ID A0A0U2UZC5_SACKO Unreviewed; 620 AA. AC A0A0U2UZC5; DT 16-MAR-2016, integrated into UniProtKB/TrEMBL. DT 16-MAR-2016, sequence version 1. DT 13-APR-2016, entry version 2. DE RecName: Full=Mothers against decapentaplegic homolog {ECO:0000256|RuleBase:RU361195}; DE Short=MAD homolog {ECO:0000256|RuleBase:RU361195}; DE Short=Mothers against DPP homolog {ECO:0000256|RuleBase:RU361195}; DE AltName: Full=SMAD family member {ECO:0000256|RuleBase:RU361195}; OS Saccoglossus kowalevskii (Acorn worm). OC Eukaryota; Metazoa; Hemichordata; Enteropneusta; Harrimaniidae; OC Saccoglossus. OX NCBI_TaxID=10224 {ECO:0000313|EMBL:ALR88691.1}; RN [1] {ECO:0000313|EMBL:ALR88691.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=26580012; DOI=10.1038/nature16150; RA Simakov O., Kawashima T., Marletaz F., Jenkins J., Koyanagi R., RA Mitros T., Hisata K., Bredeson J., Shoguchi E., Gyoja F., Yue J.X., RA Chen Y.C., Freeman R.M.Jr., Sasaki A., Hikosaka-Katayama T., Sato A., RA Fujie M., Baughman K.W., Levine J., Gonzalez P., Cameron C., RA Fritzenwanker J.H., Pani A.M., Goto H., Kanda M., Arakaki N., RA Yamasaki S., Qu J., Cree A., Ding Y., Dinh H.H., Dugan S., Holder M., RA Jhangiani S.N., Kovar C.L., Lee S.L., Lewis L.R., Morton D., RA Nazareth L.V., Okwuonu G., Santibanez J., Chen R., Richards S., RA Muzny D.M., Gillis A., Peshkin L., Wu M., Humphreys T., Su Y.H., RA Putnam N.H., Schmutz J., Fujiyama A., Yu J.K., Tagawa K., Worley K.C., RA Gibbs R.A., Kirschner M.W., Lowe C.J., Satoh N., Rokhsar D.S., RA Gerhart J.; RT "Hemichordate genomes and deuterostome origins."; RL Nature 527:459-465(2015). CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU361195}. CC Nucleus {ECO:0000256|RuleBase:RU361195}. CC -!- SIMILARITY: Belongs to the dwarfin/SMAD family. CC {ECO:0000256|RuleBase:RU361195}. CC -!- SIMILARITY: Contains 1 MH1 (MAD homology 1) domain. CC {ECO:0000256|RuleBase:RU361195}. CC -!- SIMILARITY: Contains 1 MH2 (MAD homology 2) domain. CC {ECO:0000256|RuleBase:RU361195}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KU064702; ALR88691.1; -; mRNA. DR Gene3D; 2.60.200.10; -; 1. DR Gene3D; 3.90.520.10; -; 1. DR InterPro; IPR013790; Dwarfin. DR InterPro; IPR003619; MAD_homology1_Dwarfin-type. DR InterPro; IPR013019; MAD_homology_MH1. DR InterPro; IPR017855; SMAD_dom-like. DR InterPro; IPR001132; SMAD_dom_Dwarfin-type. DR InterPro; IPR008984; SMAD_FHA_domain. DR PANTHER; PTHR13703; PTHR13703; 3. DR Pfam; PF03165; MH1; 1. DR Pfam; PF03166; MH2; 1. DR SMART; SM00523; DWA; 1. DR SMART; SM00524; DWB; 1. DR SUPFAM; SSF49879; SSF49879; 1. DR SUPFAM; SSF56366; SSF56366; 1. DR PROSITE; PS51075; MH1; 1. DR PROSITE; PS51076; MH2; 1. PE 2: Evidence at transcript level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Cytoplasm {ECO:0000256|RuleBase:RU361195}; KW DNA-binding {ECO:0000256|RuleBase:RU361195}; KW Nucleus {ECO:0000256|RuleBase:RU361195, KW ECO:0000256|SAAS:SAAS00464850}; KW Transcription {ECO:0000256|RuleBase:RU361195, KW ECO:0000256|SAAS:SAAS00464862}; KW Transcription regulation {ECO:0000256|RuleBase:RU361195, KW ECO:0000256|SAAS:SAAS00464859}. FT COILED 32 59 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 620 AA; 67340 MW; 50D86DD8F2B1FAA0 CRC64; MSNAVTSNDA CLSIVHSLMC HRQGGESESF AKRAIESLVK KLKEKRDELD SLITAITTNG AHPSKCVTIQ RTLDGRLQVA GRKGFPHVIY ARLWRWPDLH KNELKHMKFC QYAFDLKCDS VCVNPYHYER VVSPGIDLSG LTLHQTGPPS RLVKDEFVHE CVQVEGAPTG SNGSLQTIQH PAVQQTQLPH PPPTQSDGYP NRPTILPPPH TTDHVGSPPG QPVPTNSLAG SNGFIGPDPM QPSLSHMEHN IPSSAMVSHI GGPPVPPGHP PEKPYIVPQP SPHAPPVSVP VPVPVPPPPP PPGAPPKVVM DHSQPRLHQS NHSFGRESSE SSRNTTTWAG DNTRAYRGTM EAHLSANIPP SGPFWQGNSQ MQSDAALSQA LSNHPGPEHW CSIAYFELDQ QVGEIFKVPS SCPTVTVDGY VDPSGGDRFC LGQLSNVHRT EASERARLHI GRGVQLDLRG EGDVWVRCLS DHAVFVQSYY LDREAGRAPG DAVHKIYPNA YIKVFDLRQC HQQMRQQAAT AQAAAAAQAA AVAGNVPGAS SVGGIAPAVT YSAAAGIGVD DLRRLCILRM SFVKGWGPDY PRQSIKQTPC WIEIHLHRAL QLLDEVLHTM PICNARPIVE //