ID A0A0T7ZU50_STREE Unreviewed; 480 AA. AC A0A0T7ZU50; DT 17-FEB-2016, integrated into UniProtKB/TrEMBL. DT 17-FEB-2016, sequence version 1. DT 12-AUG-2020, entry version 24. DE SubName: Full=Peptidoglycan N-acetylglucosamine deacetylase A {ECO:0000313|EMBL:VMC88943.1}; GN Name=pgdA {ECO:0000313|EMBL:VMC88943.1}; GN Synonyms=pgdA_2 {ECO:0000313|EMBL:COM70805.1}; GN ORFNames=ERS020671_00916 {ECO:0000313|EMBL:COM70805.1}, GN ERS021431_01220 {ECO:0000313|EMBL:CJB29700.1}, ERS021752_00975 GN {ECO:0000313|EMBL:CKA93506.1}, ERS022641_00504 GN {ECO:0000313|EMBL:CKC52364.1}, ERS232442_01269 GN {ECO:0000313|EMBL:CKD47668.1}, ERS232469_01613 GN {ECO:0000313|EMBL:CKE30575.1}, ERS232512_02119 GN {ECO:0000313|EMBL:CKF15475.1}, SAMEA104035805_01189 GN {ECO:0000313|EMBL:VRL31247.1}, SAMEA2066126_01611 GN {ECO:0000313|EMBL:VJZ16407.1}, SAMEA2627268_00726 GN {ECO:0000313|EMBL:VMC88943.1}, SAMEA3431359_01465 GN {ECO:0000313|EMBL:VQW79987.1}, SAMEA3447943_00984 GN {ECO:0000313|EMBL:VPQ10528.1}, SAMEA4707892_02121 GN {ECO:0000313|EMBL:VPB50019.1}; OS Streptococcus pneumoniae. OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; OC Streptococcus. OX NCBI_TaxID=1313 {ECO:0000313|EMBL:VMC88943.1, ECO:0000313|Proteomes:UP000311381}; RN [1] {ECO:0000313|Proteomes:UP000311381, ECO:0000313|Proteomes:UP000329263, ECO:0000313|Proteomes:UP000338361} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=6A {ECO:0000313|EMBL:CKD47668.1, RC ECO:0000313|Proteomes:UP000044715}, 6B RC {ECO:0000313|Proteomes:UP000039618, RC ECO:0000313|Proteomes:UP000043523}, GPSC47 RC {ECO:0000313|Proteomes:UP000311381, RC ECO:0000313|Proteomes:UP000329263}, SMRU1161 RC {ECO:0000313|EMBL:COM70805.1, ECO:0000313|Proteomes:UP000040630}, RC SMRU1921 {ECO:0000313|EMBL:CJB29700.1, RC ECO:0000313|Proteomes:UP000047077}, SMRU2243 RC {ECO:0000313|EMBL:CKA93506.1, ECO:0000313|Proteomes:UP000039092}, and RC SMRU3131 {ECO:0000313|EMBL:CKC52364.1, RC ECO:0000313|Proteomes:UP000038050}; RG Pathogen Informatics; RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CGYF01000015; CJB29700.1; -; Genomic_DNA. DR EMBL; CMJU01000010; CKA93506.1; -; Genomic_DNA. DR EMBL; CMMK01000004; CKC52364.1; -; Genomic_DNA. DR EMBL; CMNT01000016; CKD47668.1; -; Genomic_DNA. DR EMBL; CMOX01000023; CKE30575.1; -; Genomic_DNA. DR EMBL; CMQE01000034; CKF15475.1; -; Genomic_DNA. DR EMBL; CROO01000011; COM70805.1; -; Genomic_DNA. DR EMBL; CAAMXR010000012; VJZ16407.1; -; Genomic_DNA. DR EMBL; CAAQRO010000003; VMC88943.1; -; Genomic_DNA. DR EMBL; CAAVXM010000020; VPB50019.1; -; Genomic_DNA. DR EMBL; CAAWYK010000004; VPQ10528.1; -; Genomic_DNA. DR EMBL; CAAZGS010000009; VQW79987.1; -; Genomic_DNA. DR EMBL; CABAHI010000007; VRL31247.1; -; Genomic_DNA. DR EnsemblBacteria; CGF00895; CGF00895; ERS019473_01275. DR EnsemblBacteria; CGF81080; CGF81080; ERS020491_01357. DR EnsemblBacteria; CJK00657; CJK00657; ERS022016_00034. DR EnsemblBacteria; CJY55639; CJY55639; ERS022329_01714. DR