DR SMR; A0A0U3D483; -. DR PeptideAtlas; A0A0U3D483; -. DR ChiTaRS; HLA-B; human. DR GO; GO:0009986; C:cell surface; IEA:UniProt. DR GO; GO:0031901; C:early endosome membrane; IEA:UniProt. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:UniProt. DR GO; GO:0030670; C:phagocytic vesicle membrane; IEA:UniProt. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW. DR GO; GO:0055038; C:recycling endosome membrane; IEA:UniProt. DR GO; GO:0019882; P:antigen processing and presentation; IEA:InterPro. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; Immunoglobulin; 1. DR SUPFAM; SSF54452; MHC antigen-recognition domain; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475}; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1..24 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 25..362 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5015048924" FT TRANSMEM 306..330 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 209..295 FT /note="Ig-like" FT /evidence="ECO:0000259|PROSITE:PS50835" FT REGION 335..362 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 339..362 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 362 AA; 40536 MW; D11DCCF8460EC551 CRC64; MRVTAPRTVL LLLWGAVALT ETWAGSHSMR YFYTAMSRPG RGEPRFIAVG YVDDTQFVRF DSDAASPRTE PRAPWIEQEG PEYWDRNTQI FKTNTQTYRE NLRIALRYYN QSEAGSHTWQ TMYGCDVGPD GRLLRGHNQY AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAARVAEQL RAYLEGLCVE WLRRHLENGK ETLQRADPPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP SSQSTIPIVG IVAGLAVLAV VVIGAVVATV MCRRKSSGGK GGSYSQAASS DSAQGSDVSL TA //