ID A0A0T7ZU50_STREE Unreviewed; 480 AA. AC A0A0T7ZU50; DT 17-FEB-2016, integrated into UniProtKB/TrEMBL. DT 17-FEB-2016, sequence version 1. DT 07-JUN-2017, entry version 13. DE SubName: Full=Peptidoglycan N-acetylglucosamine deacetylase A {ECO:0000313|EMBL:CGF81080.1}; GN Name=pgdA {ECO:0000313|EMBL:CGF81080.1}; GN ORFNames=ERS020491_01357 {ECO:0000313|EMBL:CGF81080.1}; OS Streptococcus pneumoniae. OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; OC Streptococcus. OX NCBI_TaxID=1313 {ECO:0000313|EMBL:CGF81080.1, ECO:0000313|Proteomes:UP000047188}; RN [1] {ECO:0000313|EMBL:CGF81080.1, ECO:0000313|Proteomes:UP000047188} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=SMRU981 {ECO:0000313|EMBL:CGF81080.1, RC ECO:0000313|Proteomes:UP000047188}; RA Murphy D.; RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CHOW01000015; CGF81080.1; -; Genomic_DNA. DR EnsemblBacteria; CGF00895; CGF00895; ERS019473_01275. DR EnsemblBacteria; CGF81080; CGF81080; ERS020491_01357. DR EnsemblBacteria; CJK00657; CJK00657; ERS022016_00034. DR EnsemblBacteria; CJY55639; CJY55639; ERS022329_01714. DR EnsemblBacteria; CKD47668; CKD47668; ERS232442_01269. DR EnsemblBacteria; CKF15475; CKF15475; ERS232512_02119. DR Proteomes; UP000047188; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0016810; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; IEA:InterPro. DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro. DR InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl. DR InterPro; IPR002509; NODB_dom. DR InterPro; IPR017219; Peptidoglycan_deacetylase. DR Pfam; PF01522; Polysacc_deac_1; 1. DR PIRSF; PIRSF037479; PG_GlcNAc_deacetylase; 1. DR SUPFAM; SSF88713; SSF88713; 1. DR PROSITE; PS51677; NODB; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000047188}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Metal-binding {ECO:0000256|PIRSR:PIRSR037479-3}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}; KW Zinc {ECO:0000256|PIRSR:PIRSR037479-3}. FT TRANSMEM 34 55 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 285 459 NodB homology. {ECO:0000259|PROSITE: FT PS51677}. FT ACT_SITE 292 292 Proton acceptor. {ECO:0000256|PIRSR: FT PIRSR037479-1}. FT ACT_SITE 434 434 Proton donor. {ECO:0000256|PIRSR: FT PIRSR037479-1}. FT METAL 293 293 Zinc. {ECO:0000256|PIRSR:PIRSR037479-3}. FT METAL 343 343 Zinc; via tele nitrogen. FT {ECO:0000256|PIRSR:PIRSR037479-3}. FT METAL 347 347 Zinc; via tele nitrogen. FT {ECO:0000256|PIRSR:PIRSR037479-3}. FT BINDING 384 384 Substrate; via amide nitrogen. FT {ECO:0000256|PIRSR:PIRSR037479-2}. FT SITE 408 408 Raises pKa of active site His. FT {ECO:0000256|PIRSR:PIRSR037479-4}. SQ SEQUENCE 480 AA; 54612 MW; A56912FCE3416B94 CRC64; MPNCIIEIIA QICYDINMNK SRLGRGRHGK TRHVLLALIG ILAISICLLG GFIAFKIYQQ KSFEQKIESL KKEKDDQLSE GNQKEHFRQG QAEVIAYYPL QGEKVISSVR ELINQDVKDK LESKDNLVFY YTEKEESGLK GVVNRNVTKQ IYDLVAFKIE ETEKTSLGKV HLTEDGQPFT LDQLFSDASK AKEQLIKELT SFIEDKKIEQ DQSEQIVKSF SDQDLSAWNF DYKDSQIILY PSSVVENLEE IALPVSAFFD VIQSSYLLEK DAALYQSYFD KKYQKVVALT FDDGPNPATT PQVLETLAKY DIKATFFVLG KNVSGNEDLV KRIKSEGHVV GNHSWSHPIL SQLSLDEAKK QITDTEDVLT KVLGSSSKLM RPPYGAITDD IRNSLDLSFI MWDVDSLDWK SKNEASILTE IQHQVANGSI VLMHDIHSPT VNALPRVIEY LKNQGYTFVT IPEMLNTRLK AHELYYSRDE //