ID A0A0U1XGS9_9PETR Unreviewed; 457 AA. AC A0A0U1XGS9; DT 16-MAR-2016, integrated into UniProtKB/TrEMBL. DT 16-MAR-2016, sequence version 1. DT 07-JUN-2017, entry version 7. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 4 {ECO:0000256|RuleBase:RU003297}; DE EC=1.6.5.3 {ECO:0000256|RuleBase:RU003297}; GN Name=ND4 {ECO:0000313|EMBL:AIT96671.1}; OS Ichthyomyzon fossor. OG Mitochondrion {ECO:0000313|EMBL:AIT96671.1}. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata; OC Hyperoartia; Petromyzontiformes; Petromyzontidae; Ichthyomyzon. OX NCBI_TaxID=245073 {ECO:0000313|EMBL:AIT96671.1}; RN [1] {ECO:0000313|EMBL:AIT96671.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Muscle {ECO:0000313|EMBL:AIT96671.1}; RX PubMed=25319286; RA Ren J., Buchinger T., Pu J., Jia L., Li W.; RT "Complete mitochondrial genomes of paired species northern brook RT lamprey (Ichthyomyzon fossor) and silver lamprey (I. unicuspis)."; RL Mitochondrial DNA 1-2:0-0(2014). CC -!- CATALYTIC ACTIVITY: NADH + ubiquinone + 5 H(+)(In) = NAD(+) + CC ubiquinol + 4 H(+)(Out). {ECO:0000256|RuleBase:RU003297}. CC -!- SIMILARITY: Belongs to the complex I subunit 4 family. CC {ECO:0000256|RuleBase:RU003297, ECO:0000256|SAAS:SAAS00707377}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KM267716; AIT96671.1; -; Genomic_DNA. DR RefSeq; YP_009106936.1; NC_025552.1. DR GeneID; 22161474; -. DR CTD; 4538; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC. DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:InterPro. DR InterPro; IPR000260; NADH4_N. DR InterPro; IPR010227; NADH_Q_OxRdtase_chainM/4. DR InterPro; IPR003918; NADH_UbQ_OxRdtase. DR InterPro; IPR001750; ND/Mrp_mem. DR PANTHER; PTHR43507; PTHR43507; 1. DR Pfam; PF01059; Oxidored_q5_N; 1. DR Pfam; PF00361; Proton_antipo_M; 1. DR PRINTS; PR01437; NUOXDRDTASE4. DR TIGRFAMs; TIGR01972; NDH_I_M; 1. PE 3: Inferred from homology; KW Membrane {ECO:0000256|SAAS:SAAS00707373, ECO:0000256|SAM:Phobius}; KW Mitochondrion {ECO:0000256|RuleBase:RU003297, KW ECO:0000313|EMBL:AIT96671.1}; KW NAD {ECO:0000256|RuleBase:RU003297, ECO:0000256|SAAS:SAAS00707374}; KW Oxidoreductase {ECO:0000256|RuleBase:RU003297, KW ECO:0000256|SAAS:SAAS00707388}; KW Transmembrane {ECO:0000256|SAAS:SAAS00707385, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00707361, KW ECO:0000256|SAM:Phobius}; KW Ubiquinone {ECO:0000256|RuleBase:RU003297, KW ECO:0000256|SAAS:SAAS00699082}. FT TRANSMEM 94 112 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 118 137 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 149 167 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 196 218 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 230 253 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 259 279 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 286 304 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 310 332 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 353 371 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 391 415 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 436 455 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 109 Oxidored_q5_N. {ECO:0000259|Pfam: FT PF01059}. FT DOMAIN 112 404 Proton_antipo_M. {ECO:0000259|Pfam: FT PF00361}. SQ SEQUENCE 457 AA; 51741 MW; DF6B2080A0F2D290 CRC64; MLKLIIPSMM MIPMTFLMKK NLLWTATTSF SFLIATLSTL MLNTNMTEHN LANPILSTDQ FSCPLIMLSC WLLPLTIMAS QMHMKTEPIT RQKTMISLLI LLQILLCITF GASNLLTFYI AFEATLIPTL LIITRWGNQK ERLTAGLYFL FYTLSASLPL LIALIVIQTR FNSLSTYIIP LSNLTLLSNT SWSETMWWVA CFLAFLIKMP LYIFHLWLPK AHVEAPIAGS MVLAAILLKL GGYGMIRMSS LFIPLTKDLA IPFMIIAMWG MIVSSSICLR QTDLKSMIAY SSINHMNLVV AGIFSMTPWA WSGALAMMIA HGLVSSGLFC LANITYERTH TRSIFMNRGL KTLFPLMSFW WLMMTFANMA LPPFPNFTAE ILIITSMFNW SNWTILLLGL SMTLTTLFSL NMLIMTQHEH PNKHAPINPS TTREHLLMLM HMAPIILLII NPSPIMI //