ID A0A0S7H7A3_9TELE Unreviewed; 237 AA. AC A0A0S7H7A3; DT 17-FEB-2016, integrated into UniProtKB/TrEMBL. DT 17-FEB-2016, sequence version 1. DT 03-AUG-2022, entry version 12. DE RecName: Full=Insulin-induced gene protein {ECO:0000256|RuleBase:RU241113}; GN Name=INSI2 {ECO:0000313|EMBL:JAO36881.1}; OS Poeciliopsis prolifica (blackstripe livebearer). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae; OC Poeciliopsis. OX NCBI_TaxID=188132 {ECO:0000313|EMBL:JAO36881.1}; RN [1] {ECO:0000313|EMBL:JAO36881.1} RP NUCLEOTIDE SEQUENCE. RA Jue N.K., Foley R.J., Obergfell C., Reznick D.N., O'Neill R.J., RA O'Neill M.J.; RT "Parallel Evolution in Life History Adaptation Evident in the Tissue- RT Specific Poeciliopsis prolifica transcriptome."; RL Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Mediates feedback control of cholesterol synthesis. CC {ECO:0000256|RuleBase:RU241113}. CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane CC {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU241113}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004477, CC ECO:0000256|RuleBase:RU241113}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the INSIG family. CC {ECO:0000256|ARBA:ARBA00007475, ECO:0000256|RuleBase:RU241113}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; GBYX01444538; JAO36881.1; -; Transcribed_RNA. DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW. DR InterPro; IPR025929; INSIG_fam. DR PANTHER; PTHR15301; PTHR15301; 1. DR Pfam; PF07281; INSIG; 1. PE 3: Inferred from homology; KW Cholesterol metabolism {ECO:0000256|ARBA:ARBA00022548, KW ECO:0000256|RuleBase:RU241113}; KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824, KW ECO:0000256|RuleBase:RU241113}; KW Lipid metabolism {ECO:0000256|RuleBase:RU241113}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU241113}; KW Steroid metabolism {ECO:0000256|ARBA:ARBA00023221, KW ECO:0000256|RuleBase:RU241113}; KW Sterol metabolism {ECO:0000256|ARBA:ARBA00023166}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU241113}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|RuleBase:RU241113}. FT TRANSMEM 40..61 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU241113" FT TRANSMEM 81..100 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU241113" FT TRANSMEM 143..160 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU241113" FT TRANSMEM 167..186 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU241113" FT TRANSMEM 198..218 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU241113" FT REGION 1..23 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 237 AA; 26612 MW; F5BF8AA65518D50B CRC64; MCATPTTMSS SALTSDQRSE RQHNSRGPYV SFITNRTTNL FIRGGMLFFV GVFLALVLNL LQVQRNVTLF HPDVISSIFS SVWWVPPSCG TASAMIGMLY PCIDRRLGKP HNFKREWSSV MRCVAVFVGI NHASAKVDFA NNVQLSLTLA ALSIGLWWTF DRSRSGFGLG ISIALLATLT TQILVYNGVF QYTNPDFLYI RSWLPCIYFA GVITMGNIGR QLALYEYKFL QEKTHLD //