ID A0A0S7GF40_9TELE Unreviewed; 936 AA. AC A0A0S7GF40; DT 17-FEB-2016, integrated into UniProtKB/TrEMBL. DT 17-FEB-2016, sequence version 1. DT 13-SEP-2023, entry version 23. DE SubName: Full=PKHH1 {ECO:0000313|EMBL:JAO26811.1}; GN Name=PKHH1 {ECO:0000313|EMBL:JAO26811.1}; OS Poeciliopsis prolifica (blackstripe livebearer). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae; OC Poeciliopsis. OX NCBI_TaxID=188132 {ECO:0000313|EMBL:JAO26811.1}; RN [1] {ECO:0000313|EMBL:JAO26811.1} RP NUCLEOTIDE SEQUENCE. RA Jue N.K., Foley R.J., Obergfell C., Reznick D.N., O'Neill R.J., RA O'Neill M.J.; RT "Parallel Evolution in Life History Adaptation Evident in the Tissue- RT Specific Poeciliopsis prolifica transcriptome."; RL Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; GBYX01454710; JAO26811.1; -; Transcribed_RNA. DR EMBL; GBYX01454708; JAO26813.1; -; Transcribed_RNA. DR AlphaFoldDB; A0A0S7GF40; -. DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro. DR CDD; cd14473; FERM_B-lobe; 1. DR CDD; cd13282; PH1_PLEKHH1_PLEKHH2; 1. DR Gene3D; 1.20.80.10; -; 1. DR Gene3D; 1.25.40.530; MyTH4 domain; 1. DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3. DR InterPro; IPR019749; Band_41_domain. DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf. DR InterPro; IPR035963; FERM_2. DR InterPro; IPR019748; FERM_central. DR InterPro; IPR000299; FERM_domain. DR InterPro; IPR000857; MyTH4_dom. DR InterPro; IPR038185; MyTH4_dom_sf. DR InterPro; IPR011993; PH-like_dom_sf. DR InterPro; IPR001849; PH_domain. DR InterPro; IPR029071; Ubiquitin-like_domsf. DR PANTHER; PTHR22903:SF4; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY H MEMBER 1; 1. DR PANTHER; PTHR22903; PLEKHH PROTEIN; 1. DR Pfam; PF00373; FERM_M; 1. DR Pfam; PF00784; MyTH4; 1. DR Pfam; PF00169; PH; 1. DR SMART; SM00295; B41; 1. DR SMART; SM00139; MyTH4; 1. DR SMART; SM00233; PH; 2. DR SUPFAM; SSF50729; PH domain-like; 2. DR SUPFAM; SSF47031; Second domain of FERM; 1. DR SUPFAM; SSF54236; Ubiquitin-like; 1. DR PROSITE; PS50057; FERM_3; 1. DR PROSITE; PS51016; MYTH4; 1. DR PROSITE; PS50003; PH_DOMAIN; 2. PE 4: Predicted; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1..16 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 17..936 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5007431892" FT DOMAIN 156..250 FT /note="PH" FT /evidence="ECO:0000259|PROSITE:PS50003" FT DOMAIN 264..372 FT /note="PH" FT /evidence="ECO:0000259|PROSITE:PS50003" FT DOMAIN 409..563 FT /note="MyTH4" FT /evidence="ECO:0000259|PROSITE:PS51016" FT DOMAIN 574..905 FT /note="FERM" FT /evidence="ECO:0000259|PROSITE:PS50057" FT REGION 126..152 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 936 AA; 105741 MW; 45457E6DDF5D0BE9 CRC64; MRRVLRGFML ILPAVSFFRS LIKLCNVSGS SLPQYPASGP FTQLIYKNIN VPVYTTLKGK ATQISTVPLP DDDSGSEDDS SSLASLRTSI WSPERKGSVP GSPRAVKRGV SMSSISSESD YAIPPDAYSL DSDYSEPEHK VQRTSSYSCE STGPETMEKS GYLLKMGSQV KAWKRRWFVL RNGEILYYKS PSDVIRKPQG QIELNSSCCI VRGEGAQTFQ LITEKKTFYL AADSPNILEE WIRVLQNILK VRSSSPVIVE TRAKPTVRGW LTKVKHGHSK LVWCSLVGKV FYYFRNQEDK LPLGQLQMRE ASVQEVDRSC DSDEDYEAGD RGFLSSHCTL VVQPKDQSPT YLLIGTKQEK DTWLYHLNVA AGSSATLKVG TECEQLIGKL MDVEGDPESV LWKSETLSFC KEGLRSPLTT LPSEALQTEA LKLFKSCQLF INVLVESPSV DYHTSLAQNA LQVCLTHPEL QNEMYCQLIK QTNRRTPHNY SLTQCWQLLS LCVALFLPQQ HFLWYLRQYL QHNADPRTEV GKYAIYCQRS LERTLQNGER EAKPSRMEIV SILLRNPYHH SLPFSIPVHF MNNTYQVVGF DGSTTVDEFL STLNQRIGMR KPHLTGFALF TDDPSGKDLE HCLQPSAKIC DVISKWEQTL KELHPGKNEG TRIVRLTYKN RLCFRSQVKG ETEQERLLLV YQVNDDVQQG LFPVNKELAL EVAALIAQVE HGDFERSGVA SPAGSPQSKS QLILLQALER FYPKRYKQEC TAEQLRDLTE RLASKWSMLR GCNAAECVRI YLTVARKWPL FGAKLFSAKP VPPSPVDQSQ VWLAVSEDGL CVLDGTMHTL FMYPYHSVIT FGGCRDDFMV VTSQQRESGI GKKNVEKLVF AMTKPKILEL TLLMASYINH WNPSVPSASH QPLGHWDVDS RHFPAMNYTT KGPTLL //