ID A0A0U2U0P4_9INFA Unreviewed; 97 AA. AC A0A0U2U0P4; DT 16-MAR-2016, integrated into UniProtKB/TrEMBL. DT 16-MAR-2016, sequence version 1. DT 15-MAR-2017, entry version 8. DE RecName: Full=Matrix protein 2 {ECO:0000256|RuleBase:RU361247, ECO:0000256|SAAS:SAAS00395487}; GN Name=M2 {ECO:0000313|EMBL:ALR82124.1}; OS Influenza A virus (A/wild bird/Wuhan/CDHN01/2015(H11N9)). OC Viruses; ssRNA viruses; ssRNA negative-strand viruses; OC Orthomyxoviridae; Influenzavirus A. OX NCBI_TaxID=1756083 {ECO:0000313|EMBL:ALR82124.1, ECO:0000313|Proteomes:UP000115803}; RN [1] {ECO:0000313|EMBL:ALR82124.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=A/wild bird/Wuhan/CDHN01/2015 {ECO:0000313|EMBL:ALR82124.1}; RA Chen L.-J., Lin X.-D., Guo W.-P., Tian J.-H., Zhang Y.-Z.; RT "Diversity and evolution of avian influenza viruses in live poultry RT markets, free range poultry and wetland regions in China."; RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases. CC -!- ENZYME REGULATION: The M2 protein from most influenza A strains is CC inhibited by amantadine and rimantadine, resulting in viral CC uncoating incapacity. Emergence of amantadine-resistant variants CC is usually rapid. {ECO:0000256|RuleBase:RU361247}. CC -!- SUBUNIT: Homotetramer; composed of two disulfide-linked dimers CC held together by non-covalent interactions. May interact with CC matrix protein 1. {ECO:0000256|RuleBase:RU361247}. CC -!- SUBCELLULAR LOCATION: Host apical cell membrane CC {ECO:0000256|SAAS:SAAS00581620}; Single-pass type III membrane CC protein {ECO:0000256|SAAS:SAAS00581620}. CC -!- DOMAIN: Cytoplasmic tail plays an important role in virion CC assembly and morphogenesis. {ECO:0000256|RuleBase:RU361247}. CC -!- SIMILARITY: Belongs to the influenza viruses matrix protein M2 CC family. {ECO:0000256|RuleBase:RU361247, CC ECO:0000256|SAAS:SAAS00581646}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KU143297; ALR82124.1; -; Viral_cRNA. DR SMR; A0A0U2U0P4; -. DR Proteomes; UP000115803; Genome. DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0055036; C:virion membrane; IEA:InterPro. DR GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro. DR GO; GO:0039521; P:suppression by virus of host autophagy; IEA:UniProtKB-KW. DR InterPro; IPR002089; Flu_M2. DR Pfam; PF00599; Flu_M2; 1. DR ProDom; PD001031; Flu_M2; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000115803}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00108279}; KW Host cell membrane {ECO:0000256|RuleBase:RU361247, KW ECO:0000256|SAAS:SAAS00108156}; KW Host membrane {ECO:0000256|RuleBase:RU361247, KW ECO:0000256|SAAS:SAAS00108238}; KW Host-virus interaction {ECO:0000256|SAAS:SAAS00472422}; KW Hydrogen ion transport {ECO:0000256|RuleBase:RU361247, KW ECO:0000256|SAAS:SAAS00108569}; KW Inhibition of host autophagy by virus {ECO:0000256|SAAS:SAAS00108142}; KW Ion channel {ECO:0000256|RuleBase:RU361247, KW ECO:0000256|SAAS:SAAS00108550}; KW Ion transport {ECO:0000256|RuleBase:RU361247, KW ECO:0000256|SAAS:SAAS00108149}; KW Membrane {ECO:0000256|RuleBase:RU361247, KW ECO:0000256|SAAS:SAAS00108449, ECO:0000256|SAM:Phobius}; KW Signal-anchor {ECO:0000256|RuleBase:RU361247}; KW Transmembrane {ECO:0000256|RuleBase:RU361247, KW ECO:0000256|SAAS:SAAS00108343, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|RuleBase:RU361247, KW ECO:0000256|SAAS:SAAS00108211, ECO:0000256|SAM:Phobius}; KW Transport {ECO:0000256|RuleBase:RU361247, KW ECO:0000256|SAAS:SAAS00108321}; KW Virion {ECO:0000256|RuleBase:RU361247, ECO:0000256|SAAS:SAAS00108457}. FT TRANSMEM 26 48 Helical. {ECO:0000256|SAM:Phobius}. SQ SEQUENCE 97 AA; 11158 MW; FF12EFFCB4370398 CRC64; MSLLTEVETP TRNGWECKCS DSSDPLVIAA SIIGILHLIL WILDRLFFKC IYRRLKYGLK RGPSTEGVPE SMREEYRQEQ QSAVDVDDGH FVNIELE //