ID   A0A0U1RQH4_HUMAN        Unreviewed;       467 AA.
AC   A0A0U1RQH4;
DT   17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT   17-FEB-2016, sequence version 1.
DT   24-JUL-2024, entry version 39.
DE   SubName: Full=EH domain binding protein 1 like 1 {ECO:0000313|Ensembl:ENSP00000489002.1};
DE   Flags: Fragment;
GN   Name=EHBP1L1 {ECO:0000313|Ensembl:ENSP00000489002.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000489002.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0007829|PubMed:17081983}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=17081983; DOI=10.1016/j.cell.2006.09.026;
RA   Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.;
RT   "Global, in vivo, and site-specific phosphorylation dynamics in signaling
RT   networks.";
RL   Cell 127:635-648(2006).
RN   [2] {ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [3] {ECO:0007829|PubMed:18669648}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA   Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA   Elledge S.J., Gygi S.P.;
RT   "A quantitative atlas of mitotic phosphorylation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN   [4] {ECO:0007829|PubMed:23186163}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=23186163;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
RN   [5] {ECO:0000313|Ensembl:ENSP00000489002.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (APR-2024) to UniProtKB.
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DR   EMBL; AP001362; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A0U1RQH4; -.
DR   SMR; A0A0U1RQH4; -.
DR   MassIVE; A0A0U1RQH4; -.
DR   Antibodypedia; 51069; 20 antibodies from 8 providers.
DR   Ensembl; ENST00000634639.1; ENSP00000489002.1; ENSG00000173442.13.
DR   HGNC; HGNC:30682; EHBP1L1.
DR   VEuPathDB; HostDB:ENSG00000173442; -.
DR   GeneTree; ENSGT00940000161027; -.
DR   ChiTaRS; EHBP1L1; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000173442; Expressed in granulocyte and 155 other cell types or tissues.
DR   ExpressionAtlas; A0A0U1RQH4; baseline and differential.
DR   CDD; cd21255; CH_EHBP1L1; 1.
DR   Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR   InterPro; IPR001715; CH_dom.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR050540; F-actin_Monoox_Mical.
DR   InterPro; IPR019448; NT-C2.
DR   PANTHER; PTHR23167; CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED; 1.
DR   PANTHER; PTHR23167:SF42; EH DOMAIN-BINDING PROTEIN 1-LIKE PROTEIN 1; 1.
DR   Pfam; PF00307; CH; 1.
DR   Pfam; PF10358; NT-C2; 1.
DR   SMART; SM00033; CH; 1.
DR   SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR   PROSITE; PS51840; C2_NT; 1.
DR   PROSITE; PS50021; CH; 1.
PE   1: Evidence at protein level;
KW   Proteomics identification {ECO:0007829|PeptideAtlas:A0A0U1RQH4,
KW   ECO:0007829|ProteomicsDB:A0A0U1RQH4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT   DOMAIN          8..157
FT                   /note="C2 NT-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51840"
FT   DOMAIN          266..371
FT                   /note="Calponin-homology (CH)"
FT                   /evidence="ECO:0000259|PROSITE:PS50021"
FT   REGION          179..265
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          389..467
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        223..241
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        450..467
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         467
FT                   /evidence="ECO:0000313|Ensembl:ENSP00000489002.1"
SQ   SEQUENCE   467 AA;  50868 MW;  F13C21BF197580E9 CRC64;
     MTSVWKRLQR VGKRAAKFQF VACYHELVLE CTKKWQPDKL VVVWTRRNRR ICSKAHSWQP
     GIQNPYRGTV VWMVPENVDI SVTLYRDPHV DQYEAKEWTF IIENESKGQR KVLATAEVDL
     ARHAGPVPVQ VPVRLRLKPK SVKVVQAELS LTLSGVLLRE GRATDDDMQS LASLMSVKPS
     DVGNLDDFAE SDEDEAHGPG APEARARVPQ PGRGGALRPG RFPDPSRELK TLCEEEEEGQ
     GRPQQAVASP SNAEDTSPAP APPALVSSSQ SLLEWCQEVT TGYRGVRITN FTTSWRNGLA
     FCAILHRFYP DKIDYASLDP LNIKQNNKQA FDGFAALGVS RLLEPADMVL LSVPDKLIVM
     TYLCQIRAFC TGQELQLVQL EGGGGAGTYR VGSAQPSPPD DLDAGGLAQR LRGHGAEGPQ
     EPKEAADRAD GAAPGVASRN AVAGRASKDG GAEAPRESRP AEVPAEG
//