ID A0A0T7ZU50_STREE Unreviewed; 480 AA. AC A0A0T7ZU50; DT 17-FEB-2016, integrated into UniProtKB/TrEMBL. DT 17-FEB-2016, sequence version 1. DT 19-JAN-2022, entry version 29. DE SubName: Full=Peptidoglycan N-acetylglucosamine deacetylase A {ECO:0000313|EMBL:VMC88943.1}; GN Name=pgdA {ECO:0000313|EMBL:VMC88943.1}; GN ORFNames=ERS021431_01220 {ECO:0000313|EMBL:CJB29700.1}, GN SAMEA2627268_00726 {ECO:0000313|EMBL:VMC88943.1}; OS Streptococcus pneumoniae. OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; OC Streptococcus. OX NCBI_TaxID=1313 {ECO:0000313|EMBL:VMC88943.1, ECO:0000313|Proteomes:UP000311381}; RN [1] {ECO:0000313|EMBL:VMC88943.1, ECO:0000313|Proteomes:UP000311381} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=GPSC47 {ECO:0000313|EMBL:VMC88943.1, RC ECO:0000313|Proteomes:UP000311381}, and SMRU1921 RC {ECO:0000313|EMBL:CJB29700.1, ECO:0000313|Proteomes:UP000047077}; RG Pathogen Informatics; RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CGYF01000015; CJB29700.1; -; Genomic_DNA. DR EMBL; CAAQRO010000003; VMC88943.1; -; Genomic_DNA. DR EnsemblBacteria; CGF81080; CGF81080; ERS020491_01357. DR Proteomes; UP000047077; Unassembled WGS sequence. DR Proteomes; UP000311381; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0016810; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; IEA:InterPro. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro. DR InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl. DR InterPro; IPR002509; NODB_dom. DR InterPro; IPR017219; Peptidoglycan_deacetylase. DR InterPro; IPR040802; PgdA_N. DR Pfam; PF18627; PgdA_N; 1. DR Pfam; PF01522; Polysacc_deac_1; 1. DR PIRSF; PIRSF037479; PG_GlcNAc_deacetylase; 1. DR SUPFAM; SSF88713; SSF88713; 1. DR PROSITE; PS51677; NODB; 1. PE 4: Predicted; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, KW ECO:0000256|PIRSR:PIRSR037479-3}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; Zinc {ECO:0000256|PIRSR:PIRSR037479-3}. FT TRANSMEM 34..55 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 285..459 FT /note="NodB homology" FT /evidence="ECO:0000259|PROSITE:PS51677" FT COILED 60..80 FT /evidence="ECO:0000256|SAM:Coils" FT ACT_SITE 292 FT /note="Proton acceptor" FT /evidence="ECO:0000256|PIRSR:PIRSR037479-1" FT ACT_SITE 434 FT /note="Proton donor" FT /evidence="ECO:0000256|PIRSR:PIRSR037479-1" FT METAL 293 FT /note="Zinc" FT /evidence="ECO:0000256|PIRSR:PIRSR037479-3" FT METAL 343 FT /note="Zinc; via tele nitrogen" FT /evidence="ECO:0000256|PIRSR:PIRSR037479-3" FT METAL 347 FT /note="Zinc; via tele nitrogen" FT /evidence="ECO:0000256|PIRSR:PIRSR037479-3" FT BINDING 384 FT /note="Substrate; via amide nitrogen" FT /evidence="ECO:0000256|PIRSR:PIRSR037479-2" FT SITE 408 FT /note="Raises pKa of active site His" FT /evidence="ECO:0000256|PIRSR:PIRSR037479-4" SQ SEQUENCE 480 AA; 54612 MW; A56912FCE3416B94 CRC64; MPNCIIEIIA QICYDINMNK SRLGRGRHGK TRHVLLALIG ILAISICLLG GFIAFKIYQQ KSFEQKIESL KKEKDDQLSE GNQKEHFRQG QAEVIAYYPL QGEKVISSVR ELINQDVKDK LESKDNLVFY YTEKEESGLK GVVNRNVTKQ IYDLVAFKIE ETEKTSLGKV HLTEDGQPFT LDQLFSDASK AKEQLIKELT SFIEDKKIEQ DQSEQIVKSF SDQDLSAWNF DYKDSQIILY PSSVVENLEE IALPVSAFFD VIQSSYLLEK DAALYQSYFD KKYQKVVALT FDDGPNPATT PQVLETLAKY DIKATFFVLG KNVSGNEDLV KRIKSEGHVV GNHSWSHPIL SQLSLDEAKK QITDTEDVLT KVLGSSSKLM RPPYGAITDD IRNSLDLSFI MWDVDSLDWK SKNEASILTE IQHQVANGSI VLMHDIHSPT VNALPRVIEY LKNQGYTFVT IPEMLNTRLK AHELYYSRDE //