EnsemblBacteria; CKD47668; CKD47668; ERS232442_01269. DR EnsemblBacteria; CKF15475; CKF15475; ERS232512_02119. DR Proteomes; UP000038050; Unassembled WGS sequence. DR Proteomes; UP000039092; Unassembled WGS sequence. DR Proteomes; UP000039618; Unassembled WGS sequence. DR Proteomes; UP000040630; Unassembled WGS sequence. DR Proteomes; UP000043523; Unassembled WGS sequence. DR Proteomes; UP000044715; Unassembled WGS sequence. DR Proteomes; UP000047077; Unassembled WGS sequence. DR Proteomes; UP000311381; Unassembled WGS sequence. DR Proteomes; UP000329263; Unassembled WGS sequence. DR Proteomes; UP000338361; Unassembled WGS sequence. DR Proteomes; UP000360883; Unassembled WGS sequence. DR Proteomes; UP000364527; Unassembled WGS sequence. DR Proteomes; UP000372118; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0016810; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; IEA:InterPro. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro. DR InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl. DR InterPro; IPR002509; NODB_dom. DR InterPro; IPR017219; Peptidoglycan_deacetylase. DR InterPro; IPR040802; PgdA_N. DR Pfam; PF18627; PgdA_N; 1. DR Pfam; PF01522; Polysacc_deac_1; 1. DR PIRSF; PIRSF037479; PG_GlcNAc_deacetylase; 1. DR SUPFAM; SSF88713; SSF88713; 1. DR PROSITE; PS51677; NODB; 1. PE 4: Predicted; KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius}; KW Metal-binding {ECO:0000256|PIRSR:PIRSR037479-3}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}; KW Zinc {ECO:0000256|PIRSR:PIRSR037479-3}. FT TRANSMEM 34..55 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 285..459 FT /note="NodB homology" FT /evidence="ECO:0000259|PROSITE:PS51677" FT COILED 60..80 FT /evidence="ECO:0000256|SAM:Coils" FT ACT_SITE 292 FT /note="Proton acceptor" FT /evidence="ECO:0000256|PIRSR:PIRSR037479-1" FT ACT_SITE 434 FT /note="Proton donor" FT /evidence="ECO:0000256|PIRSR:PIRSR037479-1" FT METAL 293 FT /note="Zinc" FT /evidence="ECO:0000256|PIRSR:PIRSR037479-3" FT METAL 343 FT /note="Zinc; via tele nitrogen" FT /evidence="ECO:0000256|PIRSR:PIRSR037479-3" FT METAL 347 FT /note="Zinc; via tele nitrogen" FT /evidence="ECO:0000256|PIRSR:PIRSR037479-3" FT BINDING 384 FT /note="Substrate; via amide nitrogen" FT /evidence="ECO:0000256|PIRSR:PIRSR037479-2" FT SITE 408 FT /note="Raises pKa of active site His" FT /evidence="ECO:0000256|PIRSR:PIRSR037479-4" SQ SEQUENCE 480 AA; 54612 MW; A56912FCE3416B94 CRC64; MPNCIIEIIA QICYDINMNK SRLGRGRHGK TRHVLLALIG ILAISICLLG GFIAFKIYQQ KSFEQKIESL KKEKDDQLSE GNQKEHFRQG QAEVIAYYPL QGEKVISSVR ELINQDVKDK LESKDNLVFY YTEKEESGLK GVVNRNVTKQ IYDLVAFKIE ETEKTSLGKV HLTEDGQPFT LDQLFSDASK AKEQLIKELT SFIEDKKIEQ DQSEQIVKSF SDQDLSAWNF DYKDSQIILY PSSVVENLEE IALPVSAFFD VIQSSYLLEK DAALYQSYFD KKYQKVVALT FDDGPNPATT PQVLETLAKY DIKATFFVLG KNVSGNEDLV KRIKSEGHVV GNHSWSHPIL SQLSLDEAKK QITDTEDVLT KVLGSSSKLM RPPYGAITDD IRNSLDLSFI MWDVDSLDWK SKNEASILTE IQHQVANGSI VLMHDIHSPT VNALPRVIEY LKNQGYTFVT IPEMLNTRLK AHELYYSRDE //