ID A0A0U2QTG8_HPV16 Unreviewed; 158 AA. AC A0A0U2QTG8; DT 16-MAR-2016, integrated into UniProtKB/TrEMBL. DT 16-MAR-2016, sequence version 1. DT 10-MAY-2017, entry version 7. DE RecName: Full=Protein E6 {ECO:0000256|RuleBase:RU363123, ECO:0000256|SAAS:SAAS00120197}; GN Name=E6 {ECO:0000313|EMBL:ALU65790.1}; OS Human papillomavirus type 16. OC Viruses; dsDNA viruses, no RNA stage; Papillomaviridae; OC Alphapapillomavirus. OX NCBI_TaxID=333760 {ECO:0000313|EMBL:ALU65790.1}; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] {ECO:0000313|EMBL:ALU65790.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=HPV16Hap78 {ECO:0000313|EMBL:ALU65790.1}; RX PubMed=26694554; RA Vidal J.P., Felix S.P., Chaves C.B., Patury P., Franco V.F., RA de Morais E.A., de Carvalho N.A., Carvalho A.C., Neto O.F., RA Vieira L.M., Correa F.M., Martins L.F., Negrao A., de Almeida L.M., RA Moreira M.A.; RT "Genetic diversity of HPV16 and HPV18 in Brazilian patients with RT invasive cervical cancer."; RL J. Med. Virol. 0:0-0(2015). CC -!- FUNCTION: Plays a major role in the induction and maintenance of CC cellular transformation. {ECO:0000256|RuleBase:RU363123}. CC -!- SUBCELLULAR LOCATION: Host cytoplasm CC {ECO:0000256|RuleBase:RU363123}. Host nucleus CC {ECO:0000256|RuleBase:RU363123}. CC -!- SUBCELLULAR LOCATION: Host nucleus CC {ECO:0000256|SAAS:SAAS00815919}. CC -!- SIMILARITY: Belongs to the papillomaviridae E6 protein family. CC {ECO:0000256|RuleBase:RU363123, ECO:0000256|SAAS:SAAS00586176}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KP965095; ALU65790.1; -; Genomic_DNA. DR GO; GO:0044204; C:host cell nuclear matrix; IEA:UniProtKB-SubCell. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW. DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW. DR InterPro; IPR001334; E6. DR Pfam; PF00518; E6; 1. PE 3: Inferred from homology; KW Activator {ECO:0000256|RuleBase:RU363123, KW ECO:0000256|SAAS:SAAS00478471}; KW DNA-binding {ECO:0000256|RuleBase:RU363123, KW ECO:0000256|SAAS:SAAS00478468}; KW Early protein {ECO:0000256|RuleBase:RU363123}; KW Host cytoplasm {ECO:0000256|SAAS:SAAS00815926}; KW Host nucleus {ECO:0000256|RuleBase:RU363123, KW ECO:0000256|SAAS:SAAS00120194}; KW Host-virus interaction {ECO:0000256|SAAS:SAAS00815920}; KW Inhibition of host innate immune response by virus KW {ECO:0000256|SAAS:SAAS00815923}; KW Metal-binding {ECO:0000256|RuleBase:RU363123, KW ECO:0000256|SAAS:SAAS00478473}; KW Modulation of host cell apoptosis by virus KW {ECO:0000256|SAAS:SAAS00815924}; KW Transcription {ECO:0000256|RuleBase:RU363123, KW ECO:0000256|SAAS:SAAS00478472}; KW Transcription regulation {ECO:0000256|RuleBase:RU363123, KW ECO:0000256|SAAS:SAAS00478467}; KW Viral immunoevasion {ECO:0000256|SAAS:SAAS00815923}; KW Zinc {ECO:0000256|RuleBase:RU363123, ECO:0000256|SAAS:SAAS00478469}; KW Zinc-finger {ECO:0000256|RuleBase:RU363123, KW ECO:0000256|SAAS:SAAS00478466}. SQ SEQUENCE 158 AA; 19130 MW; 9F0CF5ADCD9977FE CRC64; MHQKRTAMFQ DPQERPRKLP QLCTELQTTI HDIILECVYC KQQLLRREVY DFAFRDLCIV YRDGNPYAVC DKCLKFYSKI SEYRHYCYSV YGTTLEQQYN KPLCDLLIRC INCQKPLCPE EKQRHLDKKQ RFHNIRGLWT GRCMSCCRSS RTRRETQL //