ID A0A0U1XRK5_ATLCA Unreviewed; 324 AA. AC A0A0U1XRK5; DT 16-MAR-2016, integrated into UniProtKB/TrEMBL. DT 16-MAR-2016, sequence version 1. DT 29-MAY-2024, entry version 28. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 1 {ECO:0000256|ARBA:ARBA00021009, ECO:0000256|RuleBase:RU000473}; DE EC=7.1.1.2 {ECO:0000256|ARBA:ARBA00012944, ECO:0000256|RuleBase:RU000473}; GN Name=ND1 {ECO:0000313|EMBL:AIY61400.1}; OS Atlantoraja castelnaui (Spotback skate) (Raja castelnaui). OG Mitochondrion {ECO:0000313|EMBL:AIY61400.1}. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes; OC Elasmobranchii; Batoidea; Rajiformes; Atlantoraja. OX NCBI_TaxID=1072469 {ECO:0000313|EMBL:AIY61400.1}; RN [1] {ECO:0000313|EMBL:AIY61400.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=25418618; RA Duckett D.J., Naylor G.J.; RT "The complete mitochondrial genome of the endangered spotback skate, RT Atlantoraja castelnaui."; RL Mitochondrial DNA 1-2:0-0(2014). RN [2] {ECO:0000313|EMBL:AIY61400.1} RP NUCLEOTIDE SEQUENCE. RA Magalhaes I.L.F., Oliveira U., Santos F.R., Vidigal T.H.D.A., RA Brescovit A.D., Santos A.J.; RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA- CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2; CC Evidence={ECO:0000256|ARBA:ARBA00000766, CC ECO:0000256|RuleBase:RU000473}; CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion CC inner membrane {ECO:0000256|RuleBase:RU000471}; Multi-pass membrane CC protein {ECO:0000256|RuleBase:RU000471}. CC -!- SIMILARITY: Belongs to the complex I subunit 1 family. CC {ECO:0000256|ARBA:ARBA00010535, ECO:0000256|RuleBase:RU000471}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KM507724; AIY61400.1; -; Genomic_DNA. DR RefSeq; YP_009112278.1; NC_025942.1. DR AlphaFoldDB; A0A0U1XRK5; -. DR GeneID; 22549067; -. DR CTD; 4535; -. DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IEA:TreeGrafter. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC. DR GO; GO:0009060; P:aerobic respiration; IEA:TreeGrafter. DR HAMAP; MF_01350; NDH1_NuoH; 1. DR InterPro; IPR001694; NADH_UbQ_OxRdtase_su1/FPO. DR InterPro; IPR018086; NADH_UbQ_OxRdtase_su1_CS. DR PANTHER; PTHR11432; NADH DEHYDROGENASE SUBUNIT 1; 1. DR PANTHER; PTHR11432:SF3; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 1; 1. DR Pfam; PF00146; NADHdh; 1. DR PROSITE; PS00667; COMPLEX1_ND1_1; 1. DR PROSITE; PS00668; COMPLEX1_ND1_2; 1. PE 3: Inferred from homology; KW Electron transport {ECO:0000256|ARBA:ARBA00022982}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Mitochondrion {ECO:0000256|RuleBase:RU000473, ECO:0000313|EMBL:AIY61400.1}; KW NAD {ECO:0000256|RuleBase:RU000471}; KW Respiratory chain {ECO:0000256|ARBA:ARBA00022660}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU000471}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}; KW Ubiquinone {ECO:0000256|RuleBase:RU000473}. FT TRANSMEM 6..29 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 75..95 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 107..129 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 150..171 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 177..194 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 226..248 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 260..279 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 299..320 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" SQ SEQUENCE 324 AA; 36273 MW; B5DFF52C10933167 CRC64; MMNNILIYII HPLTYIIPVL LATAFLTLVE RKILGYMQLR KGPNVVGPYG LLQPIADGLK LFTKEPIRPS FSSHFLFLIT PTAALTLALL MWMPLPLPHS ILNLNLGLLF ILAISSLTVY TILGSGWASN SKYALMGALR AVAQTISYEV TLGLILLSLV IMTGSFTLHT FNLTQETIWL LIPAWPLAMM WYISTLAETN RAPFDLTEGE SELVSGFNIE YAGGPFALFF LAEYSNILMM NTLSVILFMG TSYNPTMPQI STLSLMIKAT LLTILFLWIR ASYPRFRYDQ LMHLVWKNFL PLTLALILWH ITLPASLASL PPLT //