ID   A0A0U2QTG8_HPV16        Unreviewed;       158 AA.
AC   A0A0U2QTG8;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   10-MAY-2017, entry version 7.
DE   RecName: Full=Protein E6 {ECO:0000256|RuleBase:RU363123, ECO:0000256|SAAS:SAAS00120197};
GN   Name=E6 {ECO:0000313|EMBL:ALU65790.1};
OS   Human papillomavirus type 16.
OC   Viruses; dsDNA viruses, no RNA stage; Papillomaviridae;
OC   Alphapapillomavirus.
OX   NCBI_TaxID=333760 {ECO:0000313|EMBL:ALU65790.1};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1] {ECO:0000313|EMBL:ALU65790.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HPV16Hap78 {ECO:0000313|EMBL:ALU65790.1};
RX   PubMed=26694554;
RA   Vidal J.P., Felix S.P., Chaves C.B., Patury P., Franco V.F.,
RA   de Morais E.A., de Carvalho N.A., Carvalho A.C., Neto O.F.,
RA   Vieira L.M., Correa F.M., Martins L.F., Negrao A., de Almeida L.M.,
RA   Moreira M.A.;
RT   "Genetic diversity of HPV16 and HPV18 in Brazilian patients with
RT   invasive cervical cancer.";
RL   J. Med. Virol. 0:0-0(2015).
CC   -!- FUNCTION: Plays a major role in the induction and maintenance of
CC       cellular transformation. {ECO:0000256|RuleBase:RU363123}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm
CC       {ECO:0000256|RuleBase:RU363123}. Host nucleus
CC       {ECO:0000256|RuleBase:RU363123}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus
CC       {ECO:0000256|SAAS:SAAS00815919}.
CC   -!- SIMILARITY: Belongs to the papillomaviridae E6 protein family.
CC       {ECO:0000256|RuleBase:RU363123, ECO:0000256|SAAS:SAAS00586176}.
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DR   EMBL; KP965095; ALU65790.1; -; Genomic_DNA.
DR   GO; GO:0044204; C:host cell nuclear matrix; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   InterPro; IPR001334; E6.
DR   Pfam; PF00518; E6; 1.
PE   3: Inferred from homology;
KW   Activator {ECO:0000256|RuleBase:RU363123,
KW   ECO:0000256|SAAS:SAAS00478471};
KW   DNA-binding {ECO:0000256|RuleBase:RU363123,
KW   ECO:0000256|SAAS:SAAS00478468};
KW   Early protein {ECO:0000256|RuleBase:RU363123};
KW   Host cytoplasm {ECO:0000256|SAAS:SAAS00815926};
KW   Host nucleus {ECO:0000256|RuleBase:RU363123,
KW   ECO:0000256|SAAS:SAAS00120194};
KW   Host-virus interaction {ECO:0000256|SAAS:SAAS00815920};
KW   Inhibition of host innate immune response by virus
KW   {ECO:0000256|SAAS:SAAS00815923};
KW   Metal-binding {ECO:0000256|RuleBase:RU363123,
KW   ECO:0000256|SAAS:SAAS00478473};
KW   Modulation of host cell apoptosis by virus
KW   {ECO:0000256|SAAS:SAAS00815924};
KW   Transcription {ECO:0000256|RuleBase:RU363123,
KW   ECO:0000256|SAAS:SAAS00478472};
KW   Transcription regulation {ECO:0000256|RuleBase:RU363123,
KW   ECO:0000256|SAAS:SAAS00478467};
KW   Viral immunoevasion {ECO:0000256|SAAS:SAAS00815923};
KW   Zinc {ECO:0000256|RuleBase:RU363123, ECO:0000256|SAAS:SAAS00478469};
KW   Zinc-finger {ECO:0000256|RuleBase:RU363123,
KW   ECO:0000256|SAAS:SAAS00478466}.
SQ   SEQUENCE   158 AA;  19130 MW;  9F0CF5ADCD9977FE CRC64;
     MHQKRTAMFQ DPQERPRKLP QLCTELQTTI HDIILECVYC KQQLLRREVY DFAFRDLCIV
     YRDGNPYAVC DKCLKFYSKI SEYRHYCYSV YGTTLEQQYN KPLCDLLIRC INCQKPLCPE
     EKQRHLDKKQ RFHNIRGLWT GRCMSCCRSS RTRRETQL
//