ID A0A0S7HS46_9TELE Unreviewed; 245 AA. AC A0A0S7HS46; DT 17-FEB-2016, integrated into UniProtKB/TrEMBL. DT 17-FEB-2016, sequence version 1. DT 27-MAR-2024, entry version 12. DE RecName: Full=Macrophage-expressed gene 1 protein {ECO:0000256|ARBA:ARBA00021365}; DE AltName: Full=Perforin-2 {ECO:0000256|ARBA:ARBA00030728}; DE Flags: Fragment; GN Name=MPEG1 {ECO:0000313|EMBL:JAO43856.1}; OS Poeciliopsis prolifica (blackstripe livebearer). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae; OC Poeciliopsis. OX NCBI_TaxID=188132 {ECO:0000313|EMBL:JAO43856.1}; RN [1] {ECO:0000313|EMBL:JAO43856.1} RP NUCLEOTIDE SEQUENCE. RA Jue N.K., Foley R.J., Obergfell C., Reznick D.N., O'Neill R.J., RA O'Neill M.J.; RT "Parallel Evolution in Life History Adaptation Evident in the Tissue- RT Specific Poeciliopsis prolifica transcriptome."; RL Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane CC {ECO:0000256|ARBA:ARBA00004439}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004439}. Cytoplasmic vesicle, phagosome CC membrane {ECO:0000256|ARBA:ARBA00004265}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004265}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the MPEG1 family. CC {ECO:0000256|ARBA:ARBA00007256}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; GBYX01437493; JAO43856.1; -; Transcribed_RNA. DR AlphaFoldDB; A0A0S7HS46; -. DR GO; GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell. DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW. DR InterPro; IPR020864; MACPF. DR InterPro; IPR039707; MPEG1. DR PANTHER; PTHR31463; MACROPHAGE-EXPRESSED GENE 1 PROTEIN; 1. DR PANTHER; PTHR31463:SF4; MACROPHAGE-EXPRESSED GENE 1 PROTEIN; 1. DR Pfam; PF01823; MACPF; 1. DR PROSITE; PS51412; MACPF_2; 1. PE 3: Inferred from homology; KW Adaptive immunity {ECO:0000256|ARBA:ARBA00023130}; KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Immunity {ECO:0000256|ARBA:ARBA00023130}; KW Membrane {ECO:0000256|ARBA:ARBA00022989}; KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692}; KW Transmembrane beta strand {ECO:0000256|ARBA:ARBA00022452}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}; KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}. FT SIGNAL 1..20 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 21..245 FT /note="Macrophage-expressed gene 1 protein" FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5006636680" FT DOMAIN 29..245 FT /note="MACPF" FT /evidence="ECO:0000259|PROSITE:PS51412" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:JAO43856.1" SQ SEQUENCE 245 AA; 27122 MW; 7F5BC823915E59DD CRC64; IMKSALTVLA ALTFFQVCCS GPVSRPTNWL RQCRASTNIS LTALEVLPGG GWDNLRNLDM GRVMNLSYFQ CQTTEDGLYL IPDEVFVIPQ KETGVETNSE IISSWLEQKS TTSHSINADA SFFSVLNGKF SSENTRMKSH QVKDSSTTAR VQVRNFIYTV KAYPDFTLDS RFSQQVKDIA DAIANNQTRN ADYLSEKMVL DYGTHVITSV DAGASLVQED YLRSTYVSDS SSDTSTVKAQ AGLNF